A Flexible, and Wireless LED Therapy Patch for Skin Wound Photomedicine with IoT-Connected Healthcare Application

Author(s):  
Duc Tri Phan ◽  
Sudip Mondal ◽  
Le Hai Tran ◽  
Thi Mai Thien Vo ◽  
Van Hieu Nguyen ◽  
...  
2016 ◽  
Vol 31 (7) ◽  
pp. 1521-1526 ◽  
Author(s):  
Marcus Vinícius de Matos Gomes ◽  
Marcelo Henrique Manfredo ◽  
Leandro Vaz Toffoli ◽  
Daniellen Christine Castro-Alves ◽  
Lucas Magnoni do Nascimento ◽  
...  

2019 ◽  
Vol 20 (15) ◽  
pp. 3679 ◽  
Author(s):  
Lin Chen ◽  
Alyne Simões ◽  
Zujian Chen ◽  
Yan Zhao ◽  
Xinming Wu ◽  
...  

Wounds within the oral mucosa are known to heal more rapidly than skin wounds. Recent studies suggest that differences in the microRNAome profiles may underlie the exceptional healing that occurs in oral mucosa. Here, we test whether skin wound-healing can be accelerating by increasing the levels of oral mucosa-specific microRNAs. A panel of 57 differentially expressed high expresser microRNAs were identified based on our previously published miR-seq dataset of paired skin and oral mucosal wound-healing [Sci. Rep. (2019) 9:7160]. These microRNAs were further grouped into 5 clusters based on their expression patterns, and their differential expression was confirmed by TaqMan-based quantification of LCM-captured epithelial cells from the wound edges. Of these 5 clusters, Cluster IV (consisting of 8 microRNAs, including miR-31) is most intriguing due to its tissue-specific expression pattern and temporal changes during wound-healing. The in vitro functional assays show that ectopic transfection of miR-31 consistently enhanced keratinocyte proliferation and migration. In vivo, miR-31 mimic treatment led to a statistically significant acceleration of wound closure. Our results demonstrate that wound-healing can be enhanced in skin through the overexpression of microRNAs that are highly expressed in the privileged healing response of the oral mucosa.


Author(s):  
Lamya Alkhariji ◽  
Nada Alhirabi ◽  
Mansour Naser Alraja ◽  
Mahmoud Barhamgi ◽  
Omer Rana ◽  
...  

Privacy by Design (PbD) is the most common approach followed by software developers who aim to reduce risks within their application designs, yet it remains commonplace for developers to retain little conceptual understanding of what is meant by privacy. A vision is to develop an intelligent privacy assistant to whom developers can easily ask questions to learn how to incorporate different privacy-preserving ideas into their IoT application designs. This article lays the foundations toward developing such a privacy assistant by synthesising existing PbD knowledge to elicit requirements. It is believed that such a privacy assistant should not just prescribe a list of privacy-preserving ideas that developers should incorporate into their design. Instead, it should explain how each prescribed idea helps to protect privacy in a given application design context—this approach is defined as “Explainable Privacy.” A total of 74 privacy patterns were analysed and reviewed using ten different PbD schemes to understand how each privacy pattern is built and how each helps to ensure privacy. Due to page limitations, we have presented a detailed analysis in Reference [3]. In addition, different real-world Internet of Things (IoT) use-cases, including a healthcare application, were used to demonstrate how each privacy pattern could be applied to a given application design. By doing so, several knowledge engineering requirements were identified that need to be considered when developing a privacy assistant. It was also found that, when compared to other IoT application domains, privacy patterns can significantly benefit healthcare applications. In conclusion, this article identifies the research challenges that must be addressed if one wishes to construct an intelligent privacy assistant that can truly augment software developers’ capabilities at the design phase.


2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
S Bhattacharya ◽  
J Jegadeeson ◽  
J Ramsingh ◽  
P Truran

Abstract Introduction Post-operative haemorrhage is a rare but potentially life-threatening complication of thyroid surgery and occurs in 1 in 100 patients. Our aim was to assess current levels of awareness of post-operative haemorrhage in the surgical department and to improve confidence in managing this. Method Questionnaires with a combination of clinical questions were distributed amongst nurses, foundation doctors, senior house officers and registrars in the surgical department. Results There was a clear gap in awareness in all grades. The British Association of Endocrine and Thyroid surgeons (BAETS) have guidance on the management of these patients and in particular the acronym SCOOP (Steristrips removed, Cut subcuticular sutures, Open skin wound, Open strap muscles, Pack wound). 18/24 of participants had not heard of the SCOOP protocol. Most nurses (6/12) all junior doctors (8/8) showed lack of confidence in managing patients with suspected bleeding. Conclusions An informative poster was created for relevant clinical areas as per the BAETS recommendation. These posters outlined the steps in the SCOOP acronymas well as the main clinical signs of haemorrhage. BAETS recommend that all first responders, including nursing staff, junior doctors and the crash team should be aware of the SCOOP protocol. Simulation training sessions are in progress for these members of staff.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jian Zhang ◽  
Yongjun Zheng ◽  
Jimmy Lee ◽  
Jieyu Hua ◽  
Shilong Li ◽  
...  

AbstractEffective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-β (TGFβ) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGFβ signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGFβ can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for skin wounds. The material enhances skin wound closure while effectively suppressing scar formation in murine skin wounds and large animal preclinical models. Our study presents a strategy for scarless wound repair.


Author(s):  
Parisa Heydari ◽  
Mahshid Kharaziha ◽  
Jaleh Varshosaz ◽  
Shaghayegh Haghjooy Javanmard

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