scholarly journals Predictive Value of Plasma Long Noncoding RNA Associated With Microvascular Invasion in Hepatic Carcinoma for Preeclampsia

2020 ◽  
Vol 33 (8) ◽  
pp. 791-791
Author(s):  
Ying Li ◽  
Ning Yang ◽  
Xiao-yi Zou ◽  
Yuan-bing Li ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Predictive Value ◽  
Long Noncoding Rna ◽  
Plasma Levels ◽  
Noncoding Rna ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Microvascular Invasion ◽  
Hepatic Carcinoma ◽  
Urine Protein

Abstract Background To investigate plasma levels of long noncoding RNA associated with microvascular invasion in hepatic carcinoma (LncRNA MVIH) in patients with preeclampsia (PE) and to explore its predictive value for PE either alone or in combination with other indicators. Methods Plasma samples were obtained from patients in a prospective pregnancy cohort at 7–16 weeks of gestation. Patients were divided into PE and control groups according to pregnancy outcomes. Real-time polymerase chain reaction was used to detect plasma levels of LncRNA MVIH. A univariate analysis was conducted on all indicators. Logistic regression analysis was performed on indexes with statistical differences. The receiver operating characteristic curve was used to evaluate the predict value of each independent risk factor and regression model. Results Before 16 weeks of pregnancy, body mass index, systolic blood pressure, diastolic blood pressure, mean arterial pressure, white blood cell (WBC), hemoglobin, alanine aminotransferase (ALT), uric acid (UA), and urine protein were positively correlated with PE while LncRNA MVIH was negatively correlated with PE. Independent markers with predictive value were LncRNA MVIH, UA, WBC, ALT, and urine protein, with the area under curve (AUC) in predicting PE of 0.763, 0.741, 0.663, 0.666, and 0.601, respectively. After combining these indexes, the AUC increased to 0.890 with sensitivity, specificity, and accuracy of 86.4%, 83.1%, and 84.7% respectively. Conclusions Plasma levels of LncRNA MVIH are negatively correlated with PE and have a predictive value for PE. The combination of LncRNA MVIH, UA, WBC, ALT, and urine protein has a greater predictive value.

scholarly journals Predictive value of a novel lncRNA LINC02518 in evaluating the prognosis of patients with hepatocellular carcinoma

2021 ◽  
Author(s):  
Wei Cui ◽  
Jingzhi Huang ◽  
Ruiqi Wang ◽  
Yu Wang ◽  
Xiaoming Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Receiver Operating Characteristic Curve ◽  
Receiver Operating Characteristic ◽  
Predictive Value ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Operating Characteristic Curve ◽  
Receiver Operating

Aim: The potential of long noncoding RNA in hepatocellular carcinoma (HCC) has led to promising insights into therapeutic intervention. The clinical significance of LINC02518 in HCC is unclear. This study aimed to evaluate the predictive value of a novel long noncoding RNA, LINC02518, for the prognosis of patients with HCC. Methods: Between December 2005 and November 2011, 125 and 75 HCC patients in the training and validation groups, respectively, who underwent liver surgery were included in our study. The LINC02518 expression of HCC and corresponding nontumor liver tissues was detected using microarray and reverse transcription quantitative polymerase chain reaction (RT-qPCR). These HCC patients were assigned into high and low LINC02518 expression groups based on the threshold of the receiver operating characteristic curve. Kaplan-Meier analysis was performed to determine the prognosis of HCC patients. Results: LINC02518 expression was upregulated in paired tumor samples compared with corresponding nontumor samples in the two groups. The area under the receiver operating characteristic curve for the levels of LINC02518 in the diagnosis of HCC was 0.66, 95% CI: 0.59–0.73. HCC patients with high LINC02518 expression had significantly worse tumor recurrence-free, metastasis-free, disease-free and overall survival than those with low LINC02518 expression. Conclusion: LINC02518 is negatively correlated with the prognosis of HCC and provides a promising strategy for the treatment and prognosis of HCC.

A novel three-long noncoding RNA risk score system for the prognostic prediction of triple-negative breast cancer

2021 ◽  
Vol 15 (1) ◽  
pp. 43-55
Author(s):  
Chao Yuan ◽  
Hongjun Yuan ◽  
Li Chen ◽  
Miaomiao Sheng ◽  
Wenru Tang
Keyword(s):  
Breast Cancer ◽  
Risk Score ◽  
Triple Negative Breast Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Triple Negative ◽  
Cox Regression ◽  
Characteristic Curve ◽  
Gene Expression Omnibus ◽  
Prognostic Prediction

Background: Triple-negative breast cancer (TNBC) is characterized by fast tumor increase, rapid recurrence and natural metastasis. We aimed to identify a genetic signature for predicting the prognosis of TNBC. Materials & methods: We conducted a weighted correlation network analysis of datasets from the Gene Expression Omnibus. Multivariate Cox regression was used to construct a risk score model. Results: The multi-factor risk scoring model was meaningfully associated with the prognosis of patients with TBNC. The predictive power of the model was demonstrated by the time-dependent receiver operating characteristic curve and Kaplan–Meier curve, and verified using a validation set. Conclusion: We established a long noncoding RNA-based model for the prognostic prediction of TNBC.

scholarly journals Long Noncoding RNA Serve as a Potential Predictive Biomarker for Breast Cancer: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Xuefeng Jiang ◽  
Guijuan Zhang ◽  
Jieyan Wu ◽  
Shujun Lin ◽  
Yusheng Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Characteristic Curve ◽  
Breast Cancer Diagnosis ◽  
Predictive Biomarker ◽  
Cochrane Library ◽  
Summary Receiver Operating Characteristic ◽  
Diagnostic Efficacy

Purpose. The detection of long noncoding RNA (lncRNA) is a novel method for breast cancer diagnosis. The purpose of this meta-analysis was to evaluate the clinical significance of lncRNAs in identification of human breast cancer. Methods. Electronic databases, including PubMed (176), EMBASE (167), Cochrane Library (4), Web of Science (273), CNKI (41), VIP (18), and wanfang (21), were searched for relevant original articles. Diagnostic capacity of lncRNAs was assessed by pooled sensitivity and specificity, area under the summary receiver operating characteristic curve (AUC), diagnostic odds ratio (DOR), and subgroup and meta-regression analysis. Stata and Meta-Disc software were used to conduct the meta-analysis. Results. 33 articles including 4500 cases were identified in our meta-analysis. lncRNAs sustained a high diagnostic efficacy; the pooled sensitivity, specificity, AUC, and DOR of lncRNAs in differentiating BC from controls were 0.74 (95% CI: 0.69-0.78), 0.78 (95% CI: 0.72-0.83), 0.82 (95% CI: 0.79-0.85), and 10.01 (95% CI: 7.13-14.06), respectively. The subgroup analysis showed that the diagnostic efficacy of lncRNAs in Asian populations was higher than that in Caucasians; lncRNAs in BC were lower than those in TNBC and were higher in plasma and serum specimens than in tissues. In addition, heterogeneity was clearly apparent but was not caused by the threshold effect. Conclusion. This meta-analysis suggested that lncRNAs might be promising biomarkers for identifying breast cancer, and its clinical application warrants further investigation.

scholarly journals Circulating Long Noncoding RNA GAS5 as a novel biomarker for patients with atrial fibrillation

2019 ◽  
Author(s):  
Jiaran Shi ◽  
Shi Chen ◽  
Bifeng Wu ◽  
Kun Yang ◽  
Xiaosheng Hu
Keyword(s):  
Atrial Fibrillation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Characteristic Curve ◽  
Diagnostic Value ◽  
Vital Role ◽  
Potential Biomarker ◽  
Circulating Levels ◽  
Screening Trial ◽  
Lncrna Gas5

Abstract Background Long noncoding RNA (LncRNA) played a vital role in pathophysiology of cardiovascular diseases. However, its role in the diagnosis of atrial fibrillation (AF) remains unknown. The aim of this study is to identify the diagnostic value of lncRNA GAS5 for AF patients.Methods Four lncRNAs (NEAT1, GAS5, UCA1, and TUG1) were selected as potential biomarkers of AF. The circulating expression of lncRNAs were measured by qRT-PCR. Receiver operating characteristic curve (ROC) and area under the ROC curve (AUC) were applied to assess their diagnostic value for AF.Results In screening trial, LncRNA GAS5 was down-regulated in AF patients, with no significant differences in other three lncRNAs. Then a total of 128 participants were enrolled including 85 AF patients and 43 controls. Circulating levels of GAS5 in AF patients were remarkably reduced compared with controls ( P <0.001). The AUC was 0.858, with 81.2% sensitivity and 86.0% specificity. Further, the downregulation of GAS5 was more significant in persistent rather than paroxysmal AF. Correlation analysis showed that GAS5 was negatively correlated with CHA2DS2-VASc score and several echocardiography indexes.Conclusions Circulating lncRNA GAS5 is a potential biomarker for AF diagnosis and may prognose AF progression and stroke risk.

Identification of an immune-related long noncoding RNA signature that predicts prognosis in breast cancer patients

2021 ◽  
Vol 15 (3) ◽  
pp. 167-180
Author(s):  
Na Li ◽  
Zubin Li ◽  
Xin Li ◽  
Bingjie Chen ◽  
Huibo Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cox Regression ◽  
Expression Profiles ◽  
Characteristic Curve ◽  
The Cancer Genome Atlas ◽  
Breast Cancer Patients ◽  
Cox Regression Analysis

Aim: The purpose of this study was to identify an immune-related long noncoding RNA (lncRNA) signature that predicts the prognosis of breast cancer. Materials & methods: The expression profiles of breast cancer were downloaded from The Cancer Genome Atlas. Cox regression analysis was used to identify an immune-related lncRNA signature. Results: The five immune-related lncRNAs could be used to construct a breast cancer survival prognosis model. The receiver operating characteristic curve evaluation found that the accuracy of the model for predicting the 1-, 3- and 5-year prognosis of breast cancer was 0.688, 0.708 and 0.686. Conclusion: This signature may have an important clinical significance for improving predictive results and guiding the treatment of breast cancer patients.

265Amyloid beta 1-40 and its upstream regulatory pathway BACE1-AS long noncoding RNA/BACE1 are associated with presence and severity of human atherosclerotic disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
G Georgiopoulos ◽  
I Mavroeidis ◽  
K Sopova ◽  
M Sacshe ◽  
A Mareti ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Long Noncoding Rna ◽  
Plasma Levels ◽  
Noncoding Rna ◽  
Mononuclear Cells ◽  
Atherosclerotic Cardiovascular Disease ◽  
Regulatory Pathway ◽  
Clinical Value ◽  
Peripheral Blood Mononuclear ◽  
Atheromatous Plaques

Abstract Background Amyloid-beta (1-40) (Aβ1–40), a proinflammatory and pro-atherosclerotic peptide, is associated with accelerated atherosclerosis and major adverse cardiac events. Abeta1–40 production is mainly dependent on the cleavage of amyloid precursor protein by β-amyloid cleaving enzyme-1 (BACE1), known as beta-secretase. BACE1 antisense (BACE1-AS) is a long noncoding RNA that enhances BACE1 stability. Objectives To evaluate the clinical value of plasma amyloid-beta levels and its upstream regulatory pathway BACE1/BACE1-AS in patients with subclinical and established atherosclerotic cardiovascular disease. Methods Plasma levels of Aβ40 were measured in 642 consecutively recruited patients with and without clinically overt coronary artery disease (CAD). BACE1-AS lncRNA and BACE1 mRNA expression were measured in peripheral blood mononuclear cells derived from 214 study participants. Intima-media thickness and atheromatous plaques by ultrasonography, markers of arterial wave reflections and pulse wave velocity were used as surrogate markers of subclinical CVD. Cardiovascular risk factors (CVRFs), including impaired glomerular filtration rate (<60 ml/min), smoking, hypertension, hyperlipidemia, diabetes, obesity and increased hsCRP (>2 mg/l) were assessed as a measure of CVRF burden. Results Both in non-CAD (n=369) and CAD (n=273) patients, Aβ1–40 was associated with age, aortic and peripheral systolic and pulse pressure, and low GFR (p<0.05 for all). In non-CAD subjects Aβ1–40 also correlated with diabetes and low HDL. Importantly, Aβ1–40 was associated with the presence of any plaque in subjects without CAD (p=0.035) and with increased number of diseased coronary arteries (p=0.022) independently of age, gender and CVRFs. Aβ1–40 plasma levels were increased in the highest tertile of BACE1 and BACE1AS (p<0.05) while their expression levels were highly intercorrelated (r=0.825, P<0.001). BACE1 and BACE1-AS levels progressively increased across the 3 groups of non-CAD (n=145), stable CAD (n=43) and acute myocardial infarction (n=26) patients (p for trend<0.001). Among non-CAD subjects, both BACE1 and BACE1-AS were increased in individuals with >2 CVRFs. Among CAD patients, BACE1-AS was associated with decreased LVEF (<50%) (adjusted OR=1.92 per 1-SD increase, p=0.047) while BACE1 in the highest tertile was associated with 5-fold higher odds for coronary multi-vessel disease (p=0.004) after adjustment for age, gender and CVRFs. Conclusions Circulating Aβ1–40 and increased expression of its upstream regulators BACE1/BACE1-AS are intercorrelated and associated with the presence and severity of subclinical and clinically overt atherosclerosis. These findings suggest that BACE1-AS/BACE1-mediated increased availability of Aβ1–40 may play a pivotal role in its adverse cardiovascular effects.

Determinants of Arterial Stiffness in Female Patients with Takayasu Arteritis

2014 ◽  
Vol 41 (7) ◽  
pp. 1374-1378 ◽  
Author(s):  
Nilton Salles Rosa Neto ◽  
Maurício Levy-Neto ◽  
Elaine Cristina Tolezani ◽  
Eloísa Bonfá ◽  
Luiz Aparecido Bortolotto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Takayasu Arteritis ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Receiver Operator Characteristic Curve ◽  
Healthy Controls ◽  
Average Systolic Blood Pressure ◽  
Female Patients ◽  
Logistic Analysis

Objective.The assessment of pulse wave velocity (PWV) in Takayasu arteritis (TA) is complex because of many confounding factors. We evaluated PWV in female patients with TA and controls with comparable anthropometric and clinical variables and assessed a possible association of TA with disease variables.Methods.We evaluated 27 patients with TA consecutively. Exclusion criteria were menopause, smoking, diabetes, renal insufficiency, poorly controlled hypertension, cardiac arrhythmias, obesity, inflammatory comorbidities, pregnancy, and surgical procedures involving the aorta. Disease activity was determined by clinical and laboratory variables. As healthy controls, 27 subjects with comparable age, blood pressure, height, and weight were selected. Carotid-femoral PWV measurements were obtained using the Complior system.Results.The mean PWV in patients with TA was higher than in healthy controls (9.77 ± 3.49 vs 7.83 ± 1.06 m/s; p = 0.009). Despite our strict selection criteria, patients with TA had an average systolic blood pressure (SBP) 8 mmHg higher than controls (p = NS), and significantly higher pulse pressure values. The multivariate linear regression model shows that 93.8% of the PWV variability is explained by the variables age, mean BP, and the disease itself (adjusted R2= 0.938). Stepwise logistic analysis using the PWV cutoff value established by the receiver-operator characteristic curve (> 8.34 m/s) as dependent variable, and measures with significance in univariate analysis as independent variables revealed that TA (OR 4.69; 95% CI 1.31–16.72; p = 0.017) and mean BP (OR 1.06; 95% CI 1.00–1.12; p = 0.048) were independently associated with higher PWV. Further analysis of disease variables revealed that PWV values were not correlated with erythrocyte sedimentation rate, C-reactive protein, cumulative dose of glucocorticoid, or ejection fraction (p > 0.05).Conclusion.In our cohort of female patients with TA, the disease itself and mean BP were the strongest determinants associated with arterial stiffness.

scholarly journals Value of gadoxetic acid-enhanced MRI for microvascular invasion of small hepatocellular carcinoma: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Meng Zhou ◽  
Dan Shan ◽  
Chunhui Zhang ◽  
Jianhua Nie ◽  
Guangyu Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Predictive Value ◽  
Univariate Analysis ◽  
Microvascular Invasion ◽  
Hepatobiliary Phase ◽  
Phase Imaging ◽  
Imaging Features ◽  
Small Hepatocellular Carcinoma ◽  
Halo Sign ◽  
Rim Enhancement

Abstract Background The objective of this study was to analyze the accuracy of gadolinium–ethoxybenzyl–diethylenetriamine penta–acetic acid enhanced magnetic resonance imaging (Gd–EOB–DTPA–MRI) for predicting microvascular invasion (MVI) in patients with small hepatocellular carcinoma (sHCC) preoperatively. Methods A total of 60 sHCC patients performed with preoperative Gd–EOB–DTPA–MRI in the Harbin Medical University Cancer Hospital from October 2018 to October 2019 were involved in the study. Univariate and multivariate analyses were performed by chi–square test and logistic regression analysis. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of Gd–EOB–DTPA–MRI were performed by receiver operating characteristic (ROC) curves. Results Univariate analysis indicated that alanine aminotransferase (≥ 39.00U/L), poorly differentiated pathology, and imaging features including grim enhancement, capsule enhancement, arterial halo sign and hepatobiliary features (tumor highly uptake, halo sign, spicule sign and brush sign) were associated with the occurrence of MVI (p < 0.05). Multivariate analysis revealed that rim enhancement and hepatobiliary spicule sign were independent predictors of MVI (p < 0.05). The area under the ROC curve was 0.917 (95% confidence interval 0.838–0.996), and the sensitivity was 94.74%. Conclusions The morphologies of hepatobiliary phase imaging, especially the spicule sign, showed high accuracy in diagnosing MVI of sHCC. Rim enhancement played a significant role in diagnosing MVI of sHCC.

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