The Effect of a Grape Seed Extract on Radiation-Induced DNA Damage in Human Lymphocytes

2009 ◽  
Author(s):  
Tiberius Dicu ◽  
Ion D. Postescu ◽  
Vasile Foriş ◽  
Ioana Brie ◽  
Eva Fischer-Fodor ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Lymphocytes ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Radiation Induced

Modulatory role of grape seed extract on age-related oxidative DNA damage in central nervous system of rats

2006 ◽  
Vol 68 (6) ◽  
pp. 469-473 ◽  
Author(s):  
Muthaiya Balu ◽  
Purushotham Sangeetha ◽  
Ganesan Murali ◽  
Chinnakannu Panneerselvam
Keyword(s):  
Central Nervous System ◽  
Dna Damage ◽  
Nervous System ◽  
Oxidative Dna Damage ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Age Related

scholarly journals Amelioration of cisplatin-induced nephrotoxicity by grape seed extract and fish oil is mediated by lowering oxidative stress and DNA damage

2013 ◽  
Vol 66 (3) ◽  
pp. 419-429 ◽  
Author(s):  
Hanaa A. Hassan ◽  
Gamal M. Edrees ◽  
Ezz M. El-Gamel ◽  
Elsamra A. El-sayed
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Fish Oil ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract

Grape seed extract ameliorated Ehrlich solid tumor-induced hepatic tissue and DNA damage with reduction of PCNA and P53 protein expression in mice

2021 ◽  
Author(s):  
Mabrouk Attia Abd Eldaim ◽  
Ehab Tousson ◽  
Mohamed Mohamed Soliman ◽  
Ibrahim El Tantawy El Sayed ◽  
Abdel Aleem H. Abdel Aleem ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Expression ◽  
Solid Tumor ◽  
P53 Protein ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Hepatic Tissue ◽  
P53 Protein Expression

scholarly journals Encapsulated Activated Grape Seed Extract: A Novel Formulation with Anti-Aging, Skin-Brightening, and Hydration Properties

Cosmetics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Kan Tao ◽  
Lili Guo ◽  
Xincheng Hu ◽  
Corey Fitzgerald ◽  
Karl Rouzard ◽  
...  
Keyword(s):  
Dna Damage ◽  
Critical Role ◽  
Regulatory Protein ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Dermal Fibroblasts ◽  
Epidermal Keratinocytes ◽  
Sensitive Skin ◽  
Melanin Production

Protein phosphatase 2A (PP2A) is a master regulatory protein that plays a critical role in oxidative stress signaling. A novel, proprietary grape seed extract called Activated Grape Seed Extract (AGSE), enriched for PP2A-activating flavonoids, was recently developed and demonstrated to have antioxidant and anti-inflammatory activities. AGSE is a purple-colored powder, with limited solubility restricting its use in a broad range of formulations. Our aim was to develop a formulation that reduced the color and increased the solubility of AGSE, allowing its skin-health-enhancing properties to be utilized in a wider array of products, and to test it clinically. Encapsulation was performed utilizing a liposome and hydroxypropyl-β-cyclodextrin, (HPCD)-based approach to produce Encapsulated AGSE (E-AGSE). Human dermal fibroblasts and epidermal keratinocytes were used to determine expression levels of aging and dermal–epidermal junction (DEJ) markers. EpiDerm™ was UVB-irradiated to measure the effects against cytokine release, DNA damage, apoptosis, and skin barrier. Human melanocytes were used to determine melanin production and mushroom tyrosinase was used for inhibitory activity. A 4-week, 31-subject sensitive-skin clinical was performed with 2% E-AGSE Essence to assess its activity on human skin. We demonstrated that E-AGSE inhibits PP2A demethylation, increases key anti-aging (collagen I, III, elastin) and DEJ markers, protects against UVB-induced DNA damage, reduces inflammation, and promotes filaggrin in vitro. Moreover, E-AGSE reduces melanin production via tyrosinase inhibition. Clinical assessment of E-AGSE showed that it reduces the appearance of wrinkles, brightens the skin, and boosts hydration. E-AGSE is a novel grape seed extract formulation enriched for PP2A-activating flavonoids that is clinically effective in sensitive skin, providing several benefits.

Grape Seeds Extract as Brain Food: A Review

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Souad El Gengaihi ◽  
Doha H. Abou Baker
Keyword(s):  
Antioxidant Activities ◽  
Complex Mixture ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Amyloid Peptide ◽  
Grape Seeds ◽  
Potential Benefits ◽  
Reduced Risk

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

Grape Seed Extract Complex (FFM-GS) Inhibits Postmenopausal Symptoms: In Vitro and In Vivo S

2019 ◽  
Vol 48 (3) ◽  
pp. 297-305
Author(s):  
Minhee Lee ◽  
Da-Eun Nam ◽  
Soo-Jeung Park ◽  
Dakyung Kim ◽  
Jeong-Moon Yun ◽  
...  
Keyword(s):  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Postmenopausal Symptoms

scholarly journals Comparative Evaluation of Immediate Bond Strength to Bleached Enamel Following Application of Various Antioxidant Solutions

2017 ◽  
Vol 05 (02) ◽  
pp. 084-089
Author(s):  
Alisha Dhingra ◽  
Ashu Gupta ◽  
Anshu Minocha ◽  
Nayantara Sen
Keyword(s):  
Bond Strength ◽  
Shear Bond Strength ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
The Other ◽  
Sodium Ascorbate ◽  
Group V ◽  
Group I ◽  
Significant Difference

Abstract Aim: The aim of this study was to compare the reversal of shear bond strength of composite to bleached enamel immediately after bleaching followed by application of various antioxidant solutions. Material and Methods: Seventy central incisors were divided into seven groups. Groups I and II served as unbleached and bleached controls respectively. Groups III, IV, V, VI and VII served as the experimental groups and were subjected to 37.5% hydrogen peroxide bleaching followed by 10 min application of 10% sodium ascorbate, 25% alpha-tocopherol, 6.5% grape seed extract, 5% lycopene and 5% green tea extract respectively. Following composite bonding, shear bond strength was determined and the results were analyzed using ANOVA followed by Post Hoc Multiple Comparisons test. Results: The bond strength values for Group I (positive control) were maximum and significantly different than all the other groups except Grape seed extract group (Group V). When compared to Group II (bleached control), all the groups showed significantly higher bond strength. Significant difference in the bond strength values were seen between Group III (10% sodium ascorbate) and Group V. Also values for Group V were significantly different from Group VI (5% lycopene). All the other values showed insignificantly different results. Conclusion: All the antioxidant solutions improved the shear bond strength values after bleaching but only Grape seed extract application reversed the values to the non bleached levels. Lycopene was least effective. Other antioxidants showed comparable results.

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