Effect of Chia (Salvia hispanica L.) Flour on Glycemic Response and Energy Intake in Healthy Adults (P06-099-19)

Abstract Objectives Postprandial glycemic control is essential in both healthy and diabetic people, as hyperglycemia predisposes to complications associated with diabetes. The consumption of fiber-rich meals help to prevent and control undesirable glycemic changes. This study aimed to evaluate the effect of one-day consumption of chia on glycemic response and energy intake in healthy adults. Methods Single-blind, randomized, crossover design study involving healthy adults, normal weight (BMI 18.5–24.9 kg/m2), euglycemic (100 mg/dL), with no diabetes family history. They attended to the laboratory after 10–12 h fasting and received either 350 ml of a shake containing 10 g of chia flour (4.44 g of fiber) or 350 ml of a control shake (1.1 g of fiber)- similar in calories and macronutrients, containing 51 g of available carbohydrate - on two non-consecutive days (washout period). At each testing day, 60 minutes after shake intake a glucose solution (25 g) was provided. Capillary blood glucose was measured in fasting state (−60 min), immediately before (0 min), and 15, 30, 45, 60, 90, 120 minutes after glucose load. In addition, food intake was assessed 24-hour dietary recall was performed after each testing day. Habitual dietary intake was estimated using the semi-quantitative QFCA. The study was approved by the Local Ethics Committee. Repeated-measures ANOVA test was used to compare habitual dietary intake and consumption after shake. Two-way repeated measures ANOVA test followed by Bonferroni's post-hoc was used to assess the differences in postprandial blood glucose. Incremental area under the curve (AUC) of postprandial glycemia was calculated using the trapezoidal rule and paired sample t-test was used to compare them. All analyses were conducted using SPSS software. Statistical significance was set as p < 0.05. Results Fifteen subjects completed the study (14 female and 1 male). Consumption of chia (10 g of chia flour) did not change the blood glucose (p > 0.05) nor food intake (p > 0.05) among adults (25 ± 1 years), euglycemic (87.88 ± 1.21 mg/dL), normal weight (21.06 ± 0.28 kg/m2 and 23.23 ± 1.19% body fat percentual). Conclusions The one-day consumption of chia flour did not affect the glycemic response and did not interfere in energy intake in healthy individuals. The long-term effect of chia should be assessed. Funding Sources CNPq, CAPES, FAPEMIG, FUNARBE, DNS-UFV. Supporting Tables, Images and/or Graphs

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Stevia Beverage Consumption prior to Lunch Reduces Appetite and Total Energy Intake without Affecting Glycemia or Attentional Bias to Food Cues: A Double-Blind Randomized Controlled Trial in Healthy Adults

Journal of Nutrition ◽

10.1093/jn/nxaa038 ◽

2020 ◽

Vol 150 (5) ◽

pp. 1126-1134 ◽

Cited By ~ 3

Author(s):

Nikoleta S Stamataki ◽

Corey Scott ◽

Rebecca Elliott ◽

Shane McKie ◽

Douwina Bosscher ◽

...

Keyword(s):

Blood Glucose ◽

Food Intake ◽

Total Energy ◽

Attentional Bias ◽

Energy Intake ◽

Sweet Taste ◽

Healthy Adults ◽

Food Cues ◽

Double Blind ◽

Randomized Controlled

ABSTRACT Background Stevia is a zero-calorie alternative to caloric sugars. Substituting caloric sweeteners with noncaloric sweeteners reduces available energy, but their effects on appetite, subsequent food intake, and neurocognitive responses are still unclear. Objective The aim was to examine whether sweetness with or without calories influences food intake, appetite, blood glucose concentrations, and attentional bias (AB) to food cues. Methods This was a randomized, controlled, double-blind crossover study. Healthy participants [n = 20; aged 27 ± 5 y, 55% female; BMI (kg/m2): 21.8 ± 1.5] completed 5 visits, consuming 5 study beverages: 330 mL water (control, no sweet taste, no calories) and either 330 mL water containing 40 g glucose or sucrose (sweet taste; calories, both 160 kcal), maltodextrin (no sweet taste; calories, 160 kcal), or 240 ppm stevia (sweet taste, no calories). Glucose and stevia beverages were matched for sweetness. Subjective appetite ratings and blood glucose were measured at baseline and at 15, 30, and 60 min postprandially. At 15 min participants performed a visual-dot probe task to assess AB to food cues; at 30 min, participants were offered an ad libitum lunch; food intake was measured. Results Subjective appetite ratings showed that preload sweetness and calorie content both affected appetite. The total AUC for glycemia was significantly higher after the caloric beverages (mean ± SD: maltodextrin, 441 ± 57.6; glucose, 462 ± 68.1; sucrose, 425 ± 53.6 mmol × min × L−1 ) compared with both stevia (320 ± 34.2 mmol × min × L−1) and water (304 ± 32.0 mmol × min × L−1) (all P < 0.001). Total energy intake (beverage and meal) was significantly lower after the stevia beverage (727 ± 239 kcal) compared with water (832 ± 198 kcal, P = 0.013), with no significant difference between the water and caloric beverages (P = 1.00 for water vs. maltodextrin, glucose, and sucrose). However, food-related AB did not differ across conditions (P = 0.140). Conclusions This study found a beneficial and specific effect of a stevia beverage consumed prior to a meal on appetite and energy intake in healthy adults. This trial is registered at clinicaltrials.gov as NCT03711084.

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Effects of Protein Source and Quantity on Appetite Control, Satiety and Subsequent Food Intake in Healthy Adults

Current Developments in Nutrition ◽

10.1093/cdn/nzab038_021 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 409-409

Author(s):

Charlotte Griffith ◽

Kamille Piacquadio ◽

Morgan Braden ◽

Heather Leidy

Keyword(s):

Food Intake ◽

Energy Intake ◽

Food Consumption ◽

Repeated Measures ◽

Healthy Adults ◽

Protein Source ◽

Pea Protein ◽

Desire To Eat ◽

Main Effects ◽

Eating Initiation

Abstract Objectives To examine whether consumption of breakfast preloads varying in protein source and quantity affect measures of appetite, satiety and subsequent energy intake in healthy adults. Methods Thirty-seven healthy adults (Age: 26 ± 4; BMI: 23 ± 2) participated in this randomized crossover design study. On 3 consecutive days, participants consumed 325 kcal preload breakfast yogurts, varying in protein quality (Whey vs. Pea) and quantity (20, 30, 40 g) vs. an isocaloric carbohydrate preload (Control). On day 4, participants completed a 5-hr in clinic testing day. At baseline time -15 min, questionnaires assessing hunger, fullness, desire to eat, prospective food consumption, and eating initiation, were completed. At time 0 min, the respective preload was provided, and palatability assessed. At time 15 min, after consumption, similar questionnaires were completed every 30 min during the 4-h postprandial period followed by an ad libitum pizza lunch. There was a 3–7 day washout period between testing days. To assess main effects of protein source, paired sample t-tests of incremental area under the curve (iAUC) were computed for 20g Pea vs. 20g Whey preloads on 4-h hunger, fullness, desire to eat, prospective food consumption, eating initiation and lunch energy intake. To assess main effects of protein quantity, repeated measures ANOVA was computed between control and pea protein preloads of 20g, 30g, and 40g on 4-h hunger, fullness, desire to eat, and prospective food consumption niAUC, eating initiation, and lunch energy intake. P < 0.05 was considered statistically significant. Statistical analyses were performed using The R Foundation (R; version 4.0.3). Results No main effects of protein source or quantities were detected for 4-h postprandial hunger, fullness, desire to eat, and prospective food consumption niAUC. On average, participants requested to eat again 2-h after breakfast (134 ± 12 min) and consumed on average 830 ± 10 kcals at lunch with no differences between protein sources or quantities. Conclusions In the context of an acute feeding study, no differences in postprandial appetite, satiety, and subsequent food intake were detected when comparing protein preloads varying in source and quantity. These data suggest that 20 g pea protein is sufficient to elicit satiety effects and can be used as a plant-based alternative for whey protein. Funding Sources Roquette.

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Short-term effects of a low glycemic index carob-containing snack on energy intake, satiety, and glycemic response in normal-weight, healthy adults: Results from two randomized trials

Nutrition ◽

10.1016/j.nut.2017.05.011 ◽

2017 ◽

Vol 42 ◽

pp. 12-19 ◽

Cited By ~ 9

Author(s):

Emilia Papakonstantinou ◽

Nickolaos Orfanakos ◽

Paul Farajian ◽

Anastasia E. Kapetanakou ◽

Ifigenia P. Makariti ◽

...

Keyword(s):

Energy Intake ◽

Glycemic Index ◽

Randomized Trials ◽

Normal Weight ◽

Healthy Adults ◽

Glycemic Response ◽

Short Term ◽

Low Glycemic Index ◽

Short Term Effects

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An Investigation into the Effects of Stevia on food intake, satiety and blood glucose levels in adults: a small-scale study

Proceedings of The Nutrition Society ◽

10.1017/s0029665120001196 ◽

2020 ◽

Vol 79 (OCE2) ◽

Author(s):

Grace Farhat ◽

Lauren Moore ◽

Inaki Moya ◽

Lindsay Hall ◽

Victoria Berset

Keyword(s):

Blood Glucose ◽

Food Intake ◽

Energy Intake ◽

Repeated Measures ◽

Energy Content ◽

Postprandial Blood Glucose ◽

Small Scale ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Obesity And Diabetes

AbstractNon-nutritive sweeteners (NNS) are suggested to reduce sugar and energy content of diet, but there is growing evidence that they can exacerbate obesity and diabetes through increasing appetite and energy intake. Stevia (stevioside extract), a natural sweetener, is being increasingly consumed, yet limited studies have looked at their effects on satiety and energy intake. The aim of this study is to investigate the effects of preloads of stevia on food intake, satiety and postprandial blood glucose levels when compared to water and sugar. Thirty participants (10 males/20 females; 26 ± 10.5 years; BMI: 23.44 ± 3.42 Kg/m2) took part in a three-arm single-blinded crossover trial. On separate test days, they received three different preloads (300 ml) containing water, sugar (60g) and stevia (1g) followed by an ad-libitum pizza lunch after 30 minutes. Breakfast was standardized. Blood glucose samples were collected before preload and lunch, and then at 30-minute intervals until 120 min post lunch. Volunteers recorded their feelings of satiety and hunger on visual analogue scales (VAS) before preload and after meal intake. A one-day diet diary was collected for each test day. Data was analysed using repeated measures ANOVA (SPSS Inc., Chicago, IL, USA). Despite the difference in energy content between preloads, there were no significant differences in energy intake at lunch between the three interventions (F (2, 56) = 0.25, p = 0.78). Furthermore, participants did not compensate by consuming more energy during the day after the stevia preload (1660 ± 584 Kcal) compared to sugar preload (1770 ± 763 Kcal, p = 0.82). There were no significant differences in VAS scores between stevia and sugar preloads, but participants scored significantly higher rates of hunger (before and after lunch) and desire to eat (before lunch) following water preload (p < 0.05). No significant differences between water, sugar and stevia were noted for postprandial glucose levels (120 min post lunch) when adjusted from baseline (F (2, 58) = 2.56, p = 0.09). Area under the curve (AUC) for glucose did not differ between water and stevia (p = 0.2). Results are in line with several clinical trials showing that the consumption of sweeteners does not lead to an increase in hunger and energy intake, and could therefore present a useful strategy to assist with weight loss. Further studies looking at long-term effects of stevia on weight regulation are needed to support these findings.

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Pre- and within-meal effects of fluid dairy products on appetite, food intake, glycemia, and regulatory hormones in children

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2016-0251 ◽

2017 ◽

Vol 42 (3) ◽

pp. 302-310 ◽

Cited By ~ 9

Author(s):

Shirley Vien ◽

Bohdan L. Luhovyy ◽

Barkha P. Patel ◽

Shirin Panahi ◽

Dalia El Khoury ◽

...

Keyword(s):

Food Intake ◽

Repeated Measures ◽

Dairy Products ◽

Normal Weight ◽

Chocolate Milk ◽

Water Control ◽

Cumulative Energy ◽

Sugar Sweetened Beverage ◽

Repeated Measures Design ◽

Yogurt Drink

The effect of beverages commonly consumed by children in-between or with meals on short-term food intake (FI) and glycemic control has received little attention. Therefore, 2 experiments were conducted in 9- to 14-year-old children following a randomized repeated-measures design. Experiment 1 (n = 32) compared the effects of water (control) and isocaloric (130 kcal) amounts of 2% milk, chocolate milk, yogurt drink, and fruit punch on subjective appetite and FI. Experiment 2 (n = 20) compared the effects of isocaloric (130 kcal) amounts of 2% milk and fruit punch on subjective appetite, FI, and glycemic and appetite hormone responses. One serving of the beverages was given as a pre-meal drink at baseline (0 min) and a second serving 60 min later with an ad libitum pizza meal. Meal FI in experiment 1 was lower by 14% and 10%, respectively, after chocolate milk and yogurt drink (p < 0.001), but not milk, compared with water. Cumulative energy intake (beverages plus meal) was higher after caloric beverages than water. In experiment 2, no differences occurred in pre-meal but post-meal glucose was 83% higher in overweight/obese than normal-weight children (p = 0.02). Milk led to higher pre-meal glucagon-like peptide-1 and post-meal peptide tyrosine tyrosine (PYY) than fruit punch (p < 0.01) but insulin did not differ between treatments. In conclusion, dairy products consumed before and with a meal have more favourable effects on FI, appetite, and satiety hormones than a sugar-sweetened beverage, but all caloric beverages result in more cumulative calories than if water is the beverage.

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Mechanisms behind the portion size effect-visibility and bite size

10.31232/osf.io/6spb7 ◽

2017 ◽

Author(s):

Kyle Stanley Burger ◽

Susan L. Johnson

Keyword(s):

Size Effect ◽

Energy Intake ◽

Repeated Measures ◽

Visual Cues ◽

Normal Weight ◽

Portion Size ◽

Experimental Conditions ◽

Bite Size ◽

Subject Design ◽

Participant Characteristics

Increases in portion size lead to increases in energy intake, yet the mechanisms behind this ‘portion size effect’ are unclear. This study tested possible mechanisms of the portion size effect i.e., bite size and visual cues in 30 over- and normal-weight individuals (15 men, 15 women). A 2x2 repeated measures, within-subject design was used to test the effects of portion size (410g vs. 820g of a pasta dish) and visual cues (blindfolded vs. visible) on energy intake. At each meal participants were exposed to one of four experimental conditions (small portion/visible; small portion/blindfold; large portion/visible; large portion/blindfold). Participant characteristics, food intake, number of bites, meal duration, palatability measures and hunger and fullness were assessed. In response to a doubling of the portion presented, entrée energy intake increased 26% (220kcal P < 0.001) and mean bite size increased 2.4g/bite (P < 0.05). Overweight individuals consumed 40% (334kcal) more of the entrée in response to the large portion condition (P < 0.05), while lean individuals’ intakes did not differ (P < 0.56). A 12% (122kcal) decrease in entrée intake was observed in the blindfolded condition (P < 0.01), but no portion by visual cue interaction was found; indicating that blindfolding did not attenuate the portion size effect. These data suggest that the portion size effect is greater in overweight individuals and occurs via changes in bite size.

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Altering the temporal distribution of energy intake with isoenergetically dense foods given as snacks does not affect total daily energy intake in normal-weight men

British Journal Of Nutrition ◽

10.1017/s0007114500000039 ◽

2000 ◽

Vol 83 (1) ◽

pp. 7-14 ◽

Cited By ~ 43

Author(s):

A. M. Johnstone ◽

E. Shannon ◽

S. Whybrow ◽

C. A. Reid ◽

R. J. Stubbs

Keyword(s):

Food Intake ◽

Energy Density ◽

Energy Intake ◽

Real Life ◽

Latin Square ◽

Temporal Distribution ◽

Normal Weight ◽

Daily Energy ◽

Fixed Composition ◽

Ad Libitum

The objectives of the present study were to examine the effects of (1) ingesting mandatory snacks v. no snacks and (2) the composition of isoenergetically-dense snacks high in protein, fat or carbohydrate, on food intake and energy intake (EI) in eight men with ad libitum access to a diet of fixed composition. Subjects were each studied four times in a 9 d protocol per treatment. On days 1–2, subjects were given a medium-fat maintenance diet estimated at 1·6 × resting metabolic rate (RMR). On days 3–9, subjects consumed three mandatory isoenergetic, isoenergetically dense (380 kJ/100 g) snacks at fixed time intervals (11.30, 15.30 and 19.30 hours). Total snack intake comprised 30 % of the subjects' estimated daily energy requirements. The treatments were high protein (HP), high carbohydrate (HC), high fat (HF) and no snack (NS). The order was randomized across subjects in a counterbalanced, Latin-square design. During the remainder of the day, subjects had ad libitum (meal size and frequency) access to a covertly manipulated medium-fat diet of fixed composition (fat: carbohydrate: protein, 40:47:13 by energy), energy density 550 kJ/100 g. All foods eaten were investigator-weighed before ingestion and left-overs were weighed after ingestion. Subjective hunger and satiety feelings were tracked hourly during waking hours using visual analogue scales. Ad libitum EI amounted to 13·9 MJ/d on the NS treatment compared with 11·7, 11·7 and 12·2 MJ/d on the HP, HC and HF diets respectively (F(3,21) 5·35; P = 0·007, sed 0·66). Total EI values were not significantly different at 14·6, 14·5, 15·0 and 14·2 MJ/d respectively. Snack composition did not differentially affect total daily food intake or EI. Average daily hunger was unaffected by the composition of the snacks. Only at 12.00 hours did subjects feel significantly more hungry during the NS condition, relative to the other dietary treatments (F(3,18) 4·42; P = 0·017). Body weight was unaffected by dietary treatment. In conclusion, snacking per se led to compensatory adjustments in feeding behaviour in lean men. Snack composition (with energy density controlled) did not affect the amount eaten of a diet of fixed composition. Results may differ in real life where subjects can alter both composition and amount of food they eat and energy density is not controlled.

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The acute effect of D-tagatose on food intake in human subjects

British Journal Of Nutrition ◽

10.1017/s000711450000146x ◽

2000 ◽

Vol 84 (2) ◽

pp. 227-231 ◽

Cited By ~ 23

Author(s):

Benjamin Buemann ◽

Søren Toubro ◽

Anne Raben ◽

John Blundell ◽

Arne Astrup

Keyword(s):

Food Intake ◽

Energy Intake ◽

Human Subjects ◽

Acute Effect ◽

Normal Weight ◽

Double Blind ◽

Breakfast Meal ◽

Ad Libitum ◽

Osmotic Effects ◽

Randomized Crossover Study

A double-blind randomized crossover study was performed with nineteen normal-weight men to investigate the effect on subsequent ad libitum food intake of replacing 29 g sucrose with 29 g D-TAGATOSE AS SWEETENER TO A BREAKFAST MEAL. d-Tagatose is a malabsorbed stereoisomer of fructose with potential application as a bulk sweetener. Food intake was measured at lunch offered 4 h after the breakfast meal, during the afternoon with access to abundant snacks, and finally at a supper buffet 9 h after the breakfast. Energy intake at lunch and during the snacking period was similar after ingesting the two sugars, while it was 15 % lower after ingesting d-tagatose than with sucrose at supper (P < 0·05). Gastrointestinal factors such as the osmotic effects of unabsorbed d-tagatose causing distension of the gut might have mediated the acute appetite-suppressing effect. The present paper also refers to data from a preceding study in which we observed an increased self-reported energy intake after ingestion of d-tagatose compared with sucrose which, in fact, suggests a relative hyperphagic effect of d-tagatose. However, self-reported food intake may be biased by selective under-reporting and this subsequent study with a more controlled assessment of food intake was therefore conducted. This present study did not support any hyperphagic effect of d-tagatose, but rather suggests that d-tagatose may contribute to a reduced energy intake.

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Dietary Intake and Clinical Response of Hospitalized Patients with Acute Diarrhea

Food and Nutrition Bulletin ◽

10.1177/156482650802900103 ◽

2008 ◽

Vol 29 (1) ◽

pp. 25-31 ◽

Cited By ~ 2

Author(s):

Mahfuza Islam ◽

S.K. Roy ◽

Muktara Begum ◽

M. Jobayer Chisti

Keyword(s):

Food Intake ◽

Dietary Intake ◽

Clinical Response ◽

Energy Intake ◽

Acute Diarrhea ◽

Lower Energy ◽

Recovery Period ◽

Severe Illness ◽

Stool Weight ◽

Clinical Records

Background Diarrhea and malnutrition remain major health problems among children of developing countries. During diarrhea, the patient's dietary intake and absorption of nutrients are reduced while nutritional requirements are increased. Objective To determine the relationship between food intake and clinical response during the hospital stay of patients with acute diarrhea. Methods A hospital-based longitudinal study was conducted in 118 patients with acute diarrhea aged 6 to 59 months who required treatment for at least 3 days in the in-patient ward in Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B). Daily food intake was measured and anthropometric measurements were taken to assess nutritional status. Daily stool weight and clinical records were collected. The data were analyzed with SPSS/PC+, version 10, and EPI STAT, version 3.2.2. Results The duration of diarrhea was 50% greater in patients with lower energy intake (less than 50% of the recommended dietary allowance [RDA]) than in those with higher energy intake (6 vs. 4 days, p = <.001). Patients with lower energy intake had 22% greater stool output than those with higher energy intake (122.65 vs. 100.37 mL/kg body weight/day, p = .04). Among patients with lower energy intake, the weight-for-age and weight-for-height z-scores (WAZ and WHZ) at discharge from the hospital were higher than those at admission (−3.53±1.25 vs. −3.67±1.31 and 1.95±1.23 vs. −2.14±1.22, respectively; p = .001 for both comparisons), but these scores did not differ at admission and discharge among patients with higher energy intake. The Kaplan–Meier survival function showed that 80% of well-nourished children (WAZ ≥ −2), as compared with 58% of malnourished children (WAZ < −2), recovered by the 4th day of treatment ( p < .01). The length of the recovery period was related negatively with total energy intake ( p = <.001) and mid-upper-arm circumference ( p = .004) and positively with stool weight. Conclusions Food intake was reduced in the hospitalized children because of severe illness. Patients with lower energy intake as a percentaqe of RDA had delayed clinical recovery and higher stool output.

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Acute effects of extruded pulse snacks on glycemic response, insulin, appetite, and food intake in healthy young adults in a double blind, randomized crossover trial

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2020-0572 ◽

2020 ◽

Author(s):

Alie Johnston ◽

Rebecca C. Mollard ◽

Dianna Dandeneau ◽

Dylan S. MacKay ◽

Nancy Ames ◽

...

Keyword(s):

Food Intake ◽

Repeated Measures ◽

Area Under The Curve ◽

Glycemic Response ◽

Double Blind ◽

Chickpea Flour ◽

Pinto Bean ◽

Pulse Type ◽

Extruded Products ◽

Corn Snacks

Research indicates that the post-prandial glycemic benefits of consuming whole pulses are retained when consumed in a mixed meal, pureed, and ground into flours. The glycemic benefits of pulse flours when incorporated into extruded products are unknown. In a randomized, repeated-measures crossover study, adults (n = 26) consumed extruded corn snacks made with the addition of 40% pulse flour from either: whole yellow pea, split yellow pea, green lentil, chickpea, or pinto bean. The control snack was 100% corn. Food intake was measured with an ad libitum meal consumed at 120 min. Blood glucose (BG), insulin and appetite were measured regularly before (pre-meal, 0-120 min) and after (post-meal, 140-200 min) the meal. Pinto bean and chickpea snacks led to lower (p<0.05) pre-meal BG incremental area under the curve (iAUC), compared with control, whole yellow pea and green lentil snacks. Pinto bean snack also led to lower (pre-meal BG (p<0.05) and insulin (p<0.05) iAUC compared with control, whole yellow pea, and split yellow pea snacks. There were no differences in food intake or appetite. These findings indicate that effects of replacing corn with pulse flours in extruded snacks on BG, and insulin are dependent on pulse type. ClinicalTrials.gov Identifier: NCT02402504. Registered on 30 March 2015. Novelty bullets: The incorporation of pinto bean and chickpea flour into extruded corn snacks improves postprandial glycemic response. Pulse containing snacks were equally as palatable as the corn snacks. The incorporation of pulses into corn snacks increased the protein and fibre content.

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