scholarly journals P1766 Comparison of left ventricular stroke volume in healthy adults among regions around the world: results from the World Alliance of Societies of Echocardiography (WASE) Normal Values Study

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
T Miyoshi ◽  
K Addetia ◽  
A Blitz ◽  
R Lang ◽  
F Asch
Keyword(s):  
Ejection Fraction ◽  
Stroke Volume ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Normal Values ◽  
Left Ventricular ◽  
Normative Values ◽  
The World ◽  
American Society

Abstract Funding Acknowledgements WASE Normal Values Study is sponsored by American Society Echocardiography Foundation. OnBehalf the WASE Investigators Background The American Society of Echocardiography (ASE) and the European Association of Cardiovascular Imaging (EACVI) chamber quantification guidelines provide normal reference values for a variety of size and function parameters. While used worldwide, these were predominantly obtained from American and European Caucasian populations and may not represent individuals from other regions around the world. Accordingly, ASE in collaboration with its International Alliance Partners conducted the World Alliance of Societies of Echocardiography (WASE) Normal Values Study to establish and compare normal echocardiographic values across races, ethnicities and countries worldwide. While most previous studies focused on left ventricular (LV) size and ejection fraction, LV stroke volume (SV) in healthy normal subjects has not been well defined. In this report, we aim to examine similarities and differences in normal LV SV indexed by body surface area (SVI) among regions around the world. Methods WASE Normal Values Study is a multinational, observational, cross-sectional study. Individuals free from known cardiac, lung and renal disease were prospectively enrolled with even distribution among age groups and gender. Echocardiographic images were acquired following a standardized protocol. LV SV was assessed by Doppler-derived (LVOT diameter and VTI) and two-dimensional (2D) biplane Simpson’s methods. LV SVI was calculated to account for differences in body size. These measurements were analyzed (TOMTEC) in a single core laboratory following ASE/EACVI Guidelines. Results As of May 2019, LV SV has been analyzed in 1164 cases from 13 countries, representing 8 distinct regions worldwide. In this population, age, body surface area and 2D LV ejection fraction were 47 ± 17 years old (range 18-87 years old), 1.76 ± 0.22 m² (range 0.95-2.44 m²) and 63.2 ± 2.9 % (range 52.7-73.7 %), respectively. LV SV and SVI by Doppler were larger than those obtained by 2D method in all regions. LV SV and SVI in both methods had significant differences among regions (p< 0.0001, Kruskal-Wallis test). LV SV and SVI in South Asia (India) were smallest in both methods and were also significantly smaller than other Asian regions (Figure). North America and Europe had largest LV SV and SVI by Doppler method, while Oceania had largest values by 2D. Conclusions The WASE Normal Values Study shows geographical variability in LV SVI across continents and countries. This information should be considered when determining normative values for SV and SVI. Abstract P1766 Figure.

scholarly journals 104 Left ventricular stroke volume differences among echocardiographic methods in healthy adults from the World Alliance of Societies of Echocardiography (WASE) Normal Values Study

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
T Miyoshi ◽  
K Addetia ◽  
A Blitz ◽  
R Lang ◽  
F Asch
Keyword(s):  
Stroke Volume ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Normal Values ◽  
Left Ventricular ◽  
Healthy Adults ◽  
Friedman Test ◽  
2D And 3D ◽  
Simpson's Rule

Abstract Funding Acknowledgements WASE Normal Values Study is sponsored by American Society Echocardiography Foundation. OnBehalf the WASE Investigators Background Left ventricular (LV) stroke volume (SV) can be determined by multiple ultrasound methods, including Doppler, two- (2D) and three-dimensional (3D) echocardiography. However, how methods compare to each other is not well understood. In this report from the WASE study, we aim to examine and compare normal reference ranges for SV and SV index (SVI) obtained from healthy adults by Doppler, 2D Simpson’s and 3D methods. Methods WASE Normal Values Study is a multinational, observational, cross-sectional study. Individuals free from known cardiac, lung and renal disease were prospectively enrolled with even distribution among age groups and gender. Doppler, 2D and 3D datasets were acquired at the enrolling centers, following a standardized protocol. LV SV was measured by three methods: Doppler (LV outflow tract diameter and velocity time integral), 2D biplane Simpson’s rule and 3D volume method. SV was indexed by body surface area (SVI). All measurements were analyzed (TOMTEC) in two core laboratories (for 2D and 3D) following ASE Guidelines. Methods were compared by Friedman test and Bland-Altman analysis. Results As of May 2019, 646 cases have been analyzed in both 2D and 3D datasets. In this population, age was 45 ± 16 years old (range 18-85) and body surface area was 1.76 ± 0.22 m² (range 0.95-2.44). LV EF by 2D Simpson’s rule and 3D method were 63.2 ± 2.9 and 62.3 ± 5.0 %, respectively (p < 0.0001, Wilcoxon test). SVI by Doppler, 2D and 3D were 39.6 ± 7.6, 33.8 ± 6.5 and 41.0 ± 9.4 ml/m², respectively. There were significant differences between the three methods (p < 0.0001, Friedman test). 2D underestimated SVI compared to Doppler by 14.6% (mean of differences 5.8 ml/m², p < 0.0001) and 3D by 17.6% (7.2 ml/m², p < 0.001). The difference between Doppler and 3D was smaller (3.4% lower by Doppler) but still statistically significant (1.4 ml/m², p = 0.0008). The results are shown in the figure. Conclusions Comparing 3 modalities in a large population of healthy individuals, SV and SVI are underestimated by 2D Simpson’s method. Given the large differences, combining 2D and Doppler or 3D measurements for hemodynamic calculations (such as regurgitant volumes and fraction) should be done with caution. Abstract 104 Figure.

Left ventricular function in pulmonary atresia with intact ventricular septum after systemic-to-pulmonary arterial shunt

1994 ◽  
Vol 4 (2) ◽  
pp. 110-116
Author(s):  
Giuseppe Pacileo ◽  
Carlo Pisacane ◽  
Maria Giovanna Russo ◽  
Raffaele Calabrò
Keyword(s):  
Ejection Fraction ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Pulmonary Atresia ◽  
Shape Index ◽  
Left Ventricular ◽  
Ventricular Septum ◽  
Intact Ventricular Septum

AbstractTo investigate the left ventricular systolic and diastolic function in patients with pulmonary atresia with intact ventricular septum without coronary-cardiac fistulas after a modified Blalock-Taussig shunt, 14 patients (age range 15 days-16.5 months, mean 4.03±5.6 months) and eight control subjects, matched for age, body surface area and heart rate were evaluated by cross-sectional and Doppler echocardiography. The follow-up interval after palliative procedures ranged from 12 days to 16.3 months (mean 3.67±5.6 months). Compared to controls, in the group of patients the ejection fraction was decreased (61±7% vs 68±5%, p=0.022) while the left ventricular end-diastolic volume indexed for body surface area was increased (72.7±10.8 cc/m246.1±12 cc/m2p=0.0001) with normal values of left ventricular mass indexed for body surface area (67.88±20.9 g/m2vs 76±10 g/m2p=NS). Mass-to-volume ratio was lower in patients with pulmonary atresia (0.95±0.38 vs 1.24±0.3, p=0.031). The left ventricular shape index was increased in all patients with pulmonary atresia (1.27±0.26 vs 1±0.01, p=0.009). A significant inverse correlation was noted between the ejection fraction and follow-up (r=−0.71, p=0.04). as well as between the ejection fraction and shape index (r=−0.76, p=0.048). Moreover, the patients with pulmonary atresia had decreased E/A velocity ratio (0.65±0.16 vs 1.35±0.90, p=0.009), decreased normalized peak filling rate (4.16±0.13 sv/s vs 6.88±0.68 sv/s, p=0.0001), increased peak A velocity (0.95±0.17 m/s vs 0.51±0.16 m/s, p=0.0001) and prolonged isovolumic relaxation time (46±5.4 ms vs 34±6.2 ms, p=0.0001) and deceleration time (196.4±32.2 ms vs 116±21.4 ms, p=0.0001). There was a good correlation between the normalized peak filling rate and follow-up (r=−0.80, p=0.04). These data show a progressive compromise of the left ventricular systolic and diastolic function in patients with pulmonary atresia with intact ventricular septum without ventriculocoronary fistulas who had undergone systemic-to-pulmonary arterial shunting. Thus, an earlier biventricular or Fontan type procedure should be recommended.

Normalized Left Ventricular Volumes and Function in Thalassemia Major Patients with Normal Myocardial Iron.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2707-2707
Author(s):  
Mark A. Westwood ◽  
Lisa J. Anderson ◽  
Alicia M. Maceira ◽  
Emma Prescott ◽  
John B. Porter ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Ejection Fraction ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Left Ventricular ◽  
Volume Index ◽  
Iron Loading ◽  
Myocardial Iron ◽  
End Diastolic Volume

Abstract Repeated blood transfusions in Thalassemia Major (TM) may lead to myocardial iron accumulation and death. Left ventricular (LV) function is commonly used to assess for iron overload, however, the reference range in TM for these variables in the absence of myocardial iron loading is not known. We used cardiovascular magnetic resonance (CMR) in 205 TM patients and studied those (N=81) with normal myocardial T2* measurements (T2*>20ms) and by inference without excess myocardial iron. Resting LV volumes and function normalized to body surface area were compared with 40 age and gender matched healthy controls. All LV parameters were significantly different (p<0.05) in TM patients (see tables 1 and 2). The lower limit for ejection fraction was higher in TM (males 59 vs 55%, females 63 vs 59%, both P<0.001). The upper limit for end-diastolic volume index was higher in TM (males 152 vs 105 mL/m2, females 121 vs 99 mL/m2, both P<0.05). In TM the cardiac output index (P<0.001) was increased. In conclusion, at rest TM patients with normal myocardial T2* values and no excess myocardial iron loading have a hyperdynamic circulation and substantially different values for LV parameters compared with controls. Significant misdiagnosis of cardiomyopathy will result from comparison of TM patients with normal ranges. LV Parameters Normalized to Body Surface Area in Males. TM Patients (Mean±SD) Controls (Mean±SD) LV parameters normalized to body surface area for males with mean and standard deviations divided into TM patients with no myocardial iron loading and non-anemic age matched controls. The ejection fraction is not indexed to body surface area as it does not vary significantly with body habitus. LVEDVI - left ventricular end-diastolic volume index, LVESVI - left ventricular end-systolic volume index, LVSVI - left ventricular stroke volume index, LVEF - left ventricular ejection fraction, LVMI - left ventricular mass index, CO - cardiac output, COI cardiac output index. LVEDVI (mL/m 2 ) 97.2±27.2 84.1±10.5 LVESVI (mL/m 2 ) 23.1±5.2 29.6±6.1 LVSVI (mL/m 2 ) 70.8±15.8 54.4±7.1 LVEF 71.0±6.1 64.9±5.0 LVMI (g/m 2 ) 84.6±20.3 75.0±8.4 CO (L/min) 9.8±3.2 6.8±1.5 COI (L/min/m 2 ) 5.7±1.9 3.5±0.7 LV Parameters Normailzed to Body Surface Area in Females TM Patients (Mean±SD) Controls (Mean±SD) LV parameters normalized to body surface area for females with mean and standard deviations divided into TM patients with no myocardial iron loading and non-anemic age matched controls. The ejection fraction is not indexed to body surface area as it does not vary significantly with body habitus. LVEDVI - left ventricular end-diastolic volume index, LVESVI - left ventricular end-systolic volume index, LVSVI - left ventricular stroke volume index, LVEF - left ventricular ejection fraction, LVMI - left ventricular mass index, CO - cardiac output, COI cardiac output index. LVEDVI (mL/m 2 ) 87.4±16.6 79.4±9.8 LVESVI (mL/m 2 ) 20.8±7.3 26.1±4.7 LVSVI (mL/m 2 ) 66.5±12.4 53.3±7.3 LVEF 75.1±5.9 67.1±4.3 LVMI (g/m 2 ) 69.9±17.3 61.9±7.9 CO (L/min) 8.2±2.0 5.8±1.6 COI (L/min/m 2 ) 5.2±1.3 3.4±0.8

Abstract P026: Early Repolarization Pattern is Associated With Increased Left Ventricular Mass and Left Ventricular Hypertrophy: Results From the Dallas Heart Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
David A McNamara ◽  
Ari Bennett ◽  
Jarett D Berry ◽  
Mark S Link
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Left Ventricular ◽  
Percent Body Fat ◽  
Early Repolarization ◽  
Heart Study ◽  
Dallas Heart Study

Introduction: Recent studies have shown an association between early repolarization pattern (ERP) ECG morphology and sudden cardiac death. The role of left ventricular mass (LVM) as a potential mediator of ERP has not been well explored. Methods: Participants in the Dallas Heart Study who underwent an ECG and cardiac MRI (CMR) were assessed for ERP, defined as J-point elevation ≥1 mm in any 2 contiguous leads. We compared participants with and without ERP by age, gender, race/ethnicity, established cardiovascular risk factors of diabetes, hypertension and hyperlipidemia, lean body mass and percent body fat, and CMR-derived LVM, LVM/body surface area, and LVH defined by standard criteria, using Student’s T-tests and chi-squared tests where appropriate. Results: Of the 3,015 participants in our study, 276 (9.2%) had ERP. Participants with ERP were younger (43±9 vs 44±10 yrs, p=0.04), more prevalent in blacks than non-blacks (14 vs 5.0%, p<0.00001), and in men than women (18 vs 2.0%, p<0.00001). Baseline cardiovascular risk factors were not significantly different. Participants with ERP demonstrated higher lean body mass (59±10 vs 52±11 kg, p<0.00001) and lower percent body fat (27±8 vs 36±9%, p<0.00001). The presence of ERP was associated with greater LVM, increased LVM/body surface area, and the presence of LVH in the overall population and in analyses stratified by sex (Table 1). Conclusion: In a large, multi-ethnic cohort, ERP is associated with increased total LVM, increased LVM/body surface area, and LVH. These novel associations may provide insight into the biology of ERP. Further studies investigating the relationship of LVM and LVH with ERP are warranted.

MAXIMUM BREATHING CAPACITY AND VITAL CAPACITY OF MALE CHILDREN AND ADOLESCENTS

PEDIATRICS ◽  
1952 ◽  
Vol 9 (6) ◽  
pp. 659-670
Author(s):  
B. G. FERRIS ◽  
J. L. WHITTENBERGER ◽  
J. R. GALLAGHER
Keyword(s):  
Children And Adolescents ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Vital Capacity ◽  
Normal Values ◽  
Mean Values ◽  
Single Attribute ◽  
Standard Deviations ◽  
The Individual

Expected mean values and a range of normal values (plus or minus two standard deviations) are presented for the vital capacity and the maximum breathing capacity of male children and adolescents. It is recommended that calculations of the above values be based upon four attributes (age, height, weight, and body surface area) rather than upon a prediction deriving from a single attribute (especially in the individual who does not have a standard height and weight for his age).

scholarly journals Maternal Cardiac Assessment at 35 to 37 Weeks Improves Prediction of Development of Preeclampsia

Hypertension ◽  
2020 ◽  
Vol 76 (2) ◽  
pp. 514-522 ◽  
Author(s):  
Coral Garcia-Gonzalez ◽  
Georgios Georgiopoulos ◽  
Samira Abdel Azim ◽  
Fernando Macaya ◽  
Nikos Kametas ◽  
...  
Keyword(s):  
Surface Area ◽  
Left Ventricular Mass ◽  
Body Surface Area ◽  
Risk Score ◽  
Body Surface ◽  
Left Ventricular ◽  
Hazard Ratio ◽  
Interquartile Range ◽  
Ventricular Mass ◽  
Cardiac Indices

Preeclampsia at term accounts for half of maternal deaths from hypertensive disorders. We aimed to assess differences in maternal cardiac indices at 35 +0 to 36 +6 weeks’ gestation between women who subsequently developed preeclampsia at term compared with those with uncomplicated pregnancy and to evaluate whether cardiac indices offer incremental prognostic value to the available screening algorithm for preeclampsia. We recruited 1602 women with singleton pregnancies who attended for a routine hospital visit at 35 +0 to 36 +6 weeks’ gestation between April and November 2018. We recorded maternal characteristics and preeclampsia-risk-score derived from a competing risks model and measured cardiac indices. Preeclampsia developed in 3.12% (50/1602) of participants. Women with preeclampsia, compared with those without, had increased mean arterial pressure (97.6, SD, 5.53 versus 87.9, SD, 6.82 mm Hg), systemic vascular resistance (1500, interquartile range, 1393–1831 versus 1400, interquartile range, 1202–1630 PRU) and preeclampsia-risk-score (23.4, interquartile range, 9.13–40 versus 0.9, interquartile range, 0.32–3.25). Multivariable analysis demonstrated independent association between the incidence of preeclampsia and E/e′ (hazard ratio, 1.19/unit [95% CI, 1.03–1.37]; P =0.018) as well as left ventricular mass indexed for body surface area (hazard ratio, 1.03/[g·m 2 ] [95% CI, 1.003–1.051]; P =0.029). Women with E/e′ ≥7.3 and left ventricular mass indexed for body surface area ≥63.2 g/m 2 had an increased risk for developing preeclampsia, despite low preeclampsia-risk-score <5% (hazard ratio, 20.1 [95% CI, 10.5–38.7], P <0.001). Increased left ventricular mass and E/e′ offer incremental information to available scoring systems and better stratify women at risk of developing preeclampsia at term.

scholarly journals Effectiveness of bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure: an echocardiographic study of left ventricular remodeling.

2015 ◽  
Vol 17 (2) ◽  
pp. 160 ◽  
Author(s):  
Fujian Duan ◽  
Zhi Qi ◽  
Sheng Liu ◽  
Xiuzhang Lu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Left Ventricle ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Lv Mass

Aims: The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. The aim of this study was to evaluate the effectiveness of isolated coronary artery bypass graft combined with bone marrow mononuclear cells (BMMNC) delivered through graft vessels to improve left ventricular remodeling of patients with previous myocardial infarc- tion and chronic heart failure using echocardiography. Material and methods: Patients with previous myocardial infarction and chronic heart failure were randomly allocated to one of the two groups: CABG only (18 patients), or CABG with BMMNC transplantation (24 patients). Echocardiographic parameters were measured on B-mode imaging, 3D imaging and color flow imaging. Results Post-operative LVEDD (end-diastolic dimension of left ventricle), LVESD (end-systolic dimension of left ventricle), LVEDV (end-diastolic volume of left ventricle), LVESV (end-systolic volume of left ventricle), LVEDVI (LVEDV indexed to body surface area), LVESVI (LVESV indexed to body surface area), LV-mass (mass of left ventricle) and LV- massI (LV-mass indexed to body surface area) were significantly improved compared with those obtained prior to operation in CABG+BMMNC group (al p0.05). Postoperative mitral regurgitation score was not significantly different from those prior to opera- tion in both groups (al p>0.05). In Chi-square tests, LVEDD, LVESD, LVEDV, LVESV, LVEDVI, LVESVI, LV-mass, LV- massI were determinants of the left ventricular remodeling. Conclusion: The improvement of left ventricular remodeling in CABG+BMMNC group was better than in the CABG group and this improvement was verified by echocardiography.

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