Determinants of Arterial Stiffness in Female Patients with Takayasu Arteritis

2014 ◽  
Vol 41 (7) ◽  
pp. 1374-1378 ◽  
Author(s):  
Nilton Salles Rosa Neto ◽  
Maurício Levy-Neto ◽  
Elaine Cristina Tolezani ◽  
Eloísa Bonfá ◽  
Luiz Aparecido Bortolotto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Takayasu Arteritis ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Receiver Operator Characteristic Curve ◽  
Healthy Controls ◽  
Average Systolic Blood Pressure ◽  
Female Patients ◽  
Logistic Analysis

Objective.The assessment of pulse wave velocity (PWV) in Takayasu arteritis (TA) is complex because of many confounding factors. We evaluated PWV in female patients with TA and controls with comparable anthropometric and clinical variables and assessed a possible association of TA with disease variables.Methods.We evaluated 27 patients with TA consecutively. Exclusion criteria were menopause, smoking, diabetes, renal insufficiency, poorly controlled hypertension, cardiac arrhythmias, obesity, inflammatory comorbidities, pregnancy, and surgical procedures involving the aorta. Disease activity was determined by clinical and laboratory variables. As healthy controls, 27 subjects with comparable age, blood pressure, height, and weight were selected. Carotid-femoral PWV measurements were obtained using the Complior system.Results.The mean PWV in patients with TA was higher than in healthy controls (9.77 ± 3.49 vs 7.83 ± 1.06 m/s; p = 0.009). Despite our strict selection criteria, patients with TA had an average systolic blood pressure (SBP) 8 mmHg higher than controls (p = NS), and significantly higher pulse pressure values. The multivariate linear regression model shows that 93.8% of the PWV variability is explained by the variables age, mean BP, and the disease itself (adjusted R2= 0.938). Stepwise logistic analysis using the PWV cutoff value established by the receiver-operator characteristic curve (> 8.34 m/s) as dependent variable, and measures with significance in univariate analysis as independent variables revealed that TA (OR 4.69; 95% CI 1.31–16.72; p = 0.017) and mean BP (OR 1.06; 95% CI 1.00–1.12; p = 0.048) were independently associated with higher PWV. Further analysis of disease variables revealed that PWV values were not correlated with erythrocyte sedimentation rate, C-reactive protein, cumulative dose of glucocorticoid, or ejection fraction (p > 0.05).Conclusion.In our cohort of female patients with TA, the disease itself and mean BP were the strongest determinants associated with arterial stiffness.

MO570PULSE PRESSURE: A PREDICTOR OF CARDIOVASCULAR CALCIFICATION AND CARDIOVASCULAR MORTALITY IN HEMODIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Merita Rroji (Molla) ◽  
Saimir Seferi ◽  
Majlinda Cafka ◽  
Erjola Likaj ◽  
Vilma Cadri ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Abdominal Aorta ◽  
Cardiovascular Mortality ◽  
Pulse Pressure ◽  
Univariate Analysis ◽  
Hemodialysis Patients ◽  
Case Series Study ◽  
Increased Risk ◽  
Elevated Systolic Blood Pressure

Abstract Background and Aims The mortality rate is extremely high in chronic kidney disease (CKD), primarily due to the high prevalence of cardiovascular disease (CVD). Increased pulse pressure (PP), defined as the difference between inappropriately elevated systolic blood pressure (SBP) and reduced diastolic blood pressure (DBP) at any value of mean arterial pressure (MAP), is a surrogate measure of increased arterial stiffness of central elastic arteries (aorta and its major branches). CKD-MBD anomalies leading to calcification contribute to increased arterial stiffness and pulse pressure. This study aimed to evaluate the relationship of pulse pressure parameter with valve calcification and abdominal aortic calcification in hemodialysis patients and its impact on cardiovascular mortality. Method We performed a prospective case series study with 3 years follow- up. Plain X-ray images of the lateral lumbar spine from all subjects were studied to obtain images of the lower abdominal aorta using semiquantitative scores as described by Kauppila et al. Cardiac valve calcifications were evaluated by two-dimensional echocardiography with an HDI 5000 Sono CT echocardiographic machine with a 3.3-MHz multiphase array probe in subjects lying in the left decubitus position an according to the recommendations of the European Association of Echocardiography. The patient was evaluated as having vascular calcification if he had the presence of calcification in at least one of the site examined: a mitral valve, aortic valve or abdominal aorta. Results We studied 85 chronic stable hemodialysis patients. Mean age and meantime is therapy was 49.9±12.4 years and 51.5±28.7 months, respectively. Mean pulse pressure was 55.72±14.2 mmHg. Fifty-nine patients (69.4%) were identified with aortic abdominal calcification, and the mean Kauppila score was 4.91 ± 4.05. Sixty patients (70.5%) had at least one valve calcified, while thirty-three patients (38.8%) had both valves calcified. Univariate analysis revealed that every 1 mmHg increase in pulse pressure was associated with increased cardiovascular calcification risk p=0.020. In multivariate analysis, after adjustment for age, gender, diabetes mellitus, cholesterol, and triglyceride serum levels, the association also remained strong, where every increase of 1 mm Hg in pulse pressure was associated with increased risk for cardiovascular calcification (HR 1.02, 95% CI (1.00-1.03), p= 0.038). Besides, pulse pressure was an independent predictor for cardiovascular mortality (HR 1.03, 95% CI (1.02-1.05), p=0.002). Conclusion Pulse pressure may identify hemodialysis patients with subclinical cardiovascular calcification who need further evaluation. Wide pulse pressure is associated with increased cardiovascular mortality.

scholarly journals Radiomics Nomogram Based on Radiomics Score from Multiregional Diffusion-Weighted MRI and Clinical Factors for Evaluating HER-2 2+ Status of Breast Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1491
Author(s):  
Chunli Li ◽  
Jiandong Yin
Keyword(s):  
Breast Cancer ◽  
Characteristic Curve ◽  
Receiver Operator Characteristic Curve ◽  
Clinical Factors ◽  
Clinical Value ◽  
Logistic Analysis ◽  
Diffusion Weighted ◽  
Apparent Diffusion ◽  
Her 2 ◽  
Multivariate Logistic Analysis

This study aimed to establish and validate a radiomics nomogram using the radiomics score (rad-score) based on multiregional diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) features combined with clinical factors for evaluating HER-2 2+ status of breast cancer. A total of 223 patients were retrospectively included. Radiomic features were extracted from multiregional DWI and ADC images. Based on the intratumoral, peritumoral, and combined regions, three rad-scores were calculated using the logistic regression model. Independent parameters were selected among clinical factors and combined rad-score (com-rad-score) using multivariate logistic analysis and used to construct a radiomics nomogram. The performance of the nomogram was evaluated using calibration, discrimination, and clinical usefulness. The areas under the receiver operator characteristic curve (AUCs) of intratumoral and peritumoral rad-scores were 0.824/0.763 and 0.794/0.731 in the training and validation cohorts, respectively. Com-rad-score achieved the highest AUC (0.860/0.790) among three rad-scores. ER status and com-rad-score were selected to establish the nomogram, which yielded good discrimination (AUC: 0.883/0.848) and calibration. Decision curve analysis demonstrated the clinical value of the nomogram in the validation cohort. In conclusion, radiomics nomogram, including clinical factors and com-rad-score, showed favorable performance for evaluating HER-2 2+ status in breast cancer.

scholarly journals Predictive Value of Plasma Long Noncoding RNA Associated With Microvascular Invasion in Hepatic Carcinoma for Preeclampsia

2020 ◽  
Vol 33 (8) ◽  
pp. 791-791
Author(s):  
Ying Li ◽  
Ning Yang ◽  
Xiao-yi Zou ◽  
Yuan-bing Li ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Predictive Value ◽  
Long Noncoding Rna ◽  
Plasma Levels ◽  
Noncoding Rna ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Microvascular Invasion ◽  
Hepatic Carcinoma ◽  
Urine Protein

Abstract Background To investigate plasma levels of long noncoding RNA associated with microvascular invasion in hepatic carcinoma (LncRNA MVIH) in patients with preeclampsia (PE) and to explore its predictive value for PE either alone or in combination with other indicators. Methods Plasma samples were obtained from patients in a prospective pregnancy cohort at 7–16 weeks of gestation. Patients were divided into PE and control groups according to pregnancy outcomes. Real-time polymerase chain reaction was used to detect plasma levels of LncRNA MVIH. A univariate analysis was conducted on all indicators. Logistic regression analysis was performed on indexes with statistical differences. The receiver operating characteristic curve was used to evaluate the predict value of each independent risk factor and regression model. Results Before 16 weeks of pregnancy, body mass index, systolic blood pressure, diastolic blood pressure, mean arterial pressure, white blood cell (WBC), hemoglobin, alanine aminotransferase (ALT), uric acid (UA), and urine protein were positively correlated with PE while LncRNA MVIH was negatively correlated with PE. Independent markers with predictive value were LncRNA MVIH, UA, WBC, ALT, and urine protein, with the area under curve (AUC) in predicting PE of 0.763, 0.741, 0.663, 0.666, and 0.601, respectively. After combining these indexes, the AUC increased to 0.890 with sensitivity, specificity, and accuracy of 86.4%, 83.1%, and 84.7% respectively. Conclusions Plasma levels of LncRNA MVIH are negatively correlated with PE and have a predictive value for PE. The combination of LncRNA MVIH, UA, WBC, ALT, and urine protein has a greater predictive value.

scholarly journals RNU6-1 in circulating exosomes differentiates GBM from non-neoplastic brain lesions and PCNSL but not from brain metastases

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Montserrat Puigdelloses ◽  
Marisol González-Huárriz ◽  
Marc García-Moure ◽  
Naiara Martínez-Vélez ◽  
Inés Esparragosa Vázquez ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Noncoding Rna ◽  
Characteristic Curve ◽  
Central Nervous System Lymphoma ◽  
Receiver Operator Characteristic Curve ◽  
Brain Lesions ◽  
Healthy Controls ◽  
Subacute Stroke ◽  
Demyelinating Lesions

Abstract Background Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Circulating biomarkers may assist in the processes of differential diagnosis and response assessment. GBM cells release extracellular vesicles containing a subset of proteins and nucleic acids. We previously demonstrated that exosomes isolated from the serum of GBM patients had an increased expression of RNU6-1 compared to healthy subjects. In this exploratory study, we investigated the role of this small noncoding RNA as a diagnostic biomarker for GBM versus other brain lesions with some potential radiological similarities. Methods We analyzed the expression of RNU6-1 in circulating exosomes of GBM patients (n = 18), healthy controls (n = 30), and patients with subacute stroke (n = 30), acute/subacute hemorrhage (n = 30), acute demyelinating lesions (n = 18), brain metastases (n = 21), and primary central nervous system lymphoma (PCNSL; n = 12) using digital droplet PCR. Results Expression of RNU6-1 was significantly higher in GBM patients than in healthy controls (P = .002). RNU6-1 levels were also significantly higher in exosomes from GBM patients than from patients with non-neoplastic lesions (stroke [P = .05], hemorrhage [P = .01], demyelinating lesions [P = .019]) and PCNSL (P = .004). In contrast, no significant differences were found between patients with GBM and brain metastases (P = .573). Receiver operator characteristic curve analyses supported the role of this biomarker in differentiating GBM from subacute stroke, acute/subacute hemorrhage, acute demyelinating lesions, and PCNSL (P < .05), but again not from brain metastases (P = .575). Conclusions Our data suggest that the expression of RNU6-1 in circulating exosomes could be useful for the differentiation of GBM from non-neoplastic brain lesions and PCNSL, but not from brain metastases.

Abstract WMP82: The Association Between Cerebral Microbleeds And Arterial Stiffness

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Tae-Jin Song ◽  
Jinkwon Kim ◽  
Dong-Beom Song ◽  
Hye Sun Lee ◽  
Chung Mo Nam ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Multinomial Logistic Regression ◽  
Univariate Analysis ◽  
Ankle Brachial Index ◽  
Automatic Device ◽  
Cerebral Microbleeds ◽  
P Value ◽  
Amyloid Angiopathy ◽  
Small Vessels ◽  
Logistic Analysis

Background and significance: Increased arterial stiffness causes vessel damage of the end-organs. Thus, in the brain, small vessels may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically categorized as non-lobar type, mostly due to hypertensive vasculopathy and lobar type, due to cerebral amyloid angiopathy. When considering CMBs in the nonlobar region are associated with small vessel pathology, arterial stiffness may be related with CMBs in the nonlobar region. We investigated relationship between CMBs by using brachial ankle pulse wave velocity (baPWV) representing arterial stiffness. Method: Between June 2006 and January 2012, we included 1290 consecutive patients with acute ischemic stroke admitted to hospital within 7 days after symptom onset and who underwent baPWV and brain gradient echo (GRE) and Fluid Attenuated Inversion Recovery (FLAIR) MRI. Patients with potential cardiac sources of embolism or peripheral arterial occlusive disease were not included. BaPWV was measured during ankle-brachial index examination using an automatic device. CMBs were classified as lobar and nonlobar type. Severity of leukoaraiosis was determined using the Fazekas’ scoring system. Binary and multinomial logistic regression analyses were performed to determine variables that were associated with presence and location of CMBs. Results: Mean age of the patients was 64±12 years and 61.9% (799/1290) were male. Of 1290 patients, CMBs were found in 28.6%. The patients with CMBs were older than those without CMBs (69±10 years versus 63±12 years, p=0.001). Mean baPWV was higher in patients with CMBs than those without (2240±512cm/s versus 1896±505cm/s, p=0.001). On multivariate binary logistic analysis, baPWV and high grade leukoaraiosis were independent predictors of the presence of CMBs. However, after adjustment of age, sex and variables with p value of less than 0.1on the univariate analysis, baPWV was independently associated with nonlobar CMBs. Conclusion: Arterial stiffness was independently associated with nonlobar CMBs but not with lobar CMBs. These findings suggest pathophysiologic association between arterial stiffness and CMBs in the nonlobar region.

scholarly journals SIGNATURES OF ANTI-THOMSEN — FRIEDENREICH ANTIGEN ANTIBODY DIVERSITY IN COLON CANCER PATIENTS

2018 ◽  
Vol 40 (1) ◽  
pp. 48-58 ◽  
Author(s):  
O Krutenkov ◽  
M Bubina ◽  
K Klaamas
Keyword(s):  
Colon Cancer ◽  
Prognostic Value ◽  
Characteristic Curve ◽  
Ammonium Thiocyanate ◽  
Receiver Operator Characteristic Curve ◽  
Healthy Controls ◽  
Serum Samples ◽  
Antibody Diversity ◽  
Specific Antibodies ◽  
Diagnostic Potential

Aim: To determine whether the structural and functional diversities of naturally occurring antibodies to the Thomsen — Friedenreich (TF) antigen may be of diagnostic and prognostic value in colon cancer. Materials and Methods: Serum samples were taken from patients with colon cancer (n = 94) and healthy controls (n = 64). The level of TF-specific antibody isotypes and their sialylation were determined using ELISA and lectin-ELISA with synthetic TF-polyacrylamide conjugate as an antigen and a sialic acid-specific Sambucus nigra agglutinin (SNA). The avidity was determined using ammonium thiocyanate as a chaotrope. The accuracy of diagnostics was evaluated using the receiver operator characteristic curve analysis and the survival analysis employing the Kaplan — Meier method. Results: Compared to healthy controls, patients with colon cancer exhibited a lower level of anti-TF IgG antibodies, significantly lower ratios of TF-specific IgG/IgM and IgG/IgA, an increased SNA reactivity of anti-TF antibodies, mostly on account of IgG, and a lower avidity of TF-specific antibodies, especially their SNA-reactive subset. An increased SNA reactivity of anti-TF IgG was observed already at the early stages of cancer (p = 0.0004). The decrease of the ratio of IgG/IgM and IgG/IgA showed a good accuracy of diagnostics with about 60% sensitivity at 90% specificity. A similar potential was found for the SNA binding/IgG level index. The high level of TF-specific IgA antibodies was associated with a lower survival rate (hazard ratio = 0.34). Conclusion: This is the first report ever on the colon cancer-related signatures of anti-TF antibody diversity which show diagnostic potential, including in early cancer, and prognostic value. The hypersialylation of TF-specific antibodies appeared to be a common phenomenon in cancer. The signatures may be used as non-invasive antibody-based markers for colon cancer.

scholarly journals AB0406 ASSOCIATION OF ENDOTHELIN-1 WITH PULSE WAVE VELOCITY IN SYSTEMIC SCLEROSIS PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1231.2-1232
Author(s):  
A. Alvarez de Cienfuegos ◽  
L. Cantero-Nieto ◽  
J. A. García-Gómez ◽  
J. L. Callejas-Rubio ◽  
J. Martin Ibanez ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Serum Levels ◽  
Healthy Controls ◽  
Endothelin 1 ◽  
Female Patients

Background:Systemic sclerosis (SSc) is a multisystemic disease featured by vascular and immunological disorders along with an excessive accumulation of the components of the connective tissue that cause cutaneous sclerosis and fibrosis of different organs. The occurrence of endothelial dysfunction together with fibrosis indicates that endothelial cell-derived factors, such as endothelin-1 (ET-1), may have an important role in the pathogenesis of SSc. The upregulation of ET-1 activates inflammatory cells and leads to nitric oxide synthase inhibition associated with arterial stiffness.Objectives:The purpose of this study was to evaluate ET-1 serum levels in women with systemic sclerosis (SSc) compared with healthy controls and to examine possible associations between ET-1 and markers of arterial stiffness.Methods:This cross-sectional study was performed in San Cecilio Hospital, Granada (Spain) from November 2017 to May 2019. Sixty-two women with SSc and 62 age and sex matched healthy controls were enrolled in this study. Pulse Wave Velocity (PWV) was measured non-invasively along the carotid–femoral arterial segment. Serum ET-1 was analysed using indirect enzyme-linked immunosorbent assay (ELISA).Results:A total of 62 female patients were included in our study, with a mean (SD) age of 53 ± 10 years. The majority were Caucasian (90.5%). The mean disease duration was 8.8 ± 6.9 years. Forty-four (70.9%) patients had a limited form of the disease and 18 (29.1%) had a diffuse form.There was a significant difference in ET-1 serum levels between SSc female patients and healthy controls (28.4 ± 10.6 vs. 21.1 ± 11.7 pg/ml, p = 0.001). Serum levels of ET-1 were positively associated with PWV (r = 0.26, p < 0.05), within the study group. In addition, in the linear regression model, higher ET-1 concentrations were associated with higher PWV [β = 0.03 95% CI (0.001, 0.060); p < 0.05].Conclusion:This study shows that ET-1 serum levels are associated with PWV in women with SSc. Therefore, drugs that block ET-1 may be effective in reducing large artery stiffness in women with SSc, and thus cardiovascular risk.References:[1]LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, et al. Scleroderma (systemic sclerosis): classification, bubsets and pathogenesis. J Rheumatol 1988; 15(2):202-205.[2]Shi-Wen X, Denton CP, Dashwood MR, Holmes AM, Bou-Gharios G, Pearson JD, et al. Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. J Invest Dermatol 2001; 116(3):417–425.[3]Heintz B, Dörr R, Gillessen T, Walkenhorst F, Krebs W, Hanrath P, et al. Do arterial endothelin 1 levels affect local arterial stiffness?. Am Heart J 1993; 126 (4): 987–989.[4]McEniery CM, Qasem A, Schmitt M, Avolio AP, Cockcroft JR, Wilkinson IB. Endothelin-1 regulates arterial pulse wave velocity in vivo. J Am Coll Cardiol 2003; 42 (11): 1975–1981.Disclosure of Interests:None declared

Abstract 3219: Influence of Adiposity on Arterial Stiffness in Healthy Children

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Satoru Sakuragi ◽  
Katrina Abhayaratna ◽  
Christine O’Reilly ◽  
Wichat Srikusalanukul ◽  
Karen Gravenmaker ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Heart Rate ◽  
Arterial Stiffness ◽  
Univariate Analysis ◽  
Insulin Level ◽  
Healthy Children ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Fasting Insulin Level

Childhood obesity is increasingly prevalent in the community and is related to adverse cardiovascular outcomes during adulthood. Identification of intermediary markers of preclinical cardiovascular disease may identify high-risk children who would benefit greatest from primary prevention measures. In this study, we evaluated the relationship between adiposity on arterial stiffness in healthy children. In 596 healthy children (mean age 10.1 +/− 0.3 years; 51% boys), we measured body mass index (BMI) and waist circumference (WC). Percentage body fat (%BF) was quantitated by dual-energy x-ray absorptiometry (DEXA). Insulin resistance was assessed by a fasting insulin level and homeostasis model assessment as an index of insulin (HOMA-IR). Carotid-femoral pulse wave velocity (PWV), an index of aortic stiffness, was estimated by applanation tonometry. Compared to girls, boys were older (10.1 vs 10.0 years, p=0.01); and had higher WC (61 vs. 60 cm, p=0.02), lower %BF (24% vs. 29 %, p<0.001), similar BMI (18.0 vs. 18.5, p=0.05) and lower PWV (4.4 vs 4.5 m/sec, p<0.001). In univariate analysis, BMI (ρ=0.26 and ρ=0.31), WC (ρ=0.32 and ρ=0.26) and %BF (ρ=0.23 and ρ=0.30) were correlated positively with PWV in boys and girls, respectively (all p<0.001). After adjustment for age, systolic blood pressure, mean arterial pressure and heart rate, BMI, WC and %BF were significantly associated with PWV (p<0.01) (Table ). HOMA-IR and fasting insulin level were not predictors of PWV (p>0.07 for both). Increased adiposity is related to arterial stiffness in healthy children, independently of blood pressure and heart rate. Further studies are required to evaluate whether public health efforts to promote healthy lifestyles and weight loss in children will reduce arterial stiffness, attenuate the progression of subclinical cardiovascular disease, and prevent the development of subsequent cardiovascular events in the community. Table: Separate Multivariable Models relating Predictor Variable to PWV

scholarly journals Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1326 ◽  
Author(s):  
Anastasios Vamvakis ◽  
Eugenia Gkaliagkousi ◽  
Antonios Lazaridis ◽  
Maria G. Grammatikopoulou ◽  
Areti Triantafyllou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Randomized Controlled Trial ◽  
Arterial Stiffness ◽  
Controlled Trial ◽  
Univariate Analysis ◽  
Stiffness Index ◽  
Dietary Analysis ◽  
Randomized Controlled ◽  
Lifestyle Treatment ◽  
Stage 1

Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, β-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion (p ≤ 0.001), daytime systolic BP (p ≤ 0.048) and mean carotid β-stiffness index (p ≤ 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (β = 0.089, p ≤ 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness.

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