scholarly journals Surface Property Modification of Polylactic Acid by Ion Implantation

2017 ◽  
Author(s):  
Irina Vasenina ◽  
Konstantin Savkin ◽  
Olesya Laput ◽  
Daniil Zuza ◽  
Irina Kurzina
Keyword(s):  
Ion Implantation ◽  
Polylactic Acid ◽  
Negative Impact ◽  
Biomedical Application ◽  
Subsurface Layer ◽  
Coherent Scattering ◽  
Biological Properties ◽  
Electron Mass ◽  
Force Microscopy ◽  
Atomic Force

We describe our investigations of the surface physicochemical and biological properties of polylactic acid modified by silver, argon and carbon ion implantation to doses of 1 × 1014, 1 × 1015 and 1 × 1016 ion/cm2 at energies of 20 keV (for C and Ar) and 40 keV (for Ag). X-ray analysis shows enhancement of coherent scattering regions and lattice constant increase after ion implantation. Secondary electron mass-spectrometry indicates that Ag concentration in the subsurface layer is less than 80%, but at a depth of 500 nm does not exceed 1–2%. The silver forms metal particles in the subsurface layer rather than making additional chemical bonds with polymer atoms. Atomic force microscopy reveals that the higher the irradiation dose the larger the surface roughness of the samples. Ag-irradiated samples implanted to a dose of 1 × 1016 ions/cm2 have the highest roughness, 190 nm. Our investigation of the cytotoxicity of two individual donor macrophages shows that Ag-implanted polylactic acid has no negative impact on immune system cells and could be a promising material for biomedical application.

Characterization of Titanium Oxide Thin Films Produced by Plasma Immersion Ion Implantation for Biomedical Implants

2007 ◽  
Vol 361-363 ◽  
pp. 673-676
Author(s):  
E.T. Uzumaki ◽  
C.S. Lambert
Keyword(s):  
Thin Films ◽  
Ion Implantation ◽  
Titanium Oxide ◽  
Biological Properties ◽  
X Ray Diffraction ◽  
Tio2 Thin Films ◽  
Hip Joints ◽  
Force Microscopy ◽  
Atomic Force ◽  
Plasma Immersion Ion Implantation

Plasma immersion ion implantation (PIII) is a very attractive method for the surface treatment of titanium hard tissue replacements such as hip joints and enhancement of the mechanical, chemical and biological properties of titanium. It has been considered as an alternative to form protective and hard oxide films on titanium and titanium-based implants. In this study, titanium oxide (TiO2) thin films were formed on titanium using PIII, which produces films with adhesion superior to those prepared with conventional techniques. The films were analysed by atomic force microscopy (AFM), X-ray diffraction (XRD) and pull test.

scholarly journals Effect of therapeutic ultrasound on the mechanical and biological properties of fibroblasts

2021 ◽  
Author(s):  
ROSY PAOLA CARDENAS ◽  
Homero F. Pastrana-Rendón ◽  
Alba G. Ávila-Bernal ◽  
Angélica M. Ramírez-Martínez ◽  
Myriam L. Navarrete-Jimenez ◽  
...  
Keyword(s):  
Colorimetric Assay ◽  
Healing Process ◽  
Therapeutic Ultrasound ◽  
Biological Properties ◽  
Wound Healing Process ◽  
Force Microscopy ◽  
Atomic Force ◽  
High Doses ◽  
Actin Expression ◽  
Late Stages

Conventional doses of therapeutic ultrasound alter the mechanical behavior of ligament fibroblasts to improve the regenerative and remodeling stages of the wound healing process. Using a multidisciplinary approach, we applied ultrasound doses of 1.0 and 2.0 W/cm 2 at 1 MHz frequency for five days on ligament fibroblasts. Atomic force microscopy showed a decrease in cell elastic modulus for both doses, but the treated cells were still viable based on flow cytometry. Finite element method analysis exhibited visible cytoskeleton displacements and decreased harmonics in treated cells. Colorimetric assay revealed increased cell proliferation, while scratch assay showed increased migration at low doses. An increase in collagen and fibronectin was detected by enzyme-linked immunoassay at high doses, and β-actin expression for both treatments was visualized through immunofluorescence imaging. Both doses of ultrasound altered the fibroblast mechanical properties due to cytoskeletal reorganization and enhanced the early and late stages of cell repair.

Wettability and Nanotribological Response of Silicon Surfaces Functionalized by Ion Implantation

2012 ◽  
Vol 730-732 ◽  
pp. 257-262
Author(s):  
Bruno Nunes ◽  
Sergio Magalhães ◽  
Nuno Franco ◽  
Eduardo Alves ◽  
Ana Paula Serro ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Ion Implantation ◽  
Silicon Surfaces ◽  
Iron Ions ◽  
X Ray Diffraction ◽  
X Ray ◽  
Force Microscopy ◽  
Atomic Force ◽  
Scanning Electron

Aiming to improve the nanotribological response of Si-based materials we implanted silicon wafers with different fluences of iron ions (up to 2x1017 cm-2). Implantation was followed by annealing treatments at temperatures from 550°C to 1000°C. The implanted surfaces were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), atomic force microscopy (AFM) and wettability tests. Then, samples were submitted to AFM-based nanowear tests. We observe an increase of both hidrophobicity and and wear resistance of the implanted silicon, indicating that ion implantation of Si can be a route to be deeper explored in what concerns tribomechanical improvement of Si.

scholarly journals Mechanism of improvement of TiN-coated tool life by nitrogen implantation

2001 ◽  
Vol 16 (11) ◽  
pp. 3293-3303 ◽  
Author(s):  
S. J. Bull ◽  
Yu. P. Sharkeev ◽  
S. V. Fortuna ◽  
I. A. Shulepov ◽  
A. J. Perry
Keyword(s):  
Ion Implantation ◽  
Surface Composition ◽  
Slight Reduction ◽  
Nitrogen Implantation ◽  
Force Microscopy ◽  
Tin Coatings ◽  
Coated Tools ◽  
Atomic Force ◽  
Transmission Electron ◽  
Coated Tool

The life of TiN-coated tools can be improved by a post-coating ion implantation treatment, but the mechanism by which this occurs is still not clear. Nitrogen implantation of both physical-vapor-deposited TiN and CVD TiN leads to surface softening as the dose increases, which has been attributed to amorphization. In this study a combination of transmission electron microscopy and atomic force microscopy was used to characterize the microstructure of implanted TiN coatings on cemented carbide for comparison with mechanical property measurements (nanoindentation, residual stress, etc.), made on the same samples. Ion implantation leads to a slight reduction in the grain size of the TiN in the implanted zone, but there is no evidence for amorphization. Surface softening is observed for physical-vapor-deposited TiN, but this is probably due to a combination of changes in surface composition and the presence of a layer of bubbles generated by the very high implantation doses used.

scholarly journals Optimization of Anodization Parameters in Ti-30Ta Alloy

Metals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1059
Author(s):  
Patricia Capellato ◽  
Daniela Sachs ◽  
Lucas V. B. Vasconcelos ◽  
Miriam M. Melo ◽  
Gilbert Silva ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Application ◽  
Anatase Phase ◽  
X Ray Diffraction ◽  
Bulk Alloy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Anodization Process ◽  
Metallic Biomaterial ◽  
Cold Worked

The current metallic biomaterial still presents failures associated with the bulk alloy and the interface of material/human body. In previous studies, titanium alloy with tantalum showed the elastic modulus decrease in comparison with that of commercially pure (cp) titanium. In this study, surface modification on Ti-30Ta alloy was investigated. Titanium and tantalum were melted, homogenized, cold-worked by a rotary swaging process and solubilized. The anodization process was performed in electrolyte contained glycerol + NH4F 0.25% at 30 V using seven different durations—4 h, 5 h, 6 h, 7 h, 8 h, 9 h, and 10 h and annealed at 530 °C for 1 h. The surface topography was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM) measurements, X-ray diffraction analysis (XRD), and contact angle. From the results, we conclude the time of anodization process influences the shape and morphology of the anodized layer. The 5 h-anodization process produced a smooth and porous surface. The 4-, 6-, 7-, 8-, 9-, and 10-h conditions showed nanotubes morphology. All surfaces are hydrophilic (<90°). Likewise, all the investigated conditions present anatase phase. So, this surface modification presents potential for biomedical application. However, more work needs to be done to better understand the influence of time on the anodization process.

Anodic Oxidation of Titanium in Acetic Acid for Biomedical Application

2015 ◽  
Vol 1125 ◽  
pp. 455-459
Author(s):  
Mohamad Ali Selimin ◽  
Maizlinda Izwana Idris ◽  
Hasan Zuhudi Abdullah
Keyword(s):  
Acetic Acid ◽  
Anodic Oxidation ◽  
Current Density ◽  
Applied Voltage ◽  
Biomedical Application ◽  
Digital Camera ◽  
Force Microscopy ◽  
Atomic Force ◽  
Anodic Oxidation Method ◽  
Ti Films

Anodic oxidation (AO) is an electrochemical method which used to change the bio-inert (smooth) to bio-active (rough) layer of titanium (Ti) surface. The aim of this study is to evaluate the effect of anodic oxidation on characteristics of Ti in acetic acid (C2H4O2) under various conditions. Anodised Ti were prepared using anodic oxidation method on the surface of Ti films in acetic acid by varying the applied voltage (50 – 350 V) and current density (25, 50 and 75 mA.cm-2) for 10 min at room temperature. The anodised Ti films were characterised using digital camera, field emission scanning electron microscopy (FESEM), and atomic force microscopy (AFM). The results show that, roughness of the Ti films was increased with increment of applied voltage and current density. The anodised effects during anodic oxidation process change the surface roughness (porosity) of the Ti surface which meets the biomaterial need as implant material. This characteristic is needed to promote the formation of apatite when soak in simulated body fluid (SBF).

scholarly journals BODIPY-based fluorescent liposomes with sesquiterpene lactone trilobolide

2017 ◽  
Vol 13 ◽  
pp. 1316-1324 ◽  
Author(s):  
Ludmila Škorpilová ◽  
Silvie Rimpelová ◽  
Michal Jurášek ◽  
Miloš Buděšínský ◽  
Jana Lokajová ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Drug Distribution ◽  
Aqueous Solubility ◽  
Biological Properties ◽  
Liposomal Formulation ◽  
Liposomal Drug ◽  
Force Microscopy ◽  
Atomic Force ◽  
Theranostic Applications ◽  
Average Size

Like thapsigargin, which is undergoing clinical trials, trilobolide is a natural product with promising anticancer and anti-inflammatory properties. Similar to thapsigargin, it has limited aqueous solubility that strongly reduces its potential medicinal applications. The targeted delivery of hydrophobic drugs can be achieved using liposome-based carriers. Therefore, we designed a traceable liposomal drug delivery system for trilobolide. The fluorescent green-emitting dye BODIPY, cholesterol and trilobolide were used to create construct 6. The liposomes were composed of dipalmitoyl-3-trimethylammoniumpropane and phosphatidylethanolamine. The whole system was characterized by atomic force microscopy, the average size of the liposomes was 150 nm in width and 30 nm in height. We evaluated the biological activity of construct 6 and its liposomal formulation, both of which showed immunomodulatory properties in primary rat macrophages. The uptake and intracellular distribution of construct 6 and its liposomal formulation was monitored by means of live-cell fluorescence microscopy in two cancer cell lines. The encapsulation of construct 6 into the liposomes improved the drug distribution in cancer cells and was followed by cell death. This new liposomal trilobolide derivative not only retains the biological properties of pure trilobolide, but also enhances the bioavailability, and thus has potential for the use in theranostic applications.

GROWTH OF SiC NANOSTRUCTURES ON Si (100) USING LOW ENERGY CARBON ION IMPLANTATION AND ELECTRON BEAM RAPID THERMAL ANNEALING

2004 ◽  
Vol 03 (04n05) ◽  
pp. 425-430 ◽  
Author(s):  
A. MARKWITZ ◽  
S. JOHNSON ◽  
M. RUDOLPHI ◽  
H. BAUMANN
Keyword(s):  
Atomic Force Microscopy ◽  
Electron Beam ◽  
Ion Implantation ◽  
Thermal Annealing ◽  
Rapid Thermal Annealing ◽  
Low Energy ◽  
Silicon Surfaces ◽  
Force Microscopy ◽  
Atomic Force ◽  
Implantation Fluence

A combination of 10 keV 13 C low energy ion implantation and electron beam rapid thermal annealing (EB-RTA) is used to fabricate silicon carbide nanostructures on (100) silicon surfaces. These large ellipsoidal features appear after EB-RTA at 1000°C for 15 s. Prior to annealing, the silicon surfaces are virgin-like flat. Atomic force microscopy was used to study the morphology of these structures and it was found that the diameter and number of nanoboulders are linearly dependent on the implantation fluence. Further, a linear relationship between nanoboulder diameter and spacing suggests crystal coarsening is a fundamental element in the growth mechanism.

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