scholarly journals Exploring the Links between Diet and Inflammation: Dairy Foods as Case Studies

2021 ◽  
Vol 12 (Supplement_1) ◽  
pp. 1S-13S
Author(s):  
Julie M Hess ◽  
Charles B Stephensen ◽  
Mario Kratz ◽  
Bradley W Bolling
Keyword(s):  
Case Studies ◽  
Chronic Inflammation ◽  
Noncommunicable Diseases ◽  
Important Research ◽  
Dairy Foods ◽  
Dairy Fat ◽  
Research Priority ◽  
American Society ◽  
Modifiable Lifestyle Factors ◽  
Inflammatory Effect

ABSTRACT Systemic chronic inflammation may be a contributing factor to many noncommunicable diseases, including diabetes, cardiovascular disease, and obesity. With the rapid rise of these conditions, identifying the causes of and treatment for chronic inflammation is an important research priority, especially with regard to modifiable lifestyle factors such as diet. An emerging body of evidence indicates that consuming certain foods, including dairy foods like milk, cheese, and yogurt, may be linked to a decreased risk for inflammation. To discuss both broader research on diet and inflammation as well as research on links between individual foods and inflammation, the National Dairy Council sponsored a satellite session entitled “Exploring the Links between Diet and Inflammation: Dairy Foods as Case Studies” at the American Society for Nutrition's 2020 LIVE ONLINE Conference. This article, a review based on the topics discussed during that session, explores the links between diet and inflammation, focusing most closely on the relations between intake of dairy fat and dairy foods like milk, cheese, and yogurt, and biomarkers of inflammation from clinical trials. While there is currently insufficient evidence to prove an “anti-inflammatory” effect of dairy foods, the substantial body of clinical research discussed in this review indicates that dairy foods do not increase concentrations of biomarkers of chronic systemic inflammation.

Therapeutic use of lowmolecular weight heparin for capillaritis alba

Phlebologie ◽  
2008 ◽  
Vol 37 (05) ◽  
pp. 259-265 ◽  
Author(s):  
H. Kutzner ◽  
G. Hesse
Keyword(s):  
Case Studies ◽  
Randomized Study ◽  
Compression Therapy ◽  
Venous Hypertension ◽  
Therapeutic Use ◽  
Prospective Randomized Study ◽  
Anti Inflammatory ◽  
Positive Effect ◽  
Inflammatory Effect

SummaryThe reason of the so called ulcerated capillaritis alba or idiopathic atrophie blanche is vasculopathy caused by severe venous hypertension. Thrombosed and rarificated vessels worsen the oxygenation, increase permanent inflammation and impede the necessary compression therapy. The anti-inflammatory effects of heparin alleviate pain and being independent from the antithrombotic ones it needs much lower doses for treatment. This anti-inflammatory effect is now becoming more important in clinical phlebology. Case studies of more than 50 patients and one prospective randomized study of 87 patients clearly demonstrate the ameliorated healing of ulcerated atrophie blanche. In our office we could document this positive effect with 22 patients. We present the pathophysiology of low molecular heparins for ulcerated capillaritis alba and our own experiences with it.

Pandemics

2018 ◽  
pp. 646-662
Author(s):  
Kathryn H. Jacobsen
Keyword(s):  
International Trade ◽  
Global Health ◽  
Case Studies ◽  
International Cooperation ◽  
Recovery Phase ◽  
Noncommunicable Diseases ◽  
Global Studies ◽  
Global Action ◽  
History Of ◽  
Strategic Goals

This chapter discusses the history of and responses to global epidemics of serious diseases. Case studies of cholera, influenza, and HIV/AIDS illustrate typical reactions to pandemic events. The initial stages of a pandemic are often characterized by collective anxiety and a desire for isolation. As the pandemic progresses, there are calls for collective global responses to protect human security and contain outbreaks while maintaining international trade and travel. As pandemics enter a recovery phase, there is often a shift toward the use of advocacy to promote international cooperation, secure continued funding for global health activities, and advance other strategic goals. The rhetoric of pandemics is now being used to describe obesity and other emerging noncommunicable diseases because the language of pandemics connotes risk and demands global action. Pandemics are the result of global interactions and globalization processes, and studies of pandemics are, by definition, global studies.

scholarly journals Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Nabil Albaser ◽  
Najeeb Ghanem ◽  
Mohanad Shehab ◽  
Adnan Al-Adhal ◽  
Mohammed Amood AL-Kamarany
Keyword(s):  
Chronic Inflammation ◽  
Guinea Pigs ◽  
Therapeutic Potential ◽  
Histological Study ◽  
Folk Medicine ◽  
Ethanol Extract ◽  
Optimum Dose ◽  
Repeated Doses ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Caralluma is a plant that possessing a great therapeutic potential in folk medicine in Yemen, namely, Caralluma penicillata (C. penicillata) as antiulcer. The study aims to evaluate the anti-inflammatory properties and gastritis protection activity of C. penicillata against indomethacin in adult guinea pigs. The study was divided into four parts: firstly, the optimum dose of extract as anti-inflammatory effect was determined. Secondly, the acute anti-inflammatory effect of extract were estimated. Thirdly, the repeated doses of extract against chronic inflammation was estimated. The anti-inflammatory activity of extract was compared with indomethacin as a prototype of drug against inflammation. Fourthly, the gastritis protection properties of extract with/without indomethacin were performed. The results showed that a 400 mg/kg of 10% ethanol extract produced the maximum of anti-inflammatory effect. Also, the single dose of extract was equipotent for indomethacin (10 mg/kg), but shorter in duration with regard to acute anti-inflammatory effect. In addition, the repeated doses of extract against chronic inflammation were less potent than indomethacin with regard to ulcerogenic effect. On the other hand, extract-indomethacin combination reduced the gastritis effect of indomethacin based on ulcer index and histological study.

scholarly journals Technical aspects of the reconstruction of historic gardens

2021 ◽  
Keyword(s):  
Case Studies ◽  
Important Research ◽  
Technical Aspects ◽  
Original State ◽  
General Methodology ◽  
Prominent Component ◽  
Historical Authenticity ◽  
Restoration Work ◽  
The Relationship

Abstract Built elements and structures are a prominent component of our historic gardens, both in terms of function and artistic composition and garden scenery. The surveys of historic garden structures are important research tasks, which also underpins and validates restoration work. In most cases, the neglected state of historic gardens and sites and the unavailable archival materials do not allow an authentic restoration of historic gardens to their original state. Nevertheless, there is a real need to reconstruct our historic gardens, based not only on historical authenticity but also on a systematic reinterpretation of the relationship between society and landscape. The objective of this article is to present a general methodology for renewal of historic gardens through examples of specific garden reconstructions. The case studies are the authors' own design works, which demonstrate the application of different design approaches, highlighting details of the reconstruction of specific built garden elements.

Case Studies and Caveats

2019 ◽  
pp. 83-101
Author(s):  
Jonathan H. Marks
Keyword(s):  
Public Health ◽  
United States ◽  
Case Studies ◽  
The United States ◽  
Framing Effects ◽  
Noncommunicable Diseases ◽  
Systemic Effects ◽  
Public Health Agencies ◽  
Health Agencies ◽  
Food And Beverage

This chapter outlines several partnership case studies involving the food and beverage sector, especially soda companies. These case studies are drawn from the United States, Britain, and India. The analysis highlights certain problematic features—for example, use of corporate logos, trademarks, and color schemes that are likely to promote consumption of products that are exacerbating obesity and diet-related noncommunicable diseases (NCDs). But, more fundamentally, the analysis ties the case studies to the broader systemic effects discussed in the preceding chapters. These include framing effects, agenda distortion, and impacts on the integrity of and trust in public health agencies.

scholarly journals Impact of Low-Fat and Full-Fat Dairy Intake on Cardiovascular Disease Risk Factors: A Randomized Controlled Trial

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 563-563
Author(s):  
Kelsey Schmidt ◽  
Gail Cromer ◽  
Maggie Burhans ◽  
Jessica Kuzma ◽  
Derek Hagman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Density Lipoprotein ◽  
Cvd Risk Factors ◽  
Low Fat ◽  
Cvd Risk ◽  
Intervention Effect ◽  
Dairy Foods ◽  
Dairy Fat ◽  
The Metabolic Syndrome

Abstract Objectives Dairy fat has been hypothesized to promote cardiovascular disease (CVD) due to its high saturated fat content, contributing to recommendations to consume low-fat dairy foods. However, emerging evidence indicates that dairy fat does not negatively impact CVD risk, particularly when consumed in foods with a complex matrix. Though, few trials have directly compared the effect of low-fat versus full-fat dairy foods. Therefore, we aimed to test the effects of diets rich in low-fat or full-fat dairy on CVD risk factors, compared to a limited dairy diet. We hypothesized that diets rich in dairy would not impact CVD risk factors. Methods Seventy-two participants with the metabolic syndrome completed a 4-week wash-in period; limiting their dairy intake to ≤ 3 servings of skim milk per week. Participants were then randomized to either continue the limited dairy diet or switch to a diet containing 3.3 servings per day of either low-fat or full-fat milk, yogurt, and cheese for 12-weeks. The plasma lipid profile and blood pressure were assessed before and after the intervention period. Results In the per protocol analysis (n = 66), there was no intervention effect on fasting plasma total-, low-density lipoprotein-, and high-density lipoprotein-cholesterol, triglycerides, free fatty acids, or cholesterol content in 38 isolated lipoprotein fractions (p > 0.1 for all variables). There was also no intervention effect on diastolic blood pressure. There was a significant difference among the diet interventions for systolic blood pressure (P = 0.045), with a trend for a decrease in the low-fat dairy diet compared to the limited dairy diet in post hoc testing after adjustment for multiple testing. Conclusions In individuals with the metabolic syndrome, consuming 3.3 servings of dairy per day, regardless of fat content, did not affect blood lipids and modestly improved blood pressure compared to a diet virtually free of dairy. This provides further evidence that dairy fat, when consumed as part of complex whole foods, does not significantly impact CVD risk factors. Funding Sources This work was supported by the National Dairy Council, Dairy Farmers of Canada, the Dutch Dairy Association, Dairy Australia, and the French Dairy Interbranch Organization.

scholarly journals Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
R. C. M. Adams ◽  
C. Smith
Keyword(s):  
Chronic Inflammation ◽  
Current Data ◽  
Receptor Expression ◽  
Noncommunicable Diseases ◽  
Maternal Inflammation ◽  
Two Generations ◽  
Maternal Adaptation ◽  
Inflammatory Profile ◽  
As Stress

Changes in the in utero environment result in generational transfer of maladapted physiology in the context of conditions such as stress, obesity, and anxiety. Given the significant contribution of noncommunicable diseases—which are characterised by chronic inflammation—to population mortality, the potential for chronic maternal inflammation mediating foetal programming is a growing concern. The extent of generational transfer in terms of immune functionality and leukocyte glucocorticoid sensitivity was investigated over two generations of offspring (F1 and F2) in a model of chronic LPS-induced maternal inflammation in C57/BL/6 mice. Maternal inflammation resulted in glucocorticoid hypersensitivity (increased glucocorticoid receptor expression levels) in the majority of leukocyte subpopulations in both F1 and F2 offspring. Furthermore, splenocytes stimulated with LPS in vitro exhibited exacerbated inflammatory cytokine responses, which were even more prominent in F2 than F1; this effect could be ascribed to NLRP3 inflammasome hyperactivity in F1 but not F2. Current data illustrates that parental chronic inflammation may mediate the inflammatory profile in offspring, potentially propagating a maladapted proinflammatory phenotype in subsequent generations.

scholarly journals Research priorities in regional anaesthesia education and training: an international Delphi consensus survey

BMJ Open ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. e030376 ◽  
Author(s):  
Alwin Chuan ◽  
Reva Ramlogan
Keyword(s):  
Knowledge Translation ◽  
Curriculum Design ◽  
Regional Anaesthesia ◽  
Research Collaboration ◽  
Research Priorities ◽  
Education And Training ◽  
Delphi Consensus ◽  
Research Priority ◽  
American Society ◽  
And Training

ObjectivesEducation in regional anaesthesia covers several complex and diverse areas, from theoretical aspects to procedural skills, professional behaviours, simulation, curriculum design and assessment. The objectives of this study were to summarise these topics and to prioritise these topics in order of research importance.DesignElectronic structured Delphi questionnaire over three rounds.SettingInternational.Participants38 experts in regional anaesthesia education and training, identified through the American Society of Regional Anesthesia Education Special Interest Group research collaboration.Results82 topics were identified and ranked in order of prioritisation. Topics were categorised into themes of simulation, curriculum, knowledge translation, assessment of skills, research methodology, equipment and motor skills. Thirteen topics were ranked as essential research priority, with four topics each on simulation and curriculum, three topics on knowledge translation, and one topic each on methodology and assessment.ConclusionsResearchers and educators can use these identified topics to assist in planning and structuring their research and training in regional anaesthesia education.

scholarly journals Dairy Fat and Cardiovascular Health

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 838 ◽  
Author(s):  
Esther Sendra
Keyword(s):  
Blood Pressure ◽  
Serum Cholesterol ◽  
Dairy Products ◽  
Cardiovascular Health ◽  
Current Knowledge ◽  
Bioactive Lipids ◽  
Dairy Food ◽  
Dairy Foods ◽  
Dairy Fat ◽  
Dairy Fats

Current scientific evidence points to a neutral or positive effect of dairy fats intake on cardiovascular health. After years of controversy, with many guidelines recommending a reduced intake of dairy products, and preferably low or nonfat dairy foods, current knowledge points to the more appropriate recommendation of moderate consumption of full-fat dairy foods within a healthy lifestyle. Fermented dairy products seem to be the best option as a source of nutrients and cardiovascular health benefits. Previous recommendations were based on cholesterol, saturated fat, and caloric contents, in dairy fat, and their potential impact on serum cholesterol, fasting sugar levels, and blood pressure. However, experimental data point to a more complex scenario in which other actors may play major roles: calcium, bioactive lipids and peptides, and even the food-matrix effect from the dairy food side, and human genetics and environmental factors all impact dairy food-related health issues. Furthermore, cardiovascular health does not rely solely on serum cholesterol levels and blood pressure but also on inflammatory biomarkers. At present, little is known on the true mechanisms underlying the cardioprotective mechanism of dairy fats, and further research in needed to elucidate them.

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