scholarly journals Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province

2020 ◽  
Vol 37 (13) ◽  
pp. 1317-1323
Author(s):  
Wei Liu ◽  
Hongbin Cheng ◽  
Jing Wang ◽  
Lingli Ding ◽  
Zhaoxian Zhou ◽  
...  
Keyword(s):  
Neonatal Intensive Care ◽  
Throat Swab ◽  
Clinical Manifestations ◽  
Clinical Analysis ◽  
Neonatal Intensive Care Units ◽  
Key Points ◽  
Laboratory Results ◽  
Coronavirus Infection ◽  
Child Healthcare ◽  
Polymerase Chain

Objective The perinatal consequences of neonates born to severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) infected mothers are uncertain. This study aimed to compare the differences in clinical manifestation, laboratory results, and outcomes of neonates born to mothers with or without coronavirus disease 2019 (COVID-19). Study Design A total of 48 neonates were admitted to Tongji Hospital and HuangShi Maternal and Child Healthcare Hospital from January 17 to March 4, 2020. The neonates were divided into three groups according to the mothers' conditions: neonates born to mothers with confirmed COVID-19, neonates born to mothers with clinically diagnosed COVID-19, and neonates born to mothers without COVID-19. The clinical data of mothers and infants in the three groups were collected, compared, and analyzed. Results The deliveries occurred in a negative pressure isolation room, and the neonates were separated from their mothers immediately after birth for further observation and treatment. None of the neonates showed any signs of fever, cough, dyspnea, or diarrhea. SARS-CoV-2 reverse transcriptase-polymerase chain reaction of the throat swab and feces samples from the neonates in all three groups was negative. No differences were detected in the whole blood cell, lymphocytes, platelet, and liver and renal function among the three groups. All mothers and their infants showed satisfactory outcomes, including a 28-week preterm infant. Conclusion The clinical manifestations, radiological, and biochemical results did not show any difference between the three groups. No evidence of vertical transmission was found in this study whether the pregnant women developed coronavirus infection in the third (14 cases) or second trimester (1 case). Key points

REVIEW ARTICLE ABOUT PERINATALAND NEONATAL MANAGEMENT FOR THE PREVENTION AND CONTROL OF THE 2019 NOVEL CORONAVIRUS INFECTION

2021 ◽  
pp. 54-57
Author(s):  
Isra Khalil Mohammed Ali Saeed ◽  
Maha Hussein Mohammed Hamza ◽  
Hiba Hussein Ibrahim ◽  
Esmehan Elkheir Babeker ◽  
Ibrahim Ismail M.Abu ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Neonatal Intensive Care ◽  
Control Measures ◽  
Neonatal Intensive Care Units ◽  
Community Physician ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
And Control ◽  
Who Guideline ◽  
Immature Immune System

An epidemic of new coronavirus 2019 (COVID-19) has emerged in China since December 2019. WHO declared it as a pandemic on March 2020 as it has spread worldwide. Several cases among neonate were observed with rst reported 36 hours after birth. Due to the possibility of the infection and the immature immune system of the neonate there should be preventive and control measures at Neonatal Intensive Care Units. According to WHO guideline and other published articles in COVID-19 in infants and neonate a technical working group including community physician and Pediatricians has put measures for clinical management, prevention and control of COVID-19 in neonates.

scholarly journals Modern Breastfeeding Options for Preterm Children in Neonatal Hospital

2021 ◽  
Author(s):  
Irina A. Belyaeva ◽  
Leyla S. Namazova-Baranova ◽  
Elena P. Bombardirova ◽  
Tatiana V. Turti ◽  
Evgeniia A. Prikhodko
Keyword(s):  
Breast Milk ◽  
Neonatal Intensive Care ◽  
Neonatal Intensive Care Units ◽  
Processing Technologies ◽  
Perinatal Pathology ◽  
Methodological Errors ◽  
Perinatal Center ◽  
Clinical Breast ◽  
Coronavirus Infection

The literature overview on the issue of breastfeeding in neonatal departments, including neonatal intensive care units, is presented. The importance of breastfeeding for newborns with perinatal pathology is justified, as breast milk is vital for these children due to its unique sanogenetic properties. Data on special preventive and therapeutic role of breastfeeding for premature infants is presented. Reasons that complicate the use of breast milk in neonatal hospitals were analyzed (including those related to insufficient bacteriological and virological safety of native breast milk due to methodological errors during its collection and usage). Particular attention was paid to ensuring the breastfeeding safety during new coronavirus infection pandemic. This difficult period has demonstrated and confirmed the expediency of combining two breastfeeding approaches in perinatal centers: use of maternal milk and use of donor breast milk. Another section of review is devoted to modern breast milk processing technologies. Use of electric clinical breast pumps is crucial for promoting and supporting breastfeeding in the perinatal center.

Survey of Quaternary Neonatal Management of Posthemorrhagic Hydrocephalus

2021 ◽  
Author(s):  
Susan Cohen ◽  
Ulrike Mietzsch ◽  
Carl Coghill ◽  
Narendra Dereddy ◽  
Katerina Ducis ◽  
...  
Keyword(s):  
At Risk ◽  
Neonatal Intensive Care ◽  
Clinical Care ◽  
Practice Variation ◽  
Neonatal Intensive Care Units ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Posthemorrhagic Hydrocephalus ◽  
Standard Guideline ◽  
Key Points

Objective This study aimed to determine clinical care practices for infants at risk for posthemorrhagic hydrocephalus (PHH) across level IV neonatal intensive care units (NICUs). Study Design Cross-sectional survey that addressed center-specific surveillance, neurosurgical intervention, and follow-up practices within the Children's Hospitals Neonatal Consortium. Results We had a 59% (20/34 sites) response rate, with 10 sites having at least two participants. Respondents included neonatologists (53%) and neurosurgeons (35%). Most participants stated having a standard guideline for PHH (79%). Despite this, 42% of respondents perceive inconsistencies in management. Eight same-center pairs of neonatologists and neurosurgeons were used to determine response agreement. Half of these pairs disagreed on nearly all aspects of care. The greatest agreement pertained to a willingness to adopt a consensus-based protocol. Conclusion Practice variation in the management of infants at risk of PHH in level IV NICUs exists despite the perception that a common practice is available and used. Key Points

scholarly journals Inhaled corticosteroids may have a protective effect against coronavirus infection

2021 ◽  
Vol 49 (1) ◽  
pp. 113-117
Author(s):  
Alicia Armentia ◽  
Sara Fernández Cortés ◽  
Angela Moro Simón ◽  
Blanca Martín-Armentia ◽  
Sara Martín-Armentia ◽  
...  
Keyword(s):  
Nursing Home ◽  
Inhaled Corticosteroids ◽  
Clinical Manifestations ◽  
Nursing Home Residents ◽  
Good Prognosis ◽  
Uncontrolled Asthma ◽  
Protective Mechanisms ◽  
Radiological Images ◽  
Coronavirus Infection ◽  
Polymerase Chain

Background: Spain has been severely affected by the COVID-19 epidemic, with 195,944 persons infected and 20,453 deaths at the time of writing. Older people with respiratory or cardiac conditions are most at risk. Objective: The aim was to compare respiratory symptoms in nursing home residents and patients with uncontrolled asthma, who are considered vulnerable to COVID-19. Methods: We studied 134 nursing home residents and 139 patients with uncontrolled asthma, groups vulnerable to COVID-19. Demographic characteristics, clinical manifestations, outcomes, key laboratory results, and radiological images were collected from medical records. COVID-19 infection was detected by polymerase chain reaction (PCR). Results: Thirteen (9.3%) patients with uncontrolled asthma, all receiving inhaled corticosteroids were infected by COVID-19. Eighty (60%) nursing home residents were infected; only 28, all of whom had received inhaled corticosteroids, had a good prognosis. Conclusions: Early treatment with inhaled corticosteroids may be helpful in COVID-19 infection. Persons with an allergy might have some protective mechanisms against coronavirus.

scholarly journals Clinical Manifestations and Pregnancy Outcomes of Covid-19 in Indonesian Referral Hospital in Central Pandemic Area

2021 ◽  
Author(s):  
Muhammad Ilham Aldika Akbar ◽  
Khanizyah Erza Gumilar ◽  
Rino Andriya ◽  
Manggala Pasca Wardhana ◽  
Pungky Mulawardhana ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Clinical Manifestations ◽  
Referral Hospital ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Laboratory Findings ◽  
Cohort Design ◽  
Laboratory Results ◽  
Polymerase Chain

Objectives:. The data on clinical manifestations and pregnancy outcomes of pregnant women with COVID-19 are limited, particularly in developing countries. The aim of this study is to analyze the clinical manifestations and pregnancy outcomes in COVID-19 maternal cases in a large referral hospital in Indonesia Methods: The study used a prospective cohort design of all pregnant women with suspected COVID-19. Subjects were divided into COVID-19 and non COVID-19 group based on real-time polymerase chain reaction (RT-PCR) of SARS-CoV-2. The clinical characteristics, laboratory results, and pregnancy outcomes were then compared between both groups. Results: From 141 suspected maternal cases, 62 COVID-19 cases were confirmed (43.9%), while 79 suspected cases were found to be negative (56.1%). The clinical manifestations and laboratory findings between the two groups were not significantly different (p>0.05). However, the maternal mortality directly caused by COVID-19 was significantly higher compared to the non-COVID-19 group (8.3 vs 1.3%; p=0.044; OR 6.91, 95% CI: 0.79-60.81). Conclusions: The clinical manifestation and laboratory of suspected pregnant women with positive and negative RT-PCR COVID-19 result are similiar. However, within the Indonesian setting, COVID-19 strongly increases the risk of maternal death through both direct and indirect factors.

scholarly journals The outbreak of the new coronavirus infection in pediatric TB department

2020 ◽  
Vol 98 (10) ◽  
pp. 6-10
Author(s):  
M. F. Gubkina ◽  
I. Yu. Petrakova ◽  
N. V. Yukhimenko ◽  
S. S. Sterlikova ◽  
Yu. Yu. Khokhlova ◽  
...  
Keyword(s):  
Viral Infections ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Lung Damage ◽  
Igg Antibodies ◽  
Pediatric Tb ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Body Temperature Increase ◽  
Observation Period

The objective: to analyze the course of the new coronavirus infection (COVID-19) in children with active respiratory tuberculosis. Subjects and methods. The article describes results of retrospective analysis of the course of the new coronavirus infection in 25 children (3-12 years old) with active respiratory tuberculosis during the outbreak of COVID-19 in an in-patient TB unit.Results. 24 (96%) persons got infected after the close exposure to the coronavirus infection, and 1 (4%) child didn't get infected. The diagnosis was verified by polymerase chain reaction (detection of RNK of SARS-CoV-2) in 33.3%, by enzyme immunoassay (detection of IgG antibodies to SARS-CoV-2 in 1 month after quarantine removal) in 100%. 58.3% of children with respiratory tuberculosis (14 people) infected with coronavirus infection had minimal respiratory symptoms, that did not differ from signs of other respiratory viral infections; clinical manifestations of the disease were completely absent in 41.7% (10) patients. Coronavirus pneumonia was diagnosed in 4 (16.7%) children who suffered from COVID-19, they had no clinical signs of lower respiratory tract disorders and no body temperature increase; 3 patients had no signs of respiratory viral infection; in all cases, the lung damage detected by computed tomography didn't exceed 10%. In 2 months after the removal of quarantine, no IgG antibodies to SARS-CoV-2 were detected in 2 out of 10 examined children (20.0%), thus there was a chance for re-infection. No mutual aggravating effect of coronavirus infection and tuberculosis was revealed in their combination over the entire observation period (4 months).

scholarly journals Longitudinal Survey of COVID-19 Burden and Related Policies in U.S. Neonatal Intensive Care Units

2020 ◽  
Vol 38 (01) ◽  
pp. 093-098
Author(s):  
Kaashif A. Ahmad ◽  
Ashley Darcy-Mahoney ◽  
Amy S. Kelleher ◽  
Dan L. Ellsbury ◽  
Veeral N. Tolia ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Neonatal Intensive Care Units ◽  
Cross Sectional ◽  
Key Points ◽  
Hospital Policies ◽  
Expectant Mothers ◽  
Novel Coronavirus ◽  
The Impact

Objective This study aimed to determine the prevalence of confirmed novel coronavirus disease 2019 (COVID-19) disease or infants under investigation among a cohort of U.S. neonatal intensive care units (NICUs). Secondarily, to evaluate hospital policies regarding maternal COVID-19 screening and related to those infants born to mothers under investigation or confirmed to have COVID-19. Study Design Serial cross-sectional surveys of MEDNAX-affiliated NICUs from March 26 to April 3, April 8 to April 19, May 4 to May 22, and July 13 to August 2, 2020. The surveys included questions regarding COVID-19 patient burden and policies regarding infant separation, feeding practices, and universal maternal screening. Results Among 386 MEDNAX-affiliated NICUs, responses were received from 153 (42%), 160 (44%), 165 (45%), 148 (38%) across four rounds representing an active patient census of 3,465, 3,486, 3,452, and 3,442 NICU admitted patients on the day of survey completion. Confirmed COVID-19 disease in NICU admitted infants was rare, with the prevalence rising from 0.03 (1 patient) to 0.44% (15 patients) across the four survey rounds, while the prevalence of patients under investigation increased from 0.8 to 2.6%. Hospitals isolating infants from COVID-19-positive mothers fell from 46 to 20% between the second and fourth surveys, while centers permitting direct maternal breastfeeding increased 17 to 47% over the same period. Centers reporting universal severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) screening for all expectant mothers increased from 52 to 69%. Conclusion Among a large cohort of NICU infants, the prevalence of infants under investigation or with confirmed neonatal COVID-19 disease was low. Policies regarding universal maternal screening for SARS-CoV-2, infant isolation from positive mothers, and direct maternal breastfeeding for infants born to positive mothers are rapidly evolving. As universal maternal screening for SARS-CoV-2 becomes more common, the impact of these policies requires further investigation. Key Points

Handwashing Results in Incomplete Nicotine Removal from Fingers of Individuals who Smoke: A Randomized Controlled Experiment

2021 ◽  
Author(s):  
Thomas F. Northrup ◽  
Angela L. Stotts ◽  
Robert Suchting ◽  
Amir M. Khan ◽  
Michelle R. Klawans ◽  
...  
Keyword(s):  
Mixed Models ◽  
Neonatal Intensive Care ◽  
Generalized Linear Mixed Models ◽  
Neonatal Intensive Care Units ◽  
Breath Sample ◽  
Cross Sectional ◽  
Current Smoking ◽  
Randomized Controlled ◽  
Key Points ◽  
Randomized Controlled Experiment

Objective: Tobacco residue, also known as third-hand smoke (THS), contains toxicants and lingers in dust and on surfaces and clothes. THS also remains on hands of individuals who smoke, with potential transfer to infants during visitation while infants are hospitalized in neonatal intensive care units (NICUs), raising concerns (e.g., hindered respiratory development) for vulnerable infants. Previously unexplored, this study tested handwashing (HW) and sanitization efficacy for finger-nicotine removal in a sample of adults who smoked and were visiting infants in an NICU. Study Design: A cross-sectional sample was recruited to complete an interview, carbon monoxide breath samples, and three nicotine wipes of separate fingers (thumb, index, and middle). Eligible participants (n = 14) reported current smoking (verified with breath samples) and were randomly assigned to 30 seconds of HW (n = 7) or alcohol-based sanitization (n = 7), with the order of finger wipes both counterbalanced and randomly assigned. After randomization, the first finger was wiped for nicotine. Participants then washed or sanitized their hands and finger two was wiped 5 minutes later. An interview assessing tobacco/nicotine use and exposure was then administered, followed by a second breath sample and the final finger wipe (40–60 minutes after washing/sanitizing). Results: Generalized linear mixed models found that HW was more effective than sanitizer for nicotine removal but failed to completely remove nicotine. Conclusions: Without proper protections (e.g., wearing gloves and gowns), NICU visitors who smoke may inadvertently expose infants to THS. Research on cleaning protocols are needed to protect vulnerable medical populations from THS and associated risks. Key Points

scholarly journals Поражение пищеварительного тракта как проявление COVID-19 у ребенка 4 лет

Doctor Ru ◽  
2021 ◽  
Vol 20 (3) ◽  
pp. 56-59
Author(s):  
I.M. Osmanov ◽  
◽  
O.N. Solodovnikova ◽  
S.N. Borzakova ◽  
T.V. Sbrodova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Bacterial Infections ◽  
Clinical Manifestations ◽  
Enteric Infection ◽  
The Novel ◽  
Key Points ◽  
Enteric Infections ◽  
Coronavirus Infection ◽  
Novel Coronavirus

Objective of the Paper: To represent a case of the novel coronavirus infection COVID-19 in a 4-year-old child with isolated bowel damage. Key Points. COVID-19 impacts several systems and organs. Usually, children have mild or asymptomatic disease. Clinical manifestations of COVID-19 in children can be damage not only of respiratory tract, but also of GIT, requiring differential diagnosis of enteric infections (both viral and bacterial). Prompt diagnosis of COVID-19 is essential for antiepidemic measures and suppression an infectious process. The case shows challenges faced by clinicians when diagnosing COVID-19 in patients with isolated GIT damages without catarrhal signs. Course of the disease in this patient was characterised by a number of features indicative of a bacterial enteric infection: abdominal pain, diarrhoea, increased CRP, colitis syndrome in stool test, warranting differential diagnosis of acute enteric bacterial infections. Negative bacterial culture, detection of SARS-CoV2 RNA in oropharynx and nasopharynx mucous, fast stool normalisation and dyspeptic events arrest allowed diagnosing that the diarrhoea was associated with COVID-19. One month of metabolic and probiotic therapy normalised stool, arrested abdominal pain, and improved exercise tolerance. Conclusion. GIT damage in paediatric COVID-19 patients is essential and unexplored. COVID-19 should be added to differential diagnosis in case of clinical manifestations of an acute enteric infection. Keywords: children, novel coronavirus infection, COVID-19, GIT.

Attitudes of Argentinean Neonatologists toward Resuscitation of Infants with Trisomies 21, 18, and 13: A Multicenter Survey

2021 ◽  
Author(s):  
Agustín Silberberg ◽  
Adolfo Etchegaray ◽  
Sofía Juárez Peñalva ◽  
Marcelo J. Villar ◽  
Gabriel Musante
Keyword(s):  
Neonatal Intensive Care ◽  
Legal Framework ◽  
Trisomy 18 ◽  
Trisomy 13 ◽  
Delivery Room ◽  
Neonatal Intensive Care Units ◽  
Sociocultural Factors ◽  
Staffing Level ◽  
Key Points ◽  
Multicenter Survey

Objective This study was aimed to explore the attitude of Argentinean neonatologists in the delivery room on resuscitating infants with trisomies. Study Design An anonymous questionnaire was completed by neonatologists staffing level-III neonatal intensive care units (NICUs) on resuscitation of children with trisomies 21, 18, and 13. Potential sociocultural factors influencing the decision to resuscitate were included. Results Overall, 314 neonatologists in 34 units in the Buenos Aires region participated (response rate of 54%). The position of neonatologists regarding the resuscitation in the delivery room was that 98% would resuscitate newborns with trisomy 21, and 47% with trisomy 18 or trisomy 13. Resuscitation of newborns with trisomy 18 or trisomy 13 by neonatologists was significantly associated with working in the public sector, religious beliefs, and legal framework. Conclusion With improvement in the management and treatment of infants with trisomies 18 and 13, Argentinean neonatologists showed a favorable attitude toward resuscitating them in the delivery room. Key Points

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