Scope economy in positive polarity: Extreme degree quantification

Author(s):  
Raquel González-Rodríguez
2002 ◽  
Vol 16 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Timo Ruusuvirta ◽  
Heikki Hämäläinen

Abstract Human event-related potentials (ERPs) to a tone continuously alternating between its two spatial loci of origin (middle-standards, left-standards), to repetitions of left-standards (oddball-deviants), and to the tones originally representing these repetitions presented alone (alone-deviants) were recorded in free-field conditions. During the recordings (Fz, Cz, Pz, M1, and M2 referenced to nose), the subjects watched a silent movie. Oddball-deviants elicited a spatially diffuse two-peaked deflection of positive polarity. It differed from a deflection elicited by left-standards and commenced earlier than a prominent deflection of negative polarity (N1) elicited by alone-deviants. The results are discussed in the context of the mismatch negativity (MMN) and previous findings of dissociation between spatial and non-spatial information in auditory working memory.


Author(s):  
Azeb Amha

This chapter examines expressions of commands (imperatives) in Wolaitta and the ways in which the imperative is distinguished from statements and questions. Although each sentence type is formally distinct, imperatives and questions share a number of morpho-syntactic properties. Similar to declarative and interrogative sentences, imperatives in Wolaitta involve verbal grammatical categories such as the distinction of person, number, and gender of the subject as well as negative and positive polarity. In contrast to previous studies, the present contribution establishes the function of a set of morphemes based on -árk and -érk to be the expression of plea or appeal to an addressee rather than politeness when issuing a command. Instead, politeness in commands is expressed by using plural (pro)nominal and verbal elements. The imperative in Wolaitta is a robust construction which is also used in formulaic speeches such as leave-taking as well as in blessing, curses, and advice.


2017 ◽  
Vol 61 (2) ◽  
pp. 7-10 ◽  
Author(s):  
Richard Schechner

Donald J. Trump, like it or not, is POTUS. This president is also a Caligula, a fool-king, and a trickster. He is a performer rather than an actor: someone who inhabits his own (narcissistic) persona to an extreme degree, not someone who follows a prescribed script. His policies, executive orders, and appointments show he is cruel, dangerous, unpredictable, and entertaining.


1967 ◽  
Vol 36 (2) ◽  
pp. 170-188
Author(s):  
Alexander Lipski

It is generally accepted that even though rationalism was predominant during the eighteenth century, a significant mystical trend was simultaneously present. Thus it was not only the Age of Voltaire, Diderot, and Holbach, but also the Age of St. Martin, Eckartshausen and Madame Guyon. With increased Western influence on Russia, it was natural that Russia too would be affected by these contrary currents. The reforms of Peter the Great, animated by a utilitarian spirit, had brought about a secularization of Russian culture. Father Florovsky aptly summed up the state of mind of the Russian nobility as a result of the Petrine Revolution: “The consciousness of these new people had been extroverted to an extreme degree.” Some of the “new people,” indifferent to their previous Weltanschauung, Orthodoxy, adopted the philosophy of the Enlightenment, “Volter'ianstvo” (Voltairism). But “Volter'ianstvo” with its cult of reason and belief in a remote creator of the “world machine,“ did not permanently satisfy those with deeper religious longings. While conventional Orthodoxy, with its emphasis on external rites, could not fill the spiritual vacuum, Western mysticism, entering Russia chiefly through freemasonry, provided a satisfactory alternative to “Volter'ianstvo.”


Author(s):  
Е.П. Харченко

Введение. Коронавирус SARS-CoV-2 является новым вирусом, обладающим способностью осуществлять трансмиссию воздушно-капельным путем, вызывая тяжелое течение атипичной пневмонии, нередко сочетающейся с коагулопатиями. Роль структурных белков коронавируса в их патогенезе неизвестна. Цель исследования: с помощью биоинформационного анализа выявить в структурных белках коронавируса SARS-CoV-2 последовательности, гомологичные белкам системы гемостаза, и рассмотреть возможные сценарии их участия в патогенезе коагулопатий при COVID-19, а также объяснить существование вирусостатического эффекта гепарина. Материалы и методы. Для компьютерного анализа были использованы доступные в Интернете базы данных первичных структур белков коронавирусов и их рецепторов, а также поверхностных белков других вирусов, белков системы гемостаза и иммунной системы. Сравнивали аминокислотный состав белков и распределение оснόвных аминокислот (аргинина и лизина) в их первичных последовательностях. С целью выявления пептидного (иммуноэпитопного) родства структурных белков коронавирусов с белками системы гемостаза человека был выполнен поиск гомологичных последовательностей в их белках. Результаты. В структурных белках коронавируса SARS-CoV-2 выявлено множество последовательностей, гомологичных белкам системы гемостаза и иммунной системы. В отличие от коронавирусов SARS-CoV и MERS-CoV, S1-субъединица S-белка коронавируса SARS-CoV-2 имеет положительную полярность. Заключение. Множество последовательностей в структурных белках коронавируса SARS-CoV-2, гомологичных белкам системы гемостаза, потенциально способны вы- зывать различные сценарии патогенеза коагулопатий. Положительная полярность S1-субъединицы S-белка коронавируса SARS-CoV-2 позволяет объяснить неспецифическое взаимодействие ее с гепарином и его вирусостатический (неантикоагулянтный) эффект. Background. The coronavirus SARS-CoV-2 is a new virus capable of human-human transmission and inducing a severe atypical pneumonia often associated with coagulopathy. A role of SARS-CoV-2 structural proteins in coagulopathy pathogenesis is unknown. Objectives: to use a bioinformation analysis to identify SARS-CoV-2 sequences in the structural proteins that are homologous to hemostasis system proteins, regard their possible participation in coagulopathy pathogenesis and explain the antiviral effect of heparin. Materials / Methods. For computer analysis, Internet databases were used of the primary structures of coronavirus proteins and their receptors, as well as surface proteins of other viruses, proteins of hemostasis and immune systems. The amino acid composition of proteins and the distribution of basic amino acids (arginine and lysine) in their primary sequences were compared. For detection of peptide (immunoepitopic) relationship of coronaviruses structural proteins with human hemostasis proteins, a search for homologous sequences in their proteins was performed. Results. Many sequences have been identified in structural proteins of SARS-CoV-2 coronavirus that are homologous to the proteins of hemostasis and immune systems. In contrast with SARS-CoV and MERS-CoV coronaviruses, the S1-subunit of SARS-CoV-2 coronavirus S-protein has a positive polarity. Conclusions. Many sequences in SARS-CoV-2 structural proteins that homologous to hemostasis system proteins are potentially responsible for coagulopathy pathogenesis. The positive polarity of the S1-subunit of SARS-CoV-2 S-protein explains its nonspecific interaction with heparin and its virostatic (non-anticoagulant) effect.


1865 ◽  
Vol 11 (55) ◽  
pp. 327-336 ◽  
Author(s):  
Francis Edmund Anstie

The present seems to be a favorable moment for directing the attention of the profession to the condition of those insane paupers who are confined in workhouses. A general disposition to criticise the management of these establishments exists in the public mind, and the profession has given unequivocal evidence that it shares in this feeling and is determined to carry out the inquiry thoroughly. If may be safely affirmed that, if this is to be done, there is no part of the subject which demands earlier attention than the condition of those workhouse-inmates who are insane; for the circumstances which call so loudly for reform in the management of “indoor” paupers, especially those who are sick, exist in an extreme degree in the instance of the insane. The upshot of all careful inquiries into these matters, and notably of that inquiry now proceeding in the columns of ‘The Lancet’, is to make prominent the fact that those workhouses which are situated in populous cities are rapidly becoming great hospitals, instead of refuges for tired or lazy vagrants: while, as yet, the guardians who manage them cannot (or will not) understand that this is the case, but persist in treating the inmates as much as possible on the old system, by which the workhouse was a penal residence intended to disgust and repress the applicants for public relief. Under such a régime it has been shown that numbers of acutely sick persons suffer great hardship and have their chances of recovering health and strength materially interfered with; while as for the patients suffering from chronic disease and debility, it can hardly be said that they receive any proper care at all; and it is my purpose in the present paper to show particularly that the insane are the most deeply injured of all classes of indoor paupers by the system usually followed.


1997 ◽  
Vol 56 (10) ◽  
pp. R5744-R5746 ◽  
Author(s):  
Hiromichi Adachi ◽  
Hiromitsu Ino ◽  
Akihisa Koizumi ◽  
Nobuhiko Sakai ◽  
Yoshikazu Tanaka ◽  
...  

2006 ◽  
Vol 64 (3-4) ◽  
pp. 259-262 ◽  
Author(s):  
Janusz Podliński ◽  
Jarosław Dekowski ◽  
Jerzy Mizeraczyk ◽  
Drazena Brocilo ◽  
Jen-Shih Chang

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Qiuxia Li

Background. With the continuous advancement of digital technology and the accelerated development of digital finance, the rise of digital finance has had a vital impact on the true evolution of SMEs. The digital economy has a significant positive impact on the productivity of SMEs. Method. This article first analyzes the digital level of SMEs, studies the incentive effect of digital finance on the level of technological revolution of SMEs, and analyzes the mitigation effect of digital finance evolution on the financing constraints of SMEs. At the same time, it also studies how to develop the digital economy and achieve high-quality business evolution. Result. The digital economy can promote the growth of enterprise productivity through four indirect ways: scale economy effect, scope economy effect, technological revolution effect, and management benefit effect. Conclusion. The Financial Technology Optimization program helps financial leaders adopt new digital technologies to optimize financial processes while minimizing disruption.


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