scholarly journals Effects of NCAA Division I Cross-Country Training on Serum Ferritin, Monocytes, TNF-α and DKK1 (P18-126-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Chandler McDonald ◽  
Noah John Erb ◽  
David Aguilar-Alvarez

Abstract Objectives Inflammatory cytokine and immune cell production is modulated by iron status including storage measured by ferritin levels. Cross-country athletes have an elevated risk of iron depletion and stress fractures; the effects of a competitive season on inflammation, iron stores, and bone biomarkers have yet to be elucidated. The purpose of this study is to determine the influence of one season of NCAA Division I (D-I) cross-country competition has on TNF-α, serum ferritin (sFer), complete blood count (CBC), and various bone biomarkers to identify potential relationships. Methods Twelve D-I cross-country athletes, ages 19 to 25 years old, were followed for one year. Blood was collected at the beginning of each season and analyzed for CBC and sFer levels through enzymatic spectrophotometry. TNF-α, OPG, OPN, DKK1, SOST, PTH, FGF23, Insulin, and Leptin were measured through Luminex® MAGPIX® multiplex assays. Paired-samples t-test compared the 2017 preseason and 2018 preseason baselines, while Pearson correlations included both seasons. Statistical analyses were performed using IBM® SPSS Statistics 25 software. Results TNF-α levels increased significantly from 2017 to 2018 (9.5 ± 4.6 vs. 12.2 ± 4.9 pg/mL, P = 0.005) as well as DKK1 (544.4 ± 223.6 vs. 1167.0 ± 212.1 pg/mL, P < 0.001), while % Monocytes decreased significantly from 2017 to 2018 (10.7 ± 2.6 vs. 8.6 ± 1.9%, P = 0.003). sFer showed to have a moderate positive-correlation with TNF-α and OPG (r = 0.619, P = 0.002; r = 0.640, P = 0.001) throughout both preseason intervals. Conclusions Given TNF-α has shown to induce DKK1, both bone mineral density and bone biomarkers of the cross-country athlete needs to be continually assessed throughout multiple stages of their competitive season to insure proper bone health. Further investigation is needed into the potential causes for the increases of TNF-α and DKK1 observed in cross-country athletes. Funding Sources Weber State University's Office of Undergraduate Research Grant. Supporting Tables, Images and/or Graphs

2015 ◽  
Vol 10 (4) ◽  
pp. 436-439 ◽  
Author(s):  
William P. McCormack ◽  
Jay R. Hoffman ◽  
Gabriel J. Pruna ◽  
Tyler C. Scanlon ◽  
Jonathan D. Bohner ◽  
...  

Purpose:During the competitive soccer season, women’s intercollegiate matches are typically played on Friday evenings and Sunday afternoons. The efficacy of a 42-h recovery period is not well understood. This investigation was conducted to determine performance differences between Friday and Sunday matches during a competitive season.Methods:Ten NCAA Division I female soccer players (20.5 ± 1.0 y, 166.6 ± 5.1 cm, 61.1 ± 5.8 kg) were monitored with 10-Hz GPS devices across 8 weekends with matches played on Friday evenings and Sunday afternoons. The players were outside backs, midfielders, and forwards. All players had to participate in a minimum of 45 min/match to be included in the study. Average minutes played, total distance covered, total distance of high-intensity running (HIR) (defined as running at a velocity equal to or exceeding 3.61 m/s for longer than 1 s), the number of HIR efforts, and the number of sprints were calculated for each match. Data for Friday vs Sunday matches were averaged and then compared using dependent t tests.Results:No differences were seen in minutes played, distance rate, or number of sprints between Friday and Sunday matches. A significant (P = .017) decrease in rate of HIR between Friday (25.37 ± 7.22 m/min) and Sunday matches (22.90 ± 5.70 m/min) was seen. In addition, there was a trend toward a difference (P = .073) in the number of efforts of HIR between Friday (138.41 ± 36.43) and Sunday (126.92 ± 31.31).Conclusions:NCAA Division I female soccer players cover less distance of HIR in games played less than 48 h after another game. This could be due to various factors such as dehydration, glycogen depletion, or muscle damage.


2003 ◽  
Vol 12 (1) ◽  
pp. 53-65 ◽  
Author(s):  
Cheryl Govero ◽  
Barbara A. Bushman

Athletes are at a high risk for eating disorders due to the pressures placed on them by themselves as well as coaches. The purposes of this study were (1) to determine the knowledge level of eating disorders among cross country coaches, (2) to determine their level of confidence in this knowledge, and (3) to determine reported sources of educational resources. Four schools were randomly selected from each NCAA Division I conference (return rate: 48%). A two-part questionnaire assessed sources of information and knowledge of eating disorders. Literature and sponsored programs were the two most common sources of information. For the 30 knowledge questions, coaches indicated their confidence level on a 4-item Likert-type scale. The knowledge of the majority of coaches was relatively high, and those with higher accuracy also had higher confidence. The confidence level and the percent of coaches answering each question correctly were significantly correlated, r=0.56 (p<0.01) but the confidence level and the percent answering incorrectly were not significantly correlated, r=0.24 (p=0.24). There were no significant differences in knowledge scores considering years of coaching (p=0.67) nor were there any significant differences in the scores between males and females (p=0.17). Although the cross country coaches were quite knowledgeable, additional ways to increase knowledge of eating disorders are needed.


2019 ◽  
Vol 40 (07) ◽  
pp. 447-452 ◽  
Author(s):  
Madeline A. Czeck ◽  
Christiana J. Raymond-Pope ◽  
Tyler A. Bosch ◽  
Christopher W. Bach ◽  
Jonathan M. Oliver ◽  
...  

AbstractThis study’s purpose was to evaluate total, regional, and throwing versus non-throwing arm body composition measurements between various positions of NCAA Division I male baseball players using dual X-ray absorptiometry (DXA). Two hundred and one collegiate baseball athletes were measured using DXA. Visceral adipose tissue (VAT), total and regional fat mass (FM), lean mass (LM), and bone mineral density (BMD) were measured. Athletes were separated into: pitchers (n=92), catchers (n=25), outfielders (n=43), and infielders (n=41). ANOVA and Tukey’s honest significant difference assessed total and regional differences between positions. Infielders had significantly (p<0.05) lower total LM than pitchers and outfielders. Additionally, outfielders had significantly lower total FM compared to pitchers and catchers. No significant differences between positions were observed for total BMD and VAT. Pitchers’ and infielders’ throwing arm demonstrated significantly greater total mass, FM, LM, and BMD compared to the non-throwing arm. Further, outfielders’ throwing arm total mass, LM, and BMD were significantly higher vs. the non-throwing arm. Significant differences were observed in total and regional body composition measurements across position, in addition to differences in throwing arm vs. non-throwing arm composition. These measurement values are important to coaches and trainers as normative positional DXA data for collegiate baseball players.


2019 ◽  
Vol 51 (Supplement) ◽  
pp. 25
Author(s):  
Jesse A. Goodrich ◽  
Sewan Kim ◽  
Dillon J. Frisco ◽  
Kimberly Detwiler ◽  
Miguel Rueda ◽  
...  

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 5145-5145
Author(s):  
Heinz Ludwig ◽  
Georg Endler ◽  
Brigitte Klement ◽  
Wolfgang Hüubl ◽  
Tim Cushway

Abstract Abstract 5145 Introduction and aims: Iron deficiency as a major component in the pathogenesis of anemia in cancer is not acknowledged by most oncologists, possibly except when arising from GI blood loss. Iron deficiency is associated with clinical symptoms such as cognitive impairment, fatigue, and reduced exercise performance. New iron formulations are available that allow rapid iron supplementation with single infusions. This treatment could ameliorate symptoms of iron deficiency and correct anemia. Here, we studied iron parameters and their correlation with erythropoiesis and inflammatory markers in a large unselected cohort of patients with cancer. In addition, we investigated the suitability of serum ferritin and transferrin saturation (TSAT) as parameter for assessment of the iron status. Patients and methods: Data from 1627 patients (median age: 66.4 years, range: 20–97 years) presenting sequentially at the Center for Oncology and Hematology, Wilhelminenspital, Vienna between October 01, 2009 and January 26, 2010, have retrospectively been analyzed. Patients were at different stages of their disease or may not have had an established diagnosis at the time of testing. In patients with multiple testing during this period only the first sample taken was included. TSAT (n=1516), serum ferritin (n=887), serum iron, CRP, and complete blood count, were determined by using standard techniques. Commonly used definitions for absolute iron deficiency (AID), [TSAT <20% and serum ferritin <30ng/ml, in case serum ferritin was not available TSAT <10%] and for functional iron deficiency (FID), [TSAT <20% and serum ferritin ≥30ng/ml, in case serum ferritin was not available TSAT between 10 and 20%] have been applied. Fisher's exact test was used for comparison of frequencies and Pearson's product moment correlation coefficient for evaluation of correlation. Results: Table 1 shows the distribution of TSAT and serum ferritin categories in 1627 patients with cancer. AID was found in 116 patients (7.7%) of the 1516 patients for whom TSAT was available. Eighty-three (72%) of the AID patients presented with anemia (defined by hemoglobin <12g/dl). AID was most common in patients with colorectal and pancreatic cancer (12% and 11%, respectively), and not present in patients with testicular and prostate cancer (p=0.013). FID was diagnosed in 530 patients (35%) and 222 (42%) of them were found to be also anemic. Multivariate analysis revealed a statistically significant correlation between TSAT and serum ferritin (R=0.286, p<0.001), serum iron (R=0.874, p<0.001), hemoglobin (R=0.201, p<0.001) and CRP (R=-0.205, p<0.001) (figure 1). Serum ferritin, in contrast, did not correlate with serum iron (R=0.051, p=0.132), but correlated with hemoglobin (R=-0.259, p<0.001), TSAT (R=0.286, p<0.001), and CRP (R=0.396, p<0.001). Conclusion: AID (7.7%) and even more so FID (35%) are frequent co-morbidities in patients with various types of cancer. Seventy-two percent of patients with AID and 42% with FID presented with overt anemia. TSAT correlated closely with serum iron and hemoglobin levels and seems to be the preferred parameter for assessment of iron status in patients with chronic diseases often complicated by increased inflammation. Serum ferritin was found to be an inadequate parameter for assessment and monitoring of iron status. As iron deficiency has been linked with various symptoms, the question arises whether iron supplementation would benefit patients with FID without overt anemia. Future studies should evaluate the role of novel intravenous iron preparations in ameliorating the symptoms of iron deficiency with or without anemia. Disclosures: Klement: Vifor Pharma Ltd: Employment. Cushway:Vifor Pharma Ltd.: Employment.


Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Betelihem Terefe ◽  
Asaye Birhanu ◽  
Paulos Nigussie ◽  
Aster Tsegaye

Iron deficiency anemia among pregnant women is a widespread problem in developing countries including Ethiopia, though its influence on neonatal iron status was inconsistently reported in literature. This cross-sectional study was conducted to compare hematologic profiles and iron status of newborns from mothers with different anemia status and determine correlation between maternal and neonatal hematologic profiles and iron status in Ethiopian context. We included 89 mothers and their respective newborns and performed complete blood count and assessed serum ferritin and C-reactive protein levels from blood samples collected from study participants. Maternal median hemoglobin and serum ferritin levels were 12.2 g/dL and 47.0 ng/mL, respectively. The median hemoglobin and serum ferritin levels for the newborns were 16.2 g/dL and 187.6 ng/mL, respectively. The mothers were classified into two groups based on hemoglobin and serum ferritin levels as iron deficient anemic (IDA) and nonanemic (NA) and newborns of IDA mothers had significantly lower levels of serum ferritin (P=0.017) and hemoglobin concentration (P=0.024). Besides, newborns’ ferritin and hemoglobin levels showed significant correlation with maternal hemoglobin (P=0.018;P=0.039) and ferritin (P=0.000;P=0.008) levels. We concluded that maternal IDA may have an effect on the iron stores of newborns.


Sports ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 165
Author(s):  
Lauren E. Rentz ◽  
William Guy Hornsby ◽  
Wesley J. Gawel ◽  
Bobby G. Rawls ◽  
Jad Ramadan ◽  
...  

As sports technology has continued to develop, monitoring athlete workloads, performance, and recovery has demonstrated boundless benefits for athlete and team success. Specifically, technologies such as global positioning systems (GPS) and heart rate (HR) monitors have granted the opportunity to delve deeper into performance contributors, and how variations may exist based upon context. A team of NCAA Division I women’s soccer athletes were monitored during games throughout one competitive season. Individual athlete, positional groups, and team external and internal workloads were explored for differences based upon game location, opponent ranking, game result, and the final score differential. Game location and opponent ranking were found to have no effect on team-wide absolute or relative external workloads, whereas game result and score differential did. Internal workloads across the team tended to only vary by game half, independent of game context; however, the HR of defenders was determined to be higher during losses as compared to wins (p = 0.0256). Notably, the games that resulted in losses also represented the games with the fewest number of substitutions. These findings suggest high value in monitoring performance and workloads that are characteristic of varying, often multifaceted, contexts. It is hoped that this information can lead to more informed approaches to vital game-time and coaching decisions.


Author(s):  
Kurt McDowell

Body composition and power are impactful variables of athletic performance. However, few studies have assessed power and body composition changes from pre-, to mid-, to end-of-season in American Football linebackers. The purpose of this study was to determine how power and body composition respond to a competitive season in Division I Football Championship Series (FCS) American football linebackers. Participants (n=9; Age=19.7 ± 1.5 years; Weight=101.5±11.6 kg; Height=183.3±5.2 cm; [Body Fat percent (BF %) =21.31 ± 6.02%)] performed a Dual-Energy X-ray Absorptiometry (DXA) scan, and power was assessed via three vertical jumps and squat jumps at 40, 60, 80, and 100 kg at three time points: a) 1 week prior to their regular season, b) 2 days after the bye week in the middle of the season, and c) 1 week prior to the completion of the season. An Analysis of Variance (ANOVA) revealed no significant differences (p ≤ 0.05) in power or body composition. These results support past research, indicating power and body composition can be maintained throughout a competitive season. However, more research is needed to determine the optimal programming methods to maintain or improve athletic performance via optimization of body composition and power during a competitive season.


2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Paul A. Krebs ◽  
Christopher R. Dennison ◽  
Lisa Kellar ◽  
Jeff Lucas

Purpose. This study compared gender differences in eating disorder risk among NCAA Division I cross country and track distance running student-athletes. Methods. Six hundred thirty-eight male and female student-athletes competing at distances of 800m or greater completed the Eating Disorder Screen for Primary Care (ESP). Scores on the ESP were used as the risk of eating disorders. Results. Females screened positive at higher rates for risk of eating disorders than males on the ESP at a cutoff of 2 (sensitivity 90-100%, specificity 71%) with rates of 45.95%±3.03 and 13.66%±1.80, respectively. Females were also screened positive at higher rates than males at a stricter cutoff of 3 (sensitivity 81%, specificity 92%), with rates of 21.69%±2.50 compared to 4.64%±1.10, respectively. Conclusion. This study highlights that, among distance runners, both males and females are at risk of eating disorders, with females being at higher risk. It also emphasizes the need for screening for risk of eating disorders in this population.


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