scholarly journals PHENOTYPIC EXPRESSION OF A GENETIC PROPERTY INTRODUCED BY DEOXYRIBONUCLEATE

1959 ◽  
Vol 42 (4) ◽  
pp. 737-748 ◽  
Author(s):  
Maurice S. Fox
Keyword(s):  
Standard Deviation ◽  
Time Course ◽  
Distribution Curve ◽  
Phenotypic Expression ◽  
Normal Distribution Curve ◽  
Phenotypic Alteration ◽  
The Mean ◽  
Definition Of ◽  
Two Parameters ◽  
Mean Time

The time course of the appearance of cells showing a new phenotype, following treatment with a specific DNA, has been analyzed. A plot as a function of time of the number of cells showing the new property closely resembles the summation under a normal distribution curve. Describing the appearance of the new phenotype in these terms permits the definition of two parameters, the mean time, and the standard deviation of the distribution curve. This distribution is not affected either by the DNA concentration with which the transformable population has been treated, or by the streptomycin concentration with which the transformed population has been challenged. Interruptions of the expression process, by cooling to 20° or 0°C., serve only to displace the expression curves, without changing their shape, while small reductions in temperature change both the mean time of expression and the standard deviation of the distribution curve. On the basis of these observations a number of hypotheses have been examined concerning the mechanism whereby transforming DNA manifests a phenotypic alteration in the transformed cells. It can be concluded that there exist at least two stages in the process of expression. The completion of the first stage, causing the randomization, occurs with a mean time of about 60 minutes, and a terminal step, that of the transition of phenotype, occurs in less than 3 minutes.

Do methods of hospital pre-alerts influence the on-scene times for acute pre-hospital stroke patients? A retrospective observational study

2021 ◽  
Vol 6 (2) ◽  
pp. 19-25
Author(s):  
Jacob Gunn
Keyword(s):  
Standard Deviation ◽  
Observational Study ◽  
Acute Stroke ◽  
Ambulance Service ◽  
Time Saving ◽  
North East ◽  
Admission Policies ◽  
The Mean ◽  
Time Critical ◽  
Mean Time

Introduction: Stroke is one of the leading causes of death and disability worldwide. The ambulance service is often the first medical service to reach an acute stroke patient, and due to the time-critical nature of stroke, a time-critical assessment and rapid transport to a hyper acute stroke unit are essential. As stroke services have been centralised, different hospitals have implemented different pre-alert admission policies that may affect the on-scene time of the attending ambulance crew. The aim of this study is to investigate if the different pre-alert admission policies affect time on scene.Method: The current study is a retrospective quantitative observational study using data routinely collected by North East Ambulance Service NHS Foundation Trust. The time on scene was divided into two variables; group one was a telephone pre-alert in which a telephone discussion with the receiving hospital is required before they accept admission of the patient. Group two was a radio-style pre-alert in which the attending clinician makes an autonomous decision on the receiving hospital and alerts them via a short radio message of the incoming patient. These times were then compared to identify if there was any difference between them.Results: Data on 927 patients over a three-month period, from October to December 2019, who had received the full stroke bundle of care, were within the thrombolysis window and recorded as a stroke by the attending clinician, were split into the variable groups and reported on. The mean time on scene for a telephone call pre-alert was 33 minutes and 19 seconds, with a standard deviation of 13 minutes and 8 seconds. The mean on-scene time for a radio pre-alert was 28 minutes and 24 seconds, with a standard deviation of 11 minutes and 51 seconds.Conclusion: A pre-alert given via radio instead of via telephone is shown to have a mean time saving of 4 minutes and 55 seconds, representing an important decrease in time which could be beneficial to patients.

scholarly journals Preceptors in Medical Residency Programs: Epidemiological Profile and Pedagogic Training

2020 ◽  
Vol 44 (4) ◽  
Author(s):  
Aderval de Melo Carvalho Filho ◽  
Almira Alves dos Santos ◽  
Rozangela Maria de Almeida Fernandes Wyszomirska ◽  
Isabella Costa Figueiredo Medeiros
Keyword(s):  
Health Care Professionals ◽  
The State ◽  
Public Institution ◽  
Medical Residency ◽  
Residency Programs ◽  
Service Training ◽  
The Mean ◽  
Definition Of ◽  
Epidemiological Profile ◽  
Mean Time

Abstract: Introduction: Medical Residency is a specialization course characterized as in-service training, considered in Brazil as the gold standard in the development of specialist physicians’ training. The medical residency preceptorship is an activity carried out by a specialist physician, responsible for monitoring resident physicians. However, there is neither a definition of the main requirements for such a preceptor, nor of his/her academic background to carry out the due teaching training, and it was possible to notice a relative lack of preparation regarding the pedagogical aspects. Methods: Descriptive study based on a quantitative approach, comprising 200 preceptors, of both genders, from medical residency programs in Maceió, state of Alagoas, Brazil. Results: The mean age was 43.31 ± 10.31 years, with a slight majority of female participants (52.5%). The mean time since graduation was 19.5 ± 10.58 years, and 83% of the participants had graduated in the state of Alagoas. Moreover, 78.5% said they had their Medical Residency certification, with an increased trend of public institution preceptors getting their degree at the stricto sensu level. The mean time of their completed postgraduate course was 12.63 ± 10.87 years and 7.07 ± 6.99 years being a preceptor. Only 19% mentioned they had some qualification for exercising the preceptorship, and 29.5% work as the teachers at the undergraduate level. The state of Alagoas has followed the expansion of the Residency programs, justifying the mean age found, similar to other studies. The majority of female participants can be associated with the feminization of health care professionals. The high percentage of preceptors with medical residency qualification is in accordance with Resolution n. 4/1978. We found experienced preceptors, but some authors differed. The low percentage of preceptors with qualification for exercising preceptorship indicates low interest and lack of available training. Conclusion: This study population is characterized as being young, and most are females. They have had long professional experience, and most have graduated in the state of Alagoas. There is a predominance of medical residency as their main qualification, and few of them have had training in the field. Finally, preceptors from public institutions have mostly got their degrees at the stricto sensu level.

scholarly journals CORRELATIONS OF THE MEAN TIME AND MEAN MAGNITUDE OF ACCELERATING PRESHOCKS WITH THE ORIGIN TIME AND MAGNITUDE OF MAINSHOCK

2017 ◽  
Vol 43 (4) ◽  
pp. 2154
Author(s):  
E. M. Scordilis
Keyword(s):  
Standard Deviation ◽  
South America ◽  
Strain Rate ◽  
Central Asia ◽  
Earthquake Prediction ◽  
Critical Region ◽  
Origin Time ◽  
The Mean ◽  
Benioff Strain ◽  
Mean Time

Forty-five preshock sequences preceding corresponding strong (M≥6.4) mainshocks which occurred recently (since 1980) in a variety of seismotectonic regimes (W. Mediterranean, Aegean, Anatolia, California, Japan, Central Asia, South America) have been examined to identify new predictive properties. It has been observed that the mean origin time, , and the mean magnitude, of the accelerating preshocks of each sequence are correlated with the origin time, tc, and the magnitude, M, of the mainshock, respectively. The following relations have been derived: where sa (in Joule ½ /yr.104 Km2 ) is the Benioff strain rate in each preshock (critical) region and σ is the corresponding standard deviation. The possibility for using these relations as constraints in attempts for intermediate term earthquake prediction is discussed.

Metabolic control of Argyropelecus hemigymnus photophores: effects of glucose and pyruvate

1991 ◽  
Vol 69 (9) ◽  
pp. 2410-2413 ◽  
Author(s):  
J. Mallefet ◽  
F. Baguet
Keyword(s):  
Oxygen Consumption ◽  
Oxygen Uptake ◽  
Metabolic Control ◽  
Time Course ◽  
Light Emission ◽  
Mesopelagic Fish ◽  
Fresh Weight ◽  
Hypometabolic State ◽  
The Mean ◽  
Mean Time

Modifications in oxygen consumption and luminescence of isolated luminescent organs of the mesopelagic fish Argyropelecus hemigymnus following glucose and pyruvate administration were studied before and during light emission triggered by adrenaline. Isolated photophores (mean fresh weight 13.5 ± 0.9 mg) at rest, i.e., in the absence of light emission, in saline (20 °C) exhibit a respiration rate of 1.045 ± 0.082 (SE) nmol O2/min (n = 35). A significant decrease (p = 0.05) in oxygen consumption was observed after the addition of 5.5 mM glucose. Instead of the oxygen decrease usually observed as a result of control stimulations using adrenaline, photophores pretreated with glucose increased their oxygen uptake in response to adrenaline, and maximal light emission was reduced by 85% (p = 0.01). The addition of 5.5 mM pyruvate induced a significant transient increase (p = 0.05) in oxygen uptake of isolated photophores, though this treatment did not statistically modify the mean time course of oxygen consumption and light emission in response to adrenaline. The hypothesis of a hypometabolic state of the isolated photophores of A. hemigymnus during light emission is discussed.

scholarly journals Tracheostomy in the coronavirus disease 2019 patient: evaluating feasibility, challenges and early outcomes of the 14-day guidance

2020 ◽  
Vol 134 (8) ◽  
pp. 688-695 ◽  
Author(s):  
N Glibbery ◽  
K Karamali ◽  
C Walker ◽  
I Fitzgerald O'Connor ◽  
B Fish ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Standard Deviation ◽  
Intensive Care Unit Discharge ◽  
Organ Support ◽  
Unit Discharge ◽  
Surgical Tracheostomy ◽  
Ventilatory Assistance ◽  
The Mean ◽  
Mean Time

AbstractObjectivesTo report feasibility, early outcomes and challenges of implementing a 14-day threshold for undertaking surgical tracheostomy in the critically ill coronavirus disease 2019 patient.MethodsTwenty-eight coronavirus disease 2019 patients underwent tracheostomy. Demographics, risk factors, ventilatory assistance, organ support and logistics were assessed.ResultsThe mean time from intubation to tracheostomy formation was 17.0 days (standard deviation = 4.4, range 8–26 days). Mean time to decannulation was 15.8 days (standard deviation = 9.4) and mean time to intensive care unit stepdown to a ward was 19.2 days (standard deviation = 6.8). The time from intubation to tracheostomy was strongly positively correlated with: duration of mechanical ventilation (r(23) = 0.66; p < 0.001), time from intubation to decannulation (r(23) = 0.66; p < 0.001) and time from intubation to intensive care unit discharge (r(23) = 0.71; p < 0.001).ConclusionPerforming a tracheostomy in coronavirus disease 2019 positive patients at 8–14 days following intubation is compatible with favourable outcomes. Multidisciplinary team input is crucial to patient selection.

Time Progression of Hemolysis of Erythrocyte Populations Exposed to Supraphysiological Temperatures

1979 ◽  
Vol 101 (3) ◽  
pp. 213-217 ◽  
Author(s):  
N. A. Moussa ◽  
E. N. Tell ◽  
E. G. Cravalho
Keyword(s):  
Statistical Model ◽  
Distribution Curve ◽  
Time History ◽  
Kinetic Scheme ◽  
First Order ◽  
Arrhenius Dependence ◽  
History Of ◽  
The Mean ◽  
Two Parameters ◽  
Microscope Stage

Populations of erythrocytes in solution were heated “instantaneously” to and maintained at temperatures in the range of 44 to 60°C on a microscope stage specifically designed for this purpose. Simultaneously, the visually observed hemolysis-time history of these cells was measured. The results were successfully correlated on the basis of two models: 1) a kinetic scheme assuming two sequential, first-order reactions by which the cells are first reversibly altered and then irreversibly damaged; and 2) a statistical model for which the number of cells that are damaged at each instant is assumed to be normally distributed. From the experimental data the rate constants for the two reactions in the kinetic model were determined and were found to have an Arrhenius dependence on temperature. By applying the statistical model to the data, we were able to determine the mean and standard deviation of the distribution curve for this model. The logarithms of these latter two parameters vary with temperature in a linear fashion.

scholarly journals Gene-environment interactions of the eyeless mutant in Drosophila melanogaster

1969 ◽  
Vol 13 (3) ◽  
pp. 251-265 ◽  
Author(s):  
David M. Hunt ◽  
Barrie Burnet
Keyword(s):  
Drosophila Melanogaster ◽  
Standard Deviation ◽  
Ribonucleic Acid ◽  
Acid Content ◽  
Culture Medium ◽  
Phenotypic Expression ◽  
Modifier Genes ◽  
Larval Culture ◽  
Gene Environment ◽  
The Mean

A method is described for quantifying the phenotypic expression of eyeless using gauged estimates of the mean and standard deviation of the distribution of facet numbers.Gene-environment interactions of four eyeless alleles ey, ey2ey4 and eyK are compared in different genetic backgrounds and on a standardized Pacific background. The original strains differ in mean phenotypic value and in direction of response to variations in the ribonucleic acid content of the larval culture medium, whereas the four Pacific strains are more concordant. Consequently these differences are in part attributable to modifier genes present in the different genetic backgrounds of the original strains. Modifier genes also influence the periods in development at which eyeless is sensitive to nutritional treatments.On the standardized Pacific background deficiencies of cholesterol cause an increase, whereas deficiencies of RNA or thiamine cause a decrease in the expressvity of all four eyeless alleles, but non-identity of their interaction profiles over an array of different suboptimal environments suggest that they may form a group of heteroalleles.

But What About Swimming and Cycling? How to “Count” Non-Ambulatory Activity When Using Pedometers to Assess Physical Activity

2006 ◽  
Vol 3 (3) ◽  
pp. 257-266 ◽  
Author(s):  
Ruth Miller ◽  
Wendy Brown ◽  
Catrine Tudor-Locke
Keyword(s):  
Physical Activity ◽  
Standard Deviation ◽  
Step Count ◽  
Ambulatory Activity ◽  
The Mean ◽  
Ambulatory Activities ◽  
Mean Time

Background:The aims of this study were to describe the amount of non-ambulatory physical activity (PA) undertaken by a sample of Australian workers, and to evaluate different methods of accounting for non-ambulatory activities when using pedometers to measure physical activity.Methods:Adults age 18 to 64 y (N = 204) wore a pedometer and recorded steps and non-step activity in a logbook for 7 d. Non-ambulatory activity was recorded by 28% of the participants (N = 52) with cycling and swimming the most frequently reported.Results:The mean time reported for non-ambulatory activities was 82.8 (standard deviation 80.0) min/wk. On average, participants recorded 8873 (standard deviation 2757) steps/d. Time in non-ambulatory activities was converted to steps equivalents using three different conversion methods. Use of the three methods added 333 to 721 steps/d in the whole sample, but 1153 to 2566 steps/d for those who reported non-ambulatory activity.Conclusions:Suggestions are provided for accounting for non-ambulatory activities in interventions which rely on step count measures.

scholarly journals Statistical Analysis of Basketball Teams Through Normal Distribution and R Programming

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Megan Wang
Keyword(s):  
Statistical Analysis ◽  
Standard Deviation ◽  
Probability Density Function ◽  
Normal Distribution ◽  
Sports Analytics ◽  
R Programming Language ◽  
General Improvement ◽  
The Mean ◽  
R Programming ◽  
Two Parameters

Basketball has existed for almost 130 years, becoming one of the most famous sports worldwide by affecting millions of lives and having national and global tournaments. With the general improvement of people's concern and love for sports competition, sports analytics’ role will become more prominent. Hence, this paper combines the relevant knowledge of statistics and typical basketball competition cases from NBA, expounding the application of statistics in sports competition. The paper first examines the importance of normal distribution (also called Gaussian distribution) in statistics through its probability density function and the function's graph. The function has two parameters: the mean for the maximum and standard deviation for the distance away from the mean[1]. By compiling datasets of past teams and individuals for their basketball performances and making simple calculations of their standard deviation and mean, the paper constructs normal distribution graphs using the R programming language. Finally, the paper examines the Real Plus-Minus value and its importance in basketball.

Unique Pattern of Pulmonary Function after Exercise in Patients with Cystic Fibrosis

1994 ◽  
Vol 6 (3) ◽  
pp. 275-286 ◽  
Author(s):  
Ted. A. Kaplan ◽  
Gina Moccia ◽  
Robert M. McKey
Keyword(s):  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Time Course ◽  
Forced Expiratory Volume ◽  
Distinct Pattern ◽  
Degree Pattern ◽  
Function Test ◽  
The Mean ◽  
Exercise Induced ◽  
Mean Time

The purpose of this study was to assess the incidence, degree, pattern, and time course of pulmonary function test (PFT) changes measured after a dynamic exercise challenge. Forced expiratory maneuvers were performed before and serially after a 7-min run-walk in 44 patients with cystic fibrosis (CF). Twenty-four patients met at least one PFT criterion for exercise-induced bronchospasm (EIB) within 21 min after exercise, and 38 patients had >5% increase in a PFT parameter at some point after exercise. The mean time of greatest increase in PFTs occurred sooner than the greatest decrease, which was later than for 22 patients with asthma or allergic rhinitis found to have EIB. Age was inversely related to percentage fall in forced expiratory volume in 1 s (FEV,) after exercise. These results demonstrate a distinct pattern of PFTs measured after exercise in most patients with CF, with an early bronchodilation followed by a significant decrease in PFTs.

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