Mechanism of the Fibroblast Growth Factor 23/α-Klotho Axis in Peripheral Blood Mononuclear Cell Inflammation in Alzheimer’s Disease

2021 ◽  
pp. 1-14
Author(s):  
Baoshan Li ◽  
Min Zhou ◽  
Jing Peng ◽  
Qiao Yang ◽  
Jingxin Chu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Peripheral Blood Mononuclear Cell ◽  
Fibroblast Growth Factor ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Peripheral Blood Mononuclear

scholarly journals Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer’s Disease

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1504
Author(s):  
Susanna C. Larsson ◽  
Dipender Gill
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Energy Homeostasis ◽  
Disease Risk ◽  
Fibroblast Growth Factor 21 ◽  
Clinical Effects ◽  
Fibroblast Growth ◽  
Beneficial Effects

Fibroblast growth factor 21 (FGF21) is a human metabolic hormone whose effects include modification of macronutrient preference and energy homeostasis. In animal models, FGF21 has been shown to have beneficial effects on cardiometabolic outcomes, Alzheimer’s disease risk and lifespan. In this study, the single-nucleotide polymorphism rs838133 in the FGF21 gene region was leveraged to investigate the potential clinical effects of targeting FGF21. The FGF21 G allele was associated with lower intakes of total sugars and alcohol, and higher intakes of protein and fat as well as favourable with lipid levels, blood pressure traits, waist-to-hip ratio, systemic inflammation, cardiovascular outcomes, Alzheimer’s disease risk and lifespan. These findings may be used to anticipate the effects of pharmacologically increasing FGF21 signalling.

Basic fibroblast growth factor in Alzheimer's disease

1990 ◽  
Vol 171 (2) ◽  
pp. 690-696 ◽  
Author(s):  
Edward G. Stopa ◽  
Ana-Maria Gonzalez ◽  
Regina Chorsky ◽  
Robert J. Corona ◽  
Jaime Alvarez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth
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