Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line.
1989 ◽
Vol 169
(4)
◽
pp. 1485-1490
◽
Keyword(s):
Sds Page
◽
A novel basic heparin-binding monocyte chemotactic factor (MCF) was purified to homogeneity from the conditioned media of human myelomonocytic cell line THP-1 based on its in vitro monocyte chemotactic activity. The purified MCF was homogenous and estimated to be 15 kD on SDS-PAGE. Purified MCF stimulated normal human monocytes to be growth inhibitory in vitro at 2-3 d for several human tumor cell lines. This represents the first report of the identification and purification of a chemoattractant cytokine that also activates monocytes but is distinct from interferons and other known cytokines.
Keyword(s):
Keyword(s):
Keyword(s):
2007 ◽
Vol 62
(11)
◽
pp. 1459-1464
◽
1985 ◽
Vol 82
(19)
◽
pp. 6637-6641
◽
2012 ◽
Vol 77
(1)
◽
pp. 1-8
◽
2011 ◽
Vol 6
(6)
◽
pp. 1934578X1100600
Keyword(s):
2020 ◽
Vol 17
(4)
◽
pp. 512-517
Keyword(s):