Effects of a modified clinoptilolite zeolite on growth performance, health status and detoxification of aflatoxin B1 and ochratoxin A in male broiler chickens

2021 ◽  
Author(s):  
Jog Raj ◽  
Marko Vasiljević ◽  
Panagiotis Tassis ◽  
Hunor Farkaš ◽  
Jasna Bošnjak-Neumüller ◽  
...  
Keyword(s):  
Health Status ◽  
Growth Performance ◽  
Ochratoxin A ◽  
Aflatoxin B1 ◽  
Broiler Chickens ◽  
Clinoptilolite Zeolite ◽  
Modified Clinoptilolite

scholarly journals The Efficacy of a Smectite-Based Mycotoxin Binder in Reducing Aflatoxin B1 Toxicity on Performance, Health and Histopathology of Broiler Chickens

Toxins ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 856
Author(s):  
Ismail Zabiulla ◽  
Venkataramaiah Malathi ◽  
H. V. L. N. Swamy ◽  
Jaya Naik ◽  
Lane Pineda ◽  
...  
Keyword(s):  
Growth Performance ◽  
Aflatoxin B1 ◽  
Broiler Chickens ◽  
Average Daily Gain ◽  
Basal Diet ◽  
Gamma Glutamyl Transferase ◽  
Serum Globulin ◽  
Smectite Clay ◽  
Toxicological Effects ◽  
Glutamyl Transferase

The aim of the experiment was to investigate the efficacy of a smectite-based clay binder (Toxo-MX) in reducing the toxicological effects of aflatoxin B1 (AFB1) in commercial broiler chickens. A total of 450 one-day old male broiler chickens were randomly allocated into three treatment groups with ten replicates of 15 birds each in a 42-day feeding experiment. The dietary treatments included a negative control (NC, a basal diet with no AFB1 and binder), a positive control (PC, a basal diet contaminated with 500 ppb of AFB1) and a smectite-based mycotoxin binder(Toxo-MX, PC with smectite clay binder). AFB1 challenge resulted in 14 to 24% depression in growth performance, elevated levels of aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), organ enlargement and immuno-suppression.As compared to PC, feeding of Toxo-MX improved the final weight (15%; p < 0.0001), average daily gain (ADG) (15%; p < 0.001) and feed efficiency of broilers (13%; p < 0.0003) but did not have any effects on liver enzyme activities. Supplementation of smectite claysignificantly increased serum globulin levels and reduced the weight of the liver (p < 0.05) as compared to AFB1-fed broiler chickens. The severity of lesions (inflammatory and degenerative changes) observed in the liver, kidney, heart, pancreas, and lymphoid organs in PC birds was reduced by feeding smectite clay. The immuno-suppression caused by AFB1 was moderately ameliorated in Toxo-MX groupby stimulating the production of antibodies against IBD at day 42 (p < 0.05). In conclusion, dietary supplementation of a smectite-based mycotoxin binder to the diet containing AFB1 improved growth performance, reduced toxicological effects in liver and improved humoral immune response in broilers, suggesting its protective effect against aflatoxicosis.

scholarly journals The effect of <i>Myrtus communis</i> oil extract on growth performance, serum biochemistry and humoral immune responses in broiler chicks fed diet containing aflatoxin B1

2013 ◽  
Vol 56 (1) ◽  
pp. 842-850 ◽  
Author(s):  
M. M. Saei ◽  
A. A. Sadeghi ◽  
H. Ahmadvand
Keyword(s):  
Immune Responses ◽  
Growth Performance ◽  
Aflatoxin B1 ◽  
Broiler Chickens ◽  
Serum Biochemistry ◽  
Influenza Viruses ◽  
Myrtus Communis ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Antibody Titers

Abstract. A study was conducted to investigate the capability of Myrtus communis essential oil (MCE) in counteracting the deleterious effects of aflatoxin B1 (AFB1) on growth performance, serum biochemistry and humoral immune responses in broiler chickens. In a completely randomized design, 300 day-old male chicks were assigned to four treatments with five replicates of 15 birds for 42 days. Chickens, up to day 7 of age, were fed the same diet and then, they were fed the experimental diets. The dietary treatments were 1) the negative control (no dietary aflatoxin or MCE), 2) the positive control (diet containing AFB1 at 0.5 mg/kg, without MCE), 3) diet containing AFB1 at 0.5 mg/kg plus 500 mg/kg MCE, and 4) basal diet containing 500 mg/kg MCE, without AFB1. Growth performance was measured from day 7 to 42. Serum biochemical parameters, organ weights on day 42 and the antibody titers against Newcastle and influenza viruses on day 28 of age were determined. Addition of aflatoxin to diet decreased (P<0.05) the weight gain and feed intake and MCE supplementation diminished (P<0.05) the inhibitory effects of AFB1 on the growth performance. Addition of AFB1 to diet of chicks increased the serum activities of aspartate aminotransferase (AST), alkaline aminotransferase (ALT), alkaline phosphatase (ALP), and decreased the antibody titers against Newcastle and influenza viruses. Addition of MCE to diet alleviated the negative effects of AFB1 on these parameters (P<0.05). In conclusion, our results showed that addition of MCE may reduce the adverse effects of AFB1 on broiler chickens.

scholarly journals Corrigendum Effect of Dietary Supplement of Algae (Spirulina platensis) as an Alternative to Antibiotics on Growth Performance and Health Status of Broiler Chickens

2021 ◽  
Vol 20 (2) ◽  
pp. 98-98
Author(s):  
Md. Zahir Uddin Rubel ◽  
Md. Anwarul Haque Beg ◽  
K. B. M. Saiful Isl ◽  
Maksuda Begum ◽  
Md. Mahfuj Ullah Patoary
Keyword(s):  
Health Status ◽  
Growth Performance ◽  
Dietary Supplement ◽  
Spirulina Platensis ◽  
Broiler Chickens

REPLACEMENT VALUE OF MAIZE WITH OTHER CEREALS ON PERFORMANCE AND COST BENEFIT OF BROILER CHICKENS

2021 ◽  
pp. 36-46
Keyword(s):  
Adverse Effect ◽  
Weight Gain ◽  
Health Status ◽  
Growth Performance ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
Lower Cost ◽  
Cost Benefit ◽  
Broiler Chicks ◽  
Dietary Treatments

The study investigated the effect of replacing maize with alternatives (white sorghum, red sorghum, grey millet and brown millet) on the growth performance and cost benefit of broiler chicken. A total of one hundred and fifty (150) day-old Aboica strain broiler chicks were purchased for this study and were randomly allotted to five dietary treatments. The five is caloric and is nitrogenous diets for both the starter and finisher phases were formulated with the test ingredients (yellow maize, white sorghum, red sorghum, grey millet and brown millet) as the main source of energy and were designated as T1, T2, T3, T4 and T5. Each treatment was further divided into three replicates with ten (10) birds per replicate. The parameters investigated were growth performance and economics of production. This study revealed no significant (p>0.05) differences in weight gain among all the treatment. Furthermore, it showed a significantly (p>0.05) lower cost of producing the four alternatives as compared to the control (maize) and higher gross profit. It was concluded that white sorghum, red sorghum, grey millet and brown millet can replace yellow maize without any adverse effect on the health status and general performance of broiler chickens.

scholarly journals Biomarkers for Exposure as A Tool for Efficacy Testing of A Mycotoxin Detoxifier in Broiler Chickens and Pigs

Toxins ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 187 ◽  
Author(s):  
Marianne Lauwers ◽  
Siska Croubels ◽  
Ben Letor ◽  
Christos Gougoulias ◽  
Mathias Devreese
Keyword(s):  
Treatment Group ◽  
Ochratoxin A ◽  
Aflatoxin B1 ◽  
Broiler Chickens ◽  
Mitigation Strategy ◽  
Control Measures ◽  
Proof Of Concept ◽  
Target Species ◽  
Concept Study ◽  
Specific Target

Applying post-harvest control measures such as adding mycotoxin detoxifying agents is a frequently-used mitigation strategy for mycotoxins. EFSA states that the efficacy of these detoxifiers needs to be tested using specific biomarkers for exposure. However, the proposed biomarkers for exposure are not further optimized for specific target species. Hence, the goal of this study was a) to evaluate the most suitable biomarkers for deoxynivalenol (DON) and zearalenone (ZEN) in porcine plasma, urine and feces; and DON, aflatoxin B1 (AFB1) and ochratoxin A (OTA) in plasma and excreta of broiler chickens and b) to determine the efficacy of a candidate detoxifier, as a proof-of-concept study. Therefore, a mixture of mycotoxins was administered as a single oral bolus with or without detoxifying agent. In accordance with literature AFB1, OTA, and DON-sulphate (DON-S) proved optimal biomarkers in broilers plasma and excreta whereas, in pigs DON-glucuronide (DON-GlcA) and ZEN-glucuronide (ZEN-GlcA) proved the optimal biomarkers in plasma, DON and ZEN-GlcA in urine and, ZEN in feces. A statistically significant reduction was seen between control and treatment group for both AFB1 and DON in broiler plasma, under administration of the mycotoxin blend and detoxifier dose studied suggesting thus, beneficial bioactivity.

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