Validation of the Japanese version of the Lupus Damage Index Questionnaire in a large observational cohort: A two-year prospective study

2020 ◽  
pp. 1-9
Author(s):  
Yuko Okamoto ◽  
Yasuhiro Katsumata ◽  
Sayumi Baba ◽  
Yasushi Kawaguchi ◽  
Masayoshi Harigai
Keyword(s):  
Prospective Study ◽  
Damage Index ◽  
Japanese Version ◽  
Observational Cohort

scholarly journals The Epidemiology of Bruxism in Relation to Psychological Factors

2022 ◽  
Vol 19 (2) ◽  
pp. 691
Author(s):  
Mirela Ioana Flueraşu ◽  
Ioana Corina Bocşan ◽  
Ioan-Andrei Țig ◽  
Simona Maria Iacob ◽  
Daniela Popa ◽  
...  
Keyword(s):  
Prospective Study ◽  
Muscle Activity ◽  
Psychological Factors ◽  
Sleep Bruxism ◽  
Cross Sectional ◽  
Female Sex ◽  
Anonymous Questionnaire ◽  
Observational Cohort ◽  
High Degree ◽  
Awake Bruxism

The aim of the present study was to establish the prevalence of sleep/awake bruxism among young students in Transylvania and to correlate the presence of this muscle activity with behavioral variations. This analytical, observational, cohort, cross-sectional, and prospective study involved 308 volunteers aged between 19 and 30 years of different nationalities, all students of the “Iuliu Hațieganu” University of Medicine and Pharmacy in Cluj-Napoca, Romania. Subjects were asked to complete an anonymous questionnaire which was structured in five sections. The results obtained from the questionnaires were analyzed separately for sleep bruxism and for awake bruxism. We did not find any statistically significant correlation between awake bruxism or sleep bruxism and age (p = 0.30 and p = 0.37, respectively), sex (p = 0.44 and p = 0.48, respectively), or nationality (p = 0.55 and p = 0.67, respectively). Only a high degree of stress and frustration (p = 0.035 and p = 0.020) was observed in European subjects except for the Romanians and the French, likely related to the difficulties of adapting to the language and lifestyle in Romania. Female sex was statistically significantly associated with an increased level of stress (p = 0.004), duty-related depression (p = 0.006), and duty-related anxiety (p = 0.003). Stress and anxiety can be favorable factors in the appearance of both types of bruxism; however, depression is associated only with awake bruxism.

scholarly journals Blockage of interleukin-1β with canakinumab in patients with Covid-19

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Lorenza Landi ◽  
Claudia Ravaglia ◽  
Emanuele Russo ◽  
Pierluigi Cataleta ◽  
Maurizio Fusari ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prospective Study ◽  
Controlled Trials ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Randomized Controlled ◽  
Duration Of Hospitalization ◽  
Observational Cohort ◽  
Absolute Lymphocyte Counts ◽  
Overall Mortality

AbstractThere is the urgent need to study the effects of immunomodulating agents as therapy for Covid-19. An observational, cohort, prospective study with 30 days of observation was carried out to assess clinical outcomes in 88 patients hospitalized for Covid-19 pneumonia and treated with canakinumab (300 mg sc). Median time from diagnosis of Covid-19 by viral swab to administration of canakinumab was 7.5 days (range 0–30, IQR 4–11). Median PaO2/FiO2 increased from 160 (range 53–409, IQR 122–210) at baseline to 237 (range 72–533, IQR 158–331) at day 7 after treatment with canakinumab (p < 0.0001). Improvement of oxygen support category was observed in 61.4% of cases. Median duration of hospitalization following administration of canakinumab was 6 days (range 0–30, IQR 4–11). At 7 days, 58% of patients had been discharged and 12 (13.6%) had died. Significant differences between baseline and 7 days were observed for absolute lymphocyte counts (mean 0.60 vs 1.11 × 109/L, respectively, p < 0.0001) and C-reactive protein (mean 31.5 vs 5.8 mg/L, respectively, p < 0.0001).Overall survival at 1 month was 79.5% (95% CI 68.7–90.3). Oxygen-support requirements improved and overall mortality was 13.6%. Confirmation of the efficacy of canakinumab for Covid-19 warrants further study in randomized controlled trials.

Validation of the Japanese version of the Systemic Lupus Activity Questionnaire that includes physician-based assessments in a large observational cohort

Lupus ◽  
2015 ◽  
Vol 25 (5) ◽  
pp. 486-495 ◽  
Author(s):  
Y Okamoto ◽  
Y Katsumata ◽  
S Baba ◽  
Y Kawaguchi ◽  
T Gono ◽  
...  
Keyword(s):  
Japanese Version ◽  
Systemic Lupus ◽  
Observational Cohort ◽  
Activity Questionnaire

Headache Before and After Endoscopic Transsphenoidal Pituitary Tumor Surgery: A Prospective Study

2021 ◽  
Author(s):  
Agnes Andersson ◽  
Tobias Hallén ◽  
Daniel S. Olsson ◽  
Dan Farahmand ◽  
Ann-Charlotte Olofsson ◽  
...  
Keyword(s):  
Prospective Study ◽  
Pituitary Tumors ◽  
Common Symptom ◽  
Tertiary Referral Hospital ◽  
Younger Age ◽  
Before And After ◽  
Observational Cohort ◽  
Midas Questionnaire ◽  
A Prospective Study ◽  
Postoperative Improvement

Abstract Objective Headache is a common symptom among patients with pituitary tumors, as it is in the general population. The aim of the study was to investigate headache as a symptom in patients with pituitary tumors before and 6 months after endoscopic transsphenoidal surgery (TSS). Design This is a prospective observational cohort study. Setting This study was conducted at university tertiary referral hospital. Participants A total of 110 adult patients underwent endoscopic TSS for pituitary tumors. Main Outcome Measures The Migraine Disability Assessment (MIDAS) questionnaire was used before and 6 months after surgery for the assessment of headache. Clinical variables with potential influence on headache were analyzed. Results Sixty-eight (62%) patients experienced headaches at least once during the 3 months before surgery. Thirty (27%) patients reported disabling headache before surgery, with younger age being an independent associated factor (p < 0.001). In patients with disabling headache before surgery, the median (interquartile range) MIDAS score improved from 78 (27–168) to 16 (2–145; p = 0.049), headache frequency decreased from 45 (20–81) to 14 (4–35) days (p = 0.009), and headache intensity decreased from 6 (5–8) to 5 (4–7) (p = 0.011) after surgery. In total, 16 of the 30 (53%) patients reported a clinically relevant improvement and five (17%) a clinically relevant worsening. Four (5%) patients developed new disabling headache. No predictor for postoperative improvement of headache was identified. Conclusion In this prospective study, the results show that disabling headache improves following endoscopic TSS in a subset of patients with pituitary tumors. However, no predictive factors for improvement could be identified.

scholarly journals Incidence and clinical presentation of acute otitis media in children aged <6 years in European medical practices

2013 ◽  
Vol 142 (8) ◽  
pp. 1778-1788 ◽  
Author(s):  
J. G. LIESE ◽  
S. A. SILFVERDAL ◽  
C. GIAQUINTO ◽  
A. CARMONA ◽  
J. H. LARCOMBE ◽  
...  
Keyword(s):  
Prospective Study ◽  
Otitis Media ◽  
Acute Otitis Media ◽  
Diagnostic Procedures ◽  
Tympanic Membrane Perforation ◽  
Study Results ◽  
High Incidence ◽  
Membrane Perforation ◽  
Observational Cohort ◽  
The Uk

SUMMARYWe conducted an epidemiological, observational cohort study to determine the incidence and complications of acute otitis media (AOM) in children aged <6 years. Data on physician-diagnosed AOM were collected from retrospective review of medical charts for the year preceding enrolment and then prospectively in the year following enrolment. The study included 5776 children in Germany, Italy, Spain, Sweden, and the UK. AOM incidence was 256/1000 person-years [95% confidence interval (CI) 243–270] in the prospective study period. Incidence was lowest in Italy (195, 95% CI 171–222) and highest in Spain (328, 95% CI 296–363). Complications were documented in <1% of episodes. Spontaneous tympanic membrane perforation was documented in 7% of episodes. Both retrospective and prospective study results were similar and show the high incidence during childhood in these five European countries. Differences by country may reflect true differences and differences in social structure and diagnostic procedures.

scholarly journals Awareness with Recall in General Anesthesia undergoing Cesarean Section

2018 ◽  
Vol 13 (1) ◽  
pp. 18-22
Author(s):  
Tara Gurung ◽  
Sangeeta Shrestha ◽  
Ujjwal Basnet ◽  
Amirbabu Shrestha
Keyword(s):  
Cohort Study ◽  
Cesarean Section ◽  
Prospective Study ◽  
General Anesthesia ◽  
Observational Cohort Study ◽  
Observational Cohort ◽  
Retrospective Observational Cohort Study

Aims: To determine the incidence of awareness with recall in parturient undergoing cesarean section under general anesthesia in Paropakar Maternity and Women’s Hospital.Methods: Retrospective observational cohort study of the patients who underwent cesarean section under general anesthesia from April mid 2014 to April mid 2017 (Baishakh 2071 to Chaitra 2073 BS).  Awareness questionnaires filled up through the modified Brice interview.Results: A total of 162 patients underwent Cesarean Section under general anesthesia and138 were included in the study.  None of them had awareness and six patients had a dream.Conclusion: No awareness with recall found and prospective study is required to determine the condition.

scholarly journals Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies

GeroScience ◽  
2022 ◽  
Author(s):  
Setor K. Kunutsor ◽  
Nzechukwu M. Isiozor ◽  
Ari Voutilainen ◽  
Jari A. Laukkanen
Keyword(s):  
Cognitive Impairment ◽  
Cohort Studies ◽  
Prospective Study ◽  
Vascular Dementia ◽  
Handgrip Strength ◽  
Meta Analysis ◽  
Population Based ◽  
Cognitive Outcomes ◽  
Risk Indicator ◽  
Observational Cohort

AbstractHandgrip strength (HGS), a measure of muscular strength, might be a risk indicator for cognitive functioning, but the evidence is not consistent. Using a new prospective study and meta-analysis of published observational cohort studies, we aimed to evaluate the prospective associations of HGS with poor cognitive outcomes including cognitive impairment, dementia and Alzheimer’s disease (AD). Handgrip strength, measured using a Martin-Balloon-Vigorimeter, was assessed at baseline in a population-based sample of 852 men and women with good cognitive function in the Kuopio Ischemic Heart Disease cohort. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated for cognitive outcomes. Relevant published studies were sought in MEDLINE, Embase and Web of Science from inception until October 2021 and pooled using random effects meta-analysis. During a median follow-up of 16.6 years, 229 dementia cases were recorded. Comparing extreme tertiles of HGS, the multivariable adjusted HR (95% CI) for dementia, AD and vascular dementia was 0.77 (0.55–1.07), 0.75 (0.52–1.10) and 0.49 (0.16–1.48), respectively. In a meta-analysis of 16 population-based prospective cohort studies (including the current study) comprising 180,920 participants, the pooled multivariable adjusted relative risks (95% CIs) comparing the top vs bottom thirds of HGS levels were as follows: 0.58 (0.52–0.65) for cognitive impairment; 0.37 (0.07–1.85) for cognitive decline; 0.73 (0.62–0.86) for dementia; 0.68 (0.53–0.87) for AD; and 0.48 (0.32–0.73) for vascular dementia. GRADE quality of evidence ranged from low to very low. Meta-analysis of aggregate prospective data suggests that HGS may be a risk indicator for poor cognitive outcomes such as cognitive impairment, dementia and AD. Systematic review registration: PROSPERO 2021: CRD42021237750.

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