scholarly journals The Correlation Between Caffeine Intake and Brain Health in Cognitively Normal Healthy Older Adults

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 295-295
Author(s):  
Sibelle Alwatchi Alhayek ◽  
Matthew Taylor ◽  
In Young Choi ◽  
Phil Lee ◽  
Kendra Spaeth ◽  
...  
Keyword(s):  
Older Adults ◽  
Magnetic Resonance ◽  
Neurological Diseases ◽  
Caffeine Intake ◽  
Brain Metabolites ◽  
Imaging Method ◽  
Brain Health ◽  
Cognitively Normal ◽  
Healthy Older Adults ◽  
The Impact

Abstract Objectives Caffeine is associated with brain health, and it is suggested to lower the risk of neurological diseases. This cross-sectional study aimed to investigate the association between caffeine intake and concentration of brain metabolites in healthy older adults. Methods Caffeine intake was determined in 60 cognitively normal, healthy older adults aged between 60–85 years (61.9% women) using a 7-day food record (7D) that was collected seven days prior to their Magnetic Resonance scan. The 7D was entered in the Nutrition Data System for Research (NDS-R version 2012) for nutrient analysis. Brain metabolites [N-acetylaspartate, creatine, total choline, glutamate + glutamine, and myo-inositol (mI)] were measured using a 1H magnetic resonance spectroscopic imaging method at 3T. All metabolites were quantified using LCModel analysis software and concentrations are shown as a ratio to creatine. Measurements were presented as mean ± standard deviation and n(%). We assessed the relationship between caffeine intake and brain metabolite concentrations by multiple linear regression, adjusting for age and sex. Statistical analyses were performed using SPSS (v25, IBM) with significance of P ≤ 0.05. Results Participants had a mean age of 69.3 ± 7.3 years. Mean caffeine intake among the participants was 152.17 ± 133.79mg/d (range: 0–635.98mg/d). There was a significant correlation between caffeine and mI (β = 0.443; P = 0.001). The remaining metabolites were not correlated with caffeine intake. Conclusions Higher caffeine intake in older adults was associated with higher brain mI concentrations. The metabolic link between brain mI concentrations and neurological diseases is still unclear, thus, future studies are necessary regarding the mechanism for the impact of caffeine on brain metabolism. Funding Sources This study is supported by funding from National Dairy Council (IYC). The Hoglund Brain Imaging Center is supported by grants from the NIH (C76 HF00201, P30 HD002528, S10 RR29577, UL1 TR000001, and P30AG035982) and the Hoglund Family Foundation.

The Impact of Stereotype Threat on Memory and Cognition in Older Adults

2021 ◽  
pp. 019394592110297
Author(s):  
Graham J. McDougall ◽  
Todd B. Monroe ◽  
Keenan A. Pituch ◽  
Michael A. Carter ◽  
Laurie Abbott
Keyword(s):  
Older Adults ◽  
Stereotype Threat ◽  
Verbal Memory ◽  
Memory Performance ◽  
Training Group ◽  
Memory Training ◽  
Unique Contribution ◽  
Healthy Older Adults ◽  
Bivariate Correlation ◽  
The Impact

Cultural stereotypes that equate aging with decreased competence and increased forgetfulness have persisted for decades. Stereotype threat (ST) refers to the psychological discomfort people experience when confronted by a negative, self-relevant stereotype in a situation where their behavior could be construed as confirming that belief. The purpose of this study was to examine the relationships of ST on memory performance in older adults over 24 months. The ST levels on average significantly declined, or improved in the memory training, but not the health training group. Although not significant at the .01 level, the bivariate correlation indicated that change in ST was moderately related to change in verbal memory, suggesting the possibility that improvements (or reductions) in ST may be related to increases in verbal memory scores. We discovered that the unique contribution of ST into the memory performance of healthy older adults offers a possible malleable trait.

The impact of acute exercise on cognitive function in healthy older adults

Physiotherapy ◽  
2015 ◽  
Vol 101 ◽  
pp. e402-e403
Author(s):  
J. Fortune ◽  
I. Robertson ◽  
A. Kelly ◽  
J. Hussey
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Acute Exercise ◽  
Healthy Older Adults ◽  
The Impact

scholarly journals Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults

2014 ◽  
Vol 28 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Jehill Parikh ◽  
Michael J. Thrippleton ◽  
Catherine Murray ◽  
Paul A. Armitage ◽  
Bridget A. Harris ◽  
...  
Keyword(s):  
Older Adults ◽  
Basal Ganglia ◽  
Spectroscopic Imaging ◽  
Brain Metabolites ◽  
Healthy Older Adults

scholarly journals High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults

2018 ◽  
Vol 65 ◽  
pp. 158-167 ◽  
Author(s):  
Lucy V. Hiscox ◽  
Curtis L. Johnson ◽  
Matthew D.J. McGarry ◽  
Michael Perrins ◽  
Aimee Littlejohn ◽  
...  
Keyword(s):  
Older Adults ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Gray Matter ◽  
Magnetic Resonance Elastography ◽  
Healthy Older Adults

Possible selves and illness: A comparison of individuals with Parkinson's disease, early-stage Alzheimer's disease, and healthy older adults

2003 ◽  
Vol 27 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Leslie D. Frazier ◽  
Victoria Cotrell ◽  
Karen Hooker
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Possible Selves ◽  
Early Stage ◽  
Healthy Older Adults ◽  
Patient Groups ◽  
The Impact

This study examined how future self-representations are affected by two different chronic illnesses, one focused on cognitive losses, early-stage Alzheimer's disease (AD), and one focused on physical losses, Parkinson's disease (PD). The impact of illness on possible selves (perceptions of self in the future) was made salient by a comparison with healthy older adults in order to better understand developmental issues in later life. Findings show that although there were no differences in the total number of domains reported by the groups, specific domains were reported differently by patient groups and all domains were likely to become infused with illness. As expected, patient groups had less self-efficacy and lower outcome expectancies for their future selves, and PD patients reported less distance from their feared selves. Although these findings are intuitive, this is the first empirical effort to document the impact of illness on older adults' self-representations. Group differences are explained in terms of disease context, and the importance of possible selves and self-regulatory functions as therapeutic mechanisms for adaptation to illness are emphasised.

scholarly journals The Effect of Music Therapy on Cognitive Functioning Among Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 784-784
Author(s):  
Kuei-Min Chen
Keyword(s):  
Older Adults ◽  
Social Interaction ◽  
Older People ◽  
Music Therapy ◽  
Cognitive Functioning ◽  
Brain Health ◽  
Community Based Interventions ◽  
Community Based ◽  
Therapy Interventions ◽  
The Impact

Abstract Music creates and fosters connection and interrelationships between individuals and encourages social interaction. Indeed, community-based interventions are a powerful way to engage older people. This presentation will provide an overview of music therapy and the impact it can have on the cognitive functioning of older people. Examples of music therapy interventions in the community can be found in nursing homes, hospitals, or communities. Differences in receptive (passive) music therapy and active music therapy will be discussed along with the impact these therapies may have on individuals experiencing cognitive decline. Moreover, studies of music therapy combined with other activities, such as exercise or art will be discussed. This research will be presented within the context of the recommendations put forth by the Global Council on Brain Health aimed at adults aged 50+.

scholarly journals Effect of Aerobic Exercise on Amyloid Accumulation in Preclinical Alzheimer's: A 1-Year Randomized Controlled Trial

2020 ◽  
Author(s):  
Eric Vidoni ◽  
Jill K Morris ◽  
Amber Watts ◽  
Mark Perry ◽  
Jon Clutton ◽  
...  
Keyword(s):  
Older Adults ◽  
Randomized Controlled Trial ◽  
Aerobic Exercise ◽  
Brain Volume ◽  
Controlled Trial ◽  
Brain Health ◽  
Cognitively Normal ◽  
Randomized Controlled ◽  
Amyloid Accumulation ◽  
Cerebral Amyloid

Background: Our goal was to investigate the role of physical exercise to protect brain health as we age, including the potential to mitigate Alzheimer's-related pathology. We assessed the effect of 52 weeks of a supervised aerobic exercise program on amyloid accumulation, cognitive performance, and brain volume in cognitively normal older adults with elevated and sub-threshold levels of cerebral amyloid as measured by amyloid PET imaging. Methods and Findings: This 52-week randomized controlled trial compared the effects of 150 minutes per week of aerobic exercise vs. education control intervention. A total of 117 older adults (mean age 72.9 [7.7]) without evidence of cognitive impairment, with elevated (n=79) or subthreshold (n=38) levels of cerebral amyloid were randomized, and 110 participants completed the study. Exercise was conducted with supervision and monitoring by trained exercise specialists. We conducted 18F-AV45 PET imaging of cerebral amyloid and anatomical MRI for whole brain and hippocampal volume at baseline and Week 52 follow-up to index brain health. Neuropsychological tests were conducted at baseline, Week 26, and Week 52 to assess executive function, verbal memory, and visuospatial cognitive domains. Cardiorespiratory fitness testing was performed at baseline and Week 52 to assess response to exercise. The aerobic exercise group significantly improved cardiorespiratory fitness (11% vs. 1% in the control group) but there were no differences in change measures of amyloid, brain volume, or cognitive performance compared to control. Conclusions: Aerobic exercise was not associated with reduced amyloid accumulation in cognitively normal older adults with cerebral amyloid. In spite of strong systemic cardiorespiratory effects of the intervention, the observed lack of cognitive or brain structure benefits suggests brain benefits of exercise reported in other studies are likely to be related to non-amyloid effects.

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