Heterogeneous Hydrogenation of Quinoline Derivatives Effected by a Granular Cobalt Catalyst
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We communicate a convenient method for the pressure hydrogenation of quinolines in aqueous solution using a particulate Co-based catalyst that is prepared in-situ from simple Co(OAc)2 · 4 H2O through reduction with abundant zinc powder. This catalytic protocol permits a brisk and atom-efficient access to a variety of 1,2,3,4-tetrahydroquinolines thereby relying solely on easy-to-handle reagents that are all readily obtained from commercial sources. Both the reaction set-up assembly and the autoclave charging procedure are conducted on the bench outside an inert-gas-operated containment system thus rendering the overall synthesis time-saving and operationally very simple.