Protective Effects of Isoflavone on Some Biochemical Parameters Affected by Cypermethrin in Male Rabbits

2003 ◽  
Vol 38 (3) ◽  
pp. 365-378 ◽  
Author(s):  
F. M. El‐Demerdash ◽  
M. I. Yousef ◽  
K. S. Al‐Salhen
Keyword(s):  
Biochemical Parameters ◽  
Protective Effects

scholarly journals Daily Consumption of a Chocolate Rich in Flavonoids Decreases Cellular Genotoxicity and Improves Biochemical Parameters of Lipid and Glucose Metabolism

2018 ◽  
Author(s):  
Aldo Leyva-Soto ◽  
Linda Ramona Lara-Jacobo ◽  
Lina Natalia Gonzalez-Cobian ◽  
Rocío Alejandra Chavez-Santoscoy
Keyword(s):  
Biochemical Parameters ◽  
Daily Intake ◽  
Dark Chocolate ◽  
Total Phenolic ◽  
Double Blind Study ◽  
Protective Effects ◽  
Daily Consumption ◽  
Double Blind ◽  
Obesity And Diabetes ◽  
Before And After

In recent years, Atherosclerotic Cardiovascular Disease (ACVD), Obesity and Diabetes, have increase exponentially worldwide. In the present work, we evaluate the genoprotective effect of consuming a flavonoids-rich chocolate and the improvement in the biochemical parameters related to the prevention and treatment of cardiovascular risk and metabolic syndrome in young Mexican adults. A randomized, placebo-controlled, double-blind study was undertaken in the Autonomous University of Baja California. The treatments were a daily intake of 2 grams of dark chocolate containing 70% cooca or milk chocolate. Total phenolic compounds and flavonoids were evaluated in both chocolates. Anthropometrical and Biochemical parameters were measured in the 84 participants before and after the study. Buccal epithelial genotoxicity was also evaluated from the beginning to the end of the experiment in the participants. Result suggested that flavonoids of cocoa intake have protective effects against DNA damage, and Biochemical parameters (total cholesterol, triglycerides, and LDL-cholesterol level in blood) and anthropometrical parameters (waist circumference) were also improved after six months of daily intake of 2 grams of dark chocolate with a 70% of cocoa.

scholarly journals PROTECTIVE ROLE OF AERVA MONSONIAE AND SELENIUM ON CADMIUM- INDUCED OXIDATIVE LIVER DAMAGE IN RATS

2018 ◽  
Vol 11 (6) ◽  
pp. 177 ◽  
Author(s):  
Divya Jyothi Palati ◽  
Swaroopa Rani Vanapatla
Keyword(s):  
Liver Damage ◽  
Biochemical Parameters ◽  
Protective Role ◽  
Enzymatic Antioxidants ◽  
Protective Effects ◽  
Stress Markers ◽  
Whole Plant ◽  
The Individual ◽  
Glutamyl Transferase

Objective: The present study was aimed to investigate the protective effect of methanolic extract of the whole plant of Aerva monsoniae (MEAM) and selenium on cadmium (Cd)-induced oxidative liver damage in experimental rats.Methods: In the present study, albino Wistar rats were treated with Cd (5 mg/kg), selenium (1 mg/kg), and MEAM (250 and 500 mg/kg) for 21days. After 21 days of the treatment, the rats were sacrificed, and blood was collected for estimation of biochemical parameters and liver was used for histopathological studies.Results: Oral administration of Cd significantly elevated the levels of hepatic markers such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyl transferase, cholesterol, total bilirubin, direct bilirubin, and decreased levels of total proteins and albumin. We also observed that elevated oxidative stress markers such as malondialdehyde reduced the enzymatic antioxidants such as superoxide dismutase, catalase, and non-enzymatic antioxidants such as reduced glutathione in the liver. Co-administration of MEAM and selenium in Cd-intoxicated rats, the altered biochemical parameters, and pathological changes were recovered significantly (p>0.01) than the individual effects of MEAM and selenium.Conclusion: From the above findings, it was concluded that combination of MEAM and selenium exhibited remarkable protective effects against Cd-induced oxidative liver damage in rats.

scholarly journals Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Nurgül Atmaca ◽  
Ebru Yıldırım ◽  
Bayram Güner ◽  
Ruhi Kabakçı ◽  
Fatih Sultan Bilmen
Keyword(s):  
Enzyme Activity ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Treated Group ◽  
Inorganic Phosphorus ◽  
Control Group ◽  
Protective Effects ◽  
Biochemical Alterations ◽  
Fluoride Treatment ◽  
Hematological And Biochemical Parameters

We investigated the protective effects of resveratrol on hematological and biochemical changes induced by fluoride in rats. A total of 28 rats were divided into 4 groups: control, resveratrol, fluoride, and fluoride/resveratrol(n=7each), for a total of 21 days of treatment. Blood samples were taken and hematological and biochemical parameters were measured. Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio. The group that received resveratrol alone showed a decrease in WBC count compared to the control group. Furthermore, in comparison to the control group, the fluoride group showed significantly increased ALT enzyme activity and decreased inorganic phosphorus level. The hematological and biochemical parameters in the fluoride + resveratrol treated group were similar to control group. In the fluoride + resveratrol group, resveratrol restored the changes observed following fluoride treatment, including decreased counts of WBC, RBC, and PLT, decreased neutrophil ratio and inorganic phosphorus levels, and elevated ALT enzyme activity. The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure.

scholarly journals Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

2021 ◽  
Vol 15 (1) ◽  
pp. 16
Author(s):  
Petek Piner Benli ◽  
Merve Kaya ◽  
Yusuf Kenan Dağlıoğlu
Keyword(s):  
Oxidative Stress ◽  
Biochemical Parameters ◽  
Biological Activities ◽  
Hematological Parameters ◽  
Sulfated Polysaccharide ◽  
Protective Role ◽  
Protective Effects ◽  
Biochemical Alterations ◽  
Hematological And Biochemical Parameters ◽  
And Oxidative Stress

Fucoidan is a sulfated polysaccharide which can be found among a number of macroalgea species. It has a broad spectrum of biological activities including anti-oxidant, anti-tumor, immunoregulation, anti-viral and anti-coagulant. The current study was performed to investigate possible protective effects of fucoidan for sulfoxaflor-induced hematological/biochemical alterations and oxidative stress in the blood of male Swiss albino mice. For this purpose, sulfoxaflor was administered at a dose of 15 mg/kg/day (1/50 oral LD50), and fucoidan was administered at a dose of 50 mg/kg/day by oral gavage alone and combined for 24 h and 7 days. Hematological parameters (RBC, HGB, HCT, MCV, MCH, MCHC, Plt, WBC, Neu, Lym and Mon), serum biochemical parameters (AST, ALT, GGT, LDH, BUN, Cre and TBil), and serum oxidative stress/antioxidant markers (8-OHdG, MDA, POC and GSH) were analyzed. The results indicated that sulfoxaflor altered hematological and biochemical parameters and caused oxidative stress in mice; fucoidan ameliorated some hematological and biochemical parameters and exhibited a protective role as an antioxidant against sulfoxaflor-induced oxidative stress.

scholarly journals Protective Effects of Dietary Supplement Spirulina (Spirulina platensis) against Toxically Impacts of Monosodium Glutamate in Blood and Behavior of Swiss mouse

Separations ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 218
Author(s):  
Adina Lia Longodor ◽  
Aurelia Coroian ◽  
Igori Balta ◽  
Marian Taulescu ◽  
Corina Toma ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Spirulina Platensis ◽  
Biochemical Parameters ◽  
Animal Feed ◽  
Monosodium Glutamate ◽  
Food Additives ◽  
Laboratory Animals ◽  
Control Group ◽  
Protective Effects ◽  
Swiss Mice

(1) Background: Well-known monosodium glutamate (E-621, MSG), originally used as a food flavor enhancer, was approved approximately in all countries, but the toxicity versus the safety of (MSG) are still unclear due to variable scientific toxicological reports. Moreover, it was reported to trigger elevated frequencies of nausea and headaches in humans and provide deleterious effects on laboratory animals. The objectives of the present study were to (i) estimate the possible toxic effects of the food additive MSG (ii) and the ameliorating protective effects of the dietary supplement spirulina (Spirulina platensis) on the biochemical parameters of blood and the damage produced in organs of Swiss mice after applying a supplementary daily dose of MSG for 4 weeks. (2) Methods: The present study was conducted on 20 mature Swiss mice, which were randomly organized into four groups of five Swiss mice. The treatments were (I) the control group, in which Swiss mice were fed only animal feed and drinking water; group II MSG1, which received 1 mL of MSG; group III MSG0.5, which was treated with 0.5 mL of MSG; and (IV) the group MSGS, which was treated with 1 mL of monosodium glutamate and 1 mL of spirulina (aiming to reduce the MSG toxicity). (3) Results: At the end of the experiment, Swiss mice treated with MSG demonstrated a passiveness regarding behavioral aspects. As we hypothesized, the parameters of the spirulina group reached similar values to the control group, and no histopathological observations have been found. Altogether, our findings evidenced that monosodium glutamate leads to histopathological changes in Swiss mice kidneys and caused important modifications for all biochemical parameters of the blood serum. Noticeably, the potential protective effect of Spirulina platensis was proved and was described by using the FTIR spectroscopy technique. (4) Conclusions: A diet rich in antioxidants and other plant-derived bioactive compounds may provide healthy nutrition, alleviating the potential side effects of some food additives.

scholarly journals Protective Effects of N. sativa against the Adverse Effects of Aflatoxicosis in Ducklings

2014 ◽  
Vol 14 (2) ◽  
pp. 81-90
Author(s):  
SKL Karn
Keyword(s):  
Adverse Effects ◽  
Biochemical Parameters ◽  
Feed Additive ◽  
Protective Effects ◽  
Glutathione Level ◽  
Histopathological Changes ◽  
Glutathione S Transferase ◽  
Total Proteins ◽  
Test Animal ◽  
Toxigenic Strain

Aflatoxin produced by Aspergillus flavus toxigenic strain was selected as a potent and widely distributed hepatotoxin that induces much health and economic hazards in animals and humans. A. flavus was cultivated on rice to produce the aflatoxin used in the present study. It was aimed to study the adverse effects of aflatoxin on some biochemical parameters in serum and liver of ducklings as well as to evaluate the possible protective effects of N.sativa crushed seeds against the adverse effects of this. Total proteins, albumin, globulins, alanine aminotransferase (ALT) (EC 2.6.1.1) and aspartate aminotransferase (AST) (EC 2.6.1.2), cholesterol and triacylglycerols were measured in the serum of the test animal. The levels of hepatic malondialdhyde and glutathione level, glutathione S-transferase (GST) (EC: 2.5.1.18) activity, aflatoxin residues and histopathological changes were also measured. The obtained results suggest that the addition of N. sativa to duckling’s ration has a protective effect against aflatoxicosis. The result concluded that aflatoxin had hepatotoxic effects through decrease of total proteins, albumin, glutathione and glutathione S-transferase. In addition, aflatoxin induced histopathological changes of liver of the test animal and residues of aflatoxin were measured. So, we advice to use N. sativa as a feed additive for controlling aflatoxicosis in poultry farm   DOI: http://dx.doi.org/10.3126/njst.v14i2.10419   Nepal Journal of Science and Technology Vol. 14, No. 2 (2013) 81-90  

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