scholarly journals Protein and Omega-3 Polyunsaturated Fatty Acid Supplementation for 16 Weeks Improves Sleep and Mood States in Postmenopausal Women

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 9-9
Author(s):  
Jamie Baum ◽  
Aubree Hawley ◽  
Caroline Baughn ◽  
Sam Walker ◽  
Angela Tacinelli ◽  
...  
Keyword(s):  
Body Composition ◽  
Sleep Quality ◽  
Postmenopausal Women ◽  
Dietary Intervention ◽  
Sleep Time ◽  
Protein Isolate ◽  
Mood States ◽  
Current Evidence ◽  
Omega 3 ◽  
Wrist Actigraphy

Abstract Objectives Body composition shifts as we age, resulting in loss of skeletal muscle mass with an increase in fat mass, which is linked to disruptions in sleep-wake rhythms and mood disturbance. Current evidence suggests protein and omega-3 polyunsaturated fatty acids (O3FA) individually augment sleep quality and attenuate depression, but a concomitant effect is yet to be determined. The objective of this study was to determine the effect of protein and O3FA supplementation on regulation of sleep and mood states in postmenopausal women. Methods Overweight, postmenopausal women (60.6 ± 9.0 years; BMI: 28.1 ± 6.9) participated in this randomized, controlled, single-blinded, 16 wk dietary intervention. Participants were allocated to 1 of 5 groups: 1) control, no INT (n = 6); 2) whey protein isolate (PRO; 25 g/d; n = 4); 3) O3FA (DHA/EPA; 4.3 g/d; n = 10); 4) PRO + soy bean oil (4.3 g/d) placebo (n = 6), and 5) PRO + O3FA (n = 8). Sleep (via Pittsburgh Sleep Quality Index Global Sleeping Score; PSQI GSS) and total mood disturbances; (TMD; via Profile of Mood States (POMS)) including six affect states of depression, fatigue, anger, tension, confusion, and vigor subscales were assessed at 0, 4, 8, 12, and 16 wks. Sleep was measured at 0, 8, and 16 wk via wrist Actigraphy. Body composition was measured via DXA at 0 and 16 wk. Data were analyzed using two-way ANOVA to assess the relationship between diet, sleep, and mood states over time. Results Overall, all interventions improved PSQI GSS (P < 0.05) by 16 wks. There was a trend for all interventions to improve sleep efficiency (P = 0.06), with no effect on total sleep time. All interventions improved TMD (P < 0.05) and vigor (P < 0.001), with a trend on depression (P = 0.06). PRO, O3FA, and O3FA + PRO significantly improved vigor at 12-wks (P < 0.01). PRO alone significantly improved vigor at 16 wk (P < 0.001) compared to CON. There was no significant effect of intervention on body composition. However, PRO, O3FA, and PRO + O3FA had a positive (564.7 ± 681.4 g) and the CON had a negative (−171.0 ± 991.6) net change of total lean mass at 16 wks. Conclusions This pilot study suggests that PRO, O3FA, and PRO + O3FA have potential to improve sleep and mood in overweight, postmenopausal women. Additional research is needed to determine the long-term individual and concomitant effect of PRO and O3FA on sleep and mood states. NCT0303041. Funding Sources Arkansas Biosciences Institute.

scholarly journals The Impact of Supplementation With Whey Protein Isolate and/or Omega-3 Fatty Acids on Sleep and Mood in Postmenopausal Women (SHAPE Study)

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 499-499
Author(s):  
Aubree Hawley ◽  
Caroline Baughn ◽  
Angela Tacinelli ◽  
Sam Walker ◽  
Xinya Liang ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Postmenopausal Women ◽  
Whey Protein ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Mood States ◽  
Sleep Disruption ◽  
Omega 3 ◽  
Wrist Actigraphy ◽  
The Impact

Abstract Objectives Approximately 30% of adults ≥ 50 years of age suffer from poor sleep quality and the prevalence of sleep disruption is notably higher in postmenopausal women, with 35 to 60% reporting significant sleep disruption.  Sleep deprivation and low sleep quality are associated with increased energy intake, insulin resistance, elevated glucose, and mood disturbances (e.g., stress, cortisol, and depression). The objective of this study was to determine if the effect of protein and/or omega-3 fatty acid (O3FA) supplementation improves mood and sleep in postmenopausal women. Methods Thirty-nine postmenopausal women (age: 61.3 ± 8.7 years; BMI: 27.6 ± 6.6 kg/m2) were randomly allocated to one of 5 groups: 1) control (CON; no intervention free-living; n = 6), 2) whey protein isolate (PRO; 25 g/d; n = 7), 3) O3FA (DHA/EPA; 4.3 g/d; n = 10), 4) PRO + placebo soybean oil (PRO + PLA; 4.1 g/d; n = 7), or 5) PRO + O3FA (n = 9). Sleep and mood states were assessed at 0, 4, 8, 12, and 16 weeks, except objective sleep, which was assessed at 0, 8, and 16 weeks.  Sleep was measured using the Pittsburgh Sleep quality Index (PSQI) and wrist actigraphy, mood was measured using the Profile of Mood States (POMS), and markers of sleep and mood, orexin, BDNF, and cortisol, were measured using commercially available kits. Results A significant time effect (P < 0.05) was observed on subjective sleep (PSQI), subjective mood states, BDNF, and cortisol concentrations. Although not significant, a greater % decrease in PSQI Global Sleep Score was observed in PRO (-30.3%), O3FA (-23.3%), PRO + PLA (−20.2%), and PRO + O3FA (−26.4%) when compared to an increase in CON (+18%). Similarly, a decrease trend in POMS Total Mood Disturbances from baseline was observed in PRO (−10 ± 27.7), O3FA (−6.7 ± 18.2), and PRO + O3FA (−6.9 ± 27.7) compared to no change in PRO + PLA (0.1 ± 11.5) and an increase in CON (5 ± 15.8). We observed a significant treatment effect on orexin (OXA; pg/mL; P < 0.05). OXA increased significantly in PRO + O3FA compared to all other groups (P < 0.05). Conclusions Although not significant, the data suggests individual and combined supplementation of protein and O3FA have the potential to improve sleep, mood, and orexin levels in postmenopausal women. NCT0303041 Funding Sources Arkansas Biosciences Institute

scholarly journals Differential Effects of DHA- and EPA-Rich Oils on Sleep in Healthy Young Adults: A Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 248
Author(s):  
Michael J. Patan ◽  
David O. Kennedy ◽  
Cathrine Husberg ◽  
Svein Olaf Hustvedt ◽  
Philip C. Calder ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Controlled Trial ◽  
Sleep Time ◽  
Sleep Efficiency ◽  
Omega 3 ◽  
Double Blind ◽  
Differential Effects ◽  
Positive Effects ◽  
Time In Bed ◽  
Oily Fish

Emerging evidence suggests that adequate intake of omega-3 polyunsaturated fatty acids (n-3 PUFAs), which include docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), might be associated with better sleep quality. N-3 PUFAs, which must be acquired from dietary sources, are typically consumed at suboptimal levels in Western diets. Therefore, the current placebo-controlled, double-blind, randomized trial, investigated the effects of an oil rich in either DHA or EPA on sleep quality in healthy adults who habitually consumed low amounts of oily fish. Eighty-four participants aged 25–49 years completed the 26-week intervention trial. Compared to placebo, improvements in actigraphy sleep efficiency (p = 0.030) and latency (p = 0.026) were observed following the DHA-rich oil. However, these participants also reported feeling less energetic compared to the placebo (p = 0.041), and less rested (p = 0.017), and there was a trend towards feeling less ready to perform (p = 0.075) than those given EPA-rich oil. A trend towards improved sleep efficiency was identified in the EPA-rich group compared to placebo (p = 0.087), along with a significant decrease in both total time in bed (p = 0.032) and total sleep time (p = 0.019) compared to the DHA-rich oil. No significant effects of either treatment were identified for urinary excretion of the major melatonin metabolite 6-sulfatoxymelatonin. This study was the first to demonstrate some positive effects of dietary supplementation with n-3 PUFAs in healthy adult normal sleepers, and provides novel evidence showing the differential effects of n-3 PUFA supplements rich in either DHA or EPA. Further investigation into the mechanisms underpinning these observations including the effects of n-3 PUFAs on sleep architecture are required.

scholarly journals Nutrition in Menopausal Women: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2149
Author(s):  
Thais R. Silva ◽  
Karen Oppermann ◽  
Fernando M. Reis ◽  
Poli Mara Spritzer
Keyword(s):  
Body Composition ◽  
Postmenopausal Women ◽  
Bone Fractures ◽  
Blood Pressure Reduction ◽  
Antioxidant Properties ◽  
Narrative Review ◽  
Current Evidence ◽  
Beneficial Effects ◽  
Clinical Endpoints ◽  
Postmenopausal Period

Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal period, nutritional habits are essential because they concern all women, can be modified, and impact both longevity and quality of life. In this narrative review, we discuss the current evidence on the association between dietary patterns and clinical endpoints in postmenopausal women, such as body composition, bone mass, and risk markers for cardiovascular disease. Current evidence suggests that low-fat, plant-based diets are associated with beneficial effects on body composition, but further studies are needed to confirm these results in postmenopausal women. The Mediterranean diet pattern along with other healthy habits may help the primary prevention of bone, metabolic, and cardiovascular diseases in the postmenopausal period. It consists on the use of healthy foods that have anti-inflammatory and antioxidant properties, and is associated with a small but significant decrease in blood pressure, reduction of fat mass, and improvement in cholesterol levels. These effects remain to be evaluated over a longer period of time, with the assessment of hard outcomes such as bone fractures, diabetes, and coronary ischemia.

689 Objective Assessment of Inpatient Sleep Patterns and Quality: A Pilot Study

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A269-A269
Author(s):  
Sarah Sussman ◽  
Ashwin Ananth ◽  
Elie Fares ◽  
Maurits Boon ◽  
Colin Huntley ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Slow Wave Sleep ◽  
Total Sleep Time ◽  
Objective Assessment ◽  
General Medicine ◽  
Sleep Time ◽  
Sleep Medicine ◽  
Inpatient Setting ◽  
Wrist Actigraphy ◽  
Patient Reported

Abstract Introduction Sleep disruption is common among hospitalized patients due to psychological, physiological, and environmental reasons including illness, pain, anxiety, invasive interventions, frequent monitoring, and stimuli, especially noise and light. The AASM has published guidelines for the use of actigraphy in the outpatient setting, but there is a paucity of literature evaluating the validity of actigraphy in inpatients. The aim of this study is to evaluate sleep in hospitalized general medicine patients undergoing sleep medicine consultation using actigraphy and qualitative surveys. Methods A single-site prospective study in hospitalized medicine patients. Patients were observed with a Fitbit® Charge3 wrist actigraphy device overnight, then administered 7 surveys: Richards-Campbell Sleep Questionnaire (RCSQ), qualitative questionnaires assessing sleep history, sleep hygiene, barriers to sleep, STOP-BANG, Epworth Sleepiness Scale (ESS), and Patient-Health Questionniare-2 (PHQ-2). Actigraphy data including total sleep time, slow wave sleep time, and number of awakenings was compared with patient-reported data. Results In preliminary analysis, six patients met inclusion criteria and underwent sleep medicine consultation, overnight actigraphy, and completed 7 surveys. Based on subjective sleep history questionnaires, average total sleep time was 437 + 215 minutes. Actigraphy revealed average total sleep time was 228 + 80 minutes with an average of 3.6 nocturnal awakenings. Increased number of awakenings on actigraphy was not correlated with increased number of awakenings by survey. The most frequently reported barriers to sleep on patient surveys were pain and being woken up for labs or vital signs. The average STOP-BANG score was 6 out of 8 and average ESS was 14 out of 24. Conclusion Restorative sleep warrants consideration alongside complex medical care during hospitalization. Patients experience decreased total sleep time and increased number of awakenings while in the hospital compared with their subjective estimates of sleep at home. Actigraphy provides a non-invasive and reliable way to monitor some sleep parameters in the inpatient setting. An elevated STOP-BANG score could represent sleep disordered breathing and impact perceptions of sleep quality. Patient-identified barriers to sleep are targets for quality improvement. Future studies should compare inpatient actigraphy data to polysomnographic data and the effect of sleep-directed interventions on sleep quality in the hospital. Support (if any):

scholarly journals The Impact of Whey Protein and/or Omega-3 Fatty Acid Supplementation on Body Composition, Energy Expenditure and Metabolic Health in Postmenopausal Women (SHAPE Study)

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 500-500
Author(s):  
Aubree Hawley ◽  
Angela Tacinelli ◽  
Sam Walker ◽  
Xinya Liang ◽  
Jamie Baum
Keyword(s):  
Body Composition ◽  
Fatty Acid ◽  
Energy Expenditure ◽  
Postmenopausal Women ◽  
Muscle Mass ◽  
Metabolic Health ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Age Related ◽  
The Impact

Abstract Objectives Age-related deleterious shifts in body composition can lead to sarcopenia, which is the age-related loss of muscle mass, strength, and function. Furthermore, declines in endogenous estrogen production during the menopausal transition are associated with muscle mass loss and increased central adiposity, putting postmenopausal women at increased risk for negative health outcomes such as cardiovascular disease and type-2 diabetes mellitus. The objective of this study was to determine the effect of protein and/or omega-3 fatty acid (O3FA) supplementation on metabolic health in postmenopausal women. Methods Thirty-nine postmenopausal women (age: 61.3 ± 8.7 years; BMI: 27.6 ± 6.6 kg/m2) were randomly allocated to one of 5 groups: 1) control (CON; no intervention free-living; n = 6), 2) whey protein isolate (PRO; 25 g/d; n = 7), 3) O3FA (DHA/EPA; 4.3 g/d; n = 10), 4) PRO + placebo soybean oil (PRO + PLA; 4.1 g/d; n = 7), or 5) PRO + O3FA (n = 9). Energy expenditure via indirect calorimetry, dietary intake via 3-day weighed dietary records, hand grip strength (HGS), and metabolic health were assessed at 0, 4, 8, 12, and 16 weeks.  Body composition was measured via dual x-ray absorptiometry at 0 and 16 weeks. Metabolic health was assessed using waist-to-hip ratio and biomarkers such as plasma glucose, insulin, free fatty acids, and cholesterol. Results There was not an effect of treatment effect on anthropometrics, body composition, HGS, or resting energy expenditure. However, a decrease in android fat % was observed in PRO compared to baseline (P < 0.05) in the absence of anthropometric change (BMI, weight, waist, hip). A significant group by time effect was observed on resting fat oxidation (P < 0.05); O3FAs (+34.6%; P < 0.05) and PRO + O3FAs (+55.6%; P < 0.05) significantly increased and PRO decreased (−37.8%; P < 0.05) from baseline to 16 weeks.  There was a significant (P < 0.05) decrease in cholesterol in all groups compared to CON. Conclusions Although not significant, the data suggests individual and combined supplementation of protein and O3FA have the potential to improve body composition and substrate oxidation in postmenopausal women. NCT0303041 Funding Sources Arkansas Biosciences Institute

Measure of Atopic Dermatitis Disease Severity Using Actigraphy

2014 ◽  
Vol 18 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Laura F. Sandoval ◽  
Karen Huang ◽  
Jenna L. O'Neill ◽  
Cheryl J. Gustafson ◽  
Emily Hix ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Sleep Quality ◽  
Disease Severity ◽  
Sleep Disturbances ◽  
Sleep Onset ◽  
Sleep Time ◽  
Random Effects Models ◽  
Short Course ◽  
Wrist Actigraphy ◽  
The Impact

Background: Analyzing adherence to treatment and outcomes in atopic dermatitis is limited by methods to assess continual disease severity. Atopic dermatitis significantly impacts sleep quality, and monitoring sleep through actigraphy may capture disease burden. Purpose: To assess if actigraphy monitors provide continuous measures of atopic dermatitis disease severity and to preliminarily evaluate the impact of a short-course, high-potency topical corticosteroid regimen on sleep quality. Methods: Ten patients with mild to moderate atopic dermatitis applied topical fluocinonide 0.1% cream twice daily for 5 days. Sleep data were captured over 14 days using wrist actigraphy monitors. Investigator Global Assessment (IGA) and secondary measures of disease severity were recorded. Changes in quantity of in-bed time sleep were estimated with random effects models. Results: The mean daily in-bed time, total sleep time, and wake after sleep onset (WASO) were 543.7 minutes (SEM 9.4), 466.0 minutes (SEM 7.7), and 75.0 minutes (SEM 3.4), respectively. WASO, a marker of disrupted sleep, correlated with baseline (ρ = .75) and end of treatment IGA (ρ = .70). Most patients did not have marked changes in sleep. IGA scores declined by a median change of 1 point at days 7 ( p = .02) and 14 ( p = .008). Conclusions: Using actigraphy, atopic dermatitis disease severity positively correlated with sleep disturbances. Actigraphy monitors were well tolerated by this cohort of atopic dermatitis subjects.

scholarly journals The Effects of Concurrent Training on the Body Composition, Quality of Life, and Sleep Quality of Postmenopausal Women with Breast Cancer

2020 ◽  
Vol 24 (3) ◽  
Author(s):  
Amirabbas Monazzami ◽  
Roya Momenpour ◽  
Elham Alipoor ◽  
Kheirollah Yari ◽  
Mehrdad Payandeh
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Body Composition ◽  
Resistance Training ◽  
Exercise Training ◽  
Sleep Quality ◽  
Postmenopausal Women ◽  
Training Group ◽  
Concurrent Training

Background: Concurrent training is more effective in developing fitness indicators than doing endurance and resistance training separately. However, there has been limited research to evaluate the effects of this type of exercise training on improvement of body composition and quality of life indicators in postmenopausal women with cancer. Objectives: The present study aimed to determine the effects of eight-week of concurrent training on body composition, quality of life, and sleep quality in postmenopausal women with breast cancer. Methods: This study was conducted on 42 women with breast cancer who were selected randomly and divided into exercise training and control groups. The training group followed eight-week of resistance training (2 - 3 sets, 10 - 18 repetitions, and 50% - 70% 1RM) and aerobic training (50% - 70% maximum heart rate, 12 - 14 Borg scale, and 20 - 40 minutes). Anthropometric characteristics were measured based on body composition (ZEUS 9.9), the sleep quality was measured by the Pittsburgh sleep quality index (PSQI), and the quality of life was measured by the McGill quality of life (MQOL) questionnaire. Two-way repeated measures ANOVA has been used for McGill’s analysis of variance (P < 0.05). Results: The results showed a significant decrease in sleep quality score, weight, fat percentage, BMI, and waist circumference in the training group (P < 0.05), as well as an increase in quality of life index in the training group (P < 0.05). However, no significant changes were observed in the Waist-hip ratio (WHR) values of the training group compared with the control group (P > 0.05). Conclusions: Although the changes in WHR index were not significant after eight weeks of concurrent training, this type of training program could be considered as a beneficial way for improving body composition, quality of life, and sleep quality in patients with breast cancer.

scholarly journals Sleep-Wake Patterns during the Acute Phase after First-Ever Stroke

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Linda N. Bakken ◽  
Kathryn A. Lee ◽  
Hesook Suzie Kim ◽  
Arnstein Finset ◽  
Anners Lerdal
Keyword(s):  
Sleep Quality ◽  
Sleep Time ◽  
Structured Interview ◽  
Quality Data ◽  
Clinical Factors ◽  
Subjective Sleep Quality ◽  
Wake Time ◽  
Subjective Sleep ◽  
Wrist Actigraphy ◽  
Wake Patterns

This study describes the pattern of day and night sleep and explores relationships between these patterns and sociodemographic and clinical factors as well as sleep environmental context and the patient's subjective sleep quality. Data from 110 patients with first-ever stroke was collected by structured interview surveys, medical record, and objective estimated sleep data from wrist actigraphy. The variability in estimated sleep is large. Half the patients slept either <6 hours or >8 hours per night, and 78% had more than nine awakenings per night. Men slept less than women, and patients sleeping at home had fewer awakenings than those who slept in hospital. It was estimated sleep during daytime in all, except 4, patients. Longer stay in hospital was related to more daytime sleep, and the subjective sleep quality correlated with estimated sleep time, wake time, and wake percentage.

Activity Engagement in Cognitive Aging: A Review of the Evidence

2013 ◽  
Vol 23 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Yvonne Rogalski ◽  
Muriel Quintana
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Aging ◽  
Social Activity ◽  
Current Evidence ◽  
Omega 3 ◽  
Neuroprotective Effects ◽  
Activity Engagement ◽  
Age Related ◽  
Age Related Cognitive Decline

The population of older adults is rapidly increasing, as is the number and type of products and interventions proposed to prevent or reduce the risk of age-related cognitive decline. Advocacy and prevention are part of the American Speech-Language-Hearing Association’s (ASHA’s) scope of practice documents, and speech-language pathologists must have basic awareness of the evidence contributing to healthy cognitive aging. In this article, we provide a brief overview outlining the evidence on activity engagement and its effects on cognition in older adults. We explore the current evidence around the activities of eating and drinking with a discussion on the potential benefits of omega-3 fatty acids, polyphenols, alcohol, and coffee. We investigate the evidence on the hypothesized neuroprotective effects of social activity, the evidence on computerized cognitive training, and the emerging behavioral and neuroimaging evidence on physical activity. We conclude that actively aging using a combination of several strategies may be our best line of defense against cognitive decline.

Body composition and bone mineral density in postmenopausal women

2014 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliia Dzerovych ◽  
Roksolana Povoroznyuk
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density
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