scholarly journals Transfer of Magnesium across the Perfused Choroid Plexus of Sheep

1986 ◽  
Vol 39 (2) ◽  
pp. 161 ◽  
Author(s):  
TF Allsop
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Electrolyte Composition ◽  
Perfusion Fluid ◽  
Transfer Rates ◽  
Sheep Blood ◽  
Low Concentrations

Isolated perfused choroid plexus preparations from sheep were used to study the effects of low concentrations of magnesium in the perfusion fluid on the transfer of magnesium into choroid plexus fluid (CPF). A perfusion fluid of similar electrolyte composition to sheep blood resulted in CPF similar to ventricular cerebrospinal fluid at a rate of 2�2 III min - 1 mg -I dry choroidal tissue. Decreasing the concentration of magnesium in the perfusion fluid caused a fall in the concentration of magnesium in the CPF, although it remained higher than in the perfusion fluid. The rate of transfer of magnesium from the perfusion fluid to the CPF decreased in the presence of high levels of potassium in the perfusion fluid. But decreasing the concentration of calcium in the perfusion fluid had no effect on magnesium transfer rates.

Effect of acetazolamide and furosemide on the production and composition of cerebrospinal fluid from the cat choroid plexus

1982 ◽  
Vol 60 (3) ◽  
pp. 405-409 ◽  
Author(s):  
James M. Melby ◽  
Lewis C. Miner ◽  
Donal J. Reed
Keyword(s):  
Cerebrospinal Fluid ◽  
Drug Treatment ◽  
Choroid Plexus ◽  
Transport Mechanism ◽  
Electrolyte Composition ◽  
K Concentration ◽  
Drug Free ◽  
K Transport ◽  
Csf Production

The effect of acetazolamide and furosemide on choroid plexus (CP) production and electrolyte composition of cerebrospinal fluid (CSF) from the cat CP in situ was investigated. Both drugs decreased CSF production by the CP by 50–90% from a control rate of 0.53 μL ∙ min−1 ∙ mg−1 CP within 1.5–2.5 h after the start of drug treatment. The results were similar whether the drug was administered intravenously or applied directly to the CSF side of the CP. A number of experiments in which the effect of administering drugs via the chamber were studied were continued with the drugs removed by washing the preparation with drug-free artificial CSF and the responses measured. The results demonstrated that the effects of acetazolamide and furosemide were reversed during the 1st h following the washout. Both drugs decreased K concentration of nascent CSF when administered intravenously and furosemide also did so when administered on the CSF side of the CP. It is concluded from these and previous data that acetazolamide and furosemide markedly inhibit the transport mechanism(s) in the cat CP that are responsible for CP secretion which represents about 40–60% of the total CSF production and that K transport is also affected.

Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretin-null mice

1997 ◽  
Vol 272 (3) ◽  
pp. E485-E493 ◽  
Author(s):  
J. A. Palha ◽  
M. T. Hays ◽  
G. Morreale de Escobar ◽  
V. Episkopou ◽  
M. E. Gottesman ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Null Mouse ◽  
Tissue Uptake ◽  
Wild Type ◽  
Transfer Rates ◽  
Physiological Conditions ◽  
Liver And Kidney ◽  
The Brain ◽  
Brain Barriers

As part of a study on tissue uptake of thyroxine (T4) in a transthyretin (TTR)-null mouse strain, kinetic parameters of thyroxine metabolism in wild-type mice under normal physiological conditions are presented. Kinetic analysis of injected [(125)I]T4 showed that TTR-null mutants have markedly increased [(125)I]T4 transfer rate constants from plasma to the fast-exchange compartments of liver and kidney and from fast to slow kidney compartments. Transfer rates from plasma to brain, testes, and fat were little affected. The T4 tissue content in the mutants was greatly reduced in brain but relatively normal in liver and kidney. No major changes were observed in brain 3,3',5-triiodothyronine concentrations, suggesting that availability of this hormone is not markedly altered in the mutant mice. The low T4 brain content probably reflects the absence of T4-TTR complexes in the mutant choroid plexus and cerebrospinal fluid. This study indicates that TTR is not essential for T4 tissue uptake or for T4 to reach the brain across the choroid plexus-cerebrospinal fluid and/or blood-brain barriers.

Sex-Related Differences in Rat Choroid Plexus and Cerebrospinal Fluid: A cDNA Microarray and Proteomic Analysis

2016 ◽  
Vol 28 (1) ◽  
Author(s):  
T. Quintela ◽  
H. Marcelino ◽  
M. J. Deery ◽  
R. Feret ◽  
J. Howard ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Cdna Microarray ◽  
Proteomic Analysis

Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness

1973 ◽  
Vol 3 (3) ◽  
pp. 319-325 ◽  
Author(s):  
G. W. Ashcroft ◽  
Ivy M. Blackburn ◽  
D. Eccleston ◽  
A. I. M. Glen ◽  
W. Hartley ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Homovanillic Acid ◽  
Affective Illness ◽  
Normal Limits ◽  
Low Concentrations ◽  
Depressed Group ◽  
Before And After ◽  
Acid Metabolites ◽  
Bipolar Patients ◽  
Manic Patients

SYNOPSISThe concentration of the acid metabolites of dopamine, and 5-hydroxytryptamine (5-HT), homovanillic acid (HVA), and 5-hydroxyindolacetic acid (5-HIAA) respectively, were estimated in the cerebrospinal fluid of patients suffering from either unipolar or bipolar affective illness, both before and after recovery. Significantly low concentrations of HVA and 5-HIAA (P<0·01 and 0·05 respectively) were found in the unipolar depressed group and these did not return to normal on recovery. Depressed bipolar patients had levels within normal limits. In bipolar manic patients the HVA concentration fell on recovery to a level significantly lower (P<0·05) than controls. There was no difference in the levels of tryptophan in the CSF of any of the groups of patients nor was there any alteration on recovery. There was a high correlation between 5-HIAA and HVA in the same CSF. These findings are against the amine hypothesis which postulated in depression a lowered concentration of transmitter amine at synaptic junction.

Surgical removal of bilateral papillomas of the choroid plexus of the lateral ventricles with resolution of hydrocephalus

1979 ◽  
Vol 50 (5) ◽  
pp. 677-681 ◽  
Author(s):  
Steven K. Gudeman ◽  
Humbert G. Sullivan ◽  
Michael J. Rosner ◽  
Donald P. Becker
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Large Volume ◽  
Surgical Removal ◽  
Tumor Removal ◽  
Content Type ◽  
Lateral Ventricles ◽  
Csf Diversion ◽  
Csf Production ◽  
Fine Print

✓ The authors report a patient with bilateral papillomas of the choroid plexus of the lateral ventricles with documentation of cerebrospinal fluid (CSF) hypersecretion causing hydrocephalus. Special attention is given to the large volume of CSF produced by these tumors (removal of one tumor reduced CSF outflow by one-half) and to the fact that CSF diversion was not required after both tumors were removed. Since tumor removal alone was sufficient to stop the progression of hydrocephalus, we feel that this case supports the concept that elevated CSF production by itself is sufficient to cause hydrocephalus in patients with papillomas of the choroid plexus.

Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system

Neuroscience ◽  
2004 ◽  
Vol 127 (1) ◽  
pp. 43-52 ◽  
Author(s):  
A.L Gard ◽  
E Gavin ◽  
V Solodushko ◽  
D Pennica
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Circulatory System

scholarly journals The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH

2018 ◽  
Vol 596 (19) ◽  
pp. 4709-4728 ◽  
Author(s):  
Henriette L. Christensen ◽  
Dagne Barbuskaite ◽  
Aleksandra Rojek ◽  
Hans Malte ◽  
Inga B. Christensen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Sodium Bicarbonate ◽  
Choroid Plexus ◽  
Sodium Bicarbonate Cotransporter

scholarly journals OTX2 homeoprotein functions in adult choroid plexus

2021 ◽  
Author(s):  
Anabelle Planques ◽  
Vanessa Oliveira Moreira ◽  
David Benacom ◽  
Clémence Bernard ◽  
Laurent Jourdren ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Stress Responses ◽  
Subventricular Zone ◽  
Adult Mouse ◽  
Mass Spectrometry Analysis ◽  
Mrna Isoforms ◽  
Spectrometry Analysis ◽  
Protein Partners ◽  
Brain Homeostasis

AbstractChoroid plexus secretes cerebrospinal fluid important for brain development and homeostasis. The OTX2 homeoprotein is critical for choroid plexus development and remains highly expressed in adult choroid plexus. Through RNA sequencing analyses of constitutive and conditional knockdown adult mouse models, we reveal putative roles for OTX2 in choroid plexus function, including cell signaling and adhesion, and show that it regulates the expression of factors secreted into cerebrospinal fluid, notably transthyretin. We show that Otx2 expression impacts choroid plexus immune and stress responses, and also affects splicing which leads to changes in mRNA isoforms of proteins implicated in oxidative stress response and DNA repair. Through mass spectrometry analysis of OTX2 protein partners in the choroid plexus, and in known non-cell autonomous target regions such as visual cortex and ventricular-subventricular zone, we identified putative targets involved in cell adhesion, chromatin structure and RNA processing. Thus, OTX2 retains important roles in choroid plexus function and brain homeostasis throughout life.

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