scholarly journals THERMOREGULATION IN THE HEART AND THE BIOPHYSICS OF CORONARY ARTERIAL FLOW

2013 ◽  
Vol 03 (02) ◽  
pp. 058-062
Author(s):  
Arunachalam Kumar
Keyword(s):  
Systolic Pressure ◽  
Physical Force ◽  
Rapid Action ◽  
Number Of Factors ◽  
Flow Through ◽  
The Right ◽  
Muscular Pump ◽  
Physical Laws ◽  
High Degree

AbstractThe right and left coronary arteries are the principal sources of supply of oxygenated blood to the heart. Arising from the proximal rim of the ascending aorta, these arteries course along and over the surface of the organ, sending out branches that penetrate axial blood flow through arteries is governed or maintained by multifarious physical laws.The heart, an electrically stimulated muscular pump, squirts and receives circulating blood through its systolic and diastolic exertions. The non-stop life-long rapid action of the organ not just expends enormous energy but also generates considerable heat. While there are a number of factors that help the heart dissipate and reduce heat, a few other biophysical factors contribute hugely to maintain a thermostatic milieu.Circulation through vessels is maintained with a high degree of efficiency through combined actions of ejection systolic pressure, elasticity of the conducting arterial channels, and the proximo-distal decrease in diameters of arteries.This brief write-up discusses some of physics regulatng fluid flow dynamics and attempts to exemplify the significant role of 'centrifugal force' as a hitherto overlooked physical force in coronary haemodynamics. The application of biophysical postulates to cardiac cycle may help in furthering our understanding of coronary blood circulation and the multi-factorial influences on its functional integrity. It is inferenced that, the finding may have a number of applications and result in a better understanding of cardiac circulatory dynamics.

HOW OPEN LIST PROPORTIONAL REPRESENTATION WORKS IN THE 2020 LOCAL ELECTIONS AT KHARKIV REGION?

2020 ◽  
Keyword(s):  
Electoral System ◽  
Proportional Representation ◽  
Local Elections ◽  
Party Leadership ◽  
Regional Council ◽  
City Councils ◽  
Election Results ◽  
The Right ◽  
High Degree

The article examines the first approbation of the Electoral Code on the material of the 2020 local elections in the Kharkiv region. The authors pay special attention to the effects of open lists systems and the degree of influence of preferential votes on the personal distribution of seats in local councils. The article calculates the percentage of voters who used the right of preferential votes in all 14 constituencies and main party lists. We argue that according to the indicators of the use of the preferential vote right and the percentage of invalid ballots, the voters of the Kharkiv region demonstrated a high degree of adaptive readiness for the new electoral system. The article analyzes the effects of blocking mechanisms incorporated in the electoral system, which reduced the influence of preferential votes of voters and retained the control of the party leadership over the personal distribution of mandates in the councils. The ratio between the seats from the district lists and the unified closed party lists was quantified (based on election results for the regional council and 17 city councils of the region). The article analyzes the intensity of changes in the ballot position of candidates in the district lists on regional council elections. We demonstrate that only 20% of seats were received by candidates placed by the party leadership in a “no-pass” ballot position. The article argues that the electoral formula introduced in the 2020 local elections did not work as a system with open lists proportional representation. According to the statistics of the personal allocation of seats in the newly elected councils, this model seems to be something in between the systems of flexible and closed lists. In this regard, the article develops new arguments in the debate on how the norms of electoral legislation reduce the role of preferential votes of voters and proposes recommendations for amending the Electoral Code.

Experience of a Small Island State in Siting Industrial I Plants and Pollutive Facilities

1997 ◽  
Vol 12 (2) ◽  
pp. 245-263
Author(s):  
Keyword(s):  
Multinational Corporations ◽  
Manufacturing Sector ◽  
National Standards ◽  
Small Island ◽  
Industrial Plants ◽  
Number Of Factors ◽  
Island State ◽  
High Degree ◽  
Small Island State

AbstractThis paper focuses on the management of industrial plants and polluting facilities, with particular reference to the siting of such facilities. There has been no public outcry in Singapore regarding any problem associated with industrial pollution since its independence in August 1965. One notable success in Singapore is the extremely high degree of compliance with environmental regulations, about 90 per cent in the manufacturing sector today. A number of factors contributing to success in this area are pointed out, one of which is the role of the multinational corporations which tend to conduct operations within stricter parameters than those of the national standards, and this helps to raise the standards of local small and medium-sized enterprises as well.

scholarly journals A Proposed Educational Vision For Activating The Role of The Jordanian Universities Students Families In Enhancing Students Intellectual Security From The Students Perspectives

2016 ◽  
Vol 12 (16) ◽  
pp. 105
Author(s):  
Khloud Falah Ahmad Rahamneh ◽  
Mohammed Amin Hamed Al- Qudah
Keyword(s):  
Analytical Approach ◽  
Basic Function ◽  
Early Age ◽  
Educational Vision ◽  
The Social ◽  
Cultural Domain ◽  
The Right ◽  
The University ◽  
High Degree

This study aimed to find out the role of the Jordanian families in establishing intellectual security in their children from the perspective of the Jordanian students enrolled in Jordanian universities. For this purpose, a questionnaire of 36 paragraphs was created. The questionnaire was divided into three domains: the social, the cultural and the religious domains. The study was conducted on a random sample of (2700) students from three public universities (the University of Jordan, Yarmouk University, Moa'ta University and Al-Balqa' Applied University) and three private universities (Amman Al-Ahliah, Azzaytouna al-Ordiniah and Jerash). The study was conducted during the second university term of 2015/2016 CE. The descriptive analytical approach was used. The study showed that the three domains (social, cultural and religious) were of high degree. The highest of them was the cultural domain. The two paragraphs which state (the family's quest to build a cultural system emerging from our religion, values, traditions and customs, consolidating the values of the theoretical and practical dimensions of moderation among children) occupied the first rank, followed by the social domain. The paragraph which states that (The family's doing its basic function of education and socialization) occupied the first rank, whereas the religious domain occupied the last one. The paragraph which states (The family's seeking to form the right belief at an early age) occupied the first rank.

scholarly journals P1696 Intravascular leiomyomatosis with inferior vena cava and intracardiac extension, with severe obstruccion to the right ventricle.The fundamental role of transesophageal echocardiography

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
Z Y Vasquez-Ortiz ◽  
A Guzman Ayon ◽  
E D Aceves Velazquez ◽  
J Navarrete Garcia ◽  
P Hernandez-Reyes ◽  
...  
Keyword(s):  
Inferior Vena Cava ◽  
Right Atrium ◽  
Inferior Vena ◽  
Intensive Therapy ◽  
Vena Cava ◽  
Systolic Pressure ◽  
Mixed Dyslipidemia ◽  
Intracardiac Extension ◽  
The Right

Abstract Introduction Intravascular leiomyomatosis (IL) is a rare type of tumor common and was first described by Birch-Hirschfeld in 1896. There are currently few cases reported in the literature involving this type of vena cava tumor and the right atrium. This tumors are characterized by nodular, intravascular, histologically benign masses of smooth muscle with variable extensión. The most frequently affected women are pre-menopausal and multiparous. There are no specific clinical manifestations of vascular leiomyomas. Clinical case This is 51-year-old woman with a history of morbid obesity (body mass index of 47kg / m2SC) in bariatric surgery protocol, mixed dyslipidemia, is presented to the emergency service of our Institute, with uterine myomatosis diagnosed 6 months prior to admission. She was admitted for a 2-week evolution characterized by dyspnea of medium efforts that progressed at rest on the day of his admission with acute heart failure. A transthoracic and transesophageal echocardiograhy three-dimensional (TTE, TEE 3D) was made in which a solid-appearing, regular-border, heterogeneous tumor was reported from the inferior vena cava to the right atrium without being attached to the interatrial septum or other structures, with severe protrusion to the right ventricle, highly mobile, heterogeneous, without vascularity with color doppler, causing intermittent obstruction and tricuspid stenosis with a mean gradient of 8mmHg, pulmonary artery systolic pressure calculated at 46 mmHg. TAC showed invasion from the uterine leiomyoma to the inferior vena cava and right atrium. The patient was taken to emergency surgery, the vascular surgery and cardiothoracic surgery performed a long intervention. Macroscopic description reported uterine tumor of 25x19x18cm. Weight of 3.90Kg, with multiple nodular lesions, the largest being 18x15cm. Intracavitary tumor with fragment of tissue. The pathological diagnosis was uterine leiomyomatosis, intravascular leiomyomatosis in right periadnexal vessels. The patient was taken to intensive therapy, although the postoperative period was prolonged, she was discharged in functional class II NYHA. Discussion This case demonstrates the importance of recognizing this rare disease and suspecting it in patients who present with the a symptoms and the role of the echocardiography is fundamental for the characterization of the tumor and the invasion of neighboring structures. The reported cases of intravascular leiomyomas with intracardiac extension are approximately 10% and to date, less than 300 cases have been reported in the literatura. Vascular leiomyomas arise from uterine leiomyomas with vascular invasión, the etiology still remains unknown, it has been associated with high levels of estrogen. The key in its treatment is the complete resection. The prognosis is good after its resection. The recurrence rate is up to 30%. Anti-estrogenic therapy has been considered but its efficacy is controversial. Abstract P1696 Figure. Intravascular leiomyomatosis

scholarly journals Combined use of arginase II and tadalafil inhibitors for the correction of monocrotaline pulmonary hypertension

2019 ◽  
Vol 5 (3) ◽  
pp. 79-85 ◽  
Author(s):  
Ivan S. Koklin ◽  
Lyudmila M. Danilenko
Keyword(s):  
Pulmonary Hypertension ◽  
Water Solution ◽  
Systolic Pressure ◽  
Protective Effects ◽  
Combined Use ◽  
Alcohol Water ◽  
Arginase Ii ◽  
The Right ◽  
Dose Dependent

Introduction: The concept of the regulatory role of endothelium in the pathogenesis of pulmonary hypertension (PH) is fundamental. Research objective: To study the protective effects of the selective arginase II inhibitors L207-0525 and L327-0346 in combination with tadalafil in a monocrotaline model of pulmonary hypertension in rats. Materials and methods: Monocrotaline-induced pulmonary hypertension was simulated in 10 animals by a subcutaneous injection of an alcohol-water solution of monocrotaline (MCT) in the dose of 60 mg/kg. Seven days after the injection of MCT, the administration of L207-0525 and L327-0346 in the doses of 1 mg/kg and 3 mg/kg was started. The compounds were administered intragastrically once a day for 21 days. Results and discussion: It was found that L207-0525 and L327-0346 in the dose of 3 mg/kg and tadalafil in the dose of 1 mg/kg prevented the development of pulmonary hypertension, which was expressed in a statistically significant decrease in the coefficient of endothelial dysfunction (CED, prevention of an increase in systolic pressure in the right ventricle, as well as Fulton, RV/BW and WT indices. The greatest activity was shown by L207-0525 and L327-0346 in the dose of 3 mg/kg in combination with tadalafil in the dose of 0.1 mg/kg. Conclusions: The received results suggest the dose-dependent protective activity of selective arginase II inhibitors L207-0525 and L327-0346 and the development of the additive effect of their combined use with low doses of PDE-5 inhibitor tadalafil in relation to the development of monocrotaline pulmonary hypertension.

Contemporary Issues in the Analysis of Data: A Survey of 551 Psychologists

1993 ◽  
Vol 4 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Miron Zuckerman ◽  
Holley S. Hodgins ◽  
Adam Zuckerman ◽  
Robert Rosenthal
Keyword(s):  
Response Rate ◽  
Type I ◽  
Contrast Analysis ◽  
Response Preferences ◽  
The Right ◽  
Type Ii Errors ◽  
High Degree ◽  
Data Analytic ◽  
Better Than

We asked active psychological researchers to answer a survey regarding the following data-analytic issues: (a) the effect of reliability on Type I and Type II errors, (b) the interpretation of interaction, (c) contrast analysis, and (d) the role of power and effect size in successful replications. Our 551 participants (a 60% response rate) answered 59% of the questions correctly; 46%) accuracy would be expected according to participants' response preferences alone. Accuracy was higher for respondents with higher academic ranks and for questions with “no” as the right answer. It is suggested that although experienced researchers are able to answer difficult but basic data-analytic questions at better than chance levels, there is also a high degree of misunderstanding of some fundamental issues of data analysis.

scholarly journals SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Xin Xi ◽  
Jing Zhang ◽  
Jian Wang ◽  
Yuqin Chen ◽  
Wenmei Zhang ◽  
...  
Keyword(s):  
Ventricular Hypertrophy ◽  
Histological Analysis ◽  
Systolic Pressure ◽  
Macrophage Infiltration ◽  
Proinflammatory Response ◽  
Promising Target ◽  
Pulmonary Arterial ◽  
The Right

Inflammation plays a pivotal role in the development of pulmonary arterial hypertension (PAH). Meanwhile, serum glucocorticoid-regulated kinase-1 (SGK1) has been considered to be an important factor in the regulation of inflammation in some vascular disease. However, the role of SGK1 in hypoxia-induced inflammation and PAH is still unknown. WT and SGK1-/- mice were exposed to chronic hypoxia to induce PAH. The quantitative PCR and immunohistochemistry were used to determine the expression of SGK1. The right ventricular hypertrophy index (RVHI), RV/BW ratio, right ventricle systolic pressure (RVSP), and percentage of muscularised vessels and medical wall thickness were measured to evaluate PAH development. The infiltration of macrophages and localization of SGK1 on cells were examined by histological analysis. The effects of SGK1 on macrophage function and cytokine expression were assessed by comparing WT and SGK1-/- macrophages in vitro. SGK1 has high expression in hypoxia-induced PAH. Deficiency of SGK1 prevented the development of hypoxia-induced PAH and inhibited macrophage infiltration in the lung. In addition, SGK1 knockout inhibited the expression of proinflammatory cytokines in macrophages. SGK1-induced macrophage activation and proinflammatory response contributes to the development of PAH in hypoxia-treated mice. Thus, SGK1 might be considered a promising target for PAH treatment.

scholarly journals Combining Electrostimulation With Fiber Tracking to Stratify the Inferior Fronto-Occipital Fasciculus

2021 ◽  
Vol 15 ◽  
Author(s):  
Alexandre Roux ◽  
Anne-Laure Lemaitre ◽  
Jeremy Deverdun ◽  
Sam Ng ◽  
Hugues Duffau ◽  
...  
Keyword(s):  
Awake Surgery ◽  
Low Grade ◽  
Network Organization ◽  
Hemispheric Differences ◽  
Interindividual Variations ◽  
Fiber Tracts ◽  
The Right ◽  
Subcortical Mapping ◽  
High Degree

The inferior fronto-occipital fasciculus (IFOF) is one of the longest association fiber tracts of the brain. According to the most recent anatomical studies, it may be formed by several layers, suggesting a role in multiple cognitive functions. However, to date, no attempt has been made to dissociate the functional contribution of the IFOF subpathways. In this study, real-time, cortico-subcortical mapping with direct electrostimulation was performed in 111 patients operated on in wide-awake surgery for a right low-grade glioma. Patients performed two behavioral tasks during stimulation, tapping, respectively, mentalizing and visual semantic cognition—two functions supposed to be partly mediated by the IFOF. Responsive white matter sites were first subjected to a clustering analysis to assess potential topological differences in network organization. Then they were used as seeds to generate streamline tractograms based on the HC1021 diffusion dataset (template-based approach). The tractograms obtained for each function were overlapped and contrasted to determine whether some fiber pathways were more frequently involved in one or the other function. The obtained results not only provided strong evidence for a role of the right IFOF in both functions, but also revealed that the tract is dissociable into two functional strata according to a ventral (semantic) and dorsal (mentalizing) compartmentalization. Besides, they showed a high degree of anatomo-functionnal variability across patients in the functional implication of the IFOF, possibly related to symmetrical/hemispheric differences in network organization. Collectively, these findings support the view that the right IFOF is a functionally multi-layered structure, with nevertheless interindividual variations.

Sign in / Sign up

Export Citation Format

Share Document