scholarly journals Extraction of phenolic compounds from Iraqi Coriandrum Sativum L. and loaded on copolymeric hydrogels and examine there as drug delivery system and antioxidant

2021 ◽  
Vol 2063 (1) ◽  
pp. 012001
Author(s):  
Ula Ali Sadoun ◽  
Zainab Shakir Al-Ali ◽  
Athir Mahmood Haddad
Keyword(s):  
Drug Delivery ◽  
Phenolic Compounds ◽  
Drug Delivery System ◽  
Delivery System ◽  
Coriandrum Sativum ◽  
Total Flavonoids ◽  
Distilled Water ◽  
Total Phenols ◽  
Phenolic Extract ◽  
Phenolic Extracts

Abstract The phenolic extracts for leaves and stems (L+S) parts and leaves (L) part of Iraqi Coriandrum Sativum L. and their total phenols, total tannins and total flavonoids are described. Three copolymeric hydrogels prepared and loaded with phenolic extract 4 (U1-U3). The HPLC results show three phenolic compounds, while the GC-Mass results show one phenolic compound and four non-phenolic compounds. Gained results showed that there are significant (P < 0.05) variations in total phenols (9.822 ± 0.634−4.015 ± 0.118 mg GAE/g DW), total flavonoids (8.112 ± 0.115−2.811 ± 0.371 mg QE/g DW) and total condensed tannin (4.245 ± 0.276−1.135 ± 0.091 mg QE/g DW) contents for all phenolic extracts. The swelling rate for (U1-U3) in distilled water, the SGF, and the SIF was estimated. The maximum swelling was observed in copolymeric hydrogels at pH 6.9 in distilled water. The IC50 values of radical scavenging activity of the phenolic extracts 4, 8 and phenolic extract 4 released from copolymeric hydrogels (U1-U3) show varied significantly (P < 0.05). Our results indicated that Iraqi Coriandrum Sativum L. could constitute a rich and novel source of natural antioxidants. When it loaded on, copolymeric hydrogels could be used as a drug delivery system.

scholarly journals Formulation and Evaluation of Herbal Drug Loaded Self Nano Emulsifying Drug Delivery System (SNEDDS)

2018 ◽  
Vol 3 (2) ◽  
pp. 26-36
Author(s):  
Vishal N Kushare ◽  
Saravanan S
Keyword(s):  
Drug Delivery ◽  
Zeta Potential ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tween 80 ◽  
Water Soluble ◽  
Coriandrum Sativum ◽  
Polydispersity Index ◽  
Drug Dissolution ◽  
Reduced Pressure

The goal of this research was to formulate and test invitro the self-nano emulsifying drug delivery system (SNEDDS) of poorly water-soluble herbal material. Linalool, an essential of Coriandrum sativum with anti-epileptic activity, was isolated from Coriandrum sativum by using Soxhlet extraction method followed by column chromatography and fractionates are concentrated under reduced pressure by using rotary flash evaporator. It is low water soluble material; unpredictable dissolution and low bioavailability make it very difficult to administer linalool orally.The captex-200 oil was exhibited maximum solubility of linalool. Thus, it was chosen as the oil phase, while Tween 80 and PEG-200 were chosen as surfactant and co-surfactant respectively for the preparation of linalool SNEDDS. For the determination of existence zone of nanoemulsion, pseudo ternary phase diagram was developed using the Prism Software by using water titration method. Self-nanoemulsion are evaluated for scanning electron microscopy (SEM), particle size analysis, polydispersity index, zeta potential and invitro drug release.The s9 formulation showed 97.72% cumulative release higher than other selected formulations(S4-S8). The S9 formulation showed promising result on droplet size, zeta potential, polydispersity index, invitro drug dissolution. It was concluded that SNEDDS formation from captex-200, tween 80, PEG-200, Smix (4:1), is a promising approach to enhancing substance solubility and the pace of dissolution.

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug

Development and Evaluation of Floating Pulsatile Drug Delivery System Using Meloxicam

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
ShirishaG. Suddala ◽  
S. K. Sahoo ◽  
M. R. Yamsani
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Oral Dosage ◽  
Lag Phase ◽  
Pulsatile Drug Delivery

Objective: The objective of this research work was to develop and evaluate the floating– pulsatile drug delivery system (FPDDS) of meloxicam intended for Chrono pharmacotherapy of rheumatoid arthritis. Methods: The system consisting of drug containing core, coated with hydrophilic erodible polymer, which is responsible for a lag phase for pulsatile release, top cover buoyant layer was prepared with HPMC K4M and sodium bicarbonate, provides buoyancy to increase retention of the oral dosage form in the stomach. Meloxicam is a COX-2 inhibitor used to treat joint diseases such as osteoarthritis and rheumatoid arthritis. For rheumatoid arthritis Chrono pharmacotherapy has been recommended to ensure that the highest blood levels of the drug coincide with peak pain and stiffness. Result and discussion: The prepared tablets were characterized and found to exhibit satisfactory physico-chemical characteristics. Hence, the main objective of present work is to formulate FPDDS of meloxicam in order to achieve drug release after pre-determined lag phase. Developed formulations were evaluated for in vitro drug release studies, water uptake and erosion studies, floating behaviour and in vivo radiology studies. Results showed that a certain lag time before drug release which was due to the erosion of the hydrophilic erodible polymer. The lag time clearly depends on the type and amount of hydrophilic polymer which was applied on the inner cores. Floating time and floating lag time was controlled by quantity and composition of buoyant layer. In vivo radiology studies point out the capability of the system of longer residence time of the tablets in the gastric region and releasing the drug after a programmed lag time. Conclusion: The optimized formulation of the developed system provided a lag phase while showing the gastroretension followed by pulsatile drug release that would be beneficial for chronotherapy of rheumatoid arthritis and osteoarthritis.

Validation of A Simple HPLC-UV Method For the Quantification of Andrographolide in Self-Nano Emulsifying Drug Delivery System (Snedds) For Dissolution Study

2017 ◽  
Vol 7 (04) ◽  
Author(s):  
Syukri Y ◽  
Afetma D. W. ◽  
Sirin M. ◽  
Fajri R. ◽  
Ningrum A. D. K. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gastric Fluid ◽  
Hplc Method ◽  
Good Precision ◽  
Intestinal Fluid ◽  
Dissolution Medium ◽  
Relative Standard ◽  
Sufficient Precision

This research aim to validation of a simple, rapid and accurate HPLC-UV method for the quantification of andrographolide isolated from Andrographis paniculata Ness in Self Nano Emulsifying Drug Delivery System (SNEDDS) formulation during the dissolution test. The assay was performed using a XTerra® MS C18 column (150 mm X 4.6 mm, five μm) with a mobile phase of methanol and water (70: 30), at 0.8 mL/min flow rate and UV detection of 229 nm. Simulation gastric fluid (SGF) and intestinal fluid (SIF) were prepared as dissolution medium. The validation parameter was conducted including the test on linearity, precision, accuracy, LOD, and LOQ. The result showed an excellent linearity with r = 0.999 and good selectivity for both medium dissolution. The method showed sufficient precision, with a relative standard deviation (RSD) smaller than % Horwitz. The accuracy reported as % recovery was found to be 102.61 and 101.17 % in each SGF and SIF dissolution medium. LOD and LOQ were found 0.46 and 1.40 in SGF medium, 0.87 and 2.64 in SIF medium. In conclusion, the HPLC method developed showed specificity and selectivity with linearity in the working range, good precision and accuracy and suitable for quantification andrographolide in SNEDDS formulation.

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