The monograph presents data on the incidence and outbreaks of leptospirosis in the world among the population at the turn of the XX and XXI centuries. The results of scientific research by domestic and foreign authors on the history, etiology and circulation of pathogens in various types of foci are summarized, and the features of the epidemic process and clinical and laboratory diagnostics of leptospirosis are highlighted. The role of preventive and antiepidemic measures in the foci of leptospirosis is considered. The article deals with the organization of prevention of hospital infections in the intensive care units when providing medical care to patients with severe forms of leptospirosis. It is intended for doctors of various specialties (epidemiologists, infectious diseases specialists, bacteriologists, microbiologists, veterinarians), laboratory diagnostics specialists, researchers, health care organizers, sanitary and epidemiological service specialists, students, interns, residents, students and teachers of the departments of infectious diseases and epidemiology of various medical educational institutions of higher professional, postgraduate and additional education. The book is illustrated with tables and drawings.