scholarly journals Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Nurgül Atmaca ◽  
Ebru Yıldırım ◽  
Bayram Güner ◽  
Ruhi Kabakçı ◽  
Fatih Sultan Bilmen
Keyword(s):  
Enzyme Activity ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Treated Group ◽  
Inorganic Phosphorus ◽  
Control Group ◽  
Protective Effects ◽  
Biochemical Alterations ◽  
Fluoride Treatment ◽  
Hematological And Biochemical Parameters

We investigated the protective effects of resveratrol on hematological and biochemical changes induced by fluoride in rats. A total of 28 rats were divided into 4 groups: control, resveratrol, fluoride, and fluoride/resveratrol(n=7each), for a total of 21 days of treatment. Blood samples were taken and hematological and biochemical parameters were measured. Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio. The group that received resveratrol alone showed a decrease in WBC count compared to the control group. Furthermore, in comparison to the control group, the fluoride group showed significantly increased ALT enzyme activity and decreased inorganic phosphorus level. The hematological and biochemical parameters in the fluoride + resveratrol treated group were similar to control group. In the fluoride + resveratrol group, resveratrol restored the changes observed following fluoride treatment, including decreased counts of WBC, RBC, and PLT, decreased neutrophil ratio and inorganic phosphorus levels, and elevated ALT enzyme activity. The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure.

scholarly journals Effects ofSalvadora persicaExtract on the Hematological and Biochemical Alterations against Immobilization-Induced Rats

Scientifica ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Kholoud S. Ramadan ◽  
Salha A. Alshamrani
Keyword(s):  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Hdl Cholesterol ◽  
Treated Group ◽  
Control Group ◽  
Serum Samples ◽  
Salvadora Persica ◽  
Biochemical Alterations ◽  
Hematological And Biochemical Parameters

A total of 24 rats were divided into 4 groups: control, stress, extract alone, and stress + extract (n=6each), for total 21 days of treatment. The immobilization stress was induced in rats by putting them in 20 cm × 7 cm plastic tubes for 2 h/day for 21 days. Rats were postorally treated withSalvadora persicaat a dose of 900 mg/kg body weight via intragastric intubations. At the end of the test period, hematological and biochemical parameters were determined in blood and serum samples with determination of vital organs weights. The vital organ weights were not significantly affected in stressed rats as compared to control rats. Compared to the control group, the stress treated group showed significances in several hematological parameters, including decreases in WBC, RBC, and PLT counts. Furthermore, in comparison to the control group, the stress group showed significantly increased blood glucose, serum total cholesterol, LDL-cholesterol, and triacylglycerols levels and decreased HDL-cholesterol level. The hematological and biochemical parameters in the stress + extract treated group were approximately similar to control group. The SP extract restored the changes observed following stress treatment.

scholarly journals Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

2021 ◽  
Vol 15 (1) ◽  
pp. 16
Author(s):  
Petek Piner Benli ◽  
Merve Kaya ◽  
Yusuf Kenan Dağlıoğlu
Keyword(s):  
Oxidative Stress ◽  
Biochemical Parameters ◽  
Biological Activities ◽  
Hematological Parameters ◽  
Sulfated Polysaccharide ◽  
Protective Role ◽  
Protective Effects ◽  
Biochemical Alterations ◽  
Hematological And Biochemical Parameters ◽  
And Oxidative Stress

Fucoidan is a sulfated polysaccharide which can be found among a number of macroalgea species. It has a broad spectrum of biological activities including anti-oxidant, anti-tumor, immunoregulation, anti-viral and anti-coagulant. The current study was performed to investigate possible protective effects of fucoidan for sulfoxaflor-induced hematological/biochemical alterations and oxidative stress in the blood of male Swiss albino mice. For this purpose, sulfoxaflor was administered at a dose of 15 mg/kg/day (1/50 oral LD50), and fucoidan was administered at a dose of 50 mg/kg/day by oral gavage alone and combined for 24 h and 7 days. Hematological parameters (RBC, HGB, HCT, MCV, MCH, MCHC, Plt, WBC, Neu, Lym and Mon), serum biochemical parameters (AST, ALT, GGT, LDH, BUN, Cre and TBil), and serum oxidative stress/antioxidant markers (8-OHdG, MDA, POC and GSH) were analyzed. The results indicated that sulfoxaflor altered hematological and biochemical parameters and caused oxidative stress in mice; fucoidan ameliorated some hematological and biochemical parameters and exhibited a protective role as an antioxidant against sulfoxaflor-induced oxidative stress.

scholarly journals Influence of Pesticide on Biochemical and Hematological Parameters in Beninese Vegetable Farmers

2018 ◽  
Vol 9 (1) ◽  
pp. 65
Author(s):  
Lucie AYI-FANOU
Keyword(s):  
Blood Cell ◽  
Biochemical Parameters ◽  
Mean Corpuscular Volume ◽  
Hematological Parameters ◽  
Control Group ◽  
Study Group ◽  
Blood Samples ◽  
Vegetable Farmers ◽  
Insignificant Difference ◽  
Hematological And Biochemical Parameters

In several countries, a lot of researches have shown the toxicity of pesticides on farmers. Meanwhile, few of them have dealt with vegetable farmers in Benin. Therefore, this study has been carried out to assess the effects of pesticides on vegetable farmers’ health. This study is conducted on 30 vegetable farmers who used pesticides and 20 subjects as control group. Pesticides used by vegetable farmers and their risky behavior were investigated. Their blood samples were collected and some tests were performed for hematological and biochemical parameters. For the statistical analysis of the results, Student’s test was used. Our investigations revealed that vegetable farmers of Benin were exposed to different active ingredients of pesticides such as (Abamectin, Acetamiprid, Chlorpyriphos ethyl, Cyfluthrin, Cypermethrin, Emamectin benzoat, Flubendiamid, Lambdacyhalothrin, Mancozeb, Profenofos, Spinosad and Spirotétramate). The hematological parameters showed significant decrease in White blood cell (WBC), Red blood cell (RBC), Hemoglobin (HGB), Hematocrit (HTC), Mean Corpuscular Volume (MCV), Platelet (PLT) count among study group. The enzymatic activities of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) have significantly raised between vegetable farmers and the control group, while the serum concentration in urea and creatinine showed insignificant difference in the study group. These results suggest that pesticides have adverse effects on vegetable farmers of South of Benin.

scholarly journals Assessment of Toxicity and Therapeutic Effects of Goose Bone in a Rat Model

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Md. Yousuf Ali ◽  
Alamgir Kabir ◽  
Shahad Saif Khandker ◽  
Tareq Hossan ◽  
Md. Salman Shakil ◽  
...  
Keyword(s):  
Rat Model ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Atherogenic Index ◽  
Control Group ◽  
Histopathological Study ◽  
Therapeutic Effects ◽  
Related Disorder ◽  
Serum Biochemical ◽  
Hematological And Biochemical Parameters

Goose bone is traditionally used in the treatment of many ailments including in bone fracture. The aim of the present study was to evaluate the subacute toxicity of goose bone in a rat model by investigating some hematological and biochemical parameters in rats. Subsequently, a histopathological study was performed to confirm the presence of pathological lesions in the rat’s vital organs including the liver, kidney, heart, brain, pancreas, lung, spleen, and stomach. Adult Wistar rats were divided into four groups (n = 8) and were orally administrated with three doses (30, 60, and 120 mg/kg) of goose bone once daily for 21 days as compared to control animals (received only drinking water). Goose bone did not cause any significant changes on body weight, relative organ weight, and percentage water content at any of the administered doses. There were also no significant alterations in hematological parameters seen. All three doses administered significantly reduced the triglyceride levels as well as the atherogenic index of plasma (AIP). Animals treated with 120 mg/kg doses had significantly reduced alkaline phosphatase (ALP) activity as compared to the control group. There was no significant alteration on other serum biochemical parameters seen. Additionally, histopathological findings confirmed that there was no inflammatory, necrotic, or other toxicological feature seen for all three doses. It is concluded that goose bone is nontoxic and is safe for consumption besides having the potential to be investigated for the treatment of high triglycerides or liver-related disorder.

scholarly journals Haematological parameters in patients with rheumatoid arthritis and gene variants HLA-DRB1 * 04 and HLA-DRB1 * 03

2020 ◽  
Vol 4 (1) ◽  
pp. 30
Author(s):  
Biljana Klimenta ◽  
Hilada Nefić ◽  
Nenad Prodanović ◽  
Fatima Hukić ◽  
Aner Mešić
Keyword(s):  
Rheumatoid Arthritis ◽  
Sedimentation Rate ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Unknown Etiology ◽  
Control Group ◽  
Gene Variants ◽  
Underdeveloped Countries ◽  
Erythrocyte Sedimentation ◽  
Hematological And Biochemical Parameters

Rheumatoid arthritis is a polygenic disease of unknown etiology, occurs worldwide in both developed and underdeveloped countries and involves all races. The aim of this study is to determine the correlation between hematological parameters (DBC and ESR) and biomarkers of inflammation (CRP) in patients with RA predisposing gene variants HLA-DRB1*04 or HLA-DRB1*03. This study analyzed the results of hematological and biochemical parameters of 33 patients diagnosed with RA, carriers ofgene variants of HLA-DRB1*04 or HLA-DRB1*03, and 33 subjects of control group non-carriers for HLA-DRB1*04 or HLA-DRB1*03. All hematological parameters (DBC) were analyzed on a Beckman Coulter DxH 800 hematology counter. The erythrocyte sedimentation rate was expressed in mm/h. The CRP biochemical test was performed on a Cobas c311 automatic analyzer. In group of RA patients carriers of HLA-DRB1*04 or HLA-DRB1*03 gene variants, the values of HGB and HCTwere significantlylower(p < 0.05) while the values of RDW, RDW-SD, MO, BA, MO#, BA#, ESR and CRP were statistically increased (p < 0.05) from the control group without these variants.

scholarly journals The effect of the insect-acaricidal drug Delcid 7.5® on the body of rabbits

2021 ◽  
Author(s):  
M.I. Burmistrova ◽  
F.I. Vasilevich ◽  
A.A. Deltsov
Keyword(s):  
Peripheral Blood ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Spinal Column ◽  
The Body ◽  
Control Group ◽  
Toxicological Effect ◽  
Hematological And Biochemical Parameters ◽  
External Stimuli ◽  
Average Hemoglobin

The effect of the drug Delcid 7.5 ® on the clinical, hematological and biochemical parameters of rabbits of the New Zealand breed, 6 months of age, when used in doses of 2 ml or 4 ml. Three times with a cutaneous application along the vertebral column from the head to the tail. The conducted studies allow us to conclude that after applying the drug in these doses for 3 days, there were no external signs of intoxication in rabbits. All the animals of the experimental groups were active. The reaction to external stimuli is preserved. Hematological parameters of peripheral blood (number of erythrocytes, leukocytes, hemoglobin, color index, the average hemoglobin content of PG in erythrocytes, mean corpuscular volume, the exponent of anisocytosis of red blood cells, etc.) of the experimental group after treatment in 5, 15, 25 days had no significant differences from those in the control group, this suggests that the applied drug to the skin along the spine from the withers to the rump at a dose of 2 and 4 ml has no Toxicological effect on peripheral blood. The leukogram of the peripheral blood of rabbits when using the drug did not differ from the control parameters. The analysis of biochemical parameters (activity of aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatinine, urea, glucose, total protein, bilirubin, etc.) of the blood of the experimental groups when applying the drug Delcid 7.5 ® along the spinal column at the maximum therapeutic dose did not reveal statistically significant differences from the control, which indicates that the drug does not have a genotoxic effect, does not interfere with the kidneys and metabolism in the body of rabbits. The results of the conducted studies show that the insecticide-acaricide drug Delcid 7.5® for veterinary use, developed by NVC Agrovetzashchita LLC, is safe for rabbits, and therefore it can be recommended for studying the effectiveness of acarosis in rabbits and other animal species.

scholarly journals Hematological and Biochemical evaluation after different orally doses of Copper sulfate in rats

2014 ◽  
Vol 38 (1) ◽  
pp. 83-91
Author(s):  
Rajiha A. Al- Naimi
Keyword(s):  
Biochemical Parameters ◽  
Liver Enzymes ◽  
Blood Platelets ◽  
Hematological Parameters ◽  
Total Serum Protein ◽  
Total Serum ◽  
Control Group ◽  
Blood Collection ◽  
Biochemical Evaluation ◽  
Hematological And Biochemical Parameters

Objectives of this study were to evaluate hematological and biochemical parameters in rats ingested toxic doses of CuSO4.5H2O. Thirty six rats divided into 3 equal groups. First group ingested orally distilled water / day for 3 months and considered as control group , second group was drenched 8 mg /kg B.W /day of CuSO4.5H2O for 3 months and considered as Treated group1 (T1). Third group was drenched 40 mg /kg B.W /day of CuSO4.5H2O for 3 months and considered as Treated group2 (T2). Blood collection was done by direct cardiac puncture every month for hematological and biochemical examinations. Hematological parameters showed that anemia caused by CuSO4.5H2O toxicity was of microcytic hypochromic type with significant increase of neutrophils and decrease of lymphocytes and blood platelets. There was significant increase in biochemical parameters , liver enzymes (GOT,GPT,ALP) and total serum protein . It concluded that CuSO4.5H2O poisoning in rats causes significant changes in blood picture and clinical enzyme

scholarly journals The effect of dried bakery yeast addition on some hematological and biochemical parameters in Japanese quail

2014 ◽  
Vol 8 (3) ◽  
pp. 18-22
Author(s):  
Reyadh M. Redha Almashat
Keyword(s):  
Japanese Quail ◽  
Biochemical Parameters ◽  
Egg Production ◽  
Hematological Parameters ◽  
Enzyme Concentration ◽  
The Other ◽  
Control Group ◽  
Hematological And Biochemical Parameters ◽  
Bakery Yeast ◽  
In The Beginning

This study was aimed to investigate the effect of dried bakery yeast addition to the ration of Japanese quail and its effect on some hematological and biochemical parameters in treated birds in the beginning of egg production stage for two month duration. The fifty birds were divided randomly to five dietary treated groups. Each group contain two replicated five birds for each replicate. First group (control) were fed ration free from the dried bakery yeast. While the other four groups were fed ration plus dried bakery yeast with the following percentage 0.5%, 1.0%, 1.5% & 2.0% respectively. The results of this study showed significant differences with the effects of dried bakery yeast to the ration of the second group 0.5% in comparison with the control group in the hematological parameters which include an increase in the RBCs count 3.37 million/mm3, PCV 34.5% and hemoglobin 7.3 g / 100 ml of blood. There significant increase in the total protein value 5.2 g /100ml. there was significant decrease in SGPT and SGOT enzyme concentration in comparison with control group. There were no significant changes in the level of ALP in the second group 0.5% in comparison with the control group. Mean while a significant increase was noticed in the level of ALP for 1.0%, 1.5%, 2.0% groups in comparison with control group. We concluded from this study that the adding off 0.5% dried bakery yeast to the ration of birds was sufficient to induce the required effects on the hematological and biochemical parameters without need to increase the others concentrations in the rations 1.0%, 1.5%, 2.0%. Mean while that didn’t show any effects on the studying parameters.

scholarly journals Effect of silymarin supplementation on some productive and hematological parameters in meat type male Japanese quails

2019 ◽  
pp. 984
Author(s):  
Hristo Lukanov, Ivelina Pavlova ◽  
Veselin Ivanov, Todor Slavov, Yoana Petrova, Nadya Bozakova
Keyword(s):  
Body Weight ◽  
Growth Performance ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Control Group ◽  
Japanese Quails ◽  
Hematological And Biochemical Parameters ◽  
Experimental Group ◽  
Meat Type ◽  
Main Growth

A total of 90 14-day-old meat type male Japanese quails were included in the experiment and equally divided into 3 groups: control group (CG) without treatment, experimental group 1 (EG 0.5%), supplemented with silymarin 0.5% and experimental group 2 (EG 1%), supplemented with silymarin 1%. The aim of the current study was to establish the effect of supplementation with different doses of silymarin extract on the growth performance and some hematological parameters in male Japanese quails. Main growth performance (body weight, feed consumption and weight gain) were examined and FCR was calculated. Some hematological (WBC, RBC, HGB and HTC) and biochemical (triglycerides, AST and ALT) parameters were determined. The highest average body weight was observed in EG 0.5% group at 35-day-old age and the lowest in EG 1%, 239.61±2.96 g and 231.74±2.96 g respectively. The highest values of the weight gain were calculated in EG 0.5% group, 67.02±2.03 g during the first week of fattening and the lowest was observed in EG 1% group at the fifth week after hatching, 23.30±2.03 g respectively. The lowest values of FCR were observed during the first week of the trial, 2.42±0.08 kg/kg to 2.61±0.13 kg/kg in EG 1% and the control group respectively. The supplementation of 0.5% and 1% silymarin did not significantly change the studied hematological and biochemical parameters. A tendency of higher values of triglycerides and lower values of AST and ALT was observed in the groups, supplemented with silymarin compared to the controls. From the obtained results of the present study we can conclude that the silymarin supplementation at higher doses (0.5% and 1%) did not have effect on the main growth performance and some hematological and biochemical parameters of male Japanese quails.

Effect of Apricot kernel on Some Hematological,Histological and Biochemical Parameters in CCl4-induced Liver Injury in rats

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Firdaws AL-Mashhadani ◽  
Abbas QadirSalihi ◽  
Nazdar Wasman
Keyword(s):  
Liver Injury ◽  
Biochemical Parameters ◽  
Paraffin Section ◽  
Histological Section ◽  
Treated Group ◽  
Normal Diet ◽  
Control Group ◽  
Albino Rats ◽  
Apricot Kernel ◽  
Hematological And Biochemical Parameters

The purpose of the present study was to find out the effect of apricot kernel on carbon tetrachloride (CCl4) induced liver injury in male albino rats. To achieve this purpose and to explain, the histological, hematological and biochemical parameters were included. Thirty male albino rats were used and randomly divided to in to three groups. The first group represented control group which received normal diet and intraperitoneal injection with oil (0.5 ml/kg). The second  group injected with CCl4(1 ml/kg), represented the CCl4(1 ml/kg)model,the third groupwere treated like the second group with 15%/ day apricot kernelfor a month . The  apricot kernel extracts treated group showed significant differences in AST, ALT, ALP, direct bilirubin, , GSH, liver SOD, WBC, LYM and PLT when compared to CCl4 treated rats. In the current study histological section through the liver of control rats showed normal architecture of hepatocytes.Although Paraffin section of the rat liver treated with CCl4 most of the hepatocytes were degenerated, congestion of blood and inflammatory leukocyte infiltration were observed,the results showed that CCl4 injection caused significant alterations in histological and biochemical parameters but our study showed that the apricot kernel administration showed improvement of histological analysis for four weeks (March to April 2015).

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