Unlocking the Synthetic Potential of Light-Excited Aryl ketones – Applications in Direct Photochemistry and Photoredox Catalysis

Synlett ◽  
2021 ◽  
Author(s):  
Javier Mateos ◽  
Sara Cuadros ◽  
Alberto Vega-Penaloza ◽  
Luca Dell'Amico
Keyword(s):  
New Technologies ◽  
Diels Alder ◽  
Synthetic Methods ◽  
Photoredox Catalysis ◽  
New Family ◽  
Mechanistic Analysis ◽  
Aryl Ketones ◽  
The Way

In this account article, we summarize the contributions of our group to the field of photochemistry and photocatalysis. Our work deals with the development of novel synthetic methods based on the exploitation of photoexcited aryl ketones. The application of new technologies, such as microfluidic photoreactors (MFPs), have enhanced the synthetic performance and scalability of several photochemical methods i.e. Paternò–Büchi and photoenolization/Diels-Alder processes, while opening the way to unprecedented reactivity. Further, the careful mechanistic analysis of the developed methods has been instrumental to disclosing a new family of powerful organic photocatalyst able to mediate several thermodynamically extreme photoredox processes.

Rediseñando las Organizaciones del Futuro. El impacto de la transformación digital en el mundo del trabajo

2019 ◽  
Vol 1 (1) ◽  
pp. 199-226
Author(s):  
Ricardo M. Piñeyro Prins ◽  
Guadalupe E. Estrada Narvaez
Keyword(s):  
Industrial Revolution ◽  
New Technologies ◽  
Third Sector ◽  
Digital Transformation ◽  
Digital Culture ◽  
Exploratory Research ◽  
The People ◽  
Technological Advances ◽  
Current Scenario ◽  
The Way

We are witnessing how new technologies are radically changing the design of organizations, the way in which they produce and manage both their objectives and their strategies, and -above all- how digital transformation impacts the people who are part of it. Even today in our country, many organizations think that digitalizing is having a presence on social networks, a web page or venturing into cases of success in corporate social intranet. Others begin to invest a large part of their budget in training their teams and adapting them to the digital age. But given this current scenario, do we know exactly what the digital transformation of organizations means? It is necessary? Implying? Is there a roadmap to follow that leads to the success of this process? How are organizations that have been born 100% digital from their business conception to the way of producing services through the use of platforms? What role does the organizational culture play in this scenario? The challenge of the digital transformation of businesses and organizations, which is part of the paradigm of the industrial revolution 4.0, is happening here and now in all types of organizations, whether are they private, public or third sector. The challenge to take into account in this process is to identify the digital competences that each worker must face in order to accompany these changes and not be left out of it. In this sense, the present work seeks to analyze the main characteristics of the current technological advances that make up the digital transformation of organizations and how they must be accompanied by a digital culture and skills that allow their successful development. In order to approach this project, we will carry out an exploratory research, collecting data from the sector of new actors in the world of work such as employment platforms in its various areas (gastronomy, delivery, transportation, recreation, domestic service, etc) and an analysis of the main technological changes that impact on the digital transformation of organizations in Argentina.

Spin-Forbidden Excitation Enables Infrared Photoredox Catalysis

2020 ◽  
Author(s):  
Tomislav Rovis ◽  
Benjamin D. Ravetz ◽  
Nicholas E. S. Tay ◽  
Candice Joe ◽  
Melda Sezen-Edmonds ◽  
...  
Keyword(s):  
Excited State ◽  
Ground State ◽  
Intersystem Crossing ◽  
Photoredox Catalysis ◽  
Infrared Irradiation ◽  
Triplet Excitation ◽  
New Family ◽  
Ir Light

We describe a new family of catalysts that undergo direct ground state singlet to excited state triplet excitation with IR light, leading to photoredox catalysis without the energy waste associated with intersystem crossing. The finding allows a mole scale reaction in batch using infrared irradiation.

Mass Spectrometry for Proteomics and Recent Developments in ESI, MALDI and other Ionization Methodologies

2019 ◽  
Vol 16 (4) ◽  
pp. 267-276
Author(s):  
Qurat ul Ain Farooq ◽  
Noor ul Haq ◽  
Abdul Aziz ◽  
Sara Aimen ◽  
Muhammad Inam ul Haq
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
New Technologies ◽  
Protein Complexes ◽  
Imaging Techniques ◽  
Desorption Electrospray Ionization ◽  
High Throughput Analysis ◽  
Enhanced Sensitivity ◽  
Recent Developments ◽  
The Way

Background: Mass spectrometry is a tool used in analytical chemistry to identify components in a chemical compound and it is of tremendous importance in the field of biology for high throughput analysis of biomolecules, among which protein is of great interest. Objective: Advancement in proteomics based on mass spectrometry has led the way to quantify multiple protein complexes, and proteins interactions with DNA/RNA or other chemical compounds which is a breakthrough in the field of bioinformatics. Methods: Many new technologies have been introduced in electrospray ionization (ESI) and Matrixassisted Laser Desorption/Ionization (MALDI) techniques which have enhanced sensitivity, resolution and many other key features for the characterization of proteins. Results: The advent of ambient mass spectrometry and its different versions like Desorption Electrospray Ionization (DESI), DART and ELDI has brought a huge revolution in proteomics research. Different imaging techniques are also introduced in MS to map proteins and other significant biomolecules. These drastic developments have paved the way to analyze large proteins of >200kDa easily. Conclusion: Here, we discuss the recent advancement in mass spectrometry, which is of great importance and it could lead us to further deep analysis of the molecules from different perspectives and further advancement in these techniques will enable us to find better ways for prediction of molecules and their behavioral properties.

scholarly journals Laws and Emerging Technologies

Laws ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 46
Author(s):  
Esther Salmerón-Manzano
Keyword(s):  
Information Technologies ◽  
New Technologies ◽  
Legal Issues ◽  
The Other ◽  
Special Issue ◽  
Legal Challenges ◽  
The World ◽  
Huge Impact ◽  
New Challenges ◽  
The Way

New technologies and so-called communication and information technologies are transforming our society, the way in which we relate to each other, and the way we understand the world. By a wider extension, they are also influencing the world of law. That is why technologies will have a huge impact on society in the coming years and will bring new challenges and legal challenges to the legal sector worldwide. On the other hand, the new communications era also brings many new legal issues such as those derived from e-commerce and payment services, intellectual property, or the problems derived from the use of new technologies by young people. This will undoubtedly affect the development, evolution, and understanding of law. This Special Issue has become this window into the new challenges of law in relation to new technologies.

Introduction: New Technologies -the Way Forward

BMUS Bulletin ◽  
1999 ◽  
Vol 7 (3) ◽  
pp. 4-4
Author(s):  
A Pat M Smith
Keyword(s):  
New Technologies ◽  
The Way

Intramolecular Diels Alder reactions in highly organized imidazolium salt-based ionic liquid crystals

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 635-639 ◽  
Author(s):  
Tien Dat Do ◽  
Andreea R. Schmitzer
Keyword(s):  
Ionic Liquid ◽  
Liquid Crystals ◽  
Diels Alder ◽  
Imidazolium Salts ◽  
Imidazolium Salt ◽  
New Family ◽  
Ionic Liquid Crystals

This paper describes the development of a new family of ionic liquid crystals based on imidazolium salts and their applications as media for intramolecular Diels Alder reactions.

scholarly journals General, Divergent Platform for Diastereoselective Synthesis of trans-Cyclooctenes with High Reactivity and Favorable Physiochemical Properties

2021 ◽  
Author(s):  
Jessica E. Pigga ◽  
Julia Rosenberger ◽  
Andrew Jemas ◽  
Samantha Boyd ◽  
Olga Dmitrenko ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Large Scale ◽  
High Reactivity ◽  
Diels Alder ◽  
Synthetic Methods ◽  
High Yield ◽  
Physiochemical Properties ◽  
New Class ◽  
State Models

<p><i>trans</i>-Cyclooctenes (TCOs) are essential partners for the fastest known bioorthogonal reactions, but current synthetic methods are limited by poor diastereoselectivity. Especially hard to access are hydrophilic TCOs with favorable physicochemical properties for live cell or <i>in vivo </i>experiments. Described is a new class of TCOs, ‘a-TCOs’, that is prepared in high yield via stereocontrolled 1,2-additions of nucleophiles to trans-cyclooct-4-enone, which itself was prepared on large scale in two steps from 1,5-cyclooctadiene. Computational transition state models rationalize the diastereoselectivity of 1,2-additions to deliver a-TCO products, which were also shown to be more reactive than standard TCOs and less hydrophobic than even a <i>trans</i>-oxocene analog. Illustrating the favorable physicochemical properties of a-TCOs, a fluorescent TAMRA derivative in live HeLa cells was shown to be cell-permeable through intracellular Diels-Alder chemistry and to washout more rapidly than other TCOs.</p>

scholarly journals General, Divergent Platform for Diastereoselective Synthesis of trans-Cyclooctenes with High Reactivity and Favorable Physiochemical Properties

2021 ◽  
Author(s):  
Jessica E. Pigga ◽  
Julia Rosenberger ◽  
Andrew Jemas ◽  
Samantha Boyd ◽  
Olga Dmitrenko ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Large Scale ◽  
High Reactivity ◽  
Diels Alder ◽  
Synthetic Methods ◽  
High Yield ◽  
Physiochemical Properties ◽  
New Class ◽  
State Models

<p><i>trans</i>-Cyclooctenes (TCOs) are essential partners for the fastest known bioorthogonal reactions, but current synthetic methods are limited by poor diastereoselectivity. Especially hard to access are hydrophilic TCOs with favorable physicochemical properties for live cell or <i>in vivo </i>experiments. Described is a new class of TCOs, ‘a-TCOs’, that is prepared in high yield via stereocontrolled 1,2-additions of nucleophiles to trans-cyclooct-4-enone, which itself was prepared on large scale in two steps from 1,5-cyclooctadiene. Computational transition state models rationalize the diastereoselectivity of 1,2-additions to deliver a-TCO products, which were also shown to be more reactive than standard TCOs and less hydrophobic than even a <i>trans</i>-oxocene analog. Illustrating the favorable physicochemical properties of a-TCOs, a fluorescent TAMRA derivative in live HeLa cells was shown to be cell-permeable through intracellular Diels-Alder chemistry and to washout more rapidly than other TCOs.</p>

scholarly journals Semiotization of Time in Virtual Narrative

2017 ◽  
Vol 5 (1) ◽  
pp. 488
Author(s):  
Elena Samoylova
Keyword(s):  
Internet Of Things ◽  
New Technologies ◽  
Point Of View ◽  
The Internet ◽  
The Internet Of Things ◽  
The Way

This paper is dedicated to the analysis of the phenomenon of virtual narrative and its connection to the phenomenon of Internet of things. Modern virtual narrative is a complex, syncretic phenomenon, alludes to the different cultural, historical and even mythological subjects and objects. But with the development of new technologies, such as the Internet of Things, virtual narrative became to be some kind of independent phenomenon. Moreover, the Internet of things (which is not clerly identified phenomen itself from the philosophic point of view) uses the virtual narrative as one of the components, for example applaying some methond of virtual narrative in creating advertisments, creating messages in musiams, exposititions etc. So, in our paper we will analyze this both phenomena, their connections and the way of its development.

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