Preparation and spectroscopic investigations of hydroxyapatite-curcumin nanoparticles-loaded polylactic acid for biomedical application

Polylactic acid (PLA) is one of the most extensively studied biodegradable materials. PLA is a versatile material with excellent bio-compatibility, bioabsorbability, biodegradability, and low toxicity. As an environmentally friendly polymer, PLA is favored by researchers and has explored many commercial applications, playing an important role in medicine and industry to replace many traditional petrochemical-based polymers. However, the strength and mechanical properties of PLA need to be improved to meet the practical application of multiple scenarios. The purpose of this review is to explore the modification methods of grafted copolymerization and block co-polymerization to improve the performance of PLA. This review also focuses on the medical applications and covers some non-medical applications of PLA.

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Surface Property Modification of Polylactic Acid by Ion Implantation

10.20944/preprints201711.0125.v1 ◽

2017 ◽

Author(s):

Irina Vasenina ◽

Konstantin Savkin ◽

Olesya Laput ◽

Daniil Zuza ◽

Irina Kurzina

Keyword(s):

Ion Implantation ◽

Polylactic Acid ◽

Negative Impact ◽

Biomedical Application ◽

Subsurface Layer ◽

Coherent Scattering ◽

Biological Properties ◽

Electron Mass ◽

Force Microscopy ◽

Atomic Force

We describe our investigations of the surface physicochemical and biological properties of polylactic acid modified by silver, argon and carbon ion implantation to doses of 1 × 1014, 1 × 1015 and 1 × 1016 ion/cm2 at energies of 20 keV (for C and Ar) and 40 keV (for Ag). X-ray analysis shows enhancement of coherent scattering regions and lattice constant increase after ion implantation. Secondary electron mass-spectrometry indicates that Ag concentration in the subsurface layer is less than 80%, but at a depth of 500 nm does not exceed 1–2%. The silver forms metal particles in the subsurface layer rather than making additional chemical bonds with polymer atoms. Atomic force microscopy reveals that the higher the irradiation dose the larger the surface roughness of the samples. Ag-irradiated samples implanted to a dose of 1 × 1016 ions/cm2 have the highest roughness, 190 nm. Our investigation of the cytotoxicity of two individual donor macrophages shows that Ag-implanted polylactic acid has no negative impact on immune system cells and could be a promising material for biomedical application.

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Microstructure and Corrosion Behavior of Bioabsorbable Polymer Polylactic Acid-Polycaprolactone Reinforced by Magnesium-Zinc Alloy for Biomedical Application

Proceedings of the 1st International Conference on Electronics, Biomedical Engineering, and Health Informatics - Lecture Notes in Electrical Engineering ◽

10.1007/978-981-33-6926-9_32 ◽

2021 ◽

pp. 377-386

Author(s):

Aprilia Erryani ◽

Alfiyah Rahmah ◽

Talitha Asmaria ◽

Franciska Pramuji Lestari ◽

Ika Kartika

Keyword(s):

Polylactic Acid ◽

Corrosion Behavior ◽

Biomedical Application ◽

Zinc Alloy ◽

Bioabsorbable Polymer

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A Study of the Kinetics of Polylactic Acid Crystallization by Image Processing

MRS Proceedings ◽

10.1557/proc-1242-s4-p102 ◽

2009 ◽

Vol 1242 ◽

Author(s):

F. Hernández-Sánchez ◽

H. Carrillo-Escalante

Keyword(s):

Polylactic Acid ◽

Biomedical Application ◽

Crystallization Kinetic ◽

Amorphous State ◽

Physical And Mechanical Properties ◽

Video Camera ◽

Optical Microscope ◽

Degree Of Crystallinity ◽

Crystallinity Degree ◽

A New Technique

ABSTRACTThe polylactic acid (PLLA) is commonly used in the biomedical application. The physical and mechanical properties of PLLA depend on the molecular weight, crystallinity, and synthesis. In this work, we study the PLLA crystallization kinetics. One of the main attractive of these polymers is that its degree of crystallinity can easily be modified, from amorphous state to a high crystallinity degree. In this study a new technique is applied to follow the crystallization kinetic. An optical microscope with cross polarizers, warming plates and video camera were used. A series of images were obtained under isothermal conditions to observe the growth spherulite. Since an image is composed by pixels and each pixel has a value from 0 to 255, which represents gray intensity, being zero for black and 255 are white. Then, the pixels average versus time was plotting and from the plots crystallization kinetic and secondary crystallization are easily obtained.

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Effect of Calcium Phosphate on Tensile and Rheological Properties of Polylactic Acid (PLA)

Materials Science Forum ◽

10.4028/www.scientific.net/msf.969.404 ◽

2019 ◽

Vol 969 ◽

pp. 404-408

Author(s):

Govind Sahu ◽

M.S. Rajput ◽

S.P. Mahapatra

Keyword(s):

Mechanical Properties ◽

Calcium Phosphate ◽

Polylactic Acid ◽

Ring Opening ◽

Food Packaging ◽

Biomedical Application ◽

Ring Opening Polymerization ◽

Natural Environments ◽

Melt Mixing ◽

Biodegradable Composites

From the last few decades, biodegradable composites have become best alternatives over the petro based polymer because these degrade in the simple compound in the natural environments. Among the available biodegradable polymers, polylactic acid (PLA) is more popular due to its biocompatibility and mechanical properties, that can be used in the biomedical application, such as sutures, bone and ligament fixation screws etc. In this study, synthesis of PLA was performed by ring opening polymerization and Calcium phosphate/Polylactic acid (PLA) bio-composites were prepared by melt mixing technique. Tensile properties of these composites are investigated to assess its feasibility in biomedical and food packaging application.

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