scholarly journals Antiprotozoal activity of major constituents from the bioactive fraction of Verbesina encelioides

2016 ◽  
Vol 31 (6) ◽  
pp. 676-680 ◽  
Author(s):  
Shahira M Ezzat ◽  
Maha M Salama ◽  
Engy A Mahrous ◽  
Louis Maes ◽  
Cheol-Ho Pan ◽  
...  
Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
AA Zaki ◽  
Z Ali ◽  
YA El-Amier ◽  
A Ashour ◽  
BM Oluwasesan ◽  
...  

2017 ◽  
Author(s):  
S Nejad Ebrahimi ◽  
H Hashempour ◽  
F Herfati ◽  
H Valizadeh ◽  
F Mahmoudi-Kordi ◽  
...  

2017 ◽  
Vol 18 (5) ◽  
pp. 605-616 ◽  
Author(s):  
Miguel Herrera-Rueda ◽  
Gabriel Navarrete-Vázquez ◽  
Francisco Aguirre-Crespo ◽  
Maria Maldonado-Velazquez ◽  
Jorge Vergara-Galicia ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 686
Author(s):  
Valery M. Dembitsky ◽  
Ekaterina Ermolenko ◽  
Nick Savidov ◽  
Tatyana A. Gloriozova ◽  
Vladimir V. Poroikov

Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, and marine invertebrates. The purpose of this review is a comparative analysis of the pharmacological potential of these natural products. According to PASS (Prediction of Activity Spectra for Substances) estimates, they are more likely to exhibit antiprotozoal and antitumor properties. Some of them are now widely used in clinical medicine. All polycyclic endoperoxides presented in this article demonstrate antiprotozoal activity and can be divided into three groups. The third group includes endoperoxides, which show weak antiprotozoal activity with a reliability of up to 70%, and this group includes only 1.1% of metabolites. The second group includes the largest number of endoperoxides, which are 65% and show average antiprotozoal activity with a confidence level of 70 to 90%. Lastly, the third group includes endoperoxides, which are 33.9% and show strong antiprotozoal activity with a confidence level of 90 to 99.6%. Interestingly, artemisinin and its analogs show strong antiprotozoal activity with 79 to 99.6% confidence against obligate intracellular parasites which belong to the genera Plasmodium, Toxoplasma, Leishmania, and Coccidia. In addition to antiprotozoal activities, polycyclic endoperoxides show antitumor activity in the proportion: 4.6% show weak activity with a reliability of up to 70%, 65.6% show an average activity with a reliability of 70 to 90%, and 29.8% show strong activity with a reliability of 90 to 98.3%. It should also be noted that some polycyclic endoperoxides, in addition to antiprotozoal and antitumor properties, show other strong activities with a confidence level of 90 to 97%. These include antifungal activity against the genera Aspergillus, Candida, and Cryptococcus, as well as anti-inflammatory activity. This review provides insights on further utilization of polycyclic endoperoxides by medicinal chemists, pharmacologists, and the pharmaceutical industry.


Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 598
Author(s):  
Ping-Chung Kuo ◽  
Yue-Chiun Li ◽  
Anjar M. Kusuma ◽  
Jason T. C. Tzen ◽  
Tsong-Long Hwang ◽  
...  

Pinus needle tea are very popular in Eastern countries such as Japan, Russia, Korea, and China. Pine needle tea is claimed to have significant anti-aging effects, but no clear evidence has supported this until now. In the present study, five undescribed compounds (1–5) as well as seventy-two known compounds were purified and characterized from the bioactive fraction of methanol extracts of P. taiwanensis needles. Most of the isolates were examined for their anti-inflammatory bioactivity by cellular neutrophil model and six compounds (45, 47, 48, 49, 50, and 51) exhibited a significant inhibition on superoxide anion generation and elastase release with IC50 values ranging from 3.3 ± 0.9 to 8.3 ± 0.8 μM. These anti-inflammatory ingredients were subjected to docking computing to evaluate their binding affinity on the ghrelin receptor, which played an important role in regulating metabolism, with anti-aging effects. Compounds 49, 50, and 51 formed a stable complex with the ghrelin receptor via hydrogen bonds and different types of interactions. These results suggest the flavonoids are responsible for the potential anti-aging effects of pine needle tea.


2012 ◽  
Vol 78 (13) ◽  
pp. 4654-4658 ◽  
Author(s):  
Claudio Gardana ◽  
Andrea Barbieri ◽  
Paolo Simonetti ◽  
Simone Guglielmetti

ABSTRACTPropolis (bee glue) is a resinous, sticky, dark-colored material produced by honeybees. Propolis today, due to its medicinal properties, is increasingly popular and is extensively used in food, beverages, and cosmetic products. Besides its numerous positive properties, propolis may also have adverse effects, such as, principally, allergic eczematous contact dermatitis in apiarists and in consumers with an allergic predisposition. In this study, we found appropriate conditions for removing caffeate esters, which are the main allergenic components, from raw propolis. The proposed method consists of the resuspension of propolis in a food grade solvent, followed by a biotransformation based on the cinnamoyl esterase activity ofLactobacillus helveticus. We showed that the reduction of caffeate esters byL. helveticusdid not affect the content of flavonoids, which are the main bioactive molecules of propolis. Furthermore, we verified that the biotransformation of propolis did not cause a loss of antimicrobial activity. Finally, we demonstrated that the ability ofL. helveticusto hydrolyze caffeate esters in propolis is strain specific. In conclusion, the proposed strategy is simple, employs food grade materials, and is effective in selectively removing allergenic molecules without affecting the bioactive fraction of propolis. This is the first study demonstrating that the allergenic caffeate esters of propolis can be eliminated by means of a bacterial biotransformation procedure.


Molecules ◽  
2014 ◽  
Vol 19 (12) ◽  
pp. 21044-21065 ◽  
Author(s):  
Ramiro Quintanilla-Licea ◽  
Benito Mata-Cárdenas ◽  
Javier Vargas-Villarreal ◽  
Aldo Bazaldúa-Rodríguez ◽  
Isvar Kavimngeles-Hernández ◽  
...  

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