The Association Between Psychological Distress and Cancer Mortality in the United States: Results from the 1997–2014 NHIS-NDI Record Linkage Study

2021 ◽  
Author(s):  
Hyunjung Lee ◽  
Gopal K Singh
Keyword(s):  
Psychological Distress ◽  
Mortality Risk ◽  
Cancer Mortality ◽  
Well Being ◽  
The United States ◽  
Poverty Level ◽  
Adjusted Model ◽  
Distress Scale ◽  
Cancer Mortality Risk

Abstract Background/Purpose Psychological distress can influence cancer mortality through socioeconomic disadvantage, health-risk behaviors, or reduced access to care. These disadvantages can result in higher risks of cancer occurrence, a delayed cancer diagnosis, hamper adherence to treatment, and provoke inflammatory responses leading to cancer. Previous studies have linked psychological distress to cancer mortality. However, studies are lacking for the U.S. population. Methods This study examines the Kessler six-item psychological distress scale as a risk factor for U.S. cancer mortality using the pooled 1997–2014 data from the National Health Interview Survey (NHIS) linked to National Death Index (NDI) (N = 513,012). Cox proportional hazards regression was used to model survival time as a function of psychological distress and sociodemographic and behavioral covariates. Results In Cox models with 18 years of mortality follow-up, the cancer mortality risk was 80% higher (hazard ratio [HR] = 1.80; 95% CI = 1.64, 1.97) controlling for age; 61% higher (HR = 1.61; 95% CI = 1.46, 1.76) in the SES-adjusted model, and 33% higher (HR = 1.33; 95% CI = 1.21, 1.46) in the fully-adjusted model among adults with serious psychological distress (SPD), compared with adults without psychological distress. Males, non-Hispanic Whites, and adults with incomes at or above 400% of the federal poverty level had greater cancer mortality risk associated with SPD. Using an 8 years of mortality follow-up, those with SPD had 108% increased adjusted risks of mortality from breast cancer. Conclusion Our study findings underscore the significance of addressing psychological well-being in the population as a strategy for reducing cancer mortality.

scholarly journals Personality Pathways to Mortality: Interleukin-6 Links Conscientiousness to Mortality Risk

2020 ◽  
Author(s):  
Páraic S O'Súilleabháin ◽  
Nick Turiano ◽  
Denis Gerstorf ◽  
Martina Luchetti ◽  
stephen gallagher ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Interleukin 6 ◽  
The United States ◽  
Lower Mortality ◽  
Reactive Protein ◽  
Age Related ◽  
Physiological Pathways ◽  
Adjusted Model ◽  
Lower Mortality Risk

Personality is associated consistently with mortality hazards, but the physiological pathways are not yet clear. Immune system dysregulation may be one such pathway due to its role in age-related morbidity and mortality. In this preregistered study, we tested whether interleukin-6 (IL-6) and C-reactive protein (CRP) mediated the associations between personality traits and mortality hazards. The sample included 957 participants (M ± SD = 58.65 ± 11.51 years; range = 35 – 86 years) from the Midlife in the United States Survey that had 14 years of follow-up. Higher conscientiousness was associated with lower mortality hazards, with each one standard deviation higher conscientiousness associated with a 35% lower mortality risk. IL-6, but not CRP, partially mediated this association, with IL-6 accounting for 18% of this association in the fully adjusted model. While there was initial evidence that the biomarkers mediated both neuroticism and agreeableness and mortality risk, the indirect effects were not significant when controlling for the sociodemographic variables. Taken together, higher conscientiousness may lead to a longer life partially as a result of lower IL-6. This work highlights the importance of biological pathways that link personality to future mortality risk.

scholarly journals Association of Happiness and Life Satisfaction with Cancer Mortality in the United States: A Longitudinal Analysis

2020 ◽  
Vol 4 (2) ◽  
pp. 162-169
Author(s):  
Hyunjung Lee ◽  
Gopal K. Singh
Keyword(s):  
United States ◽  
Life Satisfaction ◽  
Mortality Risk ◽  
Cancer Mortality ◽  
Proportional Hazards ◽  
The United States ◽  
Cox Proportional Hazards ◽  
Cox Models ◽  
Creative Commons ◽  
Cancer Mortality Risk

Background: Theimpact of happiness and life satisfaction on cancer mortality is not well studied. Using a longitudinal dataset, we examined the association between levels of happiness/life satisfaction and cancer mortality in the United States. Methods: We analyzed the 2001 National Health Interview Survey (NHIS) prospectively linked to 2001-2014 mortality records in the National Death Index (NDI) (N=30,933). Cox proportional hazards regression was used to model survival time as a function of happiness, life satisfaction, and sociodemographic and behavioral characteristics. Results: In Cox models with 14 years of mortality follow-up, cancer mortality risk was 78% higher (hazard ratio [HR]=1.78; 95% CI=1.42,2.23) in adults with little or no happiness, controlling for age, and 53% higher (HR=1.53; 95% CI=1.19,1.97) in adults with little/no happiness, controlling for sociodemographic, behavioral and health characteristics, when compared with adults reporting happiness most or all of the time. Age-adjusted cancer mortality risk increased by 41% (HR=1.41; 95% CI=1.21,1.77) in adults who were very dissatisfied with their life. Cancer mortality did not vary by life satisfaction after adjusting for all covariates. Conclusions and Implications for Translation: Adults with lower happiness levels had significantly higher cancer mortality risks than those with higher happiness levels. Excess mortality was substantially accounted for by sociodemographic, behavioral, and health risk factors. Key words: • Happiness • Life satisfaction • Cancer • Mortality • Longitudinal • Social determinants   Copyright © 2020 Lee and Singh. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.

scholarly journals COVID-19 Pandemic and Helsinki University Hospital Personnel Psychological Well-Being: Six-Month Follow-Up Results

2021 ◽  
Vol 18 (5) ◽  
pp. 2524
Author(s):  
Tanja Laukkala ◽  
Jaana Suvisaari ◽  
Tom Rosenström ◽  
Eero Pukkala ◽  
Kristiina Junttila ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Psychosocial Support ◽  
Well Being ◽  
Incidence Rates ◽  
University Hospital ◽  
Hospital Personnel ◽  
Front Line ◽  
Hospital District ◽  
Variation Explained

The COVID-19 pandemic has caused an unequally distributed extra workload to hospital personnel and first reports have indicated that especially front-line health care personnel are psychologically challenged. A majority of the Finnish COVID-19 patients are cared for in the Helsinki University Hospital district. The psychological distress of the Helsinki University Hospital personnel has been followed via an electronic survey monthly since June 2020. We report six-month follow-up results of a prospective 18-month cohort study. Individual variation explained much more of the total variance in psychological distress (68.5%, 95% CI 65.2–71.9%) and negative changes in sleep (75.6%, 95% CI 72.2–79.2%) than the study survey wave (1.6%, CI 0.5–5.5%; and 0.3%, CI 0.1–1.2%). Regional COVID-19 incidence rates correlated with the personnel’s psychological distress. In adjusted multilevel generalized linear multiple regression models, potentially traumatic COVID-19 pandemic-related events (OR 6.54, 95% CI 5.00–8.56) and front-line COVID-19 work (OR 1.81, 95% CI 1.37–2.39) was associated with personnel psychological distress but age and gender was not. While vaccinations have been initiated, creating hope, continuous follow-up and psychosocial support is still needed for all hospital personnel.

scholarly journals Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users

2008 ◽  
Vol 99 (11) ◽  
pp. 1934-1939 ◽  
Author(s):  
H D Hosgood ◽  
R Chapman ◽  
M Shen ◽  
A Blair ◽  
E Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mortality Risk ◽  
Cancer Mortality ◽  
Lung Cancer Mortality ◽  
Lower Lung ◽  
Smoky Coal ◽  
Cancer Mortality Risk

Cancer Mortality Risk among Workers at the Mayak Nuclear Complex

2003 ◽  
Vol 159 (6) ◽  
pp. 787-798 ◽  
Author(s):  
N. S. Shilnikova ◽  
D. L. Preston ◽  
E. Ron ◽  
E. S. Gilbert ◽  
E. K. Vassilenko ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Cancer Mortality ◽  
Nuclear Complex ◽  
Cancer Mortality Risk

Mammography Surveillance and Mortality in Older Breast Cancer Survivors

2007 ◽  
Vol 25 (21) ◽  
pp. 3001-3006 ◽  
Author(s):  
Timothy L. Lash ◽  
Matthew P. Fox ◽  
Diana S.M. Buist ◽  
Feifei Wei ◽  
Terry S. Field ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Cancer Mortality ◽  
Breast Cancer Survivors ◽  
Care Delivery ◽  
Breast Cancer Mortality ◽  
The United States ◽  
Stage I ◽  
Early Stage Disease

Purpose There are more than 2,000,000 breast cancer survivors in the United States today. While surveillance for asymptomatic recurrence and second primary is included in consensus recommendations, the effectiveness of this surveillance has not been well characterized. Our purpose is to estimate the effectiveness of surveillance mammography in a cohort of breast cancer survivors with complete ascertainment of surveillance mammograms and negligible losses to follow-up. Patients and Methods We enrolled 1,846 stage I and II breast cancer patients who were at least 65 years old at six integrated health care delivery systems. We used medical record review and existing databases to ascertain patient, tumor, and therapy characteristics, as well as receipt of surveillance mammograms. We linked personal identifiers to the National Death Index to ascertain date and cause of death. We matched four controls to each breast cancer decedent to estimate the association between receipt of surveillance mammogram and breast cancer mortality. Results One hundred seventy-eight women died of breast cancer during 5 years of follow-up. Each additional surveillance mammogram was associated with a 0.69-fold decrease in the odds of breast cancer mortality (95% CI, 0.52 to 0.92). The protective association was strongest among women with stage I disease, those who received mastectomy, and those in the oldest age group. Conclusion Given existing recommendations for post-therapy surveillance, trials to compare surveillance with no surveillance are unlikely. This large observational study provides support for the recommendations, suggesting that receipt of surveillance mammograms reduces the rate of breast cancer mortality in older patients diagnosed with early-stage disease.

scholarly journals Psychological Distress Among the U.S. General Population During the COVID-19 Pandemic

2021 ◽  
Vol 12 ◽  
Author(s):  
Christi J. Guerrini ◽  
Sophie C. Schneider ◽  
Andrew G. Guzick ◽  
Gifty N. Amos Nwankwo ◽  
Isabel Canfield ◽  
...  
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Psychological Distress ◽  
Online Survey ◽  
Well Being ◽  
The United States ◽  
Healthy Behaviors ◽  
Factors Associated ◽  
Clinically Significant ◽  
Amazon's Mechanical Turk

The COVID-19 pandemic is taking a significant global toll on emotional well-being, but evidence of mental health impacts in the United States remains limited. In April 2020, we conducted an exploratory survey of U.S. residents to understand prevalence of and factors associated with psychological distress during the pandemic. Data collection was conducted using Qualtrics, an online survey platform, and U.S. adult respondents were recruited via Amazon's Mechanical Turk platform. Among 1,366 respondents, 42% (n = 571) reported clinically significant anxiety and 38% (n = 519) reported clinically significant depression. Factors associated with anxiety and depressive symptoms included Hispanic/Latino ethnicity; younger age; lower income; employment as or living with a health care worker-first responder; caregiver status; SARS-CoV-2 infection status; decreased frequency of engagement in healthy behaviors; and changed frequency of engagement in unhealthy behaviors. That some of these factors are associated with elevated distress during the pandemic is not yet widely appreciated and might be useful in informing management of mental health care resources.

Caregiving in quarantine: Humor styles, reframing, and psychological well-being among parents of children with disabilities

2021 ◽  
pp. 026540752110435
Author(s):  
Heidi L. Fritz
Keyword(s):  
Psychological Distress ◽  
Social Interactions ◽  
Children With Disabilities ◽  
Well Being ◽  
Family Satisfaction ◽  
The United States ◽  
Future Research ◽  
Humor Styles ◽  
Psychological Well Being ◽  
Over Time

Prior research links adaptive humor styles (affiliative and self-enhancing) with enhanced psychological well-being and maladaptive humor styles (aggressive and self-defeating) with worse psychological well-being, primarily through humor styles’ influence on individuals’ social interactions and efforts to positively reframe stressors. The present study examined the unique relation of each humor style with psychological well-being with a focus on understanding mechanisms of adjustment under highly stressful conditions. Ninety-nine parents of children with disabilities were surveyed at the beginning of the COVID-19 pandemic in the United States in March 2020, and 79 parents completed follow-up surveys in July 2020. As predicted, at T1, self-enhancing humor was associated with less psychological distress and greater family satisfaction, self-defeating humor was associated with greater distress, and aggressive humor was associated with lower family satisfaction. Moreover, affiliative humor predicted decreased psychological distress over time, whereas self-defeating humor predicted increased psychological distress and decreased family satisfaction over time. Relations were largely mediated by caregiver positive reappraisal, family efforts to reframe daily disability-related challenges, and negative social interactions. Future research should further examine the influence of caregiver humor styles on family dynamics, family reframing norms, and caregiving efficacy.

scholarly journals The influence of daily spiritual experiences and gender on subjective well-being over time in cancer survivors

2019 ◽  
Vol 41 (2) ◽  
pp. 159-171
Author(s):  
Myriam Rudaz ◽  
Thomas Ledermann ◽  
Joseph G. Grzywacz
Keyword(s):  
Life Satisfaction ◽  
Cancer Survivors ◽  
Well Being ◽  
The United States ◽  
Moderating Effect ◽  
Subjective Well Being ◽  
Spiritual Experiences ◽  
Daily Spiritual Experiences ◽  
Over Time

Cancer survivors are at risk for poor subjective well-being, but the potential beneficial effect of daily spiritual experiences is unknown. Using data from the second and third wave of the Midlife in the United States (MIDUS) study, we examined the extent to which daily spiritual experiences at baseline moderate the association between subjective well-being at baseline and approximately 10 years later in cancer survivors ( n = 288). Regression analyses, controlled for age, educational attainment, and religious/spiritual coping, showed that daily spiritual experiences moderated the association between life satisfaction at baseline and follow-up. Specifically, high spiritual experiences enhanced life satisfaction over time in cancer survivors with low life satisfaction at baseline. Also, daily spiritual experiences moderated the association between positive affect at baseline and follow-up, though this moderating effect was different for women and men. No moderating effect emerged for negative affect.

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