scholarly journals Dichotomous roles of leptin and adiponectin as enforcers against lipotoxicity during feast and famine

2013 ◽  
Vol 24 (19) ◽  
pp. 3011-3015 ◽  
Author(s):  
Roger H. Unger ◽  
Philipp E. Scherer ◽  
William L. Holland
Keyword(s):  
General Idea ◽  
Fibroblast Growth Factor 21 ◽  
Energy Reserves ◽  
The Past ◽  
Efficient Storage ◽  
Obesity And Diabetes ◽  
Integral Role ◽  
Term Energy ◽  
Local Accumulation

Science is marked by the death of dogmas; the discovery that adipocytes are more than just lipid-storing cells but rather produce potent hormones is one such example that caught physiologists by surprise and reshaped our views of metabolism. While we once considered the adipocyte as a passive storage organ for efficient storage of long-term energy reserves in the form of triglyceride, we now appreciate the general idea (once a radical one) that adipocytes are sophisticated enough to have potent endocrine functions. Over the past two decades, the discoveries of these adipose-derived factors (“adipokines”) and their mechanistic actions have left us marveling at and struggling to understand the role these factors serve in physiology and the pathophysiology of obesity and diabetes. These hormones may serve an integral role in protecting nonadipose tissues from lipid-induced damage during nutrient-deprived or replete states. As such, adipocytes deliver not only potentially cytotoxic free fatty acids but, along with these lipids, antilipotoxic adipokines such as leptin, adiponectin, and fibroblast growth factor 21 that potently eliminate excessive local accumulation of these lipids or their conversion to unfavorable sphingolipid intermediates.

World energy: Myths of the past and lessons of the future

2018 ◽  
pp. 49-75
Author(s):  
I. A. Bashmakov
Keyword(s):  
Energy Development ◽  
Small Scale ◽  
Low Carbon ◽  
The Past ◽  
World Energy ◽  
The Future ◽  
Term Energy ◽  
Recent Trends ◽  
Effective Development

The analysis of recent trends in the world energy development and of long-term energy development projections helps dispel 10 myths that have been viewed as copybook maxims, yet now are a barrier to forming an adequate vision of the future and effective development strategies. Many of these myths are rooted in the inability to see how the ‘small on small scale’ becomes ‘big on big scale’ , and vice versa. Projection horizon to 2050 allows to see these metamorphoses, formulate the ‘lessons of the future’ for Russia’s economic development, and to show why Russia needs to change its economic model and switch to low-carbon development path.

Long-term energy deficiency in mice induces bone alterations reversed by long-term recovery

2013 ◽  
Author(s):  
Sara Zgheib ◽  
Stephanie Lucas ◽  
Mathieu Mequinion ◽  
Odile Broux ◽  
Damien Leterme ◽  
...  
Keyword(s):  
Energy Deficiency ◽  
Term Energy

Enabling Community Well-being Self-Monitoring in the Context of Mining: The Naskapi Nation of Kawawachikamach

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Robert Klinck ◽  
Ben Bradshaw ◽  
Ruby Sandy ◽  
Silas Nabinacaboo ◽  
Mannie Mameanskum ◽  
...  
Keyword(s):  
Indigenous Peoples ◽  
Well Being ◽  
Aboriginal Community ◽  
Self Monitoring ◽  
Community Engaged Research ◽  
The Past ◽  
Mineral Development ◽  
Iron Deposits ◽  
Term Monitoring

The Naskapi Nation of Kawawachikamach is an Aboriginal community located in northern Quebec near the Labrador Border. Given the region’s rich iron deposits, the Naskapi Nation has considerable experience with major mineral development, first in the 1950s to the 1980s, and again in the past decade as companies implement plans for further extraction. This has raised concerns regarding a range of environmental and socio-economic impacts that may be caused by renewed development. These concerns have led to an interest among the Naskapi to develop a means to track community well-being over time using indicators of their own design. Exemplifying community-engaged research, this paper describes the beginning development of such a tool in fall 2012—the creation of a baseline of community well-being against which mining-induced change can be identified. Its development owes much to the remarkable and sustained contribution of many key members of the Naskapi Nation. If on-going surveying is completed based on the chosen indicators, the Nation will be better positioned to recognize shifts in its well-being and to communicate these shifts to its partners. In addition, long-term monitoring will allow the Naskapi Nation to contribute to more universal understanding of the impacts of mining for Indigenous peoples.

Humus state of chernozem at different ways of tillage in the agrosystems of the left-bank forest steppe of Ukraine

2015 ◽  
Vol 2 (3) ◽  
pp. 61-77
Author(s):  
O. Demydenko ◽  
V. Velychko
Keyword(s):  
Soil Cover ◽  
Forest Steppe ◽  
Left Bank ◽  
Energy Reserves ◽  
Soil Resources ◽  
Global Soil ◽  
Humus Accumulation ◽  
By Products ◽  
The Way

The contemporary condition of soil cover in Ukraine is characterized. The attention is focused onto widespread degradation processes in soils. The causes that determine the development of these negative processes are considered. The contemporary informational support for the condition of soil cover in Ukraine is estimated. In general, the current available information is of narrow-departmental nature, obtained by different methods and non-correlated monitoring programs. As a rule, it is stored in under-structured databases, incompatible with other information systems; mainly recorded on paper media unusable with modern technologies, whereby such information resources are diffi cult to be compiled together. These disadvantages are strong constraints against consistent usage of materials for evaluation, forecast and management of changes in the soil cover. The Soil Observation program should thereby be combined with Agrochemical Passportization and ecology-ameliora- tive monitoring; in other words, the application of innovative soil-agrochemical methodology is considered. Each individual type of surveys shall complement the others, and taken altogether, they shall constitute a con- sistent Information System, capable of solving the problems of assessing the condition, forecasting, manage- ment, usage and protection of soil resources. The monitoring procedures should be conducted on the basis of a new soil concept in line with unifi ed programs and methods, so as to meet European approaches to the maxi- mum extent. Such a technical composition enables getting information on present-day processes in soils, and is the only combination that actually helps us to “ecologize” our knowledge of soils, which is the leading trend in the scope of global soil-science. Thus obtained results will serve as a State-owned tool which would subse- quently facilitate the use and protection of soil resources all over the country, to be involved in a united global soil-information scope. The attention is focused onto social signifi cance of the information on soils and their fertility in terms of land resources optimization, as well as the formation of sustainable land use in Ukraine. Aim. To demonstrate the long-term effect of different ways of tillage of typical low-humus chernozem on the change in humus content and composition and the direction of transformation processes of organic fertili- zers. To study the changes in the structure of energy reserves in group and fractional composition of humus in typical low-humus light-loamy chernozem of the Forest-Steppe of Ukraine. Methods. Field, laboratory, microbiological, computational, mathematical and statistical. Results. It was determined that in conditions of long-term subsurface tillage the most effi cient humus accumulation occurs in the 0–20 cm layer of chernozem with simultaneous increase in its content in the lower part of the processed layer without any accumulation differentiation. Surface tillage leads to expressed differentiation in humus accumulation in the 0–20 cm layer of soil (0.005 % per year). When 6 t/ha of humus are replaced by 7 t/ha of by-products the intensity of humus accumulation is decreasing regardless of the way of tillage, but humus accumulation was found to be the most effi cient for subsurface tillage. The application of subsurface tillage leads to the increase in the ratio of C HA : C FA , which is conditioned by the increase in the humifi cation of plant remains of by-products in the 0−20 cm layer of soil by 110–112 % – for subsurface tillage, and by 105 % – for surface tillage. Conclusions. It was established that systematic subsurface tillage of typical chernozem of the Left-Bank Forest-Steppe of Ukraine leads to the structuring both of the total reserves of energy С org , and its quality content, aimed at the increase in the intensity of the processes of humifi cation and accumulation of organic carbon, and the decrease in miner- alization. The ratio of energy reserves С org of humic acids to fulvic acids in the 0−30 cm layer of chernozem is 1.85−1.87 regardless of the way of tillage, which testifi es to the repeatability of humus accumulation, but the total reserves of energy С org was higher for subsurface tillage (+ 31 Teracalorie/ha) compared to deep plough- ing. As for the surface tillage, the energy enrichment was at the level of deep ploughing.

Courting the Youth Vote in 2008: The Obama Effect

2009 ◽  
Vol 5 ◽  
Author(s):  
Lindsey C Bohl
Keyword(s):  
Presidential Elections ◽  
Voter Registration ◽  
The Internet ◽  
The Past ◽  
Several Variables ◽  
High Turnout ◽  
Short And Long Term ◽  
Use Of The Internet ◽  
Youth Vote

This paper examines a few of the numerous factors that may have led to increased youth turnout in 2008 Election. First, theories of voter behavior and turnout are related to courting the youth vote. Several variables that are perceived to affect youth turnout such as party polarization, perceived candidate difference, voter registration, effective campaigning and mobilization, and use of the Internet, are examined. Over the past 40 years, presidential elections have failed to engage the majority of young citizens (ages 18-29) to the point that they became inclined to participate. This trend began to reverse starting in 2000 Election and the youth turnout reached its peak in 2008. While both short and long-term factors played a significant role in recent elections, high turnout among youth voters in 2008 can be largely attributed to the Obama candidacy and campaign, which mobilized young citizens in unprecedented ways.

FEATURES OF MONITORING OF DEGRADED LANDS TO ASSESS POSSIBILITIES FOR THEIR REHABILITATION

2020 ◽  
pp. 37-43
Author(s):  
B.I. KORZHENEVSKIY ◽  
◽  
N.V. KOLOMIYTSEV ◽  
G.YU. TOLKACHEV
Keyword(s):  
Agricultural Land ◽  
Meteorological Data ◽  
Morphological Characteristics ◽  
Energy Reserves ◽  
Land Restoration ◽  
Degraded Land ◽  
Degraded Lands ◽  
The Past ◽  
Unused Land ◽  
Restoration Work

Putting out of using large areas of agricultural lands in the central region over the past years has led to worsening the prospects of their purposed use, although the problem of the relevance of their restoration still remains. For many years the unused land was exposed to both natural exogenous processes such as erosion, suffusion, etc. and biological and chemical changes, usually for the worse for agriculture. There are considered elements of monitoring aimed at assessing the prospects or lack of perspectives of rehabilitation of degraded lands. An energy approach to assessing the state of slopes and soils located within these slopes is presented. The main factors of natural and anthropogenic character in assessing the prospects for land restoration are their steepness, excess relative to local bases of erosion other morphological characteristics of slopes which in general is reduced to an assessment of the energy provision of slopes and soils. So the higher the energy capacity of slopes – they are less promising for development, for soils – there is a reverse picture – the higher their energy reserves, the more promising is their use. Approaches to zoning the territory for monitoring from larger taxons of natural and anthropogenic genesis to the sites of special surveillance within which the prospects for rehabilitation of the agricultural land are evaluated. The most important factor is the material expediency of such actions, i.e. before starting the restoration work it is necessary to assess the profitability or loss of the proposed event. In cases of the material expediency it is feasible as further actions to include energy assessments of slopes and soils; zoning of the object according to the steepness and oriented characteristics of soil washout; and the possibility of obtaining agronomic and meteorological data on a timely basis. The result of the work is a forecast assessment of the prospects for restoring degraded land for the intended purpose using modern databases and WEB-systems.

Impact of FII’s and FDI’s on Indian Stock Market

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Dr. Kamlesh Kumar Shukla
Keyword(s):  
Stock Market ◽  
Financial Markets ◽  
Global Economy ◽  
Short Term ◽  
Earnings Growth ◽  
The Past ◽  
Bull Market ◽  
Indian Stock Market

FIIs are companies registered outside India. In the past four years there has been more than $41 trillion worth of FII funds invested in India. This has been one of the major reasons on the bull market witnessing unprecedented growth with the BSE Sensex rising 221% in absolute terms in this span. The present downfall of the market too is influenced as these FIIs are taking out some of their invested money. Though there is a lot of value in this market and fundamentally there is a lot of upside in it. For long-term value investors, there’s little because for worry but short term traders are adversely getting affected by the role of FIIs are playing at the present. Investors should not panic and should remain invested in sectors where underlying earnings growth has little to do with financial markets or global economy.

Chinese Medicine Protein and Peptide in Gene and Cell Therapy

2019 ◽  
Vol 20 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Yinlu Feng ◽  
Zifei Yin ◽  
Daniel Zhang ◽  
Arun Srivastava ◽  
Chen Ling
Keyword(s):  
Chinese Medicine ◽  
Cell Therapy ◽  
Future Research ◽  
The Past ◽  
Promising Strategy ◽  
Wide Range ◽  
New Directions ◽  
Gene And Cell Therapy ◽  
Proteins And Peptides

The success of gene and cell therapy in clinic during the past two decades as well as our expanding ability to manipulate these biomaterials are leading to new therapeutic options for a wide range of inherited and acquired diseases. Combining conventional therapies with this emerging field is a promising strategy to treat those previously-thought untreatable diseases. Traditional Chinese medicine (TCM) has evolved for thousands of years in China and still plays an important role in human health. As part of the active ingredients of TCM, proteins and peptides have attracted long-term enthusiasm of researchers. More recently, they have been utilized in gene and cell therapy, resulting in promising novel strategies to treat both cancer and non-cancer diseases. This manuscript presents a critical review on this field, accompanied with perspectives on the challenges and new directions for future research in this emerging frontier.

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