scholarly journals E2F-mediated Growth Regulation Requires Transcription Factor Cooperation

1997 ◽  
Vol 272 (29) ◽  
pp. 18367-18374 ◽  
Author(s):  
Paul R. van Ginkel ◽  
Kuang-Ming Hsiao ◽  
Hilde Schjerven ◽  
Peggy J. Farnham
Keyword(s):  
Transcription Factor ◽  
Growth Regulation ◽  
Transcription Factor Cooperation

scholarly journals PgMYB2, a MeJA-Responsive Transcription Factor, Positively Regulates the Dammarenediol Synthase Gene Expression in Panax Ginseng

2019 ◽  
Vol 20 (9) ◽  
pp. 2219 ◽  
Author(s):  
Tuo Liu ◽  
Tiao Luo ◽  
Xiangqian Guo ◽  
Xian Zou ◽  
Donghua Zhou ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Panax Ginseng ◽  
Growth Regulation ◽  
Ginseng Root ◽  
Myb Transcription Factor ◽  
Mobility Shift ◽  
Binding Interaction ◽  
Mobility Shift Assay ◽  
Dammarenediol Synthase

The MYB transcription factor family members have been reported to play different roles in plant growth regulation, defense response, and secondary metabolism. However, MYB gene expression has not been reported in Panax ginseng. In this study, we isolated a gene from ginseng adventitious root, PgMYB2, which encodes an R2R3-MYB protein. Subcellular localization revealed that PgMYB2 protein was exclusively detected in the nucleus of Allium cepa epidermis. The highest expression level of PgMYB2 was found in ginseng root and it was significantly induced by plant hormones methyl jasmonate (MeJA). Furthermore, the binding interaction between PgMYB2 protein and the promoter of dammarenediol synthase (DDS) was found in the yeast strain Y1H Gold. Moreover, the electrophoretic mobility shift assay (EMSA) identified the binding site of the interaction and the results of transiently overexpressing PgMYB2 in plants also illustrated that it may positively regulate the expression of PgDDS. Based on the key role of PgDDS gene in ginsenoside synthesis, it is reasonable to believe that this report will be helpful for the future studies on the MYB family in P. ginseng and ultimately improving the ginsenoside production through genetic and metabolic engineering.

scholarly journals New Discoveries and Ambiguities of Nrf2 and ATF3 Signaling in Environmental Arsenic-Induced Carcinogenesis

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 77
Author(s):  
Zhuoyue Bi ◽  
Yao Fu ◽  
Priya Wadgaonkar ◽  
Yiran Qiu ◽  
Bandar Almutairy ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Growth Regulation ◽  
Arsenic Exposure ◽  
Tca Cycle ◽  
Metabolic Reprogramming ◽  
Molecular Characteristics ◽  
Human Cancers ◽  
Experimental Systems ◽  
Environment Exposure ◽  
Hexosamine Biosynthesis

Environment exposure to arsenic had been linked to increased incidents of human cancers. In cellular and animal experimental systems, arsenic has been shown to be highly capable of activating several signaling pathways that play critical roles in cell growth regulation, malignant transformation and the stemness of cancer stem-like cells. Emerging evidence indicates certain oncogenic properties of the Nrf2 transcription factor that can be activated by arsenic and many other environmental hazards. In human bronchial epithelial cells, our most recent data suggested that arsenic-activated Nrf2 signaling fosters metabolic reprogramming of the cells through shifting mitochondrial TCA cycle to cytosolic glycolysis, and some of the metabolites in glycolysis shunt the hexosamine biosynthesis and serine-glycine pathways important for the energy metabolism of the cancer cells. In the current report, we further demonstrated direct regulation of oncogenic signals by arsenic-activated Nrf2 and connection of Nrf2 with ATF3 stress transcription factor. Meanwhile, we also highlighted some unanswered questions on the molecular characteristics of the Nrf2 protein, which warrants further collaborative efforts among scientists for understanding the important role of Nrf2 in human cancers either associated or not to environmental arsenic exposure.

scholarly journals Novel oncogenic transcription factor cooperation in RB-deficient cancer

2021 ◽  
pp. canres.1159.2021
Author(s):  
Amy C Mandigo ◽  
Ayesha A Shafi ◽  
Jennifer J McCann ◽  
Wei Yuan ◽  
Talya S Laufer ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factor Cooperation ◽  
Oncogenic Transcription Factor

scholarly journals Computational identification of tissue-specific transcription factor cooperation in ten cattle tissues

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0216475 ◽  
Author(s):  
Lukas Steuernagel ◽  
Cornelia Meckbach ◽  
Felix Heinrich ◽  
Sebastian Zeidler ◽  
Armin O. Schmitt ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Tissue Specific ◽  
Specific Transcription Factor ◽  
Computational Identification ◽  
Transcription Factor Cooperation

scholarly journals Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Eunkyoo Oh ◽  
Jia-Ying Zhu ◽  
Ming-Yi Bai ◽  
Rafael Augusto Arenhart ◽  
Yu Sun ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Elongation ◽  
Growth Regulation ◽  
Target Genes ◽  
Environmental Signals ◽  
Major Mechanism ◽  
Large Numbers ◽  
Genome Wide ◽  
Brassinosteroid Signaling ◽  
Bhlh Factors

As the major mechanism of plant growth and morphogenesis, cell elongation is controlled by many hormonal and environmental signals. How these signals are coordinated at the molecular level to ensure coherent cellular responses remains unclear. In this study, we illustrate a molecular circuit that integrates all major growth-regulating signals, including auxin, brassinosteroid, gibberellin, light, and temperature. Analyses of genome-wide targets, genetic and biochemical interactions demonstrate that the auxin-response factor ARF6, the light/temperature-regulated transcription factor PIF4, and the brassinosteroid-signaling transcription factor BZR1, interact with each other and cooperatively regulate large numbers of common target genes, but their DNA-binding activities are blocked by the gibberellin-inactivated repressor RGA. In addition, a tripartite HLH/bHLH module feedback regulates PIFs and additional bHLH factors that interact with ARF6, and thereby modulates auxin sensitivity according to developmental and environmental cues. Our results demonstrate a central growth-regulation circuit that integrates hormonal, environmental, and developmental controls of cell elongation in Arabidopsis hypocotyl.

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