Use of Homeopathic Arnica montana 30cH for Postoperative Analgesia in Female Dogs Undergoing Elective Ovariohysterectomy

Homeopathy ◽  
2021 ◽  
Author(s):  
David Ronald Parra Travagin ◽  
Melina Castilho de Souza Balbueno ◽  
Cidéli de Paula Coelho
Keyword(s):  
Postoperative Analgesia ◽  
Saline Solution ◽  
Pain Scale ◽  
Immunomodulatory Activity ◽  
Arnica Montana ◽  
Elective Surgical Procedures ◽  
Inhalational Anaesthetic ◽  
Healthy Female ◽  
Effect Of Therapy ◽  
Veterinary Hospital

Abstract Background Ovariohysterectomy (OH) is one of the most frequent elective surgical procedures in routine veterinary practice. Arnica montana is a well-known medicine in phytotherapy, with proven analgesic, anti-inflammatory, antiseptic, healing, antioxidant and immunomodulatory activity. However, there is still a shortage of studies on the action and effects of the homeopathic formulation of the medicine on animals. The aim of this study was to evaluate analgesia with Arnica montana 30cH during the postoperative period after elective OH. Methods Thirty healthy female dogs, aged 1 to 3 years, weighing 7 to 14 kg, were selected at the Veterinary Hospital in Campo Mourão, Paraná, Brazil. The dogs underwent the surgical procedure with an anaesthetic protocol and analgesia that had the aim of maintaining the patient's wellbeing. After the procedure, they were randomly divided into three groups of 10. One group received Arnica montana 30cH; another received 5% hydroalcoholic solution; and the third group, 0.9% NaCl saline solution. All animals received four drops of the respective solution sublingually and under blinded conditions, every 10 minutes for 1 hour, after the inhalational anaesthetic had been withdrawn. The Glasgow Composite Measure Pain Scale was used to analyse the effect of therapy. Analysis of variance (ANOVA) followed by the Tukey test was used to evaluate the test data. Statistical differences were deemed significant when p ≤0.05. Results The Arnica montana 30cH group maintained analgesia on average for 17.8 ± 3.6 hours, whilst the hydroalcoholic solution group did so for 5.1 ± 1.2 hours and the saline solution group for 4.1 ± 0.9 hours (p ≤0.05). Conclusion These data demonstrate that Arnica montana 30cH presented a more significant analgesic effect than the control groups, thus indicating its potential for postoperative analgesia in dogs undergoing OH.

Postoperative pain control in cats: clinical trials with pre-emptive lidocaine epidural co-administered with morphine or methadone

2016 ◽  
Vol 18 (11) ◽  
pp. 882-888 ◽  
Author(s):  
Rafael DeRossi ◽  
Larissa Correa Hermeto ◽  
Paulo Henrique Affonseca Jardim ◽  
Natalia de Andrade Bicudo ◽  
Klebs Tavares de Assis
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Postoperative Analgesia ◽  
Pain Control ◽  
Pain Scale ◽  
Postoperative Pain Control ◽  
Treatment Groups ◽  
Epidural Injections ◽  
Arterial Blood ◽  
Acceptable Range

Objectives The aim of the study was to evaluate the effectiveness of epidural lidocaine in combination with either methadone or morphine for postoperative analgesia in cats undergoing ovariohysterectomy. Methods Under general anesthesia, 24 cats that underwent ovariohysterectomy were randomly allocated into three treatment groups of eight each. Treatment 1 included 2% lidocaine (4.0 mg/kg); treatment 2 included lidocaine and methadone (4.0 mg/kg and 0.3 mg/kg, respectively); and treatment 3 included lidocaine and morphine (4.0 mg/kg and 0.1 mg/kg, respectively). All drugs were injected in a total volume of 0.25 ml/kg via the lumbosacral route in all cats. During the anesthetic and surgical periods, the physiologic variables (respiratory and heart rate, arterial blood pressure and rectal temperature) were measured at intervals of time zero, 10 mins, 20 mins, 30 mins, 60 mins and 120 mins. After cats had recovered from anesthesia, a multidimensional composite pain scale was used to assess postoperative analgesia 2, 4, 8, 12, 18 and 24 h after epidural. Results The time to first rescue analgesic was significantly ( P <0.05) prolonged in cats that received both lidocaine and methadone or lidocaine and morphine treatments compared with those that received lidocaine treatment alone. All cats that received lidocaine treatment alone required rescue analgesic within 2 h of epidural injections. All treatments produced significant cardiovascular and respiratory changes but they were within an acceptable range for healthy animals during the surgical period. Conclusions and relevance The two combinations administered via epidural allowed ovariohysterectomy with sufficient analgesia in cats, and both induced prolonged postoperative analgesia.

scholarly journals Surgical sponge associated with platelets rich plasma in skin mesh grafts and layer in rabbits (Oryctolagus cuniculus)

2018 ◽  
Vol 70 (5) ◽  
pp. 1339-1348
Author(s):  
J.M. Pazzini ◽  
E.L. Serafim ◽  
R.R.A. Uscategui ◽  
V.T. Almeida ◽  
C.A.C. Oliva ◽  
...  
Keyword(s):  
Oryctolagus Cuniculus ◽  
Mononuclear Cells ◽  
Saline Solution ◽  
Platelet Rich Plasma ◽  
Fibroblast Proliferation ◽  
Surgical Sponge ◽  
Tukey Test ◽  
Cosmetic Appearance ◽  
Veterinary Hospital ◽  
Paired T Test

ABSTRACT The aim of this study was to evaluate of the efficacy of PRP employment associated with surgical sponges to improve the integration of the graft in the recipient bed. It was held at the Veterinary Hospital UNESP, Campus of Jaboticabal - SP, a study of 64 rabbits, divided into eight groups with eight animals. The groups were divided in control with saline solution 0,9%, control with PRP both without the sponge, surgical sponge with PRP, surgical sponge without PRP, and were used mesh and layer grafts in the respective groups. The data were submitted to statistical analysis (paired t-test, Kruskal-Wallis test, with subsequent use of the multiple comparison tests of Dunn, analysis of variance (F) test, Tukey test, P< 0.05). Edema and exudate with 3 and 3 and 7 days (P= 0,03 e P= 0,0049); coloring on the 14th day (P= 0,0001); cosmetic appearance on the 7th and 14th day (P= 0,0026 and P= 0,0001); mononuclear cells (P= 0,01) and polymorphonuclear (P= 0,01); fibroblast proliferation (P= 0,01); collagenous (P= 0,05); hemorrhage (P-007); necrosis and re-epithelialization (P= 0,2928 and P= 0,1). We concluded that the use of Platelet Rich Plasma Gel on skin grafts associated with a sponge as a compressive dressing promote the skin graft survival without a previous granulation tissue.

scholarly journals Anaesthetic and Perioperative Management of 14 Male New Zealand White Rabbits for Calvarial Bone Surgery

Animals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 896 ◽  
Author(s):  
Mathieu Raillard ◽  
Carlotta Detotto ◽  
Sandro Grepper ◽  
Olgica Beslac ◽  
Masako Fujioka-Kobayashi ◽  
...  
Keyword(s):  
New Zealand ◽  
Postoperative Analgesia ◽  
Perioperative Management ◽  
Pain Scale ◽  
Supraglottic Airway ◽  
Calvarial Bone ◽  
Rescue Analgesia ◽  
Bone Surgery ◽  
Arterial Blood ◽  
New Zealand White Rabbits

Calvarial bone surgery on rabbits is frequently performed. This report aims to document a simple and practical anaesthetic and perioperative management for this procedure. Fourteen male New Zealand white rabbits were included in the study. Subcutaneous (SC) dexmedetomidine, ketamine and buprenorphine ± isoflurane vaporized in oxygen administered through a supraglottic airway device (V-gel®) provided clinically suitable anaesthesia. Supplemental oxygen was administered throughout recovery. Monitoring was clinical and instrumental (pulse-oximetry, capnography, invasive blood pressure, temperature, arterial blood gas analysis). Lidocaine was infiltrated at the surgical site and meloxicam was injected subcutaneously as perioperative analgesia. After surgery, pain was assessed five times daily (composite behavioural pain scale and grimace scale). Postoperative analgesia included SC meloxicam once daily for four days and buprenorphine every 8 h for three days (unless both pain scores were at the lowest possible levels). Rescue analgesia (buprenorphine) was administered in case of the score > 3/8 in the composite pain scale, >4/10 on the grimace scale or if determined necessary by the caregivers. Airway management with a V-gel® was possible but resulted in respiratory obstruction during the surgery in two cases. Hypoventilation was observed in all rabbits. All rabbits experienced pain after the procedure. Monitoring, pain assessments and administration of postoperative analgesia were recommended for 48 h.

scholarly journals Different rates of tramadol infusion for peri and postoperative analgesia in dogs undergoing orthopedic surgery

2019 ◽  
Vol 71 (1) ◽  
pp. 127-136
Author(s):  
V.N.L.S. Oliva ◽  
V.B. Albuquerque ◽  
B.P. Floriano ◽  
T.M. Meneghetti ◽  
C.J.X. Abimussi ◽  
...  
Keyword(s):  
Postoperative Analgesia ◽  
Pain Scale ◽  
Inhalation Anesthesia ◽  
Surgical Incision ◽  
Perioperative Analgesia ◽  
Duration Of Surgery ◽  
The Mean ◽  
Mean Time ◽  
Dose Dependent ◽  
Rate Infusion

ABSTRACT The study aimed to determine the continuous rate infusion of tramadol associated with peri- and postoperative analgesia for orthopedic surgeries in dogs, as well as cardiorespiratory and adverse effects. Thirty dogs aged 4.2±1.2 years and weighing 15.1±0.9kg were enrolled in the study, premedicated intramuscularly with acepromazine (0.04mg kg-1) and tramadol (2mg kg-1); anesthesia was induced with propofol and maintained with isoflurane in oxygen. Three infusion rates were compared, comprising three experimental groups: G2: 2.0mg kg-1 h-1; G2.5: 2.5mg kg-1 h-1; and G3: 3.0mg kg-1 h-1. Surgery was initiated 15 minutes following the start of tramadol infusion. During anesthesia, animals were monitored in predefined time points: immediately after tracheal intubation and start of inhalation anesthesia (T0); surgical incision (TSI); final suture (TFS) and end of tramadol infusion (TEI), which was maintained for at least 120 minutes and prolonged according to the duration of surgery. Postoperative analgesia was evaluated through an interval pain scoring scale and the Melbourne pain scale. The mean time of tramadol infusion was greater than 120 minutes in all groups and no differences were found among them (141±27 minutes in G2, 137±27 minutes in G2.5 and 137±30 minutes in G3). Perioperative analgesia was regarded as short and did not correlate with infusion rates. Tramadol infusion provided adequate analgesia with cardiorespiratory stability Analgesia was not dose-dependent, however, and residual postoperative effects were short-lasting, which warrants proper postoperative analgesia following tramadol infusion. Additional studies are required using higher infusion rates and standardized nociceptive stimulation in order to determine how doses influence tramadol analgesia and whe therthereis a limit to its effect in dogs.

scholarly journals Controlo de Dor, Infeção Local, Satisfação, Efeitos Adversos e Dor Residual no Pós-Operatório de Cirurgia Abdominal Major: Epidural versus Infusão Contínua da Ferida Cirúrgica (PAMA Trial)

2017 ◽  
Vol 30 (10) ◽  
pp. 683 ◽  
Author(s):  
Rita Araújo ◽  
Céline Marques ◽  
David Fernandes ◽  
Emanuel Almeida ◽  
Joana Alves ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Abdominal Surgery ◽  
Epidural Analgesia ◽  
Postoperative Analgesia ◽  
Standard Technique ◽  
Hemodynamic Instability ◽  
Pain Scale ◽  
Major Abdominal Surgery ◽  
Continuous Epidural Infusion ◽  
Infusion Group

Introduction: The Management of postoperative pain after abdominal surgery is a major challenge to the anesthesiologist. The optimization of postoperative analgesia improves prognosis contributing also to patient satisfaction and reducing morbidity and mortality. The aim of this randomized control study is to perform the comparative analysis in terms of effectiveness of an unconventional and still poorly technique implemented, continuous wound infusion, and the currently most applied and gold standard technique, epidural analgesia, in the postoperative period after abdominal surgery.Material and Methods: Fifty patients, previously subjected to abdominal surgery by median laparotomy with xifo-pubic incision were randomized to receive postoperative analgesia via epidural (n = 25) or via continuous wound infusion (n = 25) during 48 hours. The primary outcome was analysis of pain at rest (< 4/10 numerical pain scale) after 24 hours postoperatively. Scores of pain at six, 12 and 48 hours and three months after surgery were also evaluated, as well as the incidence of adverse effects 48 hours postoperatively.Results: The proportion of patients with successful control of postoperative pain was 84% against 60% with epidural analgesia and continuous wound infusion, respectively. Within the continuous wound infusion group with uncontrolled pain, all patients rated the pain below 6/10 24 hours postoperatively. The incidence of nausea, vomiting, pruritus or íleus was lower in the continuous wound infusion group, with statistically significant results for recovery of intestinal function. There was one case of systemic local anesthetic toxicity with an episode of frequent ventricular extrasystoles without hemodynamic instability, which ceased after suspension of continuous epidural infusion of local anesthetic.Discussion: This study suggests that continuous wound infusion is the technique with most efficacy and safety, being even better than epidural analgesia in postoperative pain control after major abdominal surgery. This technique is associated with better analgesia, lower incidence of side effects, high level of satisfaction and no residual pain, contributing to enhanced recovery.Conclusion: Continuous wound infusion is an effective technique, which should be implemented for analgesia after major abdominal surgery, with advantages when compared with epidural analgesia, especially low incidence of adverse effects.Registration: Trial not registered.

scholarly journals Comparison of 0.2% Bupivacaine with 0.2% Ropivacaine in Femoral Nerve Block for Preoperative Positioning and Postoperative Analgesia in Femur Fractures

2016 ◽  
Vol 2 (9) ◽  
pp. 169
Author(s):  
Natarajan P ◽  
Srinivasan S. K. ◽  
Dhanasekaran C ◽  
Sekaran N. K.
Keyword(s):  
Nerve Block ◽  
Postoperative Analgesia ◽  
Femoral Nerve Block ◽  
Randomized Study ◽  
Femoral Nerve ◽  
Pain Scale ◽  
Spinal Block ◽  
Femur Fractures ◽  
Group B ◽  
Spinal Epidural

Introduction: Femur fractures are very painful. The peripheral nerve block provides good analgesia in these patients before performing regional anesthesia. This study aims to compare 2 local anesthestics in femoral nerve block for analgesia in preoperative positioning and postoperative analgesia of patientsMethods: Prospective, randomized study was conducted on 60 patients (18-60 years) of ASA I&II scheduled for femur surgery under combined spinal epidural. anaesthesia In group B (n=30), femoral nerve block(FNB) was performed with 0.2% bupivacaine (30ml) and in group R(n=30), 0.2% ropivacaine (30 ml) was used. Various parameters like numeric rating pain scale, time to spinal anaesthesia, sensory and motor block onset times and durations, time to first analgesic use, intraoperative & postoperative visual analog scale (VAS) data, post- operative epidural top ups, vitals and side effects were recorded for each patient.Results: Pain assessed on visual analogue scale (VAS) during positioning was significantly less in FNB group using 0.2%bupivacaine at 5 minutes. Time to perform spinal block was significantly shorter in FNB group using 0.2% bupivacaine (8.30 min) versus ropivacaine group (17.30 min). But postoperative analgesic requirements were more in ropivacaine group and duration of analgesia was prolonged in bupivacaine group.Conclusion: With bupivacaine time to perform spinal anesthesia was reduced and postoperative analgesia was better with bupivacaine group.

scholarly journals Oral Premedication in Children

1987 ◽  
Vol 15 (2) ◽  
pp. 151-157 ◽  
Author(s):  
J. H. Van Der Walt ◽  
B. Nicholls ◽  
M. Bentley ◽  
D. P. Tomkins
Keyword(s):  
Postoperative Analgesia ◽  
Postoperative Recovery ◽  
Double Blind Trial ◽  
Postoperative Vomiting ◽  
Double Blind ◽  
Blind Trial ◽  
Inhalational Anaesthetic ◽  
Recovery Times ◽  
Oral Premedication ◽  
Inguinal Surgery

Preoperative and postoperative sedation, postoperative analgesia and vomiting were assessed following four different oral premedications in 143 children aged 1–10 years, weighing 10–30 kg, and undergoing elective adenotonsillectomy or inguinal surgery. Diazepam, diazepam combined with droperidol, trimeprazine and trimeprazine combined with droperidol were compared in a double-blind trial in conjunction with a standardised inhalational anaesthetic technique employing an intraoperative narcotic. Trimeprazine produced significantly more preoperative sedation (P<0.001) and was associated with enhanced postoperative analgesia (P<0.01). The incidence of postoperative vomiting was significantly less in the group receiving trimeprazine (P<0.001). The addition of droperidol to diazepam and trimeprazine only marginally improved the performance of those drugs but significantly prolonged postoperative recovery times. This was more marked when droperidol was combined with trimeprazine.

A Comparison of the Postoperative Analgesic Effectiveness of Ultrasound-Guided Dorsal Penile Nerve Block and Ultrasound-Guided Pudendal Nerve Block in Circumcision

2020 ◽  
Vol 104 (11-12) ◽  
pp. 871-877
Author(s):  
Volkan Ozen ◽  
Dogakan Yigit
Keyword(s):  
Postoperative Complications ◽  
Nerve Block ◽  
Postoperative Analgesia ◽  
Pudendal Nerve ◽  
Pain Scale ◽  
Ultrasound Guided ◽  
Pudendal Nerve Block ◽  
Dorsal Penile Nerve Block ◽  
Significant Difference ◽  
Dorsal Penile Nerve

<b><i>Aim:</i></b> The aim of this study was to compare the postoperative analgesic effectiveness of the 2 block types. We also aimed to evaluate the effect of these block types on the postoperative complications and parental satisfaction. <b><i>Materials and Methods:</i></b> This prospective observational study was conducted between April and July 2019 at a training and research hospital. Patients aged between 5 and 12 years in the ASA I-II group, who were scheduled for circumcision, were included in the study. The primary outcome was the pain measured using the Children’s Hospital Eastern Ontario Pain Scale and the Faces Pain Scale-Revised. The secondary outcomes were the postoperative complications and parenteral satisfactions. <b><i>Results:</i></b> The number of patients receiving a pudendal block (<i>n</i> = 40) and dorsal penile nerve block (DPNB) block (<i>n</i> = 40) was equal. No statistically significant difference was found between the groups that were administered a DPNB and pudendal block in terms of pain scores (<i>p</i> &#x3e; 0.05). We did not observe any postoperative block-related complications or side effects. Parents reported excellent satisfaction in both groups. <b><i>Discussion:</i></b> Ultrasound (US)-guided pudendal nerve block and US-guided DPNB provided effective and long-lasting postoperative analgesia for circumcision surgery. <b><i>Conclusions:</i></b> This study has shown that both blocks provide postoperative analgesia with similar effectiveness and ensured a very comfortable period at the circumcision surgery. Clinicians can use either of these techniques depending on their clinical circumstances and experience.

scholarly journals The Use of Orbital Morphine for Postoperative Analgesia in Pterygium Surgery

2000 ◽  
Vol 28 (1) ◽  
pp. 43-45 ◽  
Author(s):  
K. Wishaw ◽  
D. Billington ◽  
D. O'Brien ◽  
P. Davies
Keyword(s):  
Side Effects ◽  
Postoperative Analgesia ◽  
Scale Effects ◽  
Pain Scale ◽  
Double Blind Study ◽  
Morphine Group ◽  
Corneal Surgery ◽  
Double Blind ◽  
Pterygium Surgery ◽  
Lower Pain Score

A prospective double-blind study compared the analgesic effectiveness of peribulbar lignocaine with peribulbar morphine and lignocaine for postoperative analgesia in pterygium surgery. Twenty patients were randomly divided to receive a peribulbar injection preoperatively of either 1% lignocaine 2 ml or 1% lignocaine 1.6 ml and 4 mg morphine. Effects on pain at injection and pain at 24 hours and 48 hours postoperatively were measured with a visual analog pain scale. Effects of the injections on sedation, pupil size and unwanted side-effects were also recorded. The groups were comparable for age, weight and surgical technique. There was a significantly lower pain score at 24 hours after operation in the morphine group (P=0.035). There were no significant differences in sedation or side-effects between the groups. The physiological effects of morphine on the eye are reviewed. The study suggests that orbital morphine may be an effective and safe form of analgesia for corneal surgery and further investigation is warranted.

scholarly journals Comparison of the effects of nefopam and tramadol on postoperative analgesia in dogs undergoing ovariohysterectomy

2017 ◽  
Vol 62 (No. 3) ◽  
pp. 131-137
Author(s):  
S. Zhang ◽  
JN Li ◽  
L. Luan ◽  
W. Guan ◽  
XY Hu ◽  
...  
Keyword(s):  
Heart Rate ◽  
Mean Arterial Pressure ◽  
Postoperative Analgesia ◽  
Pain Scale ◽  
Composite Measure ◽  
Rescue Analgesia ◽  
Analgesic Effects ◽  
Pain Scores ◽  
Mixed Breed ◽  
Group D

Relieving perioperative pain can reduce postoperative suffering and improve recovery from anaesthesia in animals. The aim of this study was to compare the analgesic effects of nefopam and tramadol in dogs undergoing ovariohysterectomy. Twenty-four adult mixed-breed female dogs were randomly divided into three groups (n = 8) and received their respective treatments immediately after surgery: Group T (2 mg/kg tramadol, i.v.), Group C (1 mg/kg nefopam, i.v.) and Group D (2 mg/kg nefopam, i.v.). The heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) and rectal temperature (RT) were measured and the level of analgesia was assessed using the Glasgow Composite Measure Pain Scale (CMPS-SF). The CMPS-SF was performed at least two days before premedication (baseline), every 2 h for the first 8 h (post-extubation), at 12 h and at 24 h. Results showed that the HR in all groups was significantly (P &lt; 0.05) higher at 2 and 6 h than at baseline. The RR in Group T was significantly higher (P &lt; 0.05) at 0 and 2 h than at baseline. Rescue analgesia (0.2 mg/kg morphine, i.v.) was provided if CMPS-SF pain scores greater than or equal to six. Four dogs required rescue analgesia: one dog in Group T at 2 h and three dogs in Group C at 2 and 6 h. No dogs in Group D required rescue analgesia. The CMPS-SF pain scores of dogs in Group C were significantly higher (P &lt; 0.05) than those in Group T at 6, 8 and 12 h. The scores in Group D were significantly lower (P &lt; 0.05) than those in Group C at 2, 4, 6, 8 and 12 h. The scores in Group D were significantly lower (P &lt; 0.05) than those in Group T at 2 and 4 h. However, the scores in Group D were not significantly different compared with Group T. In conclusion, this study suggests that nefopam at 2 mg/kg i.v. produces better postoperative analgesia compared with tramadol at 2 mg/kg i.v. or nefopam at 1 mg/kg i.v. in dogs undergoing ovariohysterectomy.

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