Role of cancer antigen 19-9 in complex ovarian tumors

Background: Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that may be elevated in healthy individuals as well as in patients with benign and malignant tumors. It is useful in the management of pancreatic and other gastrointestinal tumors. CA 19-9 is also elevated in benign and malignant ovarian tumors. Aim: To study the pattern of serum CA 19-9 in complex ovarian tumors. Methods: The study design was descriptive, based on data collected from medical records. Patients with a complex ovarian mass, who were investigated with CA 19-9 and had undergone surgery, were included in the study. The study duration was 2 years from January 2014 to December 2015. A total of 273 patients (119 benign and 154 malignant) with complex ovarian mass and elevated CA 19-9 underwent surgery during the study period. Results: CA 19-9 was elevated in 55 patients (20%). Of these, 23 patients had benign tumors while 32 had malignant tumors. Among patients with benign tumors, 21 had dermoid, 23 had mucinous tumors and 75 had other types of tumors. CA 19-9 was elevated in 10 (47.6%) of the dermoids, 7 (30.4%) of the mucinous tumors and 6 (8%) of the other benign tumors. Among patients with malignant tumors, 138 were epithelial and 16 were non epithelial tumors. Of the epithelial tumors, 31 were mucinous and 107 were nonmucinous types. Overall, 29 (21%) had elevated CA 19-9. Of the epithelial tumors, 22.6% of the mucinous type and 20.6% of the non mucinous type had elevated CA 19-9. Among the non-epithelial tumors, 3 (18.8%) had elevated CA19-9. Conclusion: CA 19-9 is elevated in several conditions but most likely to be raised in dermoid cysts and mucinous tumours. CA19-9 levels need to be interpreted along with clinical and radiological findings.

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Role of CA 19-9 in complex ovarian tumors

10.1055/s-0039-1685299 ◽

2016 ◽

Author(s):

Dhanya S. Thomas ◽

Ajit Sebastian ◽

Vinotha Thomas ◽

Anitha Thomas ◽

Rachel Chandy ◽

...

Keyword(s):

Malignant Tumors ◽

Ovarian Tumors ◽

Benign Tumors ◽

Ovarian Mass ◽

Radiological Findings ◽

Epithelial Tumors ◽

Mucin Glycoprotein ◽

Glycoprotein Antigen ◽

Mucinous Tumours

Background: Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that may be elevated in healthy individuals as well as in patients with benign and malignant tumors. It is useful in the management of pancreatic and other gastrointestinal tumors. CA 19-9 is also elevated in benign and malignant ovarian tumors. Aim: To study the pattern of serum CA19-9 in complex ovarian tumors. Methods: The study design was descriptive, based on data collected from medical records. Patients with a complex ovarian mass, who were investigated with CA 19-9 and had undergone surgery, wereincluded in the study. The study duration was 2 years from January 2014 to December 2015. A total of 273 patients (119 - benign and 154 malignant) with complex ovarian mass and elevated CA 19-9 underwent surgery during the study period. Results: CA 19-9 was elevated in 55 patients (20%). Of these, 23 patients had benign tumors while 32 had malignant tumors.Among patients with benign tumors, 21 had dermoid, 23 had mucinous tumors and 75 had other types of tumors. CA 19-9 was elevated in 10 (47.6%) of the dermoids, 7 (30.4%) of the mucinous tumors and 6 (8%) of the other benign tumors. Among patients with malignant tumors, 138 were epithelial and 16 were non epithelial tumors. Of the epithelial tumors, 31 were mucinous and 107 were non mucinous types. Overall, 29 (21%) had elevated CA 19-9. Of the epithelial tumors, 22.6% of the mucinous type and 20.6% of the non mucinous type had elevated CA 19-9. Among the non-epithelial tumors, 3 (18.8%) had elevated CA19-9. Conclusion: CA 19-9 is elevated in several conditions but most likely to be raised in dermoid cysts and mucinous tumours. CA19-9 levels need to be interpreted along with clinical and radiological findings.

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Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Journal of Pathology of Nepal ◽

10.3126/jpn.v3i5.7868 ◽

2013 ◽

Vol 3 (5) ◽

pp. 397-402 ◽

Cited By ~ 1

Author(s):

D Ghartimagar ◽

A Ghosh ◽

G KC ◽

S Ranabhat ◽

OP Talwar

Keyword(s):

Ovarian Cancer ◽

Malignant Tumors ◽

Data Bank ◽

Serous Cystadenoma ◽

Ovarian Tumors ◽

Benign Tumors ◽

Tertiary Referral ◽

Tertiary Referral Hospital ◽

Tertiary Referral Centre ◽

Epithelial Tumors

Background: Ovarian cancer accounts for 3% of all cancers in females. About 80% of these are benign, and they occur mostly in young women between 20 and 45 years. Borderline tumors occur at slightly older ages while incidence of malignant tumors increases with age, occurring predominantly in perimenopausal and postmenopausal women. About 190,000 new cases and 114,000 deaths from ovarian cancer are estimated to occur annually worldwide. The aim of the study was to fi nd the incidence of surface ovarian tumor in a tertiary referral centre. Materials and methods: This was a retrospective study carried out in the department of pathology, Manipal Teaching Hospital from January 2001 to December 2012. Specimens were received from the same and other hospitals. Records were retrieved from the departmental data bank and were analyzed. Results: : A total of 310 cases of ovarian tumors have been reported in the same period. Among them, 180 cases were of surface epithelial origin and out of which 24 cases had bilateral tumors. Benign tumors comprised of 148 cases, 6 were borderline and 44 were malignant. Among these, the commonest was serous cystadenoma (98 cases) and the least common was malignant Brenner (2 cases). Combined or mixed tumor was seen in 9 cases. Conclusion: : In our study surface epithelial tumors comprised 58% of all ovarian tumors. In both benign and malignant cases, serous tumor was the commonest followed by mucinous tumors. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 397-402 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7868

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Clinicopathological analysis of ovarian tumours: a 10 year retrospective study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183320 ◽

2018 ◽

Vol 7 (8) ◽

pp. 3216

Author(s):

Sahana N. Naik ◽

Sunil Kumar K. S. ◽

Girija B.

Keyword(s):

Malignant Tumors ◽

Female Genital Tract ◽

Germ Cell Tumors ◽

Mucinous Cystadenoma ◽

Ovarian Tumors ◽

Reproductive Age ◽

Benign Tumors ◽

Age Group ◽

Epithelial Tumors ◽

Neoplastic Lesions

Background: Ovarian tumors account for 30% of all cancers of female genital tract which represents the sixth most common cancer and fourth leading cause of death in women. The present study was done with an objective to determine the frequency and distribution of various ovarian tumors and to study their clinical and histopathological presentations.Methods: It is a retrospective observational study of patients with ovarian tumors subjected to surgery in the department of obstetrics and gynecology, SDM College of Medical Sciences and Hospital from January 2005 to December 2015.Results: There were 642 cases comprising of 77.7% of neoplastic lesions and 22.3% of non-neoplastic lesions. Majority of the ovarian tumors (83%) were seen in the age group of 20 to 50 years. Mean age for ovarian tumors was 38 years. Among the neoplastic lesions 84% were benign, 14.2% were malignant and 1.8% were borderline tumors. Surface epithelial tumors were the commonest tumors (60.9%) followed by germ cell tumors (12.8%). Serous cystadenoma was the most common benign tumors (47.1%) followed by mucinous cystadenoma (18.4%). Among the ovarian malignant tumors; serous cystadenocarcinoma was the most common (4.5%) followed by mucinous cystadenocarcinoma (2.6%). Chocolate cysts were the most common among the non-neoplastic lesions (36.4%).Conclusions: Ovarian neoplastic lesions were more common than non-neoplastic lesions. Benign ovarian tumors were common in reproductive age group. The mean age of occurrence for ovarian tumor was 38 years. The most common neoplasm was surface epithelial tumors, of which serous tumors was the commonest. Chocolate cysts were the most frequently encountered histopathological finding among the non-neoplastic lesions.

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Histopathological profile of ovarian tumors in a tertiary care center- a descriptive study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20211342 ◽

2021 ◽

Vol 9 (4) ◽

pp. 1010

Author(s):

Anitha Pallikkara V. ◽

Shameem K. Ummer Ali

Keyword(s):

Germ Cell ◽

Malignant Tumors ◽

Care Center ◽

Tertiary Care ◽

Age Groups ◽

Germ Cell Tumors ◽

Ovarian Tumors ◽

Benign Tumors ◽

Medical College ◽

Epithelial Tumors

Background: Ovarian neoplasms are a heterogeneous group of tumors with varied clinical, morphological and histological features. Ovarian cancer accounts for about 3% of all cancer in females and is the 5th most common cause of death due to cancer because most ovarian tumors spread beyond ovary by the time of diagnosis. The objective of the study was to document the histological pattern and prevalence of ovarian tumors in specimens received at department of pathology government medical college Alappuzha.Methods: This was a prospective study of 18 months duration which comprised of 245 cases of ovariectomy and ovariotomy specimens received in the department of pathology, govt. T.D medical college Alappuzha, Kerala. After detailed and thorough gross examination of the specimens, bits from representative areas were routinely processed and stained with H and E. Tumors were classified as per WHO classification. Appropriate immunohistochemical studies were performed wherever required.Results: Out of 245 cases studied, majority were benign tumors (78.36%), followed by malignant tumors (15. 11%). Borderline tumors comprised (6.53%) of the total cases. Age groups studied ranged from 11-70 years. Epithelial tumors were the most common (76.32%) followed by germ cell tumors (17.55%), sex cord stromal tumors (5.03%) and carcinoma arising in germ cell tumors (0.81%). Serous cystadenoma was found to be the commonest benign tumor and serous cystadenocarcinoma was the commonest malignant ovarian neoplasm.Conclusions: Surface epithelial tumors were the most common ovarian tumors. The maximum number of tumors were noted in the age group 21-40 years. Malignant tumors were common above 40 years.

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HISTOPATHOLOGICAL SPECTRUM OF OVARIAN TUMORS : 5 YEARS RETROSPECTIVE STUDY IN A TERTIARY REFERRAL HOSPITAL IN ASSAM

10.36106/ijsr/3004334 ◽

2021 ◽

pp. 43-44

Author(s):

Momota Naiding ◽

Nitu Mani Khakhlari ◽

Nandakanta Mahanta ◽

Shah Alam Sheikh

Keyword(s):

Retrospective Study ◽

Ovarian Tumor ◽

Malignant Tumors ◽

Ovarian Tumors ◽

Benign Tumors ◽

Age Group ◽

Histological Subtypes ◽

Epithelial Tumors ◽

Classi Cation ◽

Age Range

Introduction : Ovarian tumor accounts for 30% of female genital tract cancers and comprises of large variety of neoplastic entities. Mortality rate has due to ovarian tumor has gradually increased. The present study was undertaken to study the frequency of various histomorphological spectrum, histological subtypes and age distribution pattern of ovarian tumors. Methods: Retrospective study was carried during period of 1st January 2015 to 31st st December 2019, 455 cases of ovarian neoplastic lesions were taken from the records of the department. Classication was done according to WHO classication. Results: Of the 455 cases, 332 cases (73%) were benign, 16 cases (3.5%) cases were borderline and 107 cases (23.5%) cases were malignant. Among the histological subtypes surface epithelial tumors are common comprised of 76.9% followed by germ cell tumors (19.6%). Serous cystadenoma (42.8%) was the most common benign tumor followed by mature cystic teratoma (16.5%). Among the malignant tumors, the most common was Serous cyst adenocarcinoma (11.9%) Tumors were seen over age range of 11-81 years. Maximum number of cases were in the 4th to 6th decade. Benign tumors were primarily seen in Younger age group , whereas malignant tumors were common in elderly age group. Conclusions: In our study we analysed all the spectrum of ovarian tumors diagnosed on the basis of histomorphology. Surface epithelial tumors were the commonest ovarian tumor. Maximum numbers of ovarian tumors were in the age range 40-59years and malignant tumors were common in age >40 years

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Histopathological pattern of ovarian neoplasms in Sub-Himalayan belt of rural India: a four-year study from a tertiary care teaching hospital

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20175258 ◽

2017 ◽

Vol 6 (12) ◽

pp. 5448

Author(s):

Manupriya Sharma ◽

Anjali Soni ◽

Rashmi Kaul

Keyword(s):

Ovarian Tumor ◽

Ovarian Neoplasms ◽

Malignant Tumors ◽

Germ Cell Tumors ◽

Ovarian Tumors ◽

Rural India ◽

Benign Tumors ◽

Age Group ◽

Epithelial Tumors ◽

Himalayan Belt

Background: Ovarian tumors are one of the ubiquitous and common forms of neoplasms in women. The aim of the study was to understand the pattern of benign and malignant ovarian neoplasms and their distribution in different age groups in rural population of India.Methods: A retrospective study conducted in the Department of Pathology in close collaboration with Department of Obstetrics and Gynecology, Dr. Rajendra Prasad Government Medical College, Kangra at Tanda (HP), India. All the patients irrespective of age group who were operated for ovarian neoplasms (benign or malignant) were included in this retrospective analysis over duration of four years (2013 to 2016). “WHO classification system” was used, for classification of all these ovarian tumors. The incidence of these tumors with respect to age group was also studied.Results: During the study period (2013-2016), there were a total of 242 surgeries for ovarian neoplasms. Of these, majority of the tumours were benign 184 (76%), but an alarming number of women had malignant ovarian tumours 51 (21%), remaining 7 (3%) cases were borderline. Age wise distribution was 7% (16/242) in less than 20 years age, 19% (46/242) in 20-30 years age, 29% (69/242) in 30-40 years age group, 24% (59/242) in 40-50 years and remaining 21% (52/242) in more than 50 years age group. Pre-dominantly benign tumors were surface epithelial tumors (serous/ mucinous cystadenoma), germ cell tumors (mature cystic teratoma) and endometrioma. Major malignant tumors were surface epithelial tumors (serous/mucinous cystadeno-carcinoma), and germ cell tumors (dysgerminoma, immature teratoma).Conclusions: In this sub-Himalayan belt of rural India, the incidence of benign ovarian tumors was 76%. Borderline ovarian tumors were seen in 3% cases and the remaining 21% cases were malignant ones. Even though benign tumors were the commonest for each age group, however as the age of women increased the proportion of malignant tumors in them increased. Surface epithelial tumors are the most common class of tumors in both benign and malignant tumors. Serous cystadenoma is the most common ovarian tumor overall as well as most common benign tumor whereas serous cystadeno-carcinoma is most common malignancy. Stromal ovarian tumor (one case) is a rarity. Only one woman had bilateral ovarian tumor.

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Histopathological spectrum of ovarian tumors: an institutional perspective

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20182982 ◽

2018 ◽

Vol 6 (8) ◽

pp. 2639

Author(s):

Angela Phukan ◽

Meghna Borgogoi ◽

Shaolima Ghosh

Keyword(s):

Ovarian Tumor ◽

Malignant Tumors ◽

Age Distribution ◽

Germ Cell Tumors ◽

Cystic Teratoma ◽

Ovarian Tumors ◽

Benign Tumors ◽

Institutional Perspective ◽

Epithelial Tumors ◽

Age Range

Background: Globally ovarian tumor is one of the leading causes of cancer death among women. Ovarian tumor has varied histiogenesis, clinical behavior and malignant potential. The aims and objectives of the present study is to study the histopathological pattern and age distribution of the ovarian tumors.Methods: A total of 84 cases were studied from January 2016 to December 2016. They were reviewed and analyzed for age, histopathological findings and clinical presentations. Classification was done according to WHO histologic classification of ovarian tumors.Results: Of the 84 cases, 75% were benign, 3.6% cases were borderline and 21.4% cases were malignant. Among the histological subtypes surface epithelial tumors comprised of 66.7% followed by germ cell tumors (23.9%). Serous cystadenoma (36.9%) was the most common benign tumor followed by mature cystic teratoma (17.9%). Serous cyst adenocarcinoma (10.7%) was the most common malignant tumour. Tumors were seen over age range of 10-78 years and maximum number of cases were in the 4th to 6th decade. Younger age group primarily presented with benign tumors whereas malignant tumors were common in elderly age group.Conclusions: Surface epithelial tumors were the commonest ovarian tumor. Maximum numbers of ovarian tumors were in the age range 40-59years and malignant tumors were common in >40 years of age.

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The Privilege of Proton Magnetic Resonance Spectroscopy in Evaluating Ovarian Tumors

QJM ◽

10.1093/qjmed/hcaa068.022a ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

A A Hafez ◽

M A Nasr ◽

N L Salman

Keyword(s):

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Malignant Tumors ◽

Radiology Department ◽

Invasive Technique ◽

Resonance Spectroscopy ◽

Ovarian Mass ◽

University Hospitals ◽

Non Invasive

Abstract Background Exclusion of malignancy in ovarian mass is of paramount importance. It is the most crucial step after identification of a mass and it has a profound effect on the patient's management. So, a reliable method with which to differentiate a benign from a malignant ovarian mass would provide a basis for optimal preoperative planning and may also reduce the number of unnecessary laparotomies for patients undergoing treatment for benign disease. Objective The aim of our study is to highlight the role of magnetic resonance spectroscopy as a non-invasive technique which may effectively assist in differentiating benign from malignant ovarian masses. Patients and Methods This study included 20 patients with adnexal masses as suggested by preliminary pelvic ultrasound examination. referred from the Gynecology Department to the Radiology Department at Ain shams university hospitals. nine were benign, two were borderline, and six were malignant tumors and 3 were hemorrhagic cyst. Endometriosis, tubo-ovarian abscess. Results Our study revealed sharp choline peak in some benign as well as some malignant cases and so Cho peak could not help in the differential diagnosis between benign and malignant tumors, creatine, lipid and NAA were detected in both benign and malignant tumors, also Choline/Creatine Ratio fairly can differentiate between benign and malignant tumors with cut off point = 3.750 at sensitivity = 75.0% & specificity = 100.0% . Conclusion Our study had some factors that affect the results. First, the sample size were not enough to achieve a good results, second, diversity of samples and the complicated tumor histopathologic and morphologic features.

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Diagnostic approach using the expression profiling of the P53 tumor suppressor gene and its related proteins in ovarian epithelial tumors

International Journal of Gynecological Cancer ◽

10.1136/ijgc-00009577-200505000-00007 ◽

2005 ◽

Vol 15 (3) ◽

pp. 453-461 ◽

Cited By ~ 2

Author(s):

H. Lee ◽

G. Park ◽

J. H. Jung ◽

W. S. Ahn ◽

J. M. Lee ◽

...

Keyword(s):

Differential Diagnosis ◽

Malignant Tumors ◽

Cyclin E ◽

Receiver Operating Curve ◽

Benign Tumors ◽

Cutoff Value ◽

Borderline Tumors ◽

Expression Levels ◽

Epithelial Tumors ◽

Ovarian Epithelial Tumors

The initial aim of this study was to examine the expression profiles of P53 and its upstream genes, downstream genes, and cell cycle regulators to determine whether these markers are useful for making a differential diagnosis among the benign, borderline, and malignant ovarian epithelial tumors. Between borderline and malignant tumors, the increased expression levels of P53, Bax, Cyclin E, and cyclin-dependent kinase-2 as well as the decreased expression levels of growth arrest and DNA damage (GADD45) and murine double minute-2 (MDM2) were significantly associated with malignancy (P < 0.01, each). Using the receiver operating curve (ROC), the most reliable cutoff value of the added-up staining scores of those markers was 4.5 with 79% sensitivity and 89% specificity for malignancy. Between benign and borderline tumors, the P21 and Bax expression levels were significantly higher in borderline tumors, whereas the Bcl-2 expression level was much higher in benign tumors (P < 0.01, each). Using the ROC, the cutoff value of the added-up staining scores used to discriminate between the two groups was 2.5 with 70% sensitivity and 74% specificity for borderline tumors. Thus, for the differential diagnosis between borderline and malignant tumors, the cutoff value 4.5 of the cumulative staining scores can be used. However, the cutoff value 2.5 for discrimination between benign and borderline tumors may not be useful because of its relatively low sensitivity and specificity. In addition, the P53, GADD45, Cyclin E, and MDM2 expression levels in malignant ovarian tumors might be useful for determining the histologic grade and type.

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FSH and LH serum/tumor fluid ratios and malignant tumors of the ovary.

Endocrine Related Cancer ◽

10.1677/erc.0.0110315 ◽

2004 ◽

Vol 11 (2) ◽

pp. 315-321 ◽

Cited By ~ 23

Author(s):

I Rzepka-G√≥rska ◽

A Chudecka-G≈Çaz ◽

B Kosmowska

Keyword(s):

Ovarian Cancer ◽

Differential Diagnosis ◽

Malignant Tumors ◽

Ovarian Tumors ◽

Predictive Values ◽

Epithelial Tumors ◽

Ovarian Carcinogenesis ◽

Benign Ovarian Tumors ◽

Sensitivity Specificity

The aim of this work was to compare mean concentrations of gonadotropins in serum and fluid from malignant and benign ovarian tumors. We enrolled 126 patients diagnosed with malignant epithelial tumors (n=40), borderline epithelial tumors (n=14), benign cystadenomas (n=28) and simple cysts (n=44) of the ovary. Premenopausal and postmenopausal subgroups were formed in each group. The concentration of FSH and LH was measured in serum and tumor fluid and the serum/tumor fluid ratio was calculated. The results in each group were compared and the sensitivity, specificity, positive and negative predictive values were determined. Mean concentrations of both gonadotropins in ovarian cancer fluid were significantly higher than in the remaining groups (P ranged from <0.005 to <0.0001). Mean serum/fluid ratios were lowest in ovarian cancer (FSH=2.91, LH=4.19). Our findings support the hypothesis that gonadotropins are involved in ovarian carcinogenesis and suggest that gonadotropin serum/tumor fluid ratios could be of value in the differential diagnosis of functional and organic cysts of the ovary.

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