Effects of fish oil and conjugated linoleic acids on carnitine homeostasis in laying hens

2012 ◽  
Vol 53 (4) ◽  
pp. 431-438 ◽  
Author(s):  
M. Shibani ◽  
J. Keller ◽  
B. König ◽  
H. Kluge ◽  
F. Hirche ◽  
...  
2008 ◽  
Vol 100 (2) ◽  
pp. 355-363 ◽  
Author(s):  
Bettina König ◽  
Julia Spielmann ◽  
Kati Haase ◽  
Corinna Brandsch ◽  
Holger Kluge ◽  
...  

In mammals, (n-3) PUFA and conjugated linoleic acids (CLA) act as activators of PPARα and alter nuclear concentrations of sterol regulatory element-binding proteins (SREBP) in the liver, and thereby influence hepatic lipid catabolism and synthesis. In this study, we investigated the hypothesis that (n-3) PUFA and CLA exert similar effects in the liver of laying hens. Thirty hens (64 weeks old) were fed diets containing 30 g/kg of sunflower oil (control), fish oil (salmon oil) or CLA in TAG form (containing predominantlycis-9,trans-11 CLA andtrans-10,cis-12 CLA) for 5 weeks. Hens fed fish oil had a higher expression of some PPARα target genes and a lower nuclear concentration of SREBP-2 in the liver and lower concentrations of cholesterol and TAG in plasma than control hens. Nuclear concentration of SREBP-1 and its target genes involved in lipogenesis were not altered in hens fed fish oil. Hens fed CLA had increased concentrations of TAG and cholesterol in the liver. However, their mRNA levels of PPARα target genes and nuclear concentrations of SREBP-1 and SREBP-2 as well as mRNA levels of their target genes in the liver were largely unchanged compared to control hens. The results of this study suggest that (n-3) PUFA cause a moderate activation of PPARα and lower cholesterol synthesis but do not impair fatty acid synthesis in the liver of laying hens. CLA lead to an accumulation of TAG and cholesterol in the liver of hens by mechanisms to be elucidated in further studies.


Lipids ◽  
2001 ◽  
Vol 36 (11) ◽  
pp. 1217-1222 ◽  
Author(s):  
Klaus Schäfer ◽  
Klaus Männer ◽  
Angelos Sagredos ◽  
Klaus Eder ◽  
Ortwin Simon

2002 ◽  
Vol 132 (2) ◽  
pp. 182-189 ◽  
Author(s):  
Katleen Raes ◽  
Gerard Huyghebaert ◽  
Stefaan De Smet ◽  
Lode Nollet ◽  
Sven Arnouts ◽  
...  

2008 ◽  
Vol 77 (1) ◽  
pp. 39-44 ◽  
Author(s):  
M. Švedová ◽  
L. Vaško ◽  
A. Trebunová ◽  
R. Kašteľ ◽  
M. Tučková ◽  
...  

The metabolic and immunological indicators were determined in the blood of laying hens of ISA BROWN hybrid divided into three groups, the control group and two experimental groups. The administration of n-3 polyunsaturated fatty acids (PUFA) in the form of linseed (Group 1) and fish oil (Group 2) and α-tocopherol as antioxidant to laying hens resulted in a significant increase in concentrations of high density lipoproteins (HDL) cholesterol (P < 0.05), eicosapentaenoic (EPA), docosahexaenoic (DHA) and α-linolenic acids (AA) in blood in comparison to the control group. Significantly lower levels of cholesterol (CHOL) were determined in both experimental groups at the third sampling (P < 0.05) and arachidonic acid (AA) in the fish group (P < 0.01). The metabolic activity of phagocytes and polyclonal activation of lymphocytes showed no significant differences and remained within the physiological range. Oral administration of n-3 PUFA showed no significant increase of the immune response of experimental animals.


2017 ◽  
Vol 42 (2) ◽  
pp. 88
Author(s):  
U. Santoso ◽  
Y. Fenita ◽  
E. Sulistyowati

The objective of this study was to obtain enriched eggs with low cholesterol content. Forty-eight laying hens (strain Dekalb Warren) aged 72 weeks were distributed into six treatment groups as follows: 1) Laying hens fed diet without Sauropus androgynus leaf extracts (SALE), fish oil and vitamin E (P0) as the control; 2) Laying hens were fed diet with 27 g SALE/kg diet, but without fish oil (P1); 3) Laying hens were fed diet with 27 g SALE/kg diet, 1.5% fish oil (P2); 4) Laying hens were fed diet with 27 g SALE/kg diet, 1.5% fish oil and 60 mg vitamin E/kg diet (P3); 5) Laying hens were fed diet with 27 g SALE/kg diet, 3% fish oil (P4); 6) Laying hens were fed diet with 27 g SALE/kg 3% fish oil and 60 mg vitamin E/kg diet (P5). Experimental results showed that the treatments affected (P <0.05) egg production, thick eggshell, egg white height, yolk color, the odor of eggs after the split (P <0.05). It was shown that the treatments had no effect on the contents of protein, fat, β-carotene of eggs but affected the contents of cholesterol and vitamin E of eggs. In conclusion, the treatments improved egg quality and increased egg Vitamin E but reduced egg cholesterol.


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