Applicability of submerged jet model to describe the liquid sample load into measuring chamber of micron and submillimeter sizes

Seeing is believing, but only after the sample preparation technique has received a systematic study and a full record is made of the treatment the sample gets.For microstructured liquids and suspensions, fast-freeze thermal fixation and cold-stage microscopy is perhaps the least artifact-laden technique. In the double-film specimen preparation technique, a layer of liquid sample is trapped between 100- and 400-mesh polymer (polyimide, PI) coated grids. Blotting against filter paper drains excess liquid and provides a thin specimen, which is fast-frozen by plunging into liquid nitrogen. This frozen sandwich (Fig. 1) is mounted in a cooling holder and viewed in TEM.Though extremely promising for visualization of liquid microstructures, this double-film technique suffers from a) ireproducibility and nonuniformity of sample thickness, b) low yield of imageable grid squares and c) nonuniform spatial distribution of particulates, which results in fewer being imaged.

Download Full-text

Thermal bursting ionization for ambient mass spectrometry

RSC Advances ◽

10.1039/c5ra22626k ◽

2016 ◽

Vol 6 (3) ◽

pp. 2496-2499 ◽

Cited By ~ 4

Author(s):

Jiying Pei ◽

Kefu Yu ◽

Yinghui Wang

Keyword(s):

Mass Spectrometry ◽

Ambient Ionization ◽

Ambient Mass Spectrometry ◽

Sample Analysis ◽

Liquid Sample ◽

Ionization Source ◽

Complex Liquid

Ambient ionization source, thermal bursting ionization (TBI), was characterized for complex liquid sample analysis with mass spectrometry.

Download Full-text

Biosensing Near the Exceptional Point Based on Resonant Optical Tunneling Effect

Micromachines ◽

10.3390/mi12040426 ◽

2021 ◽

Vol 12 (4) ◽

pp. 426

Author(s):

Yang Liu ◽

Pengyun Yan ◽

Feng Liu ◽

Aoqun Jian ◽

Shengbo Sang

Keyword(s):

Exceptional Point ◽

Tunneling Effect ◽

Coupled Mode Theory ◽

Environment Protection ◽

Label Free ◽

Liquid Sample ◽

Water Safety ◽

Coupled Mode ◽

Drinking Water Safety ◽

Optical Tunneling

Inspired by exceptional point (EP) sensing in non-Hermitian systems, in this work, a label-free biosensor for detecting low-concentration analytes is proposed, via a special multilayer structure: a resonant optical tunneling resonator. Due to the square root topology near the exceptional point, a recognized target analyte perturbs the system deviated from the exceptional point, leading to resolvable modes splitting in the transmission spectrum. The performance of the designed sensor is analyzed by the coupled-mode theory and transfer matrix method, separately. Here, the simulation results demonstrate that the obtained sensitivity is 17,120 nm/imaginary part unit of refractive index (IP) and the theoretical detection limit is 4.2 × 10−8 IP (regarding carcinoembryonic antigen (CEA), the minimum detection value is 1.78 ng). Instead of the typical diffusion manner, the liquid sample is loaded by convection, which can considerably improve the efficiency of sample capture and shorten the response time of the sensor. The sketched sensor may find potential application in the fields of biomedical detection, environment protection, and drinking water safety.

Download Full-text

Nanomechanical Molecular Mass Sensing Using Suspended Microchannel Resonators

Sensors ◽

10.3390/s21103337 ◽

2021 ◽

Vol 21 (10) ◽

pp. 3337

Author(s):

Alberto Martín-Pérez ◽

Daniel Ramos ◽

Javier Tamayo ◽

Montserrat Calleja

Keyword(s):

Molecular Mass ◽

Mass Density ◽

Applied Pressure ◽

Atomic Mass ◽

Liquid Sample ◽

Mass Sensing ◽

Average Molecular Mass ◽

Fluid Properties ◽

Molecular Masses ◽

Microchannel Resonators

In this work we study the different phenomena taking place when a hydrostatic pressure is applied in the inner fluid of a suspended microchannel resonator. Additionally to pressure-induced stiffness terms, we have theoretically predicted and experimentally demonstrated that the pressure also induces mass effects which depend on both the applied pressure and the fluid properties. We have used these phenomena to characterize the frequency response of the device as a function of the fluid compressibility and molecular masses of different fluids ranging from liquids to gases. The proposed device in this work can measure the mass density of an unknown liquid sample with a resolution of 0.7 µg/mL and perform gas mixtures characterization by measuring its average molecular mass with a resolution of 0.01 atomic mass units.

Download Full-text

Analysis of the Focusing Ion Beam Microscope Ion Mirror Method for Studying Influence of the Measuring Chamber

Journal of Physics Conference Series ◽

10.1088/1742-6596/1963/1/012147 ◽

2021 ◽

Vol 1963 (1) ◽

pp. 012147

Author(s):

Luna Basil Hazime ◽

Zoory Muayyed Jabar

Keyword(s):

Ion Beam ◽

Measuring Chamber ◽

Ion Mirror

Download Full-text

Time-resolved PIV measurements of a deflected submerged jet interacting with liquid-gas and liquid-liquid interfaces

Experimental and Computational Multiphase Flow ◽

10.1007/s42757-020-0103-1 ◽

2021 ◽

Author(s):

Stefan Puttinger ◽

Mahdi Saeedipour

Keyword(s):

Liquid Layer ◽

Large Scale ◽

Free Surface Flow ◽

Industrial Applications ◽

Liquid Pool ◽

Surface Flow ◽

Two Phase ◽

Time Resolved ◽

Submerged Jet ◽

Major Interest

AbstractThis paper presents an experimental investigation on the interactions of a deflected submerged jet into a liquid pool with its above interface in the absence and presence of an additional lighter liquid. Whereas the former is a free surface flow, the latter mimics a situation of two stratified liquids where the liquid-liquid interface is disturbed by large-scale motions in the liquid pool. Such configurations are encountered in various industrial applications and, in most cases, it is of major interest to avoid the entrainment of droplets from the lighter liquid into the main flow. Therefore, it is important to understand the fluid dynamics in such configurations and to analyze the differences between the cases with and without the additional liquid layer. To study this problem, we applied time-resolved particle image velocimetry experiments with high spatial resolution. A detailed data analysis of a small layer beneath the interface shows that although the presence of an additional liquid layer stabilizes the oscillations of the submerged jet significantly, the amount of kinetic energy, enstrophy, and velocity fluctuations concentrated in the proximity of the interface is higher when the oil layer is present. In addition, we analyze the energy distribution across the eigenmodes of a proper orthogonal distribution and the distribution of strain and vortex dominated regions. As the main objective of this study, these high-resolution time-resolved experimental data provide a validation platform for the development of new models in the context of the volume of fluid-based large eddy simulation of turbulent two-phase flows.

Download Full-text