Formulation Development and Stability Studies of Aqueous Metronidazole Benzoate Suspensions Containing Various Suspending Agents

2007 ◽  
Vol 33 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Sharon Zietsman ◽  
Gareth Kilian ◽  
Matthew Worthington ◽  
Chris Stubbs
Keyword(s):  
Stability Studies ◽  
Formulation Development ◽  
Suspending Agents ◽  
Metronidazole Benzoate

Evaluation of Carboxymethylated Plectranthus edulis Starch as Suspending Agent in Metronidazole Benzoate Suspension Formulation

2019 ◽  
Vol 12 (5) ◽  
pp. 4672-4681
Author(s):  
Yonas Brhane
Keyword(s):  
Potassium Dihydrogen Phosphate ◽  
Dihydrogen Phosphate ◽  
Stability Studies ◽  
Potassium Dihydrogen ◽  
Suspension Formulation ◽  
Sedimentation Volume ◽  
Suspending Agents ◽  
Metronidazole Benzoate ◽  
Concentration Levels ◽  
Better Than

Carboxymethylated Plectranthus edulis, Vatke (P. edulis) [fam., Lamiaceae] starch was evaluated as a suspending agent in metronidazole benzoate suspensions in comparison with sodium carboxymethyl cellulose (NaCMC) at concentration range of 1-4% (w/v). The resulting suspensions were evaluated for their sedimentation volume (%), degree of flocculation, rheology, redispersibility, and dissolution rate. Stability studies were performed for 3 months. The apparent viscosities of the formulations prepared with carboxymethylated P. edulis starch at reaction condition E (CMPS-E) was significantly lower than that of NaCMC (p < 0.05). The flowability of the suspensions, at all concentration levels of the suspending agents, were in the order of CMPS-E > NaCMC. AT 1% concentrations, carboxymethylated P. edulis starch (76 ± 1.5%) provided significantly higher (p < 0.05) sedimentation volume than NaCMC (40 ± 1.5%). At 3% and 4%, both gave comparable sedimentation volume (100%). Potassium dihydrogen phosphate (KH2PO4) employed as a flocculating agent significantly increased (p < 0.05) the sedimentation volume of the suspensions prepared with carboxy-methylated P.edulis starch and NaCMC. The redispersibilities of CMPS-E was better than those of NaCMC. All suspensions showed a release of greater than 85% of drug within 1 h. The results of stability studies showed that all suspension formulations were stable. From the foregoing, it can be concluded that carboxymethylated P. edulis starch could be used as an alternative suspending agent.

scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF PRONIOSOMAL GEL OF ETHINYLESTRADIOL AND LEVONORGESTREL FOR ANTIFERTILITY TREATMENT

2019 ◽  
Vol 12 (1) ◽  
pp. 364
Author(s):  
Shikha Baghel Chauhan ◽  
Tanveer Naved ◽  
Nayyar Parvez
Keyword(s):  
Optical Microscopy ◽  
Encapsulation Efficiency ◽  
In Vitro Release ◽  
Stability Studies ◽  
Formulation Development ◽  
Promising Alternative ◽  
Size And Shape ◽  
Permeation Studies ◽  
Gel Formulations

Objective: The purpose of this research was to develop and formulate proniosomal gel drug delivery system of ethinylestradiol and levonorgestrel for antifertility treatment that is capable of efficiently delivering entrapped drug over an extended period of time.Methods: Ethinylestradiol and levonorgestrel are encapsulated in various formulations of proniosomal gel composed of various ratios of span surfactant, cholesterol, soya lecithin, and alcohol as aqueous phase prepared by coacervation-phase separation method. The prepared formulations characterized for drug encapsulation efficiency, size distribution, in vitro release studies, and vesicular stability at different storage conditions were carried. Stability studies for proniosomal gel were carried out for a few weeks. Morphological size and shape of the vesicles are characterized using optical microscopy and scanning electron microscopy (SEM). Stability studies for proniosomal gel were carried out for 3 months.Results: Morphological size and shape of the vesicles are characterized using optical microscopy and SEM, particles are found to be spherical, size of the particles is in the range of 46.4–80.6 nm, and permeation studies showed good control release for prolonged period of time. The encapsulation efficiency of proniosomal gel formulations is in the range of 74–80% and in vitro permeation studies proved that good amount of drug is permeated and has reasonably good stability characteristics as well.Conclusions: The results suggest that proniosomal gel formulations of ethinylestradiol and levonorgestrel may be used for transdermal delivery for antifertility treatment. The dried proniosomal formulation could act as a promising alternative to niosomes.

Accelerating Vaccine Formulation Development Using Design of Experiment Stability Studies

2016 ◽  
Vol 105 (10) ◽  
pp. 3046-3056 ◽  
Author(s):  
Patrick L. Ahl ◽  
Christopher Mensch ◽  
Binghua Hu ◽  
Heidi Pixley ◽  
Lan Zhang ◽  
...  
Keyword(s):  
Design Of Experiment ◽  
Vaccine Formulation ◽  
Stability Studies ◽  
Formulation Development

scholarly journals Fixed Dose Formulation Development and Evaluation of Bilastine and Montelukast Sodium Tablets

2021 ◽  
pp. 55-67
Author(s):  
Umesh Chandra ◽  
Manish Kumar ◽  
Arun Garg ◽  
Shrestha Sharma ◽  
Pankaj Gupta
Keyword(s):  
Scale Up ◽  
Research Work ◽  
Angle Of Repose ◽  
Fixed Dose ◽  
Average Weight ◽  
Stability Studies ◽  
Formulation Development ◽  
Sodium Starch Glycolate ◽  
Montelukast Sodium ◽  
Significant Difference

Aim: The present research work was carried out to formulate stable fixed dose combination tablets of Bilastine and Montelukast Sodium, used to treat allergic rhinitis associated with asthma and rhino-conjunctivitis on basis of pre and post post-compression parameters evaluation and drug-drug-excipients compatibility studies. Methods: Direct compression methodology was used for tablet production and final composition of drugs and excipients was optimized by evaluating pre and post compression evaluations of blend and tablets respectively. The chemical instability and stability studies were carried out using HPLC method. Results: The Evaluation of pre-compression parameters of batch F1 to F5 shows that as we increase the amount of sodium starch glycolate and colloidal silicon dioxide from F1 to F5, bulk density and tapped density increases slightly whereas the compressibility index and hausner’s ratio of tablets was shifted from excellent to good. Angle of repose shows excellent flow property from F3-F5. After evaluation of post-compression parameters from F1 to F5, there is no significant difference in diameter, thickness and average weight of tablets. The hardness of tablets was decreased slightly from F1 to F5 therefore, the % friability was found to be increased from F1 to F5 and disintegration time was found to be decreased from F1 to F5. Dissolution studies shows % release of Bilastine and Montelukast was increased towards F1 to F5 as the percentage of Sodium Starch Glycolate increases. The drug-drug-excipients compatibility shows that there is no physical and chemical incompatibility between the drug-drug-excipients at accelerated conditions. The stability studies show that % assay of long term and accelerated samples are within 100±2%. Conclusion: The optimized composition found in order to scale up the production of tablets.

scholarly journals Formulation, development and evaluation of injectable formulation of Aspirin

2013 ◽  
Vol 3 (1) ◽  
pp. 2
Author(s):  
Rakesh P. Patel ◽  
Kaushal P. Patel ◽  
Kushal A. Modi ◽  
Chirayu J. Pathak
Keyword(s):  
Aqueous Solubility ◽  
Solvent System ◽  
Water Soluble ◽  
Stability Studies ◽  
Formulation Development ◽  
Parenteral Formulation ◽  
Polyethylene Glycol 400 ◽  
Accelerated Stability ◽  
Aqueous Solvent ◽  
Water Soluble Drugs

The objective of this study was to develop and manufacture a stable parenteral formulation for Aspirin, a non steroidal anti-inflammatory agent. The solubility and stability of the drug was determined. Solubility studies suggested that Aspirin exhibited poor aqueous solubility but showed appreciable solubility in non-aqueous solvents. Based on the preformulation studies, a lyophilized parenteral formulation containing 25 mg/mL of Aspirin was prepared in a solvent system containing of 80% v/v water and 20% v/v polyethylene glycol-400 (PEG-400). Rubber closures, filter membranes, and liquid transfer tubing were selected on the basis of compatibility studies. The formulation was subjected to accelerated stability studies. After reconstitution with sterile water for injection, Aspirin injection was stable for a period of 8 hr at 2°C to 8°C. Accelerated stability studies suggested that the lyophilized product should be kept at controlled room temperature for longterm storage. The proposed non-aqueous solvent concentration used, are known to safe hence, toxicities/safety related issues may not raise. The proposed techniques would be economical, convenient and safe. Thus, the study opens the chances of preparing lyophilized formulation of poorly-water soluble drugs.

scholarly journals Formulation development and characterization of fast dissolving tablets of oxcarbazepine

2015 ◽  
Vol 3 (01) ◽  
pp. 11-17
Author(s):  
Krishnamurthy A. Kamalapurkar ◽  
Mahesh P. Chitali ◽  
Revansidh R. Pujari
Keyword(s):  
Anticonvulsant Drug ◽  
In Vitro Dissolution ◽  
Dissolution Time ◽  
Stability Studies ◽  
Formulation Development ◽  
Disintegration Time ◽  
Hot Air ◽  
Weight Variation ◽  
The Stability

The objective of this study was formulation development and evaluation of Oxcarbazepine Fast Dissolving Tablets (FDTs) prepared by sublimation technique where different sublimating agents like camphor and menthol were used with L-HPC and crospovidone as a superdisintegrants. Oxcarbazepine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. Each sublimating agent was used in concentration of 10-20 mg per tablet. Tablets were first prepared and then kept in hot air oven for sublimation. The prepared FDTs were evaluated for weight variation, thickness, drug content, friability, hardness, wetting time, water absorption ratio, in-vitro dispersion time, in-vitro disintegration time and in-vitro dissolution time. All formulations showed disintegration time ranging from 8 to 332sec. Optimized batch (SA6) was selected for the stability studies. The results of stability studies revealed that there was no remarkable difference in the tested parameters of promising formulation after storage for 3 months at 400 c ± 20 c 75% ± 5%RH and at room temperature 65% ± 5%RH as compared to initial results All the prepared formulae complied with Pharmacopoeia requirements of drug contents.

scholarly journals Formulation development and in-vitro evaluation of Molsidomine matrix tablets for colon specific release

2020 ◽  
Vol 10 (2) ◽  
pp. 59-68
Author(s):  
D. Hema Naga Durga ◽  
T. Lakshmi Sowjanya ◽  
T. Pavani ◽  
Lohithasu Duppala
Keyword(s):  
Drug Release ◽  
Ethyl Cellulose ◽  
Matrix Tablets ◽  
Stability Studies ◽  
Formulation Development ◽  
Eudragit L100 ◽  
Ir Studies ◽  
Ft Ir ◽  
Ph Dependent

Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as coating polymers. FT-IR studies were carried out to find out the possible interaction between the selected drugs and polymer. FT-IR studies revealed that there  was  no  interaction between the selected drug and excipients. The pre-compression blend of all formulations was subjected to various flow property tests and all the formulations passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets passed all the tests. Among all the formulations F3 formulation was found to be optimized as it was retarded the drug release up to 12 hours and showed maximum of 97.57% drug release. It followed zero order kinetics mechanism. The ideal formulation was subjected to stability studies at 40°C/75%RH. The stability studies indicated that the formulation was stable and retained its pharmaceutical properties at 40°C/75%RH over a period of 1 month. Keywords: Colon target, Ethyl cellulose, Eudragit L100 and S100, pH dependent polymers.

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