Time-dependency in brain lesion enhancement with gadodiamide injection

1997 ◽  
Vol 38 (1) ◽  
pp. 19-24 ◽  
Author(s):  
P. Åkeson ◽  
C.-H. Nordström ◽  
S. Holtås
Keyword(s):  
Time Window ◽  
Spin Echo ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Time Dependency ◽  
Contrast Injection ◽  
Effective Time ◽  
Peak Enhancement ◽  
Spin Echo Sequence ◽  
Major Increase

Purpose: To determine the effective time window for MR imaging of tumors with blood-brain barrier (BBB) damage after injection of Gd-containing contrast media. Material and Methods: Eleven patients with 15 brain lesions (metastasis, glioma, abscess) were studied with a T1-weighted spin-echo sequence repeated over periods of up to 43 min after contrast injection. A quotient was calculated between the signals in the lesion and in the gray matter, and plotted against time. Results: All lesions reached 70% of the maximum RATIO within 3.5 min. After 25 min 12 out of 15 lesions showed persistent enhancement within 15% of the maximal RATIO. Conclusion: The peak enhancement of BBB damage occurs around 3.5 min after injection. The effect does not change during the next 25 min. Scanning should not be started until 2–5 min after injection of the contrast medium, and there is no advantage in waiting longer as no major increase (or decline) of contrast can be expected.

The value of chemical fat-saturation pulse added to T1-weighted spin-echo sequence in evaluating gadolinium-enhancing brain lesions in multiple sclerosis

2007 ◽  
Vol 112 (8) ◽  
pp. 1244-1251 ◽  
Author(s):  
F. Sardanelli ◽  
S. Schiavoni ◽  
A. Iozzelli ◽  
A. Fausto ◽  
A. Aliprandi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spin Echo ◽  
Brain Lesions ◽  
Saturation Pulse ◽  
Fat Saturation ◽  
Spin Echo Sequence

Time-dependency in brain lesion enhancement with gadodiamide injection

1997 ◽  
Vol 38 (1) ◽  
pp. 19-24 ◽  
Author(s):  
P. Åkeson ◽  
C. H. Nordstrom ◽  
S. Holtås
Keyword(s):  
Brain Lesion ◽  
Time Dependency

scholarly journals CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria L. Elkjaer ◽  
Arkadiusz Nawrocki ◽  
Tim Kacprowski ◽  
Pernille Lassen ◽  
Anja Hviid Simonsen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Protein Phosphatase ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Cns Diseases ◽  
Secondary Progressive ◽  
Apolipoprotein A ◽  
Proteomic Approach ◽  
Apolipoprotein C ◽  
Altered Proteins

AbstractTo identify markers in the CSF of multiple sclerosis (MS) subtypes, we used a two-step proteomic approach: (i) Discovery proteomics compared 169 pooled CSF from MS subtypes and inflammatory/degenerative CNS diseases (NMO spectrum and Alzheimer disease) and healthy controls. (ii) Next, 299 proteins selected by comprehensive statistics were quantified in 170 individual CSF samples. (iii) Genes of the identified proteins were also screened among transcripts in 73 MS brain lesions compared to 25 control brains. F-test based feature selection resulted in 8 proteins differentiating the MS subtypes, and secondary progressive (SP)MS was the most different also from controls. Genes of 7 out these 8 proteins were present in MS brain lesions: GOLM was significantly differentially expressed in active, chronic active, inactive and remyelinating lesions, FRZB in active and chronic active lesions, and SELENBP1 in inactive lesions. Volcano maps of normalized proteins in the different disease groups also indicated the highest amount of altered proteins in SPMS. Apolipoprotein C-I, apolipoprotein A-II, augurin, receptor-type tyrosine-protein phosphatase gamma, and trypsin-1 were upregulated in the CSF of MS subtypes compared to controls. This CSF profile and associated brain lesion spectrum highlight non-inflammatory mechanisms in differentiating CNS diseases and MS subtypes and the uniqueness of SPMS.

scholarly journals Risk factors for hip dislocation in dyskinetic cerebral palsy

2021 ◽  
Vol 29 (1) ◽  
pp. 230949902110011
Author(s):  
Kyoko Okuno ◽  
Yukihiro Kitai ◽  
Toru Shibata ◽  
Hiroshi Arai
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Birth Weight ◽  
Gestational Age ◽  
Brain Mri ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Lesion Location ◽  
Hip Displacement ◽  
Gmfcs Level

Purpose: To investigate the risk factors for hip displacement in patients with dyskinetic cerebral palsy (DCP). Methods: We evaluated 81 patients with DCP, 45 males and 36 females, aged 10–22 years, risk factors for hip displacement were evaluated using multivariate logistic regression analysis with primary brain lesions, Gross Motor Function Classification System (GMFCS) level, gestational age, birth weight, Cobb’s angle, and complication of epilepsy as independent factors. Hip displacement was defined as migration percentage >30%. Primary brain lesions were classified into globus pallidus (GP), thalamus and putamen (TP), and others using brain magnetic resonance imaging (MRI). Perinatal and clinical features were compared between patients with GP lesions and those with TP lesions. Results: Hip displacement was observed in 53 patients (67%). Higher GMFCS levels (p = 0.013, odds ratio [OR] 2.6) and the presence of GP lesions (p = 0.04, OR 16.5) were independent risk factors for hip displacement. Patients with GP lesions showed significantly higher GMFCS levels, more frequent hip displacement, and lower gestational age and birth weight than those with TP lesions. Conclusion: Primary brain lesion location may be an important factor in predicting hip displacement among patients with DCP. Appropriate risk assessment using brain MRI may contribute to the early detection and intervention of hip displacement because brain lesion location can be assessed during infancy before GMFCS level is decided.

Cerebral Mechanisms in Obsessive-Compulsive Disorder

CNS Spectrums ◽  
1998 ◽  
Vol 3 (7) ◽  
pp. 44-46
Author(s):  
Juan Carlos Goldar ◽  
Dario Rojas ◽  
Mariano Outes
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Cingulate Gyrus ◽  
Cerebral Function ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Level Change ◽  
Clinical Level ◽  
Cerebral Mechanisms

AbstractBrain lesions cause different level change in cerebral function. They may conflict with the existing antagonistic mechanisms between the dorsal and ventral brain. At a clinical level, a dorsal brain lesion may constitute praxis disorders, while a ventral lesion may represent preventive inhibition. Further instinctive symptoms originate in the cingulate gyrus and its connections with the thalamic peduncle. This area may be an importan obsessive-compulsive disorder (OCD) pathway, that is utilized therapeutically during neurosurgical interventions in OCD.

scholarly journals Sialolithiasis and Salivary Ductal Stenosis: Diagnostic Accuracy of MR Sialography with a Three-dimensional Extended-Phase Conjugate-Symmetry Rapid Spin-Echo Sequence

Radiology ◽  
2000 ◽  
Vol 217 (2) ◽  
pp. 347-358 ◽  
Author(s):  
Minerva Becker ◽  
Francis Marchal ◽  
Christoph D. Becker ◽  
Pavel Dulguerov ◽  
Georges Georgakopoulos ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Spin Echo ◽  
Three Dimensional ◽  
Extended Phase ◽  
Phase Conjugate ◽  
Spin Echo Sequence ◽  
Conjugate Symmetry

scholarly journals Dynamic diffusion‐weighted hyperpolarized 13 C imaging based on a slice‐selective double spin echo sequence for measurements of cellular transport

2018 ◽  
Vol 81 (3) ◽  
pp. 2001-2010 ◽  
Author(s):  
Xucheng Zhu ◽  
Jeremy W. Gordon ◽  
Robert A. Bok ◽  
John Kurhanewicz ◽  
Peder E.Z. Larson
Keyword(s):  
Spin Echo ◽  
Cellular Transport ◽  
Double Spin ◽  
Diffusion Weighted ◽  
Spin Echo Sequence ◽  
Dynamic Diffusion

scholarly journals Magnetic resonance findings in amyotrophic lateral sclerosis using a spin echo magnetization transfer sequence: preliminary report

1999 ◽  
Vol 57 (4) ◽  
pp. 912-915 ◽  
Author(s):  
ANTÔNIO JOSÉ DA ROCHA ◽  
ANTONIO CARLOS MARTINS MAIA JUNIOR ◽  
ROBERTO GOMES NOGUEIRA ◽  
HENRIQUE MANOEL LEDERMAN
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Magnetic Resonance ◽  
Preliminary Report ◽  
Corticospinal Tract ◽  
Spin Echo ◽  
Magnetization Transfer ◽  
Control Group ◽  
Spin Echo Sequence ◽  
Lateral Sclerosis

We present the magnetic resonance (MR) findings of five patients with amyotrophic lateral sclerosis (ALS) using a spin-echo sequence with an additional magnetization transfer (MT) pulse on T1-weighted images (T1 SE/MT). These findings were absent in the control group and consisted of hyperintensity of the corticospinal tract. Moreover we discuss the principles and the use of this fast but simple MR technique in the diagnosis of ALS

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