Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome

Hyaluronic acid (HA) is a glycosaminoglycan that was first isolated and identified from the vitreous body of a bull’s eye. HA is ubiquitous in the soft connective tissues of animals and therefore has high tissue compatibility for use in medication. Because of HA’s biological safety and water retention properties, it has many ophthalmology-related applications, such as in intravitreal injection, dry eye treatment, and contact lenses. Due to its broad range of applications, the identification and quantification of HA is a critical topic. This review article discusses current methods for analyzing HA. Contact lenses have become a widely used medical device, with HA commonly used as an additive to their production material, surface coating, and multipurpose solution. HA molecules on contact lenses retain moisture and increase the wearer’s comfort. HA absorbed by contact lenses can also gradually release to the anterior segment of the eyes to treat dry eye. This review discusses applications of HA in ophthalmology.

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A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18052383 ◽

2021 ◽

Vol 18 (5) ◽

pp. 2383

Author(s):

Yun-Jung Yang ◽

Won-Young Lee ◽

Young-jin Kim ◽

Yeon-pyo Hong

Keyword(s):

Hyaluronic Acid ◽

Confidence Interval ◽

Dry Eye ◽

Test Scores ◽

Meta Analysis ◽

Mean Difference ◽

Dry Eye Syndrome ◽

Eye Drops ◽

Cochrane Central Register ◽

Standard Mean Difference

Hyaluronic acid (HA) is commonly used for treating dry eye syndrome (DES). This meta-analysis was performed to compare the efficacies of HA- and non-HA-based eye drops, including saline and conventional artificial tears (ATs), for the treatment of dry eye disease. Eight databases (PubMed, EMBASE, Cochrane Central Register of Controlled Trials, DBpia, KoreaMed, KMBASE, RISS, KISS) were searched for studies comparing the efficacies of HA- and non-HA-based ATs in patients with DES published up to September 2020. Two independent reviewers assessed the quality and extracted the relevant data. The mean differences of Schirmer’s (SH) test scores, tear breakup times (TBUT), corneal fluorescein staining scores (Oxford scale, 0–4), and ocular surface disease indexes were calculated. The standard mean difference and 95% confidence interval were calculated using a random effect model. Nineteen studies, including 2078 cases, were included. HA eye drops significantly improved tear production compared with non-HA-based eye drops (standard mean difference (SMD) 0.18; 95% confidence interval (CI) 0.03, 0.33). In a subgroup analysis, the SH test scores and TBUT values after using HA significantly increased compared to those measured after using saline (SMD 0.27; 95% CI 0.05, 0.49 and SMD 0.28; 95% CI 0.03, 0.52, respectively). Based on these results, HA eye drops may be superior to non-HA eye drops including normal saline and ATs. Further research is needed to assess the efficacies stratified by age, treatment duration, the severity of dry eye, and optimal dosages.

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OKVision ® SMARTFIT™ Scleral Contact Lens Manufacturing Technology

The Eye ◽

10.33791/2222-4408-2021-2-47-52 ◽

2021 ◽

Vol 23 (2) ◽

pp. 47-52

Author(s):

S. V. Listratov ◽

N. A. Bakalova ◽

V. V. Averich

Keyword(s):

Dry Eye ◽

Contact Lens ◽

Conventional Treatment ◽

Contact Lenses ◽

Manufacturing Technology ◽

Eye Diseases ◽

Dry Eye Syndrome ◽

Annual Increase ◽

Treatment Methods

Corneal keratoectasia and dry eye syndrome (DES) are two of the most prevalent eye diseases. A number of studies is being carried out aimed at identifying and analyzing the annual increase in incidence of these diseases in population strata. Treatment and rehabilitation of patients with keratoectasia and DES remain topical issues in modern ophthalmology. Conventional treatment methods are not always effective, and scleral lenses (SCLs) may be considered an alternative. In this article, the authors expand on technology of manufacturing of OKVision® SMARTFIT™ scleral contact lenses.

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The Functional State of Meibomian Glands and Tear Production in Pregnant Women

Ophthalmology in Russia ◽

10.18008/1816-5095-2018-2-151-159 ◽

2018 ◽

Vol 15 (2) ◽

pp. 151-159

Author(s):

V. N. Trubilin ◽

E. G. Poluninа ◽

D. V. Andzhelova ◽

Yu. V. Evstigneeva ◽

K. V. Chinenova

Keyword(s):

Quality Of Life ◽

Pregnant Women ◽

Functional State ◽

Dry Eye ◽

Ocular Surface ◽

Contact Lenses ◽

Dry Eye Syndrome ◽

Symptom Complex ◽

Meibomian Glands

Pregnant women are objects of special medical attention due to the fact that the new life — the life of her child — depends on the health and quality of life of the future mother. Pregnancy is a physiological load. It makes temporary changes in the functional state of all organs and systems, including the organ of vision. This study was aimed at identifying risk factors for the occurrence of disturbances in the tear-producing system — dysfunction of the Meibomian glands and/or dry eye syndrome (SSH), as well as to develop recommendations for compensating of disturbance. The study showed that physiological pregnancy does not affect to the condition of the ocular surface in case of absence of dry eye syndrome manifestations and Meibomian gland dysfunction before pregnancy. However, there is a predisposition for the development of the symptom complex of dry eye syndrome — a reliable decrease Schirmer test indicators of the test of in the group of pregnant women, it requires preventive control, — reduction in the mode of wearing contact lenses, which are a risk factor for the development of dry eye syndrome. It was determined that in vitro fertilization (IVF) affects to the condition of the ocular surface, namely, on the occurrence of dysfunction of Meibomian glands and dry eye syndrome, and is accompanied by corresponding complaints. There is a direct correlation between the duration of gestation, age indicators, the severity of complaints and their relationship to pregnancy. A direct was established, with a noticeable tightness of communication, between taking thyrotrophic drugs and complaints on dryness and discomfort. Therefore, special attention should be given to pregnant patients taking thyrotrophic medications and using contact lenses, since both of these factors provoke the development of the dry eye symptom complex. Patients with IVF pregnancy and accompanied by taking thyrotrophic drugs are recommended to limit the mode of wearing contact lenses, in case of complaints on dryness, discomfort, it is necessary to conduct therapeutic and prophylactic effects in the form of non-conserved tear-replacement therapy and eyelid hygiene. Timely diagnosis and subsequent prevention of Meibomian glands and dry eye syndrome in pregnant women will improve the quality of life of this patients group and prevent the development of complications related to this condition.

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THE RELATION BETWEEN WATER CONTENT IN CONTACT LENS AND DRY EYE SYNDROME (DES) IN STUDENTS OF ATMA JAYA CATHOLIC UNIVERSITY OF INDONESIA SCHOOL OF MEDICINE AND HEALTH SCIENCES

Damianus: Journal of Medicine ◽

10.25170/djm.v18i2.2216 ◽

2019 ◽

Vol 18 (2) ◽

pp. 50-57

Author(s):

Levina Benita ◽

Cisca Kuswidyati ◽

Febie Chriestya

Keyword(s):

Water Content ◽

Dry Eye ◽

Contact Lenses ◽

Tear Film ◽

Health Sciences ◽

Dry Eye Syndrome ◽

Schirmer Test ◽

Cross Sectional ◽

Significance Level ◽

School Of Medicine

Introduction: Dry Eye Syndrome (DES) is a multifactorial disease of the eye characterized by loss of homeostasis from the tear film and is accompanied by ocular symptoms. One of many factors that can cause DES is the use of contact lenses. This research was conducted to determine the relationship of water content in contact lenses with the occurrence of DES. Methods: This research was conducted in 2019 with a cross-sectional study design with the Tear Break Up Time (TBUT) test, Schirmer test and questionnaire. The research respondents were students of Atma Jaya School of Medicine and Health Sciences (FKIK UAJ) whose eyes were examined as samples (n = 84). The water content of the respondent's contact lenses was obtained using a questionnaire. The inspection methods used to determine DES are TBUT test and Schirmer test. Data analysis using chi-square test with significance level of p <0.05. Results: The prevalence of DES obtained in students with a water content <50% is 25.9%, while the DES in students with a water content >50% is 25.5% . Conclusion: There is no significant relationship between water content in contact lenses with the occurrence of DES in FKIK UAJ students (p=0.963).

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