Inter- and intra-individual variations in the saliva/blood alcohol ratio during ethanol metabolism in man.

1979 ◽  
Vol 25 (8) ◽  
pp. 1394-1398 ◽  
Author(s):  
A W Jones
Keyword(s):  
Coefficient Of Variation ◽  
Ethanol Metabolism ◽  
Single Individual ◽  
Blood Alcohol ◽  
Individual Variations ◽  
Sources Of Variation ◽  
The Mean ◽  
The Difference ◽  
The Individual ◽  
Male Subjects

Abstract The inter- and intra-individual components of variation in the saliva/blood alcohol ratio have been calculated from experiments with 48 male subjects after they drank 0.72 g of ethanol per kilogram of body weight as neat whisky after a short fast. Saliva and blood ethanol profiles were monitored at 30--60 min intervals for up to 7 h after intake. The analytical component of variation inherent in an estimate of the saliva/blood alcohol ratio, expressed as coefficient of variation, was 1.75%. I calculated saliva/blood ethanol ratios for each subject at each sampling time by taking the antilogarithm of the difference (log saliva alcohol--log blood alcohol). The mean ratio between 60 and 360 min after drinking was 1.077 (n = 336) with 95% confidence limits of 1.065 and 1.088. Moreover, the individual ratios showed no systematic variation throughout the absorption, distribution, and elimination phases of ethanol metabolism. Using a two-way analysis of variance and allowing for analytical sources of variation, I determined that the inter- and intra-subject variance components were 53 and 47% of the total biological variation. The saliva/blood alcohol ratio during ethanol metabolism, determined once in a single individual, had a biologically derived coefficient of variation of 10%.

scholarly journals Genetic homozygosity as a marker of smoking dependency

Genetika ◽  
2020 ◽  
Vol 52 (3) ◽  
pp. 1009-1019
Author(s):  
Slavko Brankovic ◽  
Dejan Nikolic ◽  
Dragoslav Marinkovic ◽  
Suzana Cvjeticanin
Keyword(s):  
Cross Sectional Study ◽  
Male Gender ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male And Female ◽  
Mean Values ◽  
Individual Variations ◽  
Significant Difference ◽  
The Mean ◽  
The Individual

The aim of our study was to evaluate the morphogenetic variability as a marker of smoking dependency in adult smokers versus controls and to investigate the presence and the degree of morphogenetic variability difference between male and female smokers versus same gender controls. The cross-sectional study evaluated 241 smokers and 185 nonsmoker individuals as controls. We analyzed 17 homozygous recessive characteristics (HRC). There was a significant difference in the individual variations of 17 HRCs between the controls and smokers (??2=61.400, p<0.001; for females ??2=79.440, p<0.001; for males ??2=84.972, p<0.001). The mean values of HRCs significantly differed between smokers and controls (MV?SEM(Controls) -4.79?0.13, MV?SEM(Smokers) -5.70?0.12; p<0.001). For males, presence of 6/17 (35.29% genetic homozygosity) HRCs (OR=6.12) was to the certain degree predictor for smoking dependency. Higher degree of genetic homozygosity, changed variability and male gender, might be some among potential numerous factors that could have impact on smoking development and dependence.

scholarly journals Tri-Ponderal Mass Index: A Screening Tool for Risk of Central Fat Accumulation in Brazilian Preschool Children

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 577 ◽  
Author(s):  
Viviane Gabriela Nascimento ◽  
Ciro João Bertoli ◽  
Paulo Rogerio Gallo ◽  
Luiz Carlos de Abreu ◽  
Claudio Leone
Keyword(s):  
Preschool Children ◽  
Roc Curve ◽  
Screening Tool ◽  
The Body ◽  
Fat Accumulation ◽  
Central Fat ◽  
The Mean ◽  
The Difference ◽  
The Individual ◽  
Higher Sensitivity

Background and Objectives: To verify the use of the tri-ponderalmass index (TMI) as a screening tool for risk of central fat accumulation in preschool children. Materials and Methods: An observational, analytical study was carried out on samples from children 2 to 5 years of age. The body mass index (BMI) and the tri-ponderalmass index (TMI: Weight/height3) were calculated. The waist circumference-to-height ratio (WHtR) was used to classify central fat accumulation risk. Preschoolers whose WHtRwas in the upper tertile of the sample were classified as at risk for central fat accumulation. A comparison of the two indicators (BMI and TMI) was made from the area under the receiver operator characteristics (ROC) curve (AUC) in the discrimination of the WHtR. Results: The sample used for analysis was 919 preschoolers. The mean age of the children was 3.9 years (SD = 0.7). The difference in AUC was 5% higher for TMI (p < 0.0001). In the individual analysis of the ROC curve of the TMI, favoring a higher sensitivity, the cutoff point of 14.0 kg/m3 showed a sensitivity of 99.3% (95% CI: 97.6–99.9). Conclusion: Considering WHtR as a marker of possible future metabolic risk among preschool children, TMI proved to be a useful tool, superior to BMI, in screening for risk of central fat accumulation in preschool children.

Comparison of two noninvasive techniques for estimating cardiac output during exercise

1986 ◽  
Vol 61 (1) ◽  
pp. 155-159 ◽  
Author(s):  
D. D. Hatcher ◽  
O. D. Srb
Keyword(s):  
Cardiac Output ◽  
Large Range ◽  
Impedance Plethysmography ◽  
Cycle Ergometer ◽  
O2 Consumption ◽  
Noninvasive Techniques ◽  
Transthoracic Impedance ◽  
The Mean ◽  
The Difference ◽  
Male Subjects

This study presents the comparison of two different noninvasive techniques for the estimation of cardiac output (Q). The two techniques used were transthoracic impedance plethysmography (Z) and the indirect Fick CO2 rebreathing (RB) method. Paired estimates of Q were made on 60 different male subjects at rest and during graded increments of work on a cycle ergometer. The mean resting Q as measured by the Z technique (COZ) was 7.46 +/- 0.35 and 5.96 +/- 0.43 l/min using the RB (CORB) technique. At 200 W the mean COZ was 18.67 +/- 0.72 l/min and the CORB was 23.73 +/- 0.84 l/min. Both the techniques were linearly correlated (R) with O2 consumption; i.e., RZ = 0.752, RRB = 0.855. The difference between these two R values is statistically significant (P less than 0.001). A linear relationship was found between the Z and RB techniques at all work loads (R = 0.75). This study suggests that both techniques are equally as reliable over a large range of work loads, with the Z technique being the simplest and most efficient to implement. It was also found that lung volume had no effect on the calculated COZ.

Monitoring Training Volume Through Maximal Number of Repetitions or Velocity-Based Approach

2020 ◽  
pp. 1-8
Author(s):  
Miguel Sánchez-Moreno ◽  
Gonçalo Rendeiro-Pinho ◽  
Pedro V. Mil-Homens ◽  
Fernando Pareja-Blanco
Keyword(s):  
Coefficient Of Variation ◽  
Bench Press ◽  
Interindividual Variability ◽  
Load Condition ◽  
Velocity Relationship ◽  
The Mean ◽  
Monitoring Training ◽  
The Individual ◽  
The Relationship ◽  
Level Of Effort

Purpose: This study aimed (1) to analyze the interindividual variability in the maximal number of repetitions (MNR) performed against a given relative load (percentage of 1-repetition maximum [%1RM]) and (2) to examine the relationship between the velocity loss (VL) magnitude and the percentage of completed repetitions with regard to the MNR (%Rep), when the %1RM is based on individual load–velocity relationships. Methods: Following an assessment of 1RM strength and individual load–velocity relationships, 14 resistance-trained men completed 5 MNR tests against loads of 50%, 60%, 70%, 80%, and 90% 1RM in the Smith machine bench-press exercise. The relative loads were determined from the individual load–velocity relationship. Results: Individual relationships between load and velocity displayed coefficients of determination (R2) ranging from .986 to .998. The MNR showed an interindividual coefficient of variation ranging from 8.6% to 33.1%, increasing as the %1RM increased. The relationship between %Rep and the magnitude of VL showed a general R2 of .92 to .94 between 50% and 80% 1RM, which decreased to .80 for 90% 1RM. The mean individual R2 values were between .97 and .99 for all loading conditions. The %Rep when a given percentage of VL was reached showed interindividual coefficient of variation values ranging from 5% to 20%, decreasing as the %Rep increased in each load condition. Conclusions: Setting a number of repetitions had acceptable interindividual variability, with moderate relative loads being adjusted based on the individual load–velocity relationship. However, to provide a more homogeneous level of effort between athletes, the VL approach should be considered, mainly when using individual VL–%Rep relationships.

Mechanisms of gas exchange with different gases during constant-flow ventilation

1990 ◽  
Vol 68 (1) ◽  
pp. 88-93 ◽  
Author(s):  
F. J. Chen ◽  
A. S. Menon ◽  
S. V. Lichtenstein ◽  
N. Zamel ◽  
A. S. Slutsky
Keyword(s):  
Gas Exchange ◽  
Physical Properties ◽  
Flow Rate ◽  
Constant Flow ◽  
Catheter Position ◽  
Arterial Pco2 ◽  
The Mean ◽  
The Difference ◽  
The Individual ◽  
Different Gases

To investigate the mechanisms responsible for the difference in gas exchange during constant-flow ventilation (CFV) when using gases with different physical properties, we used mixtures of 70% N2-30% O2 (N2-O2) and 70% He-30% O2 (He-O2) as the insufflating gases in 12 dogs. All dogs but one had higher arterial PCO2 (PaCO2) with He-O2 compared with N2-O2. At a flow of 0.37 +/- 0.12 l/s, the mean PaCO2's with N2-O2 and He-O2 were 41.3 +/- 13.9 and 53.7 +/- 20.3 Torr, respectively (P less than 0.01); at a flow rate of 0.84 +/- 0.17 l/s, the mean PaCO2's were 29.1 +/- 11.3 and 35.3 +/- 13.6 Torr, respectively (P less than 0.01). The chest was then opened to alter the apposition between heart and the lungs, thereby reducing the extent of cardiogenic oscillations by 58.4 +/- 18.4%. This intervention did not significantly alter the difference in PaCO2 between N2-O2 and He-O2 from that observed in the intact animals, although the individual PaCO2 values for each gas mixture did increase. When the PaCO2 was plotted against stagnation pressure (rho V2), the difference in PaCO2 between N2-O2 and He-O2 was nearly abolished in both the closed- and open-chest animals. These findings suggest that the different PaCO2's obtained by insufflating gases with different physical properties at a fixed flow rate, catheter position, and lung volume result mainly from a difference in the properties of the jet.

scholarly journals Comparison of Gut Microbiota between Sasang Constitutions

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Bong-Soo Kim ◽  
Hyo Sang Bae ◽  
Chi-yeon Lim ◽  
Mi Jeong Kim ◽  
Jae-gu Seo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Scientific Evidence ◽  
Human Microbiome ◽  
Health Conditions ◽  
Plot Analysis ◽  
Individual Variations ◽  
The Difference ◽  
Constitutional Medicine ◽  
Age Range ◽  
Male Subjects

The Sasang constitutional medicine has long been applied to diagnose and treat patients with various diseases. Studies have been conducted for establishment of scientific evidence supporting Sasang Constitutional (SC) diagnosis. Recent human microbiome studies have demonstrated individual variations of gut microbiota which can be dependent on lifestyle and health conditions. We hypothesized that gut microbial similarities and discrepancies may exist across SC types. We compared the difference of gut microbiota among three constitutions (So-Yang, So-Eum, and Tae-Eum), along with the investigation of anthropometric and biochemical parameters. Firmicutes and Bacteroidetes were predominant phyla in all SC types. The median plot analysis suggested that Firmicutes and Bacteroidetes appeared more abundant in SE and TE, respectively, in the male subjects of 20–29 years old. At the genus level,BifidobacteriumandBacteroidesmanifested the difference between SE and TE types. For anthropometry, body weight, body mass index, and waist circumference of the TE type were significantly higher than those of the other types. Overall, findings indicated a possible link between SC types and gut microbiota within a narrow age range. Further investigations are deemed necessary to elucidate the influences of age, gender, and other factors in the context of SC types and gut microbiota.

scholarly journals Metadiscursive Markers and Text Genre: A Metareview

Publications ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 56
Author(s):  
Miguel Cuevas-Alonso ◽  
Carla Míguez-Álvarez
Keyword(s):  
Academic Discipline ◽  
Mean Values ◽  
Academic Texts ◽  
Units Of Analysis ◽  
Individual Variations ◽  
Text Genre ◽  
The Mean ◽  
The Difference ◽  
Academic Genres ◽  
Object Of Study

Given the interest in the study of metadiscourse as the communication of ideas and the way people use language in different communicative situations, this paper attempted to find the degree of confluence between metadiscourse markers from different studies and to show how patterns of metadiscourse analysis based on various written genres can be applied to a wider range. The mean values for the frequency of marker use and their respective deviations were determined by comparing a significant number of studies on metadiscourse elements. To ensure comparability, those following Hyland’s model were chosen. The units of analysis were grouped into two broad categories based on discursive characteristics: Academic genres (research articles, theses, and textbooks) and non-academic genres, which included documents ranging from newspaper editorials or opinion columns to Internet texts and other forms of digital communication. The results of our study highlight that the disparity in interactive markers between academic and non-academic texts is relatively small. This difference has been identified by previous studies, and it is confirmed herein that the difference may be related to the use of academic language, the topic, or the object of study. In contrast, the mean values of the interactive markers in non-academic texts are considerably higher than those in academic texts. At the same time, the texts seem to be organised along two axes (interactional and interactive) in distinct areas. Despite our initial assumptions that the data would be subject to individual variations, that differences would be found between different sections of the same genre within the same academic discipline, and that the results would vary if certain texts were added or excluded, we observed certain trends in the behaviour of the documents, although it prevailed that, within each category, the texts should be studied individually.

scholarly journals Agreement analysis between critical power and intensity corresponding to 50% in cycling exercise

2016 ◽  
Vol 18 (2) ◽  
pp. 197 ◽  
Author(s):  
Kristopher Mendes de Souza ◽  
Ricardo Dantas de Lucas ◽  
Paulo Cesar do Nascimento Salvador ◽  
Lucas Crescenti Abdalla Saad Helal ◽  
Luiz Guilherme Antonacci Guglielmo ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Lactate Threshold ◽  
Critical Power ◽  
Limits Of Agreement ◽  
Cycling Exercise ◽  
Significant Difference ◽  
The Mean ◽  
The Difference ◽  
Male Subjects ◽  
Level Of Agreement

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n2p197 The purpose of this study was to determine the level of agreement between critical power (CP) and intensity corresponding to 50% of the difference (50% Δ) between oxygen uptake (VO2) at lactate threshold (LT) and maximal oxygen uptake (VO2max) in untrained subjects during cycling exercise. Fifteen healthy male subjects (age: 26.0 ± 3.5 years; body weight: 76.6 ± 10.4 kg; height: 178.2 ± 7.6 cm) volunteered to participate in the study. Each subject performed a series of tests to determine LT, VO2LT, CP, VO2CP, 50% Δ, VO250% Δ, and VO2max. The values of LT, VO2LT, CP, VO2CP, 50% Δ, VO250% Δ and VO2max were 109 ± 15 W, 1.84 ± 0.23 L.min-1, 207 ± 17 W, 2.78 ± 0.27 L.min-1, 206 ± 19 W, 2.77 ± 0.29 L.min-1, and 3.71 ± 0.49 L.min-1, respectively. No significant difference was found between CP and 50% Δ (t = 0.16; p = 0.87) or between VO2CP and VO250% Δ (t = 0.12; p = 0.90). However, the bias ± 95% limits of agreement for comparison between CP and 50% Δ and between VO2CP and VO250% Δ were 1 ± 27 W (0.3 ± 14.1%) and 0.01 ± 0.24 L.min-1 (0.2 ± 8.9%), respectively. In summary, the mean CP and 50% Δ values were not significantly different. However, considering the limits of agreement between the two intensities, CP estimated based on 50% Δ might result in a remarkable error when the absolute variability of individual differences is taken into account

scholarly journals Analysis of Individual Variations in Autonomic Responses to Urban and Forest Environments

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hiromitsu Kobayashi ◽  
Chorong Song ◽  
Harumi Ikei ◽  
Takahide Kagawa ◽  
Yoshifumi Miyazaki
Keyword(s):  
Heart Rate ◽  
Urban Areas ◽  
Young Male ◽  
Autonomic Activity ◽  
Mean Values ◽  
Autonomic Responses ◽  
Conventional Analysis ◽  
Individual Variations ◽  
The Difference ◽  
Male Subjects

Autonomic responses to urban and forest environments were studied in 625 young male subjects. The experimental sites were 57 forests and 57 urban areas across Japan. The subjects viewed the landscape (forest or urban environment) for a period of 15 min while sitting on a chair. During this period, heart rate variability (HRV) was monitored continuously. The results were presented as histograms and analyzed with special reference to individual variations. Approximately 80% of the subjects showed an increase in the parasympathetic indicator of HRV (lnHF), whereas the remaining subjects showed a decrease in the parasympathetic activity. Similarly, 64.0% of the subjects exhibited decreases in the sympathetic indicator of HRV (ln[LF/HF]), whereas the remaining subjects showed opposite responses. Analysis of the distribution of HRV indices (lnHF and ln[LF/HF]) demonstrated the effect of forest environments on autonomic activity more specifically than the conventional analysis based on the difference in mean values.

STUDIES ON THE PATTERN OF CIRCULATING STEROIDS IN THE NORMAL MENSTRUAL CYCLE

1977 ◽  
Vol 84 (2) ◽  
pp. 320-332 ◽  
Author(s):  
A. R. Aedo ◽  
M. Nuñez ◽  
B.-M. Landgren ◽  
S. Z. Cekan ◽  
E. Diczfalusy
Keyword(s):  
Circadian Rhythm ◽  
Plasma Levels ◽  
Circadian Variation ◽  
Circadian Variations ◽  
Mean Values ◽  
Normal Menstrual Cycle ◽  
Menstruating Women ◽  
The Mean ◽  
The Difference ◽  
The Individual

ABSTRACT Circadian variations of the plasma levels of dehydroepiandrosterone, 17-hydroxypregnenolone, pregnenolone and testosterone were investigated by radioimmunoassay in 10 normally menstruating women during the periovulatory period. In seven of the subjects it was also possible to estimate androstenedione and dihydrotestosterone levels. Blood was withdrawn continuously over a period of 48 h at a rate of 4 ml/h by means of a non-thrombogenic pump. The circadian rhythm was studied during 13 3-hour sampling periods (39 h) which were identical in all subjects. Dehydroepiandrosterone, 17-hydroxypregnenolone and pregnenolone showed a marked circadian rhythm with highest mean levels in the morning between 06.00 and 09.00 h and lowest mean levels during the night between 21.00 and 24.00 h. The peak levels of individual subjects coincided completely with the highest mean levels in the case of dehydroepiandrosterone, in 9 out of 10 cases with regard to 17-hydroxypregnenolone and in 8 of 10 cases as far as pregnenolone levels were concerned. The lowest individual levels were more dispersed around the means than were the individual peaks. The difference between the highest (morning hours: 06.00–09.00) and lowest (evening hours: 21.00–24.00) geometeric mean values was 404% for 17-hydroxypregnenolone, 163 % for dehydroepiandrosterone and 71 % for pregnenolone. The mean testosterone levels also exhibited an elevation between 06.00 and 09.00 h which was significant (P < 0.05). However, the individual peak values were scattered from 21.00 h of the first day to 18.00 h of the second day. The mean concentrations of androstenedione showed a significant increase between 06.00 and 18.00 h. The individual peaks were widely dispersed. Hence a uniform circadian rhythm correlated to the levels of the Δl5-steroids mentioned above could not be demonstrated in the case of testosterone and androstenedione. An analysis of variance indicated no significant differences between sampling periods as far as dihydrotestosterone levels were concerned. The extent and regularity of the circadian variation in the plasma levels of the Δl5-steroids studied makes it mandatory to standardize very carefully the exact time of blood withdrawal in any longitudinal study. In view of the sharp changes in the plasma levels during the morning hours, it is suggested that sampling during the afternoon period may provide more constant values.

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