scholarly journals Support for a career in science

2021 ◽  
Vol 32 (22) ◽  
Author(s):  
Sandra L. Wolin
Keyword(s):  
Graduate Student ◽  
Cell Biology ◽  
Senior Leadership ◽  
American Society ◽  
To Receive ◽  
Leadership Award

I am so very honored to receive the Women in Cell Biology Sandra K. Masur Senior Leadership Award from the American Society for Cell Biology (ASCB), particularly because many of the previous awardees have served as mentors and sources of inspiration throughout my own career. I also thank the ASCB for always striving to be maximally inclusive, in terms of both the scientists it supports and its broad vision of what constitutes cell biology. As a graduate student I gave one of my first talks at an ASCB meeting, and I am proud to have been an ASCB member for almost 30 years. In this essay, I describe my own career to illustrate the support that I believe is needed to achieve a career in science.

scholarly journals Basic Science and The NIH

1994 ◽  
Vol 5 (3) ◽  
pp. 267-272 ◽  
Author(s):  
Harold Varmus
Keyword(s):  
Public Policy ◽  
New Orleans ◽  
Annual Meeting ◽  
Basic Science ◽  
Cell Biology ◽  
National Institutes Of Health ◽  
Keynote Speech ◽  
American Society

The following is an edited version of the Keynote Speech delivered at the Annual Meeting of the American Society for Cell Biology by Harold Varmus, Director of the National Institutes of Health. The address, entitled Basic Science and the NIH, was given at the opening of the meeting in New Orleans on December 11, 1993. It was Varmus' first public policy talk as NIH Director.

Adding a Low Dose of Fentanyl to Propofol in Patients Receiving Electroconvulsive Therapy: A Randomized Controlled Trial

2021 ◽  
Vol 104 (10) ◽  
pp. 1692-1697
Keyword(s):  
Blood Pressure ◽  
Electroconvulsive Therapy ◽  
Low Dose ◽  
Controlled Trial ◽  
Optimal Dose ◽  
Hemodynamic Response ◽  
Mean Difference ◽  
Seizure Duration ◽  
American Society ◽  
To Receive

Objective: To evaluate the effects of low-dose fentanyl combined with a reduced dose of propofol on seizure duration and hemodynamic response during electroconvulsive therapy (ECT). Materials and Methods: Twenty-two patients with the American Society of Anesthesiologist Physical Status II to III undergoing ECT were enrolled in the present study. One hundred and five bilateral ECT sessions randomized to receive thiopental 2 mg/kg, propofol 1 mg/kg, and fentanyl 0.3 mcg/kg, followed by propofol 0.5 mg/kg. Succinylcholine 0.5 mg/kg was used for muscle paralysis. Seizure duration, awakening time and hemodynamic changes were compared between groups. Results: One hundred and five bilateral ECT treatments were randomized into thiopental group (n=35), propofol group (n=35), and fentanyl plus propofol group (n=35). The thiopental and fentanyl plus propofol groups had longer EEG and motor seizure durations than the propofol group, but the differences were not statistically significant. There was no difference in stimulus intensity across groups. However, fentanyl plus propofol group had statistically significant prolonged awakening time compare with thiopental group [mean difference 2.71, (95% CI 0.37 to 5.06, p=0.019)] and propofol group (mean difference 2.77, 95% CI 0.42 to 5.12, p=0.016). Only systolic blood pressure in propofol group was significantly lower than thiopental group [mean difference –10.4, (95% CI –19.4 to –1.38, p=0.018)]. There were no significant differences in diastolic blood pressure (df=2, F=2.546, p=0.083), heart rate (df=2, F=0.596, p=0.553), or oxygen saturation across group (df=2, F=2.914, p=0.059). Conclusion: Using a combination of low-dose fentanyl and low-dose propofol during ECT could be beneficial. Further investigation is needed to establish the optimal dose of propofol and fentanyl. Keywords: Electroconvulsive therapy; Fentanyl, Hemodynamic response; Propofol; Thiopental; Seizure duration

scholarly journals Clinical benefits of preemptive oral clonidine versus oral tramadol for abdominal hysterectomy conducted under subarachnoid block with 0.5% hyperbaric bupivacaine: a comparative evaluation

2017 ◽  
Vol 5 (7) ◽  
pp. 3129
Author(s):  
Kumkum Gupta ◽  
Swati Sharma ◽  
Prashant K. Gupta ◽  
Guljeet Kaur ◽  
Vasundra Tyagi ◽  
...  
Keyword(s):  
Muscle Relaxation ◽  
Abdominal Hysterectomy ◽  
Hyperbaric Bupivacaine ◽  
Subarachnoid Block ◽  
Oral Clonidine ◽  
Significant Difference ◽  
Clinical Benefits ◽  
Intraoperative Period ◽  
American Society ◽  
To Receive

Background: Neuraxial techniques possess many benefits for elective abdominal hysterectomy due to profound surgical anesthesia and muscle relaxation. The present study was aimed to compare the clinical benefits of pre-emptive oral clonidine with oral tramadol for abdominal hysterectomy conducted under subarachnoid block with 0.5% hyperbaric bupivacaine.Methods: Sixty adult female patients of American Society of Anaesthesiologists (ASA) physical status I and II, aged 42 to 65 years, were randomized into two groups of 30 patients each to receive either oral clonidine, 100 µg (Group C) or oral tramadol 50 mg tramadol (Group T), 90 min before initiation of subarachnoid block with 3.5 mL of 0.5% hyperbaric bupivacaine. Intraoperative hemodynamic changes, duration of analgesia and incidence of shivering were recorded as primary end points. Drug related effects of pruritus, sedation, nausea, vomiting, and respiratory depression were recorded as secondary outcomes.Results: The onset of sensory and motor block was comparable between the groups but the time to two dermatome regression were prolonged in patients of Group C with statistical significant difference (p=0.05). Duration of analgesia was also enhanced in patients of Group C (268.27±12.18 min versus 223.15±14.31 min in Group T) with statistically highly significant difference (p=0.000). The incidence of shivering was lower in the patients of clonidine group. The heart rate was lower in patients of clonidine throughout intraoperative period and no incidence of bradycardia, hypotension or sedation occurred in any patient.Conclusions: Both drugs showed clinical benefits as pre-emptive oral medication for abdominal hysterectomy conducted under subarachnoid block but oral clonidine (100 µg) proved to be more beneficial.

Epidural Neostigmine versus Fentanyl to Decrease Bupivacaine Use in Patient-controlled Epidural Analgesia during Labor

2017 ◽  
Vol 127 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Jessica L. Booth ◽  
Vernon H. Ross ◽  
Kenneth E. Nelson ◽  
Lynnette Harris ◽  
James C. Eisenach ◽  
...  
Keyword(s):  
Epidural Analgesia ◽  
Local Anesthetic ◽  
Primary Outcome ◽  
A Priori ◽  
Regulatory Compliance ◽  
Epidural Bupivacaine ◽  
American Society ◽  
American Society Of Anesthesiologists ◽  
Labor Epidural ◽  
To Receive

Abstract Background The addition of opioids to epidural local anesthetic reduces local anesthetic consumption by 20% but at the expense of side effects and time spent for regulatory compliance paperwork. Epidural neostigmine also reduces local anesthetic use. The authors hypothesized that epidural bupivacaine with neostigmine would decrease total hourly bupivacaine use compared with epidural bupivacaine with fentanyl for patient-controlled epidural analgesia. Methods A total of 215 American Society of Anesthesiologists physical status II, laboring parturients requesting labor epidural analgesia consented to the study and were randomized to receive 0.125% bupivacaine with the addition of either fentanyl (2 μg/ml) or neostigmine (2, 4, or 8 μg/ml). The primary outcome was total hourly local anesthetic consumption, defined as total patient-controlled epidural analgesia use and top-ups (expressed as milliliters of 0.125% bupivacaine) divided by the infusion duration. A priori analysis determined a group size of 35 was needed to have 80% power at α = 0.05 to detect a 20% difference in the primary outcome. Results Of 215 subjects consented, 151 patients were evaluable. Demographics, maternal and fetal outcomes, and labor characteristics were similar among groups. Total hourly local anesthetic consumption did not differ among groups (P = 0.55). The total median hourly bupivacaine consumption in the fentanyl group was 16.0 ml/h compared with 15.3, 14.6, and 16.2 ml/h in the 2, 4, and 8 μg/ml neostigmine groups, respectively (P = 0.55). Conclusions The data do not support any difference in bupivacaine requirements for labor patient-controlled epidural analgesia whether patients receive epidural bupivacaine with 2 to 8 μg/ml neostigmine or epidural bupivacaine with 2 μg/ml fentanyl.

scholarly journals Establishing an academic laboratory: mentoring as a business model

2014 ◽  
Vol 25 (21) ◽  
pp. 3251-3253 ◽  
Author(s):  
Valentina Greco
Keyword(s):  
Business Model ◽  
Cell Biology ◽  
Critical Components ◽  
Academic Laboratory ◽  
To Receive

It is a tremendous honor for my group and me to receive the recognition of the 2014 Women in Cell Biology Junior Award. I would like to take the opportunity of this essay to describe my scientific journey, discuss my philosophy about running a group, and propose what I think is a generalizable model to efficiently establish an academic laboratory. This essay is about my view on the critical components that go into establishing a highly functional academic laboratory during the current tough, competitive times.

Reflections on race, ethnicity, and NIH research awards

2022 ◽  
Vol 33 (1) ◽  
Author(s):  
Donna K. Ginther
Keyword(s):  
Public Service ◽  
Cell Biology ◽  
Ethnic Disparities ◽  
Important Work ◽  
Professional Networks ◽  
Service Award ◽  
Race Ethnicity ◽  
American Society ◽  
Nih Funding

It has been a decade since “Race, Ethnicity, and NIH Research Awards” was published. Receiving the American Society for Cell Biology Public Service Award allows me to reflect on this research and its impact. In this essay, I share the story of how my research interests and professional networks provided the opportunity to do this important work. I also make the case for improved data and mentoring to address race and ethnic disparities in NIH funding.

scholarly journals Declaración de San Francisco de Evaluación de la Investigación DORA. Poniendo ciencia en la evaluación de la investigación

2020 ◽  
Vol 25 ◽  
pp. 279-283
Author(s):  
Eva Aladro Vico
Keyword(s):  
San Francisco ◽  
Cell Biology ◽  
La Réunion ◽  
American Society

Este texto es la célebre Declaración sobre la Evaluación de la Investigación firmada en San Francisco, desarrollada por un grupo de editores de revistas académicas durante la Reunión anual de la American Society for Cell Biology(ASCB) en San Francisco, California, el 16 de diciembre de 2012. Este grupo desarrolló una serie de recomendaciones, conocidas como la Declaración de San Francisco sobre la Evaluación de la Investigación. La declaración DORA, que pide una serie de cambios fundamentales en el modo como se evalúa y se publica la ciencia y el conocimiento, ha sido asumida y respaldada por la inmensa mayoría de las publicaciones científicas en abierto, y buena parte de las cabeceras más prestigiosas de todos los ámbitos del conocimiento. En ella se acusa a los sistemas de evaluación e indexación de sesos debidos al interés comercial minoritario, y por ello, de perjuicio grave al avance de la investigación en todos los sectores. La Declaración recomienda una serie de actuaciones para preservar la difusión del avance investigador de la trama de intereses y distorsiones que hoy la amenazan.

scholarly journals The day the residents left: lessons learnt from COVID-19 for ambulatory clinics

2020 ◽  
Vol 8 (3) ◽  
pp. e000513
Author(s):  
Benjamin R Doolittle ◽  
Bradley Richards ◽  
Amerisa Tarabar ◽  
Matthew Ellman ◽  
Daniel Tobin
Keyword(s):  
Medical Students ◽  
Patient Care ◽  
Social Isolation ◽  
Video Conferencing ◽  
Senior Leadership ◽  
Key Stakeholders ◽  
Vulnerable Patients ◽  
Hospitalised Patients ◽  
To Receive ◽  
Future Practice

As the COVID-19 pandemic began, the residents from our ambulatory clinics were pulled to cover the increasing numbers of hospitalised patients. To provide care for our 40 000 patients, without resident support, we needed to develop quickly a new culture of communication and innovation. We accomplished this by regular, transparent meetings with senior leadership and key stakeholders who were empowered to make rapid decisions. We then convened regular meetings with clinic leadership and frontline providers to receive feedback and implement new practices. These rapid meeting cycles allowed for a nimble response to a changing landscape. We optimised our video-conferencing and telehealth services, reached out to our most vulnerable patients and engaged other providers and medical students who were not engaged in patient care due to social isolation practices. We discuss the implications of these innovations on our future practice.

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