scholarly journals Angiostrongylus costaricensis infection in Martinique, Lesser Antilles, from 2000 to 2017

Parasite ◽  
2018 ◽  
Vol 25 ◽  
pp. 22 ◽  
Author(s):  
Céline Dard ◽  
Duc Nguyen ◽  
Charline Miossec ◽  
Katia de Meuron ◽  
Dorothée Harrois ◽  
...  
Keyword(s):  
Descriptive Analysis ◽  
Case Series ◽  
Epidemiological Studies ◽  
Human Infection ◽  
University Hospital ◽  
Medical Community ◽  
Diagnostic Tools ◽  
Intestinal Lesions ◽  
Life Threatening ◽  
The University

Human abdominal angiostrongyliasis (HAA) is a parasitic disease caused by the accidental ingestion of the nematode Angiostrongylus costaricensis in its larval form. Human infection can lead to severe ischemic and inflammatory intestinal lesions, sometimes complicated by life-threatening ileal perforations. Only one case had been reported in Martinique, an Island in the French Antilles, in 1988. We retrospectively reviewed the medical charts of patients diagnosed with abdominal angiostrongyliasis at the University Hospital of Martinique between 2000 and 2017. The objectives of this study were to evaluate the incidence and perform a descriptive analysis of the clinical, biological, radiological, and histopathological features of HAA in Martinique. Two confirmed cases and two probable cases were identified in patients aged from 1 to 21 years during the 18-year period, with an estimated incidence of 0.2 cases per year (0.003 case/year/100.000 inhabitants (IC95% = 0.00–0.05)). All patients presented with abdominal pain associated with high blood eosinophilia (median: 7.24 G/L [min 4.25; max 52.28 G/L]). Two developed ileal perforation and were managed by surgery, with diagnostic confirmation based on histopathological findings on surgical specimens. The other two cases were probable, with serum specimens reactive to Angiostrongylus sp. antigen in the absence of surgery. All cases improved without sequelae. The description of this case series highlights the need to increase awareness of this life-threatening disease in the medical community and to facilitate access to specific diagnostic tools in Martinique. Environmental and epidemiological studies are needed to broaden our knowledge of the burden of this disease.

scholarly journals Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study

2021 ◽  
Vol 18 (21) ◽  
pp. 11534
Author(s):  
Stefano Sartini ◽  
Laura Massobrio ◽  
Ombretta Cutuli ◽  
Paola Campodonico ◽  
Cristina Bernini ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Adverse Outcome ◽  
University Hospital ◽  
Rt Pcr ◽  
Threatening Condition ◽  
Life Threatening ◽  
Group A ◽  
Group B ◽  
The University

COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive for SARS-CoV-2. PaO2, PaO2/FiO2 and SatO2% were collected and analyzed at time 0 and in case of admission, patients who required or not C-PAP (groups A and B) were categorized. Each measurement was correlated to adverse outcome. A total of 483 patients were enrolled, and 369 were admitted to hospital. Of these, 153 required C-PAP and 266 had an adverse outcome. Patients with PaO2 <60 and >100 had a higher rate of adverse outcome at time 0, in groups A and B (OR 2.52, 3.45, 2.01, respectively). About the PaO2/FiO2 ratio, the OR for < 300 was 3.10 at time 0, 4.01 in group A and 4.79 in group B. Similar odds were found for < 200 in any groups and < 100 except for group B (OR 11.57). SatO2 < 94% showed OR 1.34, 3.52 and 19.12 at time 0, in groups A and B, respectively. PaO2 < 60 and >100, SatO2 < 94% and PaO2/FiO2 ratio < 300 showed at least two- to three-fold correlation to adverse outcome. This may provide simple but clear targets for clinicians facing COVID-19 respiratory failure in a non ICU-setting.

Fetal Profile Markers for the Detection of Robin Sequence in Fetuses with Retrognathia

2021 ◽  
Author(s):  
Cornelia Wiechers ◽  
Christian Poets ◽  
Markus Hoopmann ◽  
Karl Oliver Kagan
Keyword(s):  
Normal Population ◽  
False Positive Rate ◽  
University Hospital ◽  
Robin Sequence ◽  
Profile Line ◽  
Positive Rate ◽  
Life Threatening ◽  
Matched Case ◽  
The University ◽  
Control Study

Abstract Objective To determine whether the prefrontal space ratio (PSFR), inferior facial (IFA) and maxilla-nasion-mandible angle (MNM), and the fetal profile line (FPL) are helpful in identifying fetuses with Robin sequence (RS) in cases with isolated retrognathia, and thus better predict the likelihood of immediate need for postnatal respiratory support. Methods This was a retrospective matched case-control study of fetuses/infants with isolated retrognathia with or without RS receiving pre- and postnatal treatment at the University Hospital of Tübingen, Germany between 2008 and 2020. The PFSR, IFA, MNM, and FPL were measured in affected and normal fetuses according to standardized protocols. Cases were stratified into isolated retrognathia and RS. Results 21 (n=7 isolated retrognathia, n=14 RS) affected fetuses and 252 normal fetuses were included. Their median gestational age at ultrasound examination was 23.6 and 24.1 weeks, respectively. In fetuses with isolated retrognathia and RS, the PSFR, IFA, and FPL were significantly different from the normal population. At a false-positive rate of 5%, the detection rate was 76.2% for the PFSR, 85.7% for the IFA, and 90.5% for both parameters combined. However, all parameters failed to distinguish between isolated retrognathia and RS. Conclusion PSFR and IFA are simple markers for identifying retrognathia prenatally. However, they are not helpful for the detection of RS in fetuses with isolated retrognathia. Therefore, delivery should take place in a center experienced with RS and potentially life-threatening airway obstruction immediately after birth.

Spectrum of conjunctival tumours in a Spanish series: A review of 462 cases

2019 ◽  
Vol 30 (6) ◽  
pp. 1403-1409
Author(s):  
Luis García Onrubia ◽  
Gabriela Estefanía Pacheco-Callirgos ◽  
Alejandro Portero-Benito ◽  
Ciro García-Álvarez ◽  
Ester Carreño Salas ◽  
...  
Keyword(s):  
Precancerous Lesions ◽  
Case Series ◽  
University Hospital ◽  
Malignant Tumours ◽  
Benign Lesions ◽  
Routine Examination ◽  
Retrospective Case ◽  
Main Complaint ◽  
Oncology Unit ◽  
The University

Introduction: To report the spectrum and frequency of conjunctiva tumours in an ocular oncology unit analysing the clinical profile of benign, precancerous and malignant conjunctival lesions. Methods: A retrospective case series of 462 consecutive patients diagnosed at the Ocular Oncology Unit of the University Hospital of Valladolid from 1992 to 2017. Results: Among 462 consecutive patients, the tumour was classified as melanocytic in 252 (54.5%) and non-melanocytic in 210 (45.5). Two hundred forty-eight males (mean age 51.63 (SD = 23.20)) and 214 females (mean age 48.27 (SD = 21.77)) were included. Mean patient age at diagnosis was 50.07 years (range = 1-92 years). The majority of tumours were benign (n = 307 (66.5%)) followed by precancerous (n = 103 (22.3%)) and finally by malignant ones (n = 52 (11.3%)). Benign lesions were predominantly found in younger individuals rather than premalignant (p < 0.05) and malignant ones (p < 0.05). Most of the melanocytic lesions were benign (88.5%), most epithelial ones were precancerous (61.4%) and most lymphoid lesions were malignant (56.3%). Tumours involving one or four quadrants of the ocular surface usually were benign, unlike tumours involving three quadrants that were malignant (16 (48.5%) p < 0.05). The majority of benign lesions were detected on females (n = 163 (53.1%)) by routine examination (n = 178 (86.4%)). However, main complaint in malignant tumours was the growth of the lesion (n = 39 (76.5%)). Conclusion: Most of the conjunctival tumours were melanocytic, mostly benign, closely followed by those of epithelial origin, with a predominance of precancerous lesions. Melanocytic, epithelial and lymphoid tumours accounted for over 90% of cases. A trend was identified with benign lesions being found in younger female patients on routine examination.

scholarly journals First cases of Angiostrongylus cantonensis infection reported in Martinique, 2002–2017

Parasite ◽  
2020 ◽  
Vol 27 ◽  
pp. 31 ◽  
Author(s):  
Céline Dard ◽  
Eve Tessier ◽  
Duc Nguyen ◽  
Loïc Epelboin ◽  
Dorothée Harrois ◽  
...  
Keyword(s):  
West Indies ◽  
Human Infection ◽  
Angiostrongylus Cantonensis ◽  
Medical Community ◽  
Parasitic Disease ◽  
Larval Form ◽  
Accidental Ingestion ◽  
Neurological Sequelae ◽  
Caribbean Islands ◽  
Life Threatening

Neuroangiostrongyliasis is a parasitic disease caused by the accidental ingestion of the nematode Angiostrongylus cantonensis in its larval form. Human infection can lead to eosinophilic meningitis, sometimes complicated by life-threatening radiculomyelitis or encephalitis. Although some cases have been reported from other Caribbean Islands, no cases have been diagnosed in Martinique so far. Here, we report the first eight laboratory-confirmed cases of neuroangiostrongyliasis on the island of Martinique, French West Indies, between 1 January 2002 and 31 December 2017. One case was fatal and five resulted in neurological sequelae. The medical community should consider the risk of A. cantonensis infection in patients living in or returning from Martinique.

Odontogenic phlegmon of the mouth floor: a case report

2016 ◽  
Vol 6 (2) ◽  
pp. 0-0
Author(s):  
P. Bortnik ◽  
P. Wieczorek ◽  
P. Załęski ◽  
P. Kosierkiewicz ◽  
A. Siemiątkowski ◽  
...  
Keyword(s):  
Case Report ◽  
Antibiotic Therapy ◽  
Plastic Surgery ◽  
Successful Treatment ◽  
Surgical Intervention ◽  
University Hospital ◽  
Local Complication ◽  
Life Threatening ◽  
Ludwig’S Angina ◽  
The University

Odontogenic phlegmon of the mouth floor—Ludwig's angina (phlegmonae fundi cavi oris seu angina Ludovici)—is a rare, life-threatening, local complication in most cases of odontogenic inflammation. This study presents the case of a patient treated in the Department of Maxillofacial and Plastic Surgery of the University Hospital in Białystok due to phlegmon of the mouth floor resulting from odontogenic inflammation with a dynamic course. Quick diagnostics, surgical intervention as well as antibiotic therapy contributed to its efficient and successful treatment.

scholarly journals Silk Vista Baby Is a Safe and Technically Feasible Flow Diverting Stent for Distal Aneurysm Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Vladimir Gavrilovic ◽  
Annarita Dapoto ◽  
Nicola Marotti ◽  
Andrea Pellegrin ◽  
Alessandro Pauro ◽  
...  
Keyword(s):  
Case Series ◽  
Flow Diverter ◽  
Side Branch ◽  
University Hospital ◽  
Complete Occlusion ◽  
Magnetic Resonance Imaging Mri ◽  
The University ◽  
Santa Maria ◽  
Flow Diverting Stent

Background and Purpose: Flow diverting stents are designed to divert blood flow from the aneurysm sac, allowing for eventual occlusion following endovascular therapy. This case series reports clinical experience using the Silk Vista Baby (SVB, Balt Extrusion, Montmorency, France), a flow diverter (FD) designed to treat intracranial aneurysms in small, distal vessels.Methods: All patients who underwent treatment with SVB at the University Hospital “Santa Maria della Misericordia” of Udine between July 2018 and September 2020 were retrospectively identified. Baseline patient and aneurysm characteristics, intraprocedural technical outcomes, periprocedural complications, modified Rankin Scale (mRS) at discharge, magnetic resonance imaging (MRI) results at 3-month follow-up, and angiographic results at 6-month follow-up were collected.Results: A total of 18 patients (55.6% [10/18] male; mean age 62.6 years, range: 42–77 years) were retrospectively identified, receiving treatment for 22 aneurysms. Most patients were symptomatic (14/18, 77.8%) and approximately half had subarachnoid hemorrhage (10/18, 55.6%). Sufficient aneurysm coverage was achieved in 88.9% (16/18) of patients with a single device. Mortality did not occur (0/18, 0%); adverse device-related events included side branch occlusion (1/18, 5.6%) and in-stent thrombosis (1/18, 5.6%). At discharge, 77.8% (14/18) had an mRS of 0. In most cases, patients showed complete occlusion (10/15, 66.7%) or a small aneurysmal remnant (3/15, 20.0%) upon MRI; upon angiography, most showed complete occlusion (10/13, 76.9%) or only a small aneurysmal remnant (2/13, 15.4%).Conclusion: This case series showed that the SVB FD is safe and feasible to use in patients with aneurysms in small, distal vessels. Additional randomized, prospective studies with larger cohorts are needed for the SVB.

scholarly journals Detect it so you can treat it: a case series and proposed checklist to detect neurotoxicity in checkpoint therapy

2020 ◽  
Author(s):  
Saskia Bolz ◽  
Thivyah Ramakrishnan ◽  
Michael Fleischer ◽  
Elisabeth Livingstone ◽  
Benjamin Stolte ◽  
...  
Keyword(s):  
Adverse Events ◽  
Checkpoint Inhibitor ◽  
Checkpoint Inhibitors ◽  
Case Series ◽  
Transverse Myelitis ◽  
University Hospital ◽  
Life Threatening ◽  
Checkpoint Inhibitor Therapy ◽  
Cancer Types ◽  
Brachial Plexus Neuritis

Abstract Background: Checkpoint inhibitors show impressive and durable responses in various cancer types and provide new avenues for cancer immunotherapy. However, these drugs have a variety of adverse events. Common autoimmune-related adverse effects include fatigue, hepatitis, skin rash, endocrine deficiencies, and colitis. Neurotoxicity has been reported, but its incidence and course remain unclear.Methods: To illustrate the broad spectrum of neurotoxicity, we exemplarily report the neurological adverse events of five patients with melanoma and one patient with differentiated thyroid cancer who received checkpoint inhibitors at Essen University Hospital (Essen, Germany).Results: After treatment with ipilimumab, nivolumab or pembrolizumab, neurotoxic effects included hypophysitis-associated neck pain and headache, Guillain-Barré syndrome, transverse myelitis, acute brachial plexus neuritis, and ocular myasthenia gravis.Conclusions: Checkpoint inhibitor therapy remains a success story; however, neurological immune-related adverse events may cause severe life-threatening conditions. We propose a checklist for the early detection of neurological adverse events during routine clinical treatment to prevent more severe courses of checkpoint inhibitor-induced neurotoxicity.

scholarly journals Cancer Diagnosis of Microscopic Biopsy Images Using a Social Spider Optimisation-Tuned Neural Network

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 11
Author(s):  
Prasanalakshmi Balaji ◽  
Kumarappan Chidambaram
Keyword(s):  
Neural Network ◽  
Performance Metrics ◽  
Disease Diagnosis ◽  
Medical Community ◽  
Diagnostic Tools ◽  
Clinical Cancer Research ◽  
Cancer Disease ◽  
Social Spider ◽  
Life Threatening ◽  
Sensitivity Specificity

One of the most dangerous diseases that threaten people is cancer. If diagnosed in earlier stages, cancer, with its life-threatening consequences, has the possibility of eradication. In addition, accuracy in prediction plays a significant role. Hence, developing a reliable model that contributes much towards the medical community in the early diagnosis of biopsy images with perfect accuracy comes to the forefront. This article aims to develop better predictive models using multivariate data and high-resolution diagnostic tools in clinical cancer research. This paper proposes the social spider optimisation (SSO) algorithm-tuned neural network to classify microscopic biopsy images of cancer. The significance of the proposed model relies on the effective tuning of the weights of the neural network classifier by the SSO algorithm. The performance of the proposed strategy is analysed with performance metrics such as accuracy, sensitivity, specificity, and MCC measures, and the attained results are 95.9181%, 94.2515%, 97.125%, and 97.68%, respectively, which shows the effectiveness of the proposed method for cancer disease diagnosis.

scholarly journals Profile of cases suspected of attempted suicide by exogenous intoxication

2018 ◽  
Vol 9 (2) ◽  
pp. 123
Author(s):  
Fernanda Pamela Machado ◽  
Marcos Hirata Soares ◽  
Patricia Dias Francisquini ◽  
Layla Karina Ferrari Ramos
Keyword(s):  
Medical Records ◽  
Attempted Suicide ◽  
Suicide Attempts ◽  
University Hospital ◽  
Professional Service ◽  
Information Center ◽  
Life Threatening ◽  
Physical Consequences ◽  
The University ◽  
Present Life

Objective: To characterize the profile of patients suspected of attempting suicide, based on cases reported by the Toxicological Information Center of the University hospital of Southern Brazil.Methods: This is a retrospective aggregate study, based on the analysis of medical records and files between January 2009 and December 2012, aiming to collect information that would create the profile of patients suspected of attempting suicide, from the cases notified by the Toxicological Information Center.Results: Regarding the physical consequences and the danger of the suicide attempt, 97% of the suicide attempts did not present life threatening (n = 1,605); 85.4% were not referred to any professional service (n = 1,412). The year 2012 was the year with the highest number of suicide attempts that the other years.Conclusions: It is considered important to improve the notification form for poisoning injuries, to better detect information about suicide attempts.

scholarly journals Severity and pattern of injuries caused by Swiss wrestling (Schwingen): first retrospective study at a level I University Emergency Department in Switzerland

2018 ◽  
Vol 4 (1) ◽  
pp. e000270
Author(s):  
Nikolaos K Maliachovas ◽  
Jolanta Klukowska-Rötzler ◽  
Thomas C Sauter ◽  
Beat Lehmann ◽  
Gert Krummrey ◽  
...  
Keyword(s):  
Head Injuries ◽  
Economic Loss ◽  
Neurological Complications ◽  
University Hospital ◽  
Neurological Deficits ◽  
Single Woman ◽  
Injury Patterns ◽  
Life Threatening ◽  
Level I ◽  
The University

BackgroundThis article addresses typical injury patterns related to the traditional Swiss folk wrestling, ‘Schwingen’. This is a fight between two competitors with its own rules, grips and throws. A variety of injuries have been occasionally reported. The aim of this study was to characterise all cases of Schwingen injuries treated in the University Hospital of Bern from January 2006 to July 2016.MethodsTo assess the frequency, type and outcome of Schwingen injuries, database search was performed of all inpatient and outpatient cases related to Schwingen that were admitted to Bern University Hospital from January 2006 to December 2016.ResultsA total of 32 such patients could be identified. Apart from a single woman, all patients were male. 31 of the 32 players were Swiss. One patient was admitted to the intermediate care unit, eight patients underwent surgery, two were hospitalised for further treatment and two were given a plaster. 17 other patients were given medications such as painkillers. One was dismissed without further treatment and another one left the hospital on his own. Typical injury patterns varied from simple lesions to distortions and fractures as well as head injuries and other neurological complications.ConclusionThe majority of injuries caused by Schwingen are not life threatening. Nevertheless, there is always the potential of head injuries and neurological deficits. Apart from the economic loss due to treatment costs and sick leave, these injuries can be disabling for life. It should therefore be obligatory for all players to evaluate preventive measures.

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