A comprehensive examination and health improvement of 40 patients has been performed using therapeutic physical factors of the sanatorium «Belokurikha», JSC «Belokurikha Resort». High incidence of overweight, hereditary burden of cardiovascular diseases, hyperglycemia, low physical activity, dyslipidemia and atherogenic cholesterol fraction has been revealed. At the same time, 60 % of the examined patients had combination of 3–4 risk factors for cardiovascular diseases, most often obesity, dyslipidemia, hyperglycemia. It is established that appointment of pathogenetically based treatment complex, including physical therapy, manual massage, general mineral baths, peloidotherapy, Nordic walking, therapy with elastic pseudo-boiling layer has signifi cant anti-infl ammatory and hypolipidemic eff ects, helps to reduce the severity of endogenous intoxication, and to increase adaptive potential.