scholarly journals Systematic pathological component scores for skin-containing vascularized composite allografts

2016 ◽  
Vol 3 (1-2) ◽  
pp. 62-74 ◽  
Author(s):  
Ivy A. Rosales ◽  
Ruth K. Foreman ◽  
Matthew DeFazio ◽  
David H. Sachs ◽  
Curtis L. Cetrulo ◽  
...  
Keyword(s):  
2017 ◽  
Vol 38 (2) ◽  
pp. 83-93
Author(s):  
Jeffrey M. Cucina ◽  
Nicholas L. Vasilopoulos ◽  
Arwen H. DeCostanza

Abstract. Varimax rotated principal component scores (VRPCS) have previously been offered as a possible solution to the non-orthogonality of scores for the Big Five factors. However, few researchers have examined the reliability and validity of VRPCS. To address this gap, we use a lab study and a field study to investigate whether using VRPCS increase orthogonality, reliability, and criterion-related validity. Compared to the traditional unit-weighting scoring method, the use of VRPCS enhanced the reliability and discriminant validity of the Big Five factors, although there was little improvement in criterion-related validity. Results are discussed in terms of the benefit of using VRPCS instead of traditional unit-weighted sum scores.


2019 ◽  
Vol 14 (3) ◽  
pp. 224-228
Author(s):  
Steffen Mickenautsch

Background: Inductive reasoning relies on an infinite regress without sufficient factual basis and verification is at any time vulnerable to single contrary observation. Thus, appraisal based on inductive verification, as applied in current clinical trial appraisal scales, checklists or grading systems, cannot prove or justify trial validity. Discussion: Trial appraisal based on deductive falsification can identify invalid trials and give evidence for the recommendation to exclude these from clinical decision-making. Such appraisal remains agnostic towards corroborated trials that pass all appraisal criteria. The results of corroborated trials cannot be considered more robust than falsified trials since nothing within a particular set of complied trial criteria can give certainty for trial compliance with any other appraisal criterion in future. A corroborated trial may or may not reflect therapeutic truth and may thus be the basis for clinical guidance, pending results of any future trial re-appraisal. Conclusion: Trial grading following appraisal based on deductive falsification should be binary (0 = Invalid or 1 = Unclear) and single component scores should be multiplied. Appraisal criteria for the judgment of trial characteristics require a clear rationale, quantification of such rationale and empirical evidence concerning the effect of trial characteristics on trial results.


2021 ◽  
Vol 9 (7_suppl3) ◽  
pp. 2325967121S0017
Author(s):  
Sophia M. Ulman ◽  
Laura Saleem ◽  
Kirsten Tulchin-Francis

Background: The Functional Movement Screen (FMS) is a tool designed to establish a baseline for fundamental movement capacity, highlight limitations and limb asymmetries, and identify potential injury risk. Previous research has shown that individual components of the screen are also indicative of injury risk, as well as potential predictors of athletic performance unlike the FMS composite scores. However, this literature is limited and lacks statistical power. Identifying which component scores are predictive of injury risk and athletic performance would provide a quick, powerful tool for coaches and trainers to evaluate athletes. Purpose: To determine if individual component scores of the FMS are associated with athletic performance in highly-active youth athletes. Methods: Youth athletes participated in the Specialized Athlete Functional Evaluation (SAFE) Program. Data collection was extensive, however, for the purpose of this abstract, only a selection of data was analyzed – age, BMI, years played, total number of past injuries, isokinetic knee strength, 10- and 20-meter sprint, single-leg hop (SLH) distance, and FMS scores. Seated knee flexion/extension strength was collected at 120°/second using a Biodex System 4, and peak torque was normalized by body weight. The maximum distance of three SLHs was recorded for each leg and normalized to leg length. FMS scores used for analysis included the total composite and component scores, including the deep squat, hurdle step, in-line lunge, shoulder mobility, active straight-leg raise, trunk stability push-up, and rotary stability. Wilcoxon Signed Ranks Tests were used to determine side-to-side differences, and Kruskal-Wallis tests were performed to determine differences in athletic performance based on FMS scores ( α<0.05). Results: A total of 38 highly-active, youth athletes (26F; 15.4±2.6 years; BMI 21.0±5.3) were tested. Participants reported playing organized sports for 8.7±3.4 years, having 2.0±1.2 past sports-related injuries, and 74% reported specializing in a single sport. No side-to-side differences were found. While the composite FMS score significantly differed by number of past injuries ( p=0.036), it was not associated with athletic performance. Alternatively, left knee strength, sprint speeds, and right hop distance significantly differed by the hurdle step component score (Table 1). Conclusion: While the composite FMS score was not an indicator of athletic performance, the hurdle step component score was associated with strength, speed, and jump performance. This individual task could be a beneficial tool for coaches and trainers when evaluating athletic ability and injury risk of athletes. Tables/Figures: [Table: see text]


2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Rainer Lüdtke ◽  
Stefan N. Willich ◽  
Thomas Ostermann

Background. Cohort studies have reported that patients improve considerably after individualised homeopathic treatment. However, these results may be biased by regression to the mean (RTM).Objective. To evaluate whether the observed changes in previous cohort studies are due to RTM and to estimate RTM adjusted effects.Methods. SF-36 quality-of-life (QoL) data from a German cohort of 2827 chronically diseased adults treated by a homeopath were reanalysed by Mee and Chua’s modifiedt-test.Results. RTM adjusted effects, standardized by the respective standard deviation at baseline, were 0.12 (95% CI: 0.06–0.19,P<0.001) in the mental and 0.25 (0.22–0.28,P<0.001) in the physical summary score. Small-to-moderate effects were confirmed for the most individual diagnoses in physical, but not in mental component scores. Under the assumption that the true population mean equals the mean of all actually diseased patients, RTM adjusted effects were confirmed for both scores in most diagnoses.Conclusions. Changes in QoL after treatment by a homeopath are small but cannot be explained by RTM alone. As all analyses made conservative assumptions, true RTM adjusted effects are probably larger than presented.


Neurosurgery ◽  
2009 ◽  
Vol 64 (2) ◽  
pp. 297-307 ◽  
Author(s):  
Gregory J. Gagnon ◽  
Nadim M. Nasr ◽  
Jay J. Liao ◽  
Inge Molzahn ◽  
David Marsh ◽  
...  

Abstract OBJECTIVE Benign and malignant tumors of the spine significantly impair the function and quality of life of many patients. Standard treatment options, including conventional radiotherapy and surgery, are often limited by anatomic constraints and previous treatment. Image-guided stereotactic radiosurgery using the CyberKnife system (Accuray, Inc., Sunnyvale, CA) is a novel approach in the multidisciplinary management of spinal tumors. The aim of this study was to evaluate the effects of CyberKnife stereotactic radiosurgery on pain and quality-of-life outcomes of patients with spinal tumors. METHODS We conducted a prospective study of 200 patients with benign or malignant spinal tumors treated at Georgetown University Hospital between March 2002 and September 2006. Patients were treated by means of multisession stereotactic radiosurgery using the CyberKnife as initial treatment, postoperative treatment, or retreatment. Pain scores were assessed by the Visual Analog Scale, quality of life was assessed by the SF-12 survey, and neurological examinations were conducted after treatment. RESULTS Mean pain scores decreased significantly from 40.1 to 28.6 after treatment (P &lt; 0.001) and continued to decrease over the entire 4-year follow-up period (P &lt; 0.05). SF-12 Physical Component scores demonstrated no significant change throughout the follow-up period. Mental Component scores were significantly higher after treatment (P &lt; 0.01), representing a quality-of-life improvement. Early side effects of radiosurgery were mild and self-limited, and no late radiation toxicity was observed. CONCLUSION CyberKnife stereotactic radiosurgery is a safe and effective modality in the treatment of patients with spinal tumors. CyberKnife offers durable pain relief and maintenance of quality of life with a very favorable side effect profile.


Author(s):  
O. J. Kehinde ◽  
A. T. Adeboyejo

Susceptibility to ill health among aged people had been linked with climate change impacts in rapidly urbanising cities. Therefore, this study evaluates to the vulnerability of aged people to the health impacts of climate change in Ibadan, Nigeria. Data on clinically diagnosed climate related diseases (CRDs) (2000 – 2014) among aged people (>50 years) and temperature and rainfall parameters (1970 – 2007) in Ibadan were obtained and projected to year 2050. Also, the relationship between the climatic parameters and incidence of the five most prevalent CRDs were analysed using multiple regression. The increasing trend of mean maximum temperature (r = 0.47) and rainfall (r = 0.15) is associated with incidences of hypertension (34.4%), respiratory diseases (21.2%) and diarrhoea (14.3%) among aged people (> 60 years), mostly male folk (67.2%). The linear composite of disease communalities extracted 84.0% variance of the data set with the following component scores: skin disease (0.98), hypertension (0.96), respiratory disease (0.92), diarrhoea (0.89) and malaria (0.45). Further, CRDs (R2 = 27%, p = 0.012) in Ibadan among aged people could be significantly attributed to influences of climatic parameters. The study suggests building aged peoples’ resilience to emanating impacts through health and nutritional improvement programs, and re-introduction of neighbourhood parks and gardens.


Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Suzanne H Lo ◽  
Anne M Chang ◽  
Janita P Chau ◽  
Glenn E Gardner

Introduction: Health-related quality of life is a significant outcome of stroke survivors’ recovery. The 49-item English version of the Stroke Specific Quality of Life Scale (SSQOL) (Williams et al., 2009) is a stroke-specific assessment of stroke survivors’ health-related quality of life in 12 domains. However there has been no Chinese version of the scale for Chinese stroke survivors in Hong Kong. Aim: To examine the reliability and validity of the Chinese version of Stroke Specific Quality of Life Scale (SSQOL-C) in stroke survivors. Methods: SSQOL was translated into Chinese and blind back-translated by independent bilingual baccalaureate nursing students. Content validity was reviewed by an expert panel which consisted of one nurse academic, one nurse manager, three advanced practice nurses, and two registered nurses. A cross-sectional study was conducted to validate the translated version. A convenience sample of 135 adult stroke survivors were recruited from three community centres and a stroke support group in Hong Kong. Internal consistency analysis was performed. Pearson’s correlation coefficients were calculated between SSQOL-C, SF-36, and Frenchay Activities Index (FAI) to determine the convergent validity. Results: Content validity index of SSQOL-C was 0.99. SSQOL-C had high internal consistency with Cronbach’s alpha of 0.94 for the total scale, and between 0.65 and 0.90 for the 12 domains. The total SSQOL-C scores showed significant positive correlations with SF-36 physical health (r=0.58, p<0.01) and mental health (r=0.54, p<0.01) component scores, and FAI score (r=0.59, p<0.01). SSQOL-C physical subtotal scores showed significant positive correlations with SF-36 physical health (r=0.55, p<0.01) and mental health (r=0.43, p<0.01) component scores, and FAI score (r=0.54, p<0.01). SSQOL-C psychosocial subtotal scores showed significant positive correlations with SF-36 physical health (r=0.52, p<0.01) and mental health (r=0.56, p<0.01) component scores, and FAI score (r=0.56, p<0.01). Conclusion: The results showed SSQOL-C had good content and convergent validity, and reliability in Chinese stroke survivors. Further evaluation of factor structure of SSQOL-C will be conducted to determine its validity.


2021 ◽  
pp. 36-38
Author(s):  
Jitendra Kumar Barad ◽  
Raghuveer Pedamallu ◽  
Rahul Devraj ◽  
Ram Reddy. Ch

Background: Partial nephrectomy became more preferred option in the treatment of localized small renal tumours due to recent advances in imaging modalities and surgical techniques. Renal scoring systems are known to compliment urologist in aiding surgical decision process on extent of surgery in small localized renal tumours. There are few scoring systems described in the literature with their own limitations. Methods: This is a retrospective study of patients with localized renal cell tumours who underwent nephrectomy at Nizam Institute of Medical Sciences (NIMS), Hyderabad fromJanuary 2017 to January 2019. Patients with advanced renal cell cancer disease at presentation were excluded. Total RENAL nephrometry Score (RNS), its individual component scores and complexity category were calculated based on CT report. The study cases were categorized into Group A (Partial Nephrectomy) and as Group B (Radical Nephrectomy). Mean and standard deviation value of the RENAL nephrometry scores and its component scores were calculated for each group. Statistical signicance was calculated using unpaired T-test, using SPSS statistics 21.0 software. Results: The mean age for all patients included in this study is 52.1 years. Out of 80 patients, 32 patients had partial nephrectomy (Group A) and 48 patients had radical nephrectomy (Group B). Based on RENAL nephrometry score complexity, Group A and Group B were further categorized into low, intermediate and high complexity score categories. The total RENAL score, individual component scores and RENAL score complexity were found to be signicantly different between the two group in addition to the tumor size. No statistical signicance was found between the two groups for age and type of tumour on histopathology (benign or malignant). Conclusion: We conclude that preoperative RENAL nephrometry scoring is a useful aid to surgeons to classify the renal tumour complexity before deciding on effective surgical strategy for better patient outcomes


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