scholarly journals Prolonged Suppressive Effects of Periodontitis on Salivary TFF3 Production

2019 ◽  
Vol 13 (02) ◽  
pp. 193-198
Author(s):  
Doosadee Hormdee ◽  
Saengsome Prajaneh ◽  
Amonrujee Kampichai ◽  
Ranuch Tak ◽  
Ponlatham Chaiyarit
Keyword(s):  
Categorical Data ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Post Treatment ◽  
Periodontal Treatment ◽  
Enzyme Linked Immunosorbent Assay ◽  
Chi Squared ◽  
Trefoil Factor Family ◽  
Post Hoc

Abstract Objective As a follow-up to our previous study that demonstrated decreased salivary trefoil factor family 3 (TFF3) peptide levels in chronic periodontitis patients, this current study aimed to observe the effects of nonsurgical periodontal treatment on salivary TFF3 peptides in patients with periodontal diseases. Materials and Methods Eighty-seven volunteers that comprised of 30 individuals with healthy periodontium, 31 with gingivitis, and 26 with chronic periodontitis were considered for the study. Prior to periodontal treatment, a general periodontal examination was performed along with collection of saliva samples from each volunteer. Nonsurgical periodontal treatments were provided to patients with gingivitis and periodontitis. Two weeks post-treatment, saliva samples were recollected, and the periodontal status was re-evaluated. Salivary TFF3 concentrations were measured by enzyme-linked immunosorbent assay. Statistical Analysis Mann–Whitney U test was used when the investigated data were not normally distributed. Chi-squared test was used when dealing with categorical data. Kruskal–Wallis test with post-hoc corrections was used to compare data among the three investigated groups. Two-tailed p < 0.05 was considered as statistically significant. Results Prior to the periodontal treatment, salivary TFF3 concentrations in patients with gingivitis and periodontitis were significantly lower than those with healthy periodontium. Two weeks post-treatment, increased levels of salivary TFF3 were observed in patients with gingivitis, whereas the concentrations decreased in patients with chronic periodontitis. Conclusion This study demonstrated the effects of periodontal disease on the production of salivary TFF3 peptides. Interestingly, nonsurgical periodontal treatment also affected the recovery of salivary TFF3 peptides but varied in their outcomes between gingivitis and periodontitis patients.

scholarly journals The Association of Periodontal Treatment and Decreased Pneumonia: A Nationwide Population-Based Cohort Study

2020 ◽  
Vol 17 (1) ◽  
pp. 356 ◽  
Author(s):  
Li-Chiu Yang ◽  
Yih-Jane Suen ◽  
Yu-Hsun Wang ◽  
Tai-Chen Lin ◽  
Hui-Chieh Yu ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Periodontal Diseases ◽  
Population Based ◽  
Periodontal Treatment ◽  
Rank Test ◽  
Research Database ◽  
Comparison Cohort ◽  
Comparison Groups

Pneumonia is a common respiratory infectious disease that involves the inflammation of the pulmonary parenchyma. Periodontal disease is widespread and correlated with pneumonia. However, the relationship between periodontal treatment and clinical infectious outcomes in patients with pneumonia has remained undetermined. The aim of this study was to investigate the association between periodontal treatment and the risk of pneumonia events in the Taiwanese population. A nationwide population-based cohort study was conducted using data from the Taiwanese National Health Insurance Research Database (NHIRD). A total of 49,400 chronic periodontitis patients who received periodontal treatment from 2001 to 2012 were selected. In addition, 49,400 healthy individuals without periodontal diseases were picked randomly from the general population after propensity score matching according to age, gender, monthly income, urbanization, and comorbidities. The Cox proportional hazard regression analysis was adopted to assess the hazard ratio (HR) of pneumonia between the periodontal treatment cohort and the comparison cohort. The average ages of the periodontal treatment and comparison groups were 44.25 ± 14.82 years and 44.15 ± 14.5 years, respectively. The follow up durations were 7.66 and 7.41 years for the periodontal treatment and comparison groups, respectively. We found 2504 and 1922 patients with newly diagnosed pneumonia in the comparison cohort and the periodontal treatment cohort, respectively. The Kaplan–Meier plot revealed that the cumulative incidence of pneumonia was significantly lower over the 12 year follow-up period in the periodontal treatment group (using the log-rank test, p < 0.001). In conclusion, this nationwide population-based study indicated that the patients with periodontal treatment exhibited a significantly lower risk of pneumonia than the general population.

scholarly journals Salivary Melatonin and the Severity of Attachment Loss: A Case-Control Study

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Leila Golpasand-Hagh ◽  
Faramarz Zakavi ◽  
Arash Daraeighadikolaei ◽  
Akram Ahangarpour ◽  
Sara Hajati ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Healthy Subjects ◽  
Type I Collagen ◽  
Periodontal Diseases ◽  
Protective Role ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
Melatonin Level ◽  
Type I ◽  
Salivary Melatonin

Background. Melatonin (MT: N-acetyl-5-methoxytryptamine) is a neuroendocrine hormone secreted mainly by the pineal gland in the brain. MT is produced with a circadian rhythm characterized by elevated blood levels during the night. In healthy individuals, maximal secretion of MT occurs between midnight and 2:00 am, whereas the minimal production occurs during the day. MT can be determined by repeated measurement of plasma or salivary MT or urine sulfatoxy-melatonin. Melatonin has powerful antioxidant effects, has an immunomodulatory role, stimulates the synthesis of type I collagen fibers, and promotes bone formation. Melatonin is also secreted in the saliva, although its role in the mouth is not known well. The purpose of this study was to examine the correlation between salivary melatonin level and periodontal diseases. Methods. Fifty subjects by mean age of 40.44±6.38 years were equally divided into 5 groups: 10 healthy subjects, 10 subjects with gingivitis, 10 subjects with localized moderate chronic periodontitis, 10 subjects with generalized moderate chronic periodontitis, and 10 subjects with generalized severe chronic periodontitis. Saliva samples were collected from all the subjects and melatonin levels were determined using an enzyme-linked immunosorbent assay. Two-way and one-way ANOVA and Tukey test were used to analyze relationships among variables. Results. Healthy subjects had significantly higher salivary melatonin level (5.29±0.50 pg/mL) compared to patients with gingivitis (4.35±0.30 pg/mL) (P<0.001). The difference between salivary melatonin level in patients with gingivitis and periodontitis was significant (P<0.001). Level of melatonin in patients with generalized severe chronic periodontitis (3.39±0.10 pg/mL) was significantly lower than that in other groups (P<0.01). Conclusions. This study determined that salivary melatonin level in patients with periodontal diseases is lower than that in healthy subjects. Consequently we conclude that there is a negative correlation between melatonin level and the severity of disease, suggesting that melatonin might have a protective role against periodontal diseases, although further research is required to validate this hypothesis.

scholarly journals Effect of Nonsurgical Periodontal Therapy on Crevicular Fluid and Serum Glutathione Peroxidase Levels

2012 ◽  
Vol 32 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Swati Pradeep Patel ◽  
Nishanth S. Rao ◽  
A. R. Pradeep
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pocket Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Crevicular Fluid

Background: Plasma glutathione peroxidase (eGPx) is an important selenium containing antioxidant in human defense against oxidative stress. While crevicular fluid (GCF) eGPx levels and its association with periodontal disease is well documented, there is no data on correlation of GCF and serum eGPx levels in chronic periodontitis. Hence this study was undertaken to further probe into the role of oxidative stress in periodontal diseases and effect of nonsurgical periodontal therapy (NSPT) by correlating GCF and serum levels of eGPx.Materials and methods: Thirty subjects (16-Males and 14-Females; age: 30–38 years) participated in the study. The subjects were divided, based on gingival index, probing pocket depth and clinical attachment level into: Healthy (group-1,n=10), Gingivitis (group-2,n=10) and Periodontitis (group-3,n=10). Chronic periodontitis patients after NSPT constituted group 4. GCF and serum samples collected from each subject were quantified for eGPx levels using Enzyme linked Immunosorbent Assay.Results: The mean eGPx concentrations increased from health (14.01 ng/μl and 78.26 ng/ml) to gingivitis (22.86 ng/μl and 90.44 ng/ml) and then to periodontitis (29.89 ng/μl and 103.43 ng/ml), in GCF and serum respectively. After NSPT, there was statistically significant reduction in eGPx concentration in GCF and serum (19.41 ng/μl and 85.21 ng/ml). Further, all the GCF eGPx values showed a positive correlation to that of serum eGPx level.Conclusion: Thus, increased eGPx concentration in GCF can be considered as an indicator of local increase in oxidative stress. While, increase in serum eGPx levels indicates that periodontal disease can also lead to increased oxidative stress at the systemic level.

Caries experience after periodontal treatment in aggressive and chronic periodontitis: Results of a 10-year follow-up

2013 ◽  
Vol 71 (5) ◽  
pp. 1129-1135 ◽  
Author(s):  
Amelie Meyer-Bäumer ◽  
Peter Eickholz ◽  
Peter Reitmeir ◽  
Hans Jörg Staehle ◽  
Cornelia Frese ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Caries Experience

scholarly journals Effect of non-surgical periodontal treatment on serum albumin levels in patients with chronic periodontitis

2018 ◽  
Vol 10 (1) ◽  
pp. 18-23
Author(s):  
Adileh Shirmohammadi ◽  
Masoumeh Faramarzi ◽  
Ashkan Salari ◽  
Mehrnoosh Sadighi Shamami ◽  
Amir Reza Babaloo ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Serum Albumin ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Statistical Significance ◽  
Serum Levels ◽  
T Test ◽  
Periodontal Treatment ◽  
Case Group ◽  
Clinical Parameters

Background. Albumin is a protein whose serum levels decrease in inflammatory conditions such as periodontal diseases. This study was undertaken to evaluate changes in serum albumin levels in patients with and without periodontal diseases prior and subsequent to non-surgical periodontal treatment and its relationship with clinical parameters of periodontal disease.Methods. Twenty patients diagnosed as having chronic periodontitis and 20 periodontally healthy subjects, referring to Tabriz Faculty of Dentistry, were selected. Serum albumin levels and clinical variables of periodontal disease (probing pocket depth, gingival index, bleeding index, clinical attachment level and plaque index) were determined before treatment and three months subsequent to non-surgical periodontal treatment. Data were subjected to descriptive statistical analyses (mean ± SD). Serum levels of albumin and clinical parameters were compared between the two groups with independent-samples t-test. Paired-samples t-test was applied to compare the variables before and after treatment in the case group. Statistical significance was defined at P<0.05.Results. The mean serum albumin level of chronic periodontitis patients (3.62±0.11 mg/dL) exhibited a significantly lower value compared to subjects who were periodontally healthy (4.17±0.29 mg/dL), with the serum albumin levels increasing significantly three months postoperatively (3.78±0.33 mg/dL), approaching the level in subjects who were periodontally healthy (P<0.05).Conclusion. Decreases and increases in serum albumin levels under the effect of periodontal disease and its treatment indi-cated an inverse relationship between the albumin levels of serum and chronic periodontitis.

scholarly journals Periodontal treatment in a generalized severe chronic periodontitis patient: A case report with 7-year follow-up

2015 ◽  
Vol 09 (02) ◽  
pp. 288-292 ◽  
Author(s):  
Omer Birkan Agrali ◽  
Bahar Eren Kuru
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Periodontitis Patient ◽  
Keratinized Tissue ◽  
Functional Dentition ◽  
Enamel Matrix Derivatives ◽  
Periodontal Destruction ◽  
Matrix Derivatives ◽  
Xenogenic Bone

ABSTRACTThe aim of the periodontal treatment is to provide healthy and functional dentition all through a lifetime. In this report, periodontal treatment of a 42-year-old male patient with generalized severe chronic periodontitis is presented. He received initial periodontal treatment together with adjunctive antimicrobials. The devital teeth were endodontically treated, and free gingival grafts were placed at the inadequate keratinized tissue zones before regenerative surgery. Following the surgical treatment using enamel matrix derivatives and xenogenic bone graft combination, the patient was put on a strict recall program. After 12 months, favorable clinical and radiographical improvements were obtained. The 7-year maintenance of the present case with several initially hopeless teeth has been shown and discussed in this report. It can be concluded that optimum oral hygiene level as well as the positive cooperation of the patient enhanced the success of periodontal treatment results even in extremely severe periodontal destruction.

Secondary Prophylaxis with rFVIIa Improves Quality of Life of Hemophilia Patients with Inhibitors and Frequent Bleeds.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1028-1028 ◽  
Author(s):  
Barbara A. Konkle ◽  
Liselotte S. Ebbesen ◽  
Guenter K.H. Auerswald ◽  
Ute Friedrich ◽  
Rolf C.R. Ljung ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Treatment Period ◽  
Secondary Prophylaxis ◽  
Post Treatment ◽  
School Work ◽  
Post Hoc Analysis ◽  
On Demand ◽  
Post Hoc

Abstract Introduction: Patients with hemophilia and neutralizing antibodies (inhibitors) against exogenous factor VIII or factor IX characteristically have impaired joint function and more hospitalizations compared with those without inhibitors. We investigated the impact of secondary prophylaxis with activated recombinant factor VII (rFVIIa) on quality of life (QoL) and health-related quality of life (HRQL) in patients with congenital hemophilia A or B with inhibitors and high requirements for on-demand therapy. Methods: In a prospective, randomized, double-blind, uncontrolled trial, 22 patients (inhibitor titer &gt;2 BU/mL; and ≥4 bleeds/month) received secondary prophylaxis with rFVIIa (90 or 270 μg/kg) once daily. This was preceded by a 3-month observation (baseline) period and followed by a 3-month post-treatment follow-up period in which patients were treated on-demand for their bleeds. QoL was evaluated by hospitalizations related to bleeds, days unable to attend/absence from school or work, or days requiring mobility aids. HRQL was assessed with the EuroQoL (EQ-5D), a 5-dimensional measure of health (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) with 3 levels (no problem; some or moderate problems; and extreme problems/impossible to do). Results: The clinically relevant reductions in bleed frequency observed with rFVIIa 90 or 270 μg/kg during prophylaxis (45% and 59%; p&lt;0.0001 for both) compared with on-demand therapy during the observation period (baseline) were maintained during the 3-month follow-up period and were associated with improvements in QoL. The proportion of days during prophylaxis where patients were unable to attend/absent from school/work was significantly less than at baseline (16.7% vs 38.7%; p=0.0127, in a post-hoc analysis of the two treatment arms combined) and a significantly lower percentage of days was spent in hospital (5.9% vs 13.5%; p=0.0026 [post-hoc analysis]). During the post-treatment period, there were non-significant trends towards this effect being maintained (28.1% days absent from school/work, and 10.3% days spent in hospital). Overall use of mobility aids during prophylaxis and during the post-treatment period remained unchanged from that at baseline (post-hoc analysis). With EQ-5D, 2 of the measures (pain and mobility) showed trends towards improvement over time. Fewer patients tended to have pain and mobility problems during prophylaxis and during the post-treatment period. Conclusion: Prior to entry, patients enrolled in this trial bled frequently and overall had significant joint disease. Clinically relevant reductions in the number of bleeds observed during prophylaxis with rFVIIa compared with conventional on-demand therapy were associated with considerable improvements in QoL, reflected in a variety of important measures. Our results support the concept that secondary prophylaxis with rFVIIa in patients with severe hemophilia A or B with inhibitors and frequent bleeds improves the QoL of these disabled patients.

scholarly journals Influence of smoking on salivary interleukin-8 levels in chronic periodontitis

2020 ◽  
Vol 32 (1) ◽  
pp. 28-34
Author(s):  
Haween T Nanakaly ◽  
Aveen E Ismail ◽  
Daldar A Othmn
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Mean Value ◽  
Interleukin 8 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Control Subjects ◽  
Healthy Control ◽  
Increased Susceptibility

Background: Smoking is the major environmental risk factor that has been associated with the pathogenesis and progression of periodontal diseases. Interleukin-8 (IL-8), has been associated with the immunopathology of periodontitis. Objectives: To determine the influence of smoking on salivary Interleukin-8 level from smokers and non-smokers with periodontitis and periodontally healthy control subjects. Materials and Methods: Un-stimulated saliva samples were collected of 90 participants: 30 smokers and 30 non-smokers with chronic periodontitis, as well as 30 periodontally healthy control subjects. The clinical parameters such as the pocket depth, clinical attachment loss, plaque index, and gingival index were measured. IL-8 level in the saliva was measured by Enzyme Linked Immunosorbent Assay (ELISA) kit. Results: It was found that the mean value of salivary IL-8 levels was significantly higher in smokers (461.76 ± 329.66 ng/L) than in non-smokers periodontitis (257.83 ± 247.19 ng/L) and the controls (96.55 ± 62.35 ng/L) (p < 0.001). Moreover, salivary IL-8 levels were significantly higher in smokers compared with non-smokers periodontitis (p< 0.001). Conclusion: Smoking subjects showed increased level of salivary IL-8 and a worse periodontal condition than non-smoking subjects. Our results suggest that smoking alters an immune response which may contribute to an increased susceptibility to periodontal disease among smokers Keywords: Smoking; Chronic periodontitis; Saliva; Interleukine-8

scholarly journals Comparative Studies of the Effect of Different Types of Iron Tonics on Umbilical and Middle Cerebral Blood Flow in Cases of Moderate Iron Deficiency Anemia in Late Second Trimester of Pregnant Women

2021 ◽  
pp. 116-126
Author(s):  
Basma M. Elbehiry ◽  
Raghda A. El-Dakhakhni ◽  
Mohamed F. Dawood ◽  
Mohamed M. Esmail
Keyword(s):  
Umbilical Artery ◽  
Resistance Index ◽  
Post Treatment ◽  
Maternal Anemia ◽  
Once Daily ◽  
Post Hoc Analysis ◽  
Different Types ◽  
Doppler Indices ◽  
Post Hoc

Background: Maternal anemia is frequently associated with premature delivery, reduced neonatal weight, infant iron deficiency, neonatal death, and low Apgar scores at 1 min. It is also suspected to reduce the oxygen supply to the growing fetus, leading to the redistribution of fetal blood flow. This study aims to evaluate the effect of the different types of iron medications given to anemic patients on fetal Doppler indices namely umbilical artery and middle cerebral artery in the late second trimester of pregnancy. Materials and Methods: This cohort prospective study. This study conducted at department of obstetrics and gynecology at Tanta university hospital. Participants consisted of 90 pregnant women during their gestational age (20-28 weeks) they were attended or admitted to obstetric unit.divided into 3 groups. Lactoferrin group included 30 cases received 250 mg lactoferrin capsules once daily for 4 weeks. Iron amino acid chelated group included 30 cases received ferrous bis – glycine chelate (FeBC) 15 mg/day for 4 weeks. Ferrous fumarate group included 30 cases received 350 mg dried ferrous fumarate capsules once daily for 4 weeks. Pre-and post-treatment Doppler measurement of umbilical artery and middle cerebral artery parameter compared 4 weeks after the start of treatment for patients whose anemia successfully treated. Results: Post hoc analysis of maternal serum hemoglobin of the studied groups show insignificant different between the groups. Pre- and Post-treatment follow-up of resistance index (RI) of the studied groups, Pre- and Post-treatment follow-up of pulsatility index (PI) of the studied groups, Post hoc analysis of pulsatility index (PI) of the studied groups and Post hoc analysis of resistance index (RI) of the studied groups show insignificant different between groups. Conclusion: Based on our results, it can be concluded that cerebral vasodilatation due to severe maternal anemia is a reversible condition that can be corrected through the prompt treatment of anemia. Additionally, the three therapeutics tested in the current study showed a comparable effect in treating maternal anemia, with subsequent improvement of doppler indices.

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