The relationship between UGT1A1 gene & various diseases and prevention strategies

2021 ◽  
pp. 1-21
Author(s):  
Dan Liu ◽  
Qi Yu ◽  
Qing Ning ◽  
Zhongqiu Liu ◽  
Jie Song
Keyword(s):  
Prevention Strategies ◽  
Ugt1a1 Gene ◽  
The Relationship

scholarly journals Cold Weather Conditions and Risk of Hypothermia Among People Experiencing Homelessness: Implications for Prevention Strategies

2019 ◽  
Vol 16 (18) ◽  
pp. 3259 ◽  
Author(s):  
Paige Zhang ◽  
Kathryn Wiens ◽  
Ri Wang ◽  
Linh Luong ◽  
Donna Ansara ◽  
...  
Keyword(s):  
Conditional Logistic Regression ◽  
Weather Conditions ◽  
Meteorological Conditions ◽  
Crossover Design ◽  
Cold Weather ◽  
Limited Data ◽  
Prevention Strategies ◽  
Temperature And Precipitation ◽  
Minimum Daily Temperature ◽  
The Relationship

Hypothermia is a preventable condition that disproportionately affects individuals who experience homelessness, yet limited data exist to inform the response to cold weather. To fill this gap, we examined the association between meteorological conditions and the risk of hypothermia among homeless individuals. Hypothermic events were identified from emergency department charts and coroner’s records between 2004 and 2015 in Toronto, Canada. A time-stratified case-crossover design with conditional logistic regression was used to assess the relationship between the meteorological conditions (minimum temperature and precipitation) and the risk of hypothermia. There were 97 hypothermic events identified: 79 injuries and 18 deaths. The odds of experiencing a hypothermic event increased 1.64-fold (95% CI: 1.30–2.07) with every 5 °C decrease in the minimum daily temperature and 1.10-fold (95% CI: 1.03–1.17) with every 1 mm increase in precipitation. The risk of hypothermia among individuals experiencing homelessness increased with declining temperature; however, most cases occurred during periods of low and moderate cold stress. 72% occurred when the minimum daily temperatures were warmer than −15 °C. These findings highlight the importance of providing a seasonal cold weather response to prevent hypothermia, complemented by an alert-based response on extremely cold days.

Study of Gilbert's Syndrome-Associated UGT1A1 Polymorphism in Jaundiced Neonates of ABO Incompatibility Hemolysis Disease

2019 ◽  
Vol 37 (06) ◽  
pp. 652-658
Author(s):  
Yingfang Yu ◽  
Lizhong Du ◽  
An Chen ◽  
Lihua Chen
Keyword(s):  
Gene Polymorphism ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level ◽  
Full Term ◽  
Bilirubin Concentration ◽  
Ugt1a1 Gene ◽  
Abo Incompatibility ◽  
Significant Difference ◽  
Abo Hemolytic Disease ◽  
The Relationship

Abstract Objective This study aimed to assess the probable relationship between icter in neonates with ABO incompatibility hemolysis and UGT1A1 gene polymorphism. Study Design There were 65 ABO hemolytic disease of the newborn (HDN) neonates of full term in the study group and 82 non-ABO HDN neonates of full term in the compared group. We tested the UGT1A1 gene mutation of neonates of ABO HDN and non-ABO HDN. We compared the incidence of hyperbilirubinemia between neonates with and without UGT1A1 mutations in the ABO HDN and non-ABO HDN, to determine the relationship between icter in neonates with ABO HDN and UGT1A1 gene polymorphism. SPSS 13.0 were used to analyze those two groups' data. Results There was statistically significant difference of the serum bilirubin level between the Gly71Arg homozygous and no mutation group in the ABO HDN patients (p < 0.05). When hyperbilirubinemia was defined as serum bilirubin concentration >342 μmol/L, the incidence of hyperbilirubinemia between patients of UGT1A1 and non-UGT1A1 mutations in the ABO HDN group was significantly different (p < 0.05). But in the non-ABO HDN group, no significant difference was found. Conclusion Individuals with Gly71Arg homozygous contributed to their hyperbilirubinemia in ABO HDN patients.

scholarly journals Perceived Parental Control and Disclosure of Adolescents with Disciplinary Problems

2017 ◽  
Vol 13 (11) ◽  
pp. 42
Author(s):  
Zarinah Arshat ◽  
Ang Chun Ee
Keyword(s):  
Random Sampling ◽  
Parental Control ◽  
Sampling Technique ◽  
Correlational Analysis ◽  
Prevention Strategies ◽  
Maternal Control ◽  
Disciplinary Problems ◽  
The Relationship ◽  
Cluster Random Sampling

Disciplinary violation are commonly found among school-going adolescents. The current study examined the relationship between parental control and disclosure among adolescents with disciplinary problems. A total of 354 adolescents were recruited using multistage cluster random sampling technique in Selangor. Results from the correlational analysis revealed that the higher the paternal and maternal control on adolescents, the higher the adolescents' disclosure to their father and mother. This suggests that prevention strategies focusing on parental control in relation to disclosure is applicable to adolescents with disciplinary problems.

An Investigation of Cognitive Style and Alcohol/Work-Related Problems among Naval Personnel

1992 ◽  
Vol 22 (3) ◽  
pp. 241-251 ◽  
Author(s):  
Randall M. Jones ◽  
Camille Nebeker Ross ◽  
Barbara Reed Hartmann
Keyword(s):  
Decision Making ◽  
Problem Solving ◽  
Coping Strategies ◽  
Cognitive Style ◽  
Prevention Strategies ◽  
Work Related ◽  
Orientation Scores ◽  
And Coping ◽  
The Relationship ◽  
Alcohol Related Problems

This study examines the relationship between cognitive style (i.e., information, normative, and diffuse orientation, and commitment) and alcohol/work-related problems. A random sample of Naval personnel ( n = 2000) with less than two years of service toward their first enlistment was sent a questionnaire to assess cognitive style [1] and alcohol/work-related problems. A total of 899 respondents (45.0%) returned their questionnaires. Findings support prevention strategies that incorporate problem-solving, decision-making, and coping strategies, particularly among participants who employ diffuse problem-solving/coping strategies (lack of exploration and commitment, avoidance of problems). Correlations between cognitive style and alcohol/work-related problems are theoretically compatible. Diffuse orientation scores are positively related to both alcohol- and work-related problems, while norm and information orientation scores are negatively related to both measures. Collectively, cognitive style measures explain 11.4 percent of the variability in alcohol-related problems, and 14.0 percent of the variability in work-related problems.

A study of suicidal attempts and voluntary self-harm admitted to “Al. Obregia” psychiatry clinical hospital between 2008 and 2010

2011 ◽  
Vol 26 (S2) ◽  
pp. 1627-1627
Author(s):  
M. Manea ◽  
V. Rusanu ◽  
B.E. Patrichi ◽  
A.A. Frunza ◽  
S.M. Bectas ◽  
...  
Keyword(s):  
Suicide Risk ◽  
Psychiatric Patients ◽  
Seasonal Pattern ◽  
Suicide Risk Assessment ◽  
Prevention Strategies ◽  
Number Of Children ◽  
Icd 10 ◽  
Self Harm ◽  
The Relationship ◽  
Risk Assessment And Management

IntroductionIn 2009, 8 Romanians committed suicide every day. Suicide risk assessment and management remains difficult for psychiatrists worldwide and requires further study and a better implementation of prevention strategies.AimsTo identify the relationship between demographic and clinical data in a sample of psychiatric patients admitted after a suicideattempt and voluntary self-harm (VSH-SA) to our hospital between 2008 and 2010.ObjectivesThe purpose of this study is to determine which factors, if any, influence suicidal behavior.MethodsA retrospective review of patients aged 10–84 with VSH-SA (coded by ICD-10), admitted during a three year period. The cases were sorted by age, gender, year of admission, seasonal pattern, mechanism of injury and associated psychiatric pathology. The mechanisms of injury were both violent and non-violent.Results59% of cases were female and 41% male, 18% under the age of 18 (82% female). 31,5% were in the 18-29 years of age interval. A large difference between the year 2008 (16 cases) and 2009 (51 cases) was registered in the male group. Most cases were registered during spring (34%). Drug and substance ingestion was the most common method. Violent methods were used by 25% of men and only 9,5% of women. The most frequent diagnosis was major depression.ConclusionOur results show that a large number of VSH-SA were committed by young, active members of the population and a significant number of children was noticed. These findings emphasize the importance of identifying suicide risk factors and developing prevention strategies.

scholarly journals Polymorphisms of the uridine-diphosphoglucuronosyltransferase 1A1 gene and coronary artery disease

2008 ◽  
Vol 13 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Chia-Jung Hsieh ◽  
Meng-Jung Chen ◽  
Yung-Liang Liao ◽  
Tung-Nan Liao
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Control Group ◽  
Ugt1a1 Gene ◽  
Coding Regions ◽  
Significant Difference ◽  
Polymerase Chain ◽  
Artery Disease ◽  
Highly Correlated ◽  
The Relationship

AbstractBilirubin, an antioxidant in the blood, plays a role in protection from atherosclerosis. The level of bilirubin is highly correlated to the incidence of coronary artery disease (CAD). Unconjugated bilirubin is conjugated with glucuronic acid through the reaction of uridine 5′-diphosphate-glucuronosyl transferase 1A1 (UGT1A1). The interactions of CAD and the variations in the coding regions of the UGT1A1 gene have never been evaluated. The purpose of this study was to analyze the influence of the UGT1A1 variant on the incidence of CAD. There were 135 participants in this study: 61 in the experimental group, who had CAD, and 74 in the control group, who did not have CAD. The blood samples from all 135 participants were collected and assayed to clarify the relationship between bilirubin and CAD. The assay of the polymerase chain reaction and the sequence of the UGT1A1 gene were examined to find the gene’s polymorphisms. The bilirubin levels for the participants in the control group were significantly higher than for the patients in the CAD group. Although the concentration of bilirubin in the UGT1A1 variant was higher than the wild type for the patients in the CAD group, there was no significant difference in the polymorphism of UGT1A1 between the patients in the CAD group and the participants in the control group.

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