High-precision high-sensitivity clock recovery circuit for a mobile payment application

2011 ◽  
Vol 32 (5) ◽  
pp. 055007 ◽  
Author(s):  
Lichong Sun ◽  
Wenliang Ren ◽  
Na Yan ◽  
Hao Min
Keyword(s):  
High Precision ◽  
High Sensitivity ◽  
Clock Recovery ◽  
Mobile Payment

scholarly journals Resolving Whether Inhalation of Depleted Uranium Contributed to Gulf War Illness Using High-Sensitivity Mass Spectrometry

2020 ◽  
Author(s):  
Randall Parrish ◽  
Robert Haley
Keyword(s):  
Mass Spectrometry ◽  
High Precision ◽  
Inhalation Exposure ◽  
High Sensitivity ◽  
Gulf War ◽  
Depleted Uranium ◽  
Isotopic Ratios ◽  
Gulf War Illness ◽  
Case Definitions ◽  
Standard Case

Abstract Background: Of the hypothesized causes of Gulf War Illness (GWI), a chronic multi-symptom illness afflicting approximately 25 percent of >700,000 military personnel deployed to the 1991 Gulf War, depleted uranium (DU) and exposure to nerve agents have stimulated the most intense international concern. Past depleted uranium research on Gulf War veterans has measured urinary uranium concentration [U] and uranium isotopic ratios with low precision mass spectrometry primarily in GW veterans with retained shrapnel but has not used high precision mass spectrometry to test for an association of GWI with inhaled DU and we set out to test this potential association. Methods: We applied a standard biokinetic model to predict the urinary total [U] and uranium isotopic ratios in urine 18 years after inhalation exposure. We applied high sensitivity mass spectrometry methods capable of detecting the predicted levels in 154 individuals of a population-representative sample of U.S. veterans in whom Gulf War illness had been determined by standard case definitions and DU inhalation exposures obtained by medical history. Results: Methods used in past studies are capable of detecting only the high urinary uranium excretion levels from retained DU shrapnel but not lower levels predicted from DU inhalation. Using high precision mass spectrometry, we found no difference in the 238U/235U ratio in veterans meeting the standard case definitions of GWI versus control veterans, and no differences by levels of DU inhalation exposure. Our bivariate analysis of 236U/238U by 235U/238U showed only the signature of natural dietary uranium, excluding DU inhalation exposures above 0.4 mg, far below the disease-causing threshold. Conclusion: The findings by high precision mass spectrometry support the conclusion that even the highest levels of DU inhalation played no role in the development of Gulf War illness. Other factors including exposure to aerosolized organophosphate compounds (pesticides and sarin nerve agent) remain as the most likely cause(s) of GWI.

Si Photonics Deployment Using Cu Pillar Interconnect and Chip On Wafer Platform

2016 ◽  
Vol 2016 (DPC) ◽  
pp. 001663-001681
Author(s):  
Miguel Jimarez
Keyword(s):  
Light Source ◽  
Silicon Photonics ◽  
High Speed ◽  
High Sensitivity ◽  
Optical Path ◽  
Clock Recovery ◽  
Wafer Scale ◽  
Si Photonics ◽  
Cu Pillar ◽  
Fine Pitch

We introduce a high-speed 4x25Gbps, MSA-compliant, QSFP transceiver built on a Silicon Photonics platform. The transceiver integrates high sensitivity receivers, CTLE, clock recovery, modulator drivers and BIST on a TSMC 28nm die connected to the photonic die thru a fine pitch (50um) Copper Pillar interface. A wafer-scale approach, Chip on Wafer, CoW, is used to assemble the electronic die and the light source on to the photonic die, so that the full optical path can be tested, at speed, in loopback configuration in wafer form, using a standard ATE solution. This presentation focuses on the CoW assembly development aspects of the transceiver. Wafer probe and bump, die processing services, CoW assembly and Back End of Line, BEOL, Test Services will be presented.

P2674Rapid rule-out of myocardial infarction with a novel high precision point-of-care troponin assay appears safe and effective

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
S Aldous ◽  
J Pickering ◽  
J Young ◽  
P George ◽  
A Watson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Decision Making ◽  
Emergency Department ◽  
Chest Pain ◽  
High Precision ◽  
Primary Outcome ◽  
Point Of Care ◽  
High Sensitivity ◽  
Research Fellowship ◽  
Rule Out

Abstract Background High sensitivity troponin assays were developed to improve analytical sensitivity and precision at the decision cut-points for the diagnosis and rule out of acute myocardial infarction (AMI). Central laboratory assays have achieved this but point of care assays, which have the ability to accelerate decision making due to much shorter turnaround times, have remained lacking. Purpose To ascertain the threshold for decision making and subsequent clinical utility for ruling out AMI on presentation in patients attending the emergency department acutely with chest pain, using a high precision point of care troponin assay (TnI Nx), (i-STAT, Abbott). Methods We measured arrival TnI-Nx concentrations in stored plasma samples in adults presenting acutely to the emergency department with chest pain. The primary outcome was an AMI or cardiac death on index admission or within 30 days. We used 2000 bootstrapped data sets to derive and validate a suitable threshold for TnI-Nx before calculating diagnostic test performance. We pre-specified this threshold must have a <1% false negative rate for the primary outcome. We compared this with a core laboratory high sensitivity troponin I (hs-TnI) (Abbott Architect) using the early rule-out cut-point (European Society of Cardiology) at the limit of detection (2 ng/L). Results We recruited 1320 patients of whom 192 (14.1%) had the primary outcome. The TnI-Nx threshold was determined to be 8 ng/L with subsequent sensitivity of 99.0% (95% confidence interval: 97.3% to 100%), negative predictive value of 99.7% (99.2% to 100%) and specificity of 59.0% (56.0% to 62.0%). The hs-TnI had a sensitivity of 99.5% (98.2% to 100%), negative predictive value of 99.7% (99.0% to 100%), and specificity of 28.4% (25.8% to 31.2%) at 2ng/L. Conclusion A high precision point of care assay, TnI-Nx, with a decision threshold of 8ng/L, has comparable rule out performance compared with a core laboratory high sensitivity assay and therefore could potentially be used for early decision making in the assessment of acute chest pain. Acknowledgement/Funding Research grant from Abbott Point of Care. Senior Research Fellowship from ECF, CMRF and CDHB. Clinical Research Fellowship from NZ HRC

scholarly journals PCB-Based Magnetometer as a Platform for Quantification of Lateral-Flow Assays

Sensors ◽  
2019 ◽  
Vol 19 (24) ◽  
pp. 5433 ◽  
Author(s):  
Mohammad Khodadadi ◽  
Long Chang ◽  
João R. C. Trabuco ◽  
Binh V. Vu ◽  
Katerina Kourentzi ◽  
...  
Keyword(s):  
High Precision ◽  
Fe3o4 Nanoparticles ◽  
Printed Circuit Board ◽  
Test Line ◽  
Point Of Care ◽  
Low Cost ◽  
Superparamagnetic Iron Oxide ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Circuit Board

This work presents a proof-of-concept demonstration of a novel inductive transducer, the femtoMag, that can be integrated with a lateral-flow assay (LFA) to provide detection and quantification of molecular biomarkers. The femtoMag transducer is manufactured using a low-cost printed circuit board (PCB) technology and can be controlled by relatively inexpensive electronics. It allows rapid high-precision quantification of the number (or amount) of superparamagnetic nanoparticle reporters along the length of an LFA test strip. It has a detection limit of 10−10 emu, which is equivalent to detecting 4 ng of superparamagnetic iron oxide (Fe3O4) nanoparticles. The femtoMag was used to quantify the hCG pregnancy hormone by quantifying the number of 200 nm magnetic reporters (superparamagnetic Fe3O4 nanoparticles embedded into a polymer matrix) immuno-captured within the test line of the LFA strip. A sensitivity of 100 pg/mL has been demonstrated. Upon further design and control electronics improvements, the sensitivity is projected to be better than 10 pg/mL. Analysis suggests that an average of 109 hCG molecules are needed to specifically bind 107 nanoparticles in the test line. The ratio of the number of hCG molecules in the sample to the number of reporters in the test line increases monotonically from 20 to 500 as the hCG concentration increases from 0.1 ng/mL to 10 ng/mL. The low-cost easy-to-use femtoMag platform offers high-sensitivity/high-precision target analyte quantification and promises to bring state-of-the-art medical diagnostic tests to the point of care.

Verification and Design of High Precision Eddy Current Sensor for Tip Clearance Measurement

2018 ◽  
Author(s):  
Ziyu Zhao ◽  
Zhenxia Liu ◽  
Yaguo Lyu ◽  
Xinxin Xu
Keyword(s):  
High Precision ◽  
Eddy Current ◽  
High Sensitivity ◽  
Response Speed ◽  
Measurement Range ◽  
Tip Clearance ◽  
Current Sensor ◽  
Eddy Current Sensor ◽  
Planar Coil ◽  
Sensor Coil

A high precision eddy current sensor for tip clearance measurement was proposed to assess the dynamic tip clearance measurement for aero-engine rotator. Based on the Lenz’s law, the eddy current sensor has high sensitivity, quick response speed and strong anti-interference capability, in addition, the simple geometry and easy installation are its main merits. The aim is to study the influence of planar coil structure parameters and excitation signal parameters on the sensor coil measurement, provide the basis for design of practical sensor in turbine tip clearance measurement. The dynamic calibration experiment verified the designed planar sensor coil, the results indicated the sensor resolution was 10μm and the measurement range was not less than 3mm. The dynamic experiment proved the measuring range, resolution, response speed of designed sensor can meet the requirement of turbine blade tip clearance measurement. The work provides experience in eddy current sensor design in different application, not only in turbine. And the future work will focus on the high temperature issues.

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