scholarly journals Lesions associated with the development of ataxia in vitamin A-deficient chicks

1967 ◽  
Vol 21 (3) ◽  
pp. 741-750 ◽  
Author(s):  
J. McC. Howell ◽  
J. N. Thompson
Keyword(s):  
Vitamin A ◽  
Cervical Spinal Cord ◽  
Vitamin A Deficiency ◽  
Respiratory Epithelium ◽  
Epiphyseal Cartilage ◽  
Histological Changes ◽  
Osteoblast Activity ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship

1. An investigation was made of the sequence of changes that occurred during the development of vitamin A deficiency in the chick. Particular attention was given to changes in the central nervous system (CNS) and in bone.2. Groups of birds were killed after being fed the diet for 14, 17, 20, 22, 24 and 28 days. The tissues of five deficient and five control birds were examined unfixed for gross changes and photographed. Groups of five deficient and five control chicks were perfused through the heart with Heidenhainαs Susa solution and, after decalcification, the tissues were examined for gross and histological changes. The bones of other groups of five deficient and five control chicks were examined for tetracycline-induced fluorescence.3. The first lesion seen was metaplasia of the nasal respiratory epithelium to a stratified squamous form. This was rapidly followed be decreased weight gain, the development of ataxia, compression of the CNS and Wallerian degeneration in the ventral and lateral columns of the cervical spinal cord.4. Changes in bone were first seen in chicks killed 6 days after metaplasia of nasal respiratory epithelium and 3 days after ataxia and brain compression had been seen.5. Changes were present in the epiphyseal cartilage zone of the femur and in the periosteum of the vertebrae, but not in the epiphyseal cartilage of the vertebrae. the changes in the femur were thought not to have a direct relationship to vitamin A deficiency and may have been produced by inanition.6. An increase in osteoblast activity and cartilage formation was seen in the vertebral periosteum of the vitamin A-deficient chicks and the relationship of these changes to lesions in the CNS is discussed.

On humoral factors in nervous activity

1935 ◽  
Vol 31 (6) ◽  
pp. 777-787
Author(s):  
D. S. Vorontsov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nervous Activity ◽  
Active Part ◽  
Humoral Factors ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship

Not only in the peripheral working organs, irritating substances are formed, which, as we can see, take an active part in their regulation, but also in the central nervous system, in the relationship of its individual elements, such substances apparently play an important role.

Intake of Anti-Epileptic Drugs and their Influences on Sexual Dysfunctions

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Roheela Yasmeen ◽  
Nida Mobeen ◽  
Muhammad Amjad Khan ◽  
Irfan Aslam ◽  
Samia Chaudhry
Keyword(s):  
Quality Of Life ◽  
Sexual Dysfunction ◽  
Neurological Disorders ◽  
Penile Erection ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain ◽  
Psychiatric Problems

Epilepsy which is also called seizures disorder is an uncontrolled action of the central nervous system. Itis not a single disease but a set of neurological disorders. Actually in this situation, the brain does notreceive a precise signal and as a result an abnormal condition is produced that is usually involuntary inaction. In this review, we aimed to focus on the relationship of anti-epileptic drugs with sexual dysfunctionand adaptation of better remedies that improve a patient’s family life. Sexual dysfunction is a commoncomorbidity in people with epilepsy which badly affects their quality of life. Sexual dysfunction is causedby different factors like psychiatric problems, anti-epileptic drugs (AEDs) and social factors etc. Sexualdysfunctions include ejaculatory failure, lessen libido, penile erection in men and irregular menstrual cyclein women. Common drugs such as Topiramate, Gabapentin (GBP), Valproate (VA), Carbamazepine (CBZ),Olanzapine (OL) and Risperidone (RTG) that are in practice to treat epilepsy usually produced adverseeffect on sexual dysfunction. Even though a lot of studies have been carried out to control sexualdysfunction in epilepsy’s patient, but still research is going on. Medicine such as Cyproheptadine,Mianserin, Buspirone, Yohimbine were found better to treat epilepsy with minimum side effects of sexualdysfunction. Moreover, it is also seen that certain vasodilators, folate , and vitamin supplements areeffective in improving the quality of life.

Effect of voluntary vs. artificial activation on the relationship of muscle torque to speed

1990 ◽  
Vol 69 (6) ◽  
pp. 2215-2221 ◽  
Author(s):  
G. A. Dudley ◽  
R. T. Harris ◽  
M. R. Duvoisin ◽  
B. M. Hather ◽  
P. Buchanan
Keyword(s):  
Knee Extensor ◽  
Voluntary Activation ◽  
Knee Extensors ◽  
Angular Velocities ◽  
The Central Nervous System ◽  
The Right ◽  
Artificial Activation ◽  
Relationship Of ◽  
The Relationship ◽  
Eccentric Actions

The speed-torque relationship of the right knee extensor muscle group was investigated in eight untrained subjects (28 +/- 2 yr old). Torque was measured at a specific knee angle during isokinetic concentric or eccentric actions at nine angular velocities (0.17-3.66 rad/s) and during isometric actions. Activation was by "maximal" voluntary effort or by transcutaneous tetanic electrical stimulation that induced an isometric torque equal to 60% (STIM 1) or 45% (STIM 2) of the voluntary isometric value. Torque increased (P less than 0.05) to 1.4 times isometric as the speed of eccentric actions increased to 1.57 rad/s for STIM 1 and STIM 2. Thereafter, increases in eccentric speed did not further increase torque. Torque did not increase (P greater than 0.05) above isometric for voluntary eccentric actions. As the speed of concentric actions increased from 0.00 to 3.66 rad/s, torque decreased (P less than 0.05) more (P less than 0.05) for both STIM 1 and STIM 2 (two-thirds) than for voluntary activation (one-half). As a result of these responses, torque changed three times as much (P less than 0.05) across speeds of concentric and eccentric actions with artificial (3.4-fold) than voluntary (1.1-fold) activation. The results indicate that with artificial activation the normalized speed-torque relationship of the knee extensors in situ is remarkably similar to that of isolated muscle. The relationship for voluntary activation, in contrast, suggests that the ability of the central nervous system to activate the knee extensors during maximal efforts depends on the speed and type of muscle action performed.

Inhaled Feed Particles in Experimental Pigs with and without Vitamin A Deficiency

1975 ◽  
Vol 12 (5-6) ◽  
pp. 415-427
Author(s):  
K. W. F. Jericho
Keyword(s):  
Vitamin A ◽  
Salivary Glands ◽  
Giant Cell ◽  
Respiratory Disease ◽  
Alveolar Macrophages ◽  
Vitamin A Deficiency ◽  
Respiratory Epithelium ◽  
Dust Exposure ◽  
Distinguishing Features ◽  
Experimental Pigs

An attempt was made to experimentally reproduce an unusual respiratory disease of pigs fed a dusty mixture of finely ground peas, wheat, and barley. Groups of vitamin-A-deficient piglets from this herd were either given dry feed and daily exposure to dust from the feed or were given wet feed. Vitamin-A-fortified pigs of another stock were also given the dry feed and dust exposure. The upper and lower respiratory tracts, renal pelves, and interlobular ducts of salivary glands were studied histologically. The distinguishing features of lungs were starch particles from feed (up to 31.2 μm in diameter) in all lungs (but more in lungs of pigs given dry feed), free alveolar macrophages, giant cell formations, and mild degenerative processes of respiratory epithelium. The epithelium of most renal pelves was marked by mucinous degeneration.

scholarly journals The effect of vitamin A deficiency on hepatic, renal and pulmonary glutathione S-transferase activities in the rat

1980 ◽  
Vol 188 (3) ◽  
pp. 889-893 ◽  
Author(s):  
Z H Siddik ◽  
E G Mimnaugh ◽  
M A Trush ◽  
T E Gram
Keyword(s):  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Nutritional State ◽  
Glutathione S Transferase ◽  
Chemical Carcinogens ◽  
Deficient Diet ◽  
Liver Cytosol ◽  
Weanling Rats ◽  
Glutathione S Transferases ◽  
The Relationship

Feeding male weanling rats on a vitamin A-deficient diet for 6 weeks resulted in significant increases (44-57%) in glutathione S-aryl-, S-aralkyl- S-alkyl- and S-epoxidetransferase activities in the liver cytosol. Only the S-aralkyl- (27%) and S-alkyltransferase (14%) activities were significantly increased in the kidney as a result of deficiency. There was no effect on any of the pulmonary glutathione S-transferase activities. The increases in hepatic transferase activities were due primarily to increases (25-96%) in the apparent Vmax. There were no changes in the apparant Km of any of the four drug substrates employed. With 3,4-dichloronitrobenzene as the second substrate, the apparent Km for glutathione was increased by over 2-fold in vitamin A-deficient livers as compared with controls. The relationship between these results and enhanced susceptibility to chemical carcinogens in vitamin A deficiency is briefly discussed, and comparison is made between the effects of this nutritional state and pretreatment with drug inducers on the glutathione S-transferases.

The relationship of serum cholesterol and vitamin A in hospitalized patients with and without cancer

1986 ◽  
Vol 44 (3) ◽  
pp. 370-378 ◽  
Author(s):  
E Flaim ◽  
W O Williford ◽  
J L Mullen ◽  
G P Buzby ◽  
L O Crosby
Keyword(s):  
Vitamin A ◽  
Serum Cholesterol ◽  
Hospitalized Patients ◽  
Relationship Of ◽  
The Relationship

The Relationship of Intrauterine Growth Restriction with Placental Pathologic Changes in Newborns

2020 ◽  
Author(s):  
Hossein Dalili ◽  
Fatemeh Sadat Nayeri ◽  
Seyed Reza Mirjalili ◽  
Seyyed Nasrollah Hossein ◽  
Alireza Abdollahi ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Pathological Examination ◽  
Histological Changes ◽  
Intrauterine Growth ◽  
Study Population ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship ◽  
Restriction Group

Introduction: Intrauterine growth restriction is a multifaceted problem and is associated with a significant increase in the level of morbidity and perinatal mortality. According to some studies, failure of the placenta is responsible for the most cases of intrauterine growth restriction. The aim of this study was to evaluate the placental pathologic changes in the intrauterine growth restriction (IUGR) samples and compare them with normal cases.   Methods: A study population consisted of 60 intrauterine growth restriction neonates and 60 normalized neonates born at Tehran Imam Khomeini Hospital between June 2016 and July 2017. The placenta was weighed, immediately after delivery, and the umbilical cord was separated, then stored in 10% formalin and sent for pathological examination as soon as possible. Data collection was performed according to the following items: the pathologist's report, the results of the infants' examination, and the data in the neonatal cases.   Results: The intrauterine growth restriction group showed a high frequency of placenta infarction (P < 0.001), inflammation of the villous (P < 0.001), villous fibrosis (P = 0.044), villous vascularization disorder (P = 0.001), prevalence of chorioamnionitis (P = 0.027), prevalence of Syncytiotrophoblastic knots (P < 0.001) and placental necrosis (P = 0.048) than normal group. However, the mean weight of the placenta (P < 0.001), the length and width of the macroscopic placenta changes was less (P < 0.001).   Conclusion: The results of the current study showed that a major part of the macroscopic and histological changes are detectable in the intrauterine growth restriction samples, which are considerably more common than normal, although they are not pathognomonic, but in the future, more accurate results can be obtained from more extensive studies.

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