Oral administration of ammonium metavanadate and potassium dichromate distorts the inflammatory reaction induced by turpentine oil injection in male rats

2019 ◽  
pp. 1-9
Author(s):  
Marina K. Balabekova ◽  
Yekaterina O. Ostapchuk ◽  
Yuliya V. Perfilyeva ◽  
Aliya N. Tokusheva ◽  
Adilman Nurmuhambetov ◽  
...  
Keyword(s):  
Oral Administration ◽  
Inflammatory Reaction ◽  
Potassium Dichromate ◽  
Ammonium Metavanadate ◽  
Male Rats ◽  
Oil Injection

Plasma Lipid-lowering and Lipogenesis-stimulating Actions of Ginseng Saponins in Tumor-bearing Rats

1983 ◽  
Vol 11 (01n04) ◽  
pp. 88-95 ◽  
Author(s):  
Masahiro Yamamoto ◽  
Akira Kumagai ◽  
Yuichi Yamamura
Keyword(s):  
Adipose Tissue ◽  
Oral Administration ◽  
Plasma Cholesterol ◽  
Lipid Fraction ◽  
Plasma Lipid ◽  
Male Rats ◽  
Lipid Lowering ◽  
Tumor Bearing ◽  
Saponin Content

Ascited hepatoma (AH41C or AH130) was transplanted to male rats Donryu, strain. Plasma cholesterol, triglyceride (TG) and non-esterified fatty acid levels were reduced with oral administration of ginseng principle fraction 3 (saponin content, ca. 1/5). Incorporation of 1-[14C]-acetate into total lipids and fatty acids in adipose tissue was increased by fraction 3 administration in both normal and tumor-bearing rats. The incorporation increased in earlier stage of tumor growth and decreased in the later one. Incorporation of 1-[14C]-acetate into total lipid, free and esterified cholesterol, TG and phospholipid in the liver was also enhanced by fraction 3 administration in both normal and tumor-bearing animals. In vitro addition of ginseng principle fraction 4 (saponin content, ca. 1/2) increased incorporation of 1-[14C]-acetate into lipid fraction is adipose tissue and liver. Incorporation of 1-[14C]-acetate into lipid fractions in ascites hepatoma cells remained unchanged with both oral administration of fraction 3 and in vitro addition of fraction 4. DNA and protein synthesis in the tumor cells was not changed with in vitro addition of fraction 4.

scholarly journals AMELIORATIVE EFFECTS OF GRAPE SEED OIL ON CHROMIUM-INDUCED NEPHROTOXICITY AND OXIDATIVESTRESS IN RATS

2020 ◽  
Vol 57 (3) ◽  
Author(s):  
Sahar Hassan Orabi ◽  
Sherif Mohamed Shawky
Keyword(s):  
Dna Damage ◽  
Hexavalent Chromium ◽  
Seed Oil ◽  
Potassium Dichromate ◽  
Serum Levels ◽  
Grape Seed ◽  
Renal Tissue ◽  
Male Rats ◽  
Group I ◽  
Grape Seed Oil

The current study focused on investigating the renoprotective effects of grape seed oil (GSO) against hexavalent chromium (Cr (VI))-induced nephrotoxicity. A total of 40 male rats were randomly divided into four groups: group I served as the control group, group II received 1000 mg/L potassium dichromate (353.5 mg/L Cr(VI)) in drinking water for 12 weeks, group III received 3.7 g/kg body weight/day GSO orally for 12 weeks, and group IV received GSO together with potassium dichromate for 12 weeks. Cr(VI) significantly increased serum levels of urea, creatinine, potassium and glucose. In addition, Cr(VI) increased MDA levels and induced renal tissue damage and DNA damage. On the other hand, Cr(VI) decreased serum levels of sodium and antioxidant defence system [reduced glutathione (GSH) and catalase (CAT)]. However, treatment with GSO prevented elevation levels of serum urea, creatinine, potassium and glucose. In addition, GSO enhanced sodium level, renal tissue antioxidant defense system due to its curative effect ameliorated particularly oxidative stress, renal tissue and DNA damage. In conclusion, these results demonstrate that GSO is a promising nephroprotective agent against Cr(VI)-induced nephrotoxicity.Key words: grape seed oil; hexavalent chromium; nephrotoxicity; DNA damage BLAŽILNI UČINKI OLJA GROZDNIH PEŠK PRI TOKSIČNI OBREMENITVI LEDVIC TER VPLIV NA OKSIDATIVNI STRES PODGAN, POVZROČEN S KROMOM Povzetek: Študija je bila osredotočena na proučevanje zaščitnih učinkov olja grozdnih pešk (GSO) pri toksični obremenitvi ledvic, povzročeni s heksavalentnim kromom (Cr (VI)). Štirideset samcev podgan je bilo naključno razdeljenih v štiri skupine: skupina I - kontrolna skupina, skupina II, ki je v pitni vodi 12 tednov prejemala 1000 mg/L kalijevega dikromata (353,5 mg/L Cr (VI)), skupina III, ki je peroralno 12 tednov prejemala 3,7 g/kg telesne mase/dan GSO ter skupina IV, ki je 12 tednov prejemala GSO skupaj s kalijevim dikromatom. Cr(VI) je znatno zvišal serumske ravni sečnine, kreatinina, kalija in glukoze v serumu. Poleg tega je Cr(VI) zvišal raven MDA in povzročil poškodbe ledvičnega tkiva in poškodbe DNK. Po drugi strani je Cr(VI) znižal serumsko raven natrija in antioksidativnega obrambnega sistema, zmanjšal raven glutationske peroksidaze in katalaze. Dodajanje GSO poskusnim živalim je preprečilo zvišanje ravni sečnine v serumu, kreatinina, kalija, natrija in glukoze. Poleg tega je GSO izboljšal obrambni sistem antioksidantov ledvičnega tkiva. Zaradi svojega zdravilnega učinka je izboljšal zlasti oksidativni stres, poškodbe ledvičnega tkiva in DNK. Rezultati kažejo, da je GSO obetavno zaščitno sredstvo za ledvica pri toksični obremenitvi, povzročeni s Cr(VI).Ključne besede: olje grozdnih pešk; heksavalentni krom; nefrotoksičnost; poškodba DNK

Oral administration of Centella asiatica (L.) Urb leave aqueous extract ameliorates cerebral oxidative stress, inflammation, and apoptosis in male rats with type-2 diabetes

2020 ◽  
Vol 28 (6) ◽  
pp. 1599-1622
Author(s):  
Nelli Giribabu ◽  
Kamarulzaman Karim ◽  
Eswar Kumar Kilari ◽  
Srinivasa Rao Nelli ◽  
Naguib Salleh
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Centella Asiatica ◽  
Male Rats

Effects of Neonatal Testosterone and Progesterone on Open-Field Behaviour in the RAT

1978 ◽  
Vol 30 (1) ◽  
pp. 157-166 ◽  
Author(s):  
Robin Stevens ◽  
Ralph Goldstein
Keyword(s):  
Open Field ◽  
Female Rats ◽  
Male Rats ◽  
Same Sex ◽  
Adrenal Androgens ◽  
Postnatal Treatment ◽  
Oil Injection ◽  
Increased Activity ◽  
Field Behaviour ◽  
Open Field Behaviour

Rats treated on the day of birth with progesterone (50 üg) or testosterone pro-pionate (200 üg) or the oil injection vehicle alone were tested in the open-field on four consectuve days at 45 days and 85 days of age. Averages across treatments showed that females ambulated more and reared more than males at both ages, that they groomed more than males at 45 days of age, and defaecated less at 85 days of age. Progesterone treatment significantly reduced defaecation in males at 45 days of age, and reduced grooming in both sexes. At 85 days of age progesterone significantly increased activity in females. Testosterone-treated animals of both sexes groomed significantly less than same-sex controls at 45 days of age, whereas at 85 days of age activity scores were significantly reduced only in females although testosterone treated males were less active on 2 test days and more active on 1. Early postnatal treatment with progesterone appeared to feminise male rats, and testosterone to masculinise female rats. Both hormones also altered the behaviour of opposite sexed rats, indicating that male rats may be further masculinised by exogenous testosterone and female rats further feminised by progesterone. Progesterone may have acted as an anti-androgenic agent by blocking gonadal and adrenal androgens in males and adrenal androgens in females.

Sign in / Sign up

Export Citation Format

Share Document