scholarly journals P282 Left ventricular diastolic dysfunction in asymptomatic type 2 diabetes mellitus with preserved systolic function

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Mouadili ◽  
M Sebani ◽  
C Mbauchy ◽  
M El Hattaoui ◽  
S El Karimi
Keyword(s):  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Systolic Function ◽  
Stress Test ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Type Ii ◽  
Cross Sectional ◽  
Glucose Levels

Abstract The involvement of diabetes in the occurrence of an alteration of the diastolic function of LV is well established. The objective of our study was to evaluate the prevalence of diastolic dysfunction in Type II diabetic patients in light of the latest 2016 recommendations of the American Society of Echocardiography and to identify its associated factors. It was a cross-sectional observational study with a descriptive and analytic focus spread over a 6-month period from July to December 2017.The study included 66 asymptomatic type II diabetic patients, with a normal ECG and a negative stress test ischemia. All hypertensive subjects with an ejection fraction <50%, or those with myocardial, valvular or rhythm disorder, were excluded. The mean age of our patients, was 42 years ± 9 years with extremes ranging from 39 to 84 years, we noted a female predominance (68%) with a sex ratio of 2.14. The prevalence of diastolic dysfunction was 27%. Factors associated with this change in diastolic function were advanced age (p <0.0001), age of diabetes> 10 years (p <0.0001), glycemic imbalance with HbA1c> 7% (p <0) , 0001) and elevated fasting glucose levels (p = 0.039), obesity (p <0.0001), dyslipidemia (p <0.0001) and menopause (p = 0.002). Diastolic dysfunction affects a significant percentage of patients with type II diabetes. Therefore, we propose strict glycemic control in these patients, an early cardiographic echo screening in at-risk subjects, in order to improve their management, and to limit their progression to more serious complications.

Abstract P355: Prevalence of Diastolic Dysfunction With Preserved Left Ventricular Systolic Function in Hypertensive and Type II Diabetic Patients in a Large Community Practice in Greenville, South Carolina

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Naveen R Saxena ◽  
Juhi Saxena ◽  
Anju Saxena ◽  
Vinita Srivastava
Keyword(s):  
Diastolic Dysfunction ◽  
Wave Velocity ◽  
Systolic Function ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Community Practice ◽  
Type Ii ◽  
Sex Distribution ◽  
Hypertensive Patients

Diastolic dysfunction with preserved left ventricle systolic function is a major cause for adverse cardiovascular events in hypertensive and Type II Diabetic patients. Review of medical literature reveals prevalence of diastolic dysfunction in the range of 20 to 60 percent in hypertensive and diabetic patients. The aim of this study is to examine prevalence of diastolic dysfunction with normal systolic function in hypertensive and Type II Diabetic patients in a community practice. This is a retrospective chart review of 3085 hypertensive and 899 type II Diabetic patients. All patients underwent 2D color Doppler studies for the evaluation of diastolic dysfunction using American Society of Echocardiography criteria. E wave velocity, A wave velocity, E to A ratios, and deceleration time were measured. Patients with known systolic heart failure were excluded from the study. The age distribution of the patients in the study ranged from 45 to 85 years with a mean age of 65 years. The sex distribution of the hypertensive patients were 45% male and 55% female. The sex distribution of Type II Diabetic patients were 44% male and 56% female. Given the data, we conclude prevalence of diastolic dysfunction in hypertensive patients is 29% and prevalence of diastolic dysfunction in type II Diabetic patients is 33%. Echocardiography is an excellent tool to risk stratify hypertensive and type II Diabetic patients. Aggressive management of this high-risk group may reduce cardiovascular mortality and morbidity.

scholarly journals Left ventricle diastolic dysfunction in diabetes: an update

2007 ◽  
Vol 51 (2) ◽  
pp. 168-175 ◽  
Author(s):  
Cláudia Maria V. Freire ◽  
Ana Luiza M.T. Moura ◽  
Márcia de Melo Barbosa ◽  
Lucas José de C. Machado ◽  
Anelise Impeliziere Nogueira ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Tissue Doppler ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Detailed Evaluation ◽  
Ventricular Diastolic Dysfunction ◽  
And Function

Diabetes mellitus, a disease that has been reaching epidemic proportions, is an important risk factor to the development of cardiovascular complication. Diabetes causes changes within the cardiac structure and function, even in the absence of atherosclerotic disease. The left ventricular diastolic dysfunction (VE) represents the earliest pre-clinical manifestation of diabetic cardiomyopathy, preceding the systolic dysfunction and being able to evolve to symptomatic heart failure. The doppler echocardiography has emerged as an important noninvasive diagnostic tool, providing reliable data in the stages of diastolic function, as well as for systolic function. With the advent of recent echocardiographic techniques, such as tissue Doppler and color M-mode, the accuracy in identifying the moderate diastolic dysfunction, the pseudonormal pattern, has significantly improved. Due to cardiometabolic repercussions of DM, a detailed evaluation of cardiovascular function in diabetic patients is important, and some alterations may be seen even in patients with gestational diabetes.

scholarly journals Prevalence of left ventricular diastolic dysfunction by echocardiography in type II diabetes mellitus patients

2019 ◽  
Vol 6 (4) ◽  
pp. 1334
Author(s):  
Ansari Mohammed Shoeb Himayun Kabeer ◽  
Shaikh Ambreen Fatema Abdul Hafiz
Keyword(s):  
Diastolic Dysfunction ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Type Ii ◽  
Type 2 Dm ◽  
Ventricular Diastolic Dysfunction

Background: Epidemiological data indicates a greater risk of cardiovascular morbidity and mortality, particularly congestive heart failure in diabetic patients, compared with nondiabetic patients. Heart failure in many patients is due to left Ventricular Diastolic Dysfunction (LVDD), but its prevalence among diabetic adults is still not known, especially in the primary health care settings. Present study aims to evaluate the prevalence of LVDD by Echocardiography in Type II Diabetes Mellitus (DM).Methods: Authors did a prospective study, from May 2012 to August 2014, in Department of Medicine, Dr. D. Y. Patil Hospital, Kolhapur which included 100 randomly selected patients of Type II DM. The diagnosis of Type II DM was done according to the criteria laid down by American Diabetes Association 2012. A detailed clinical history was taken using a structured questionnaire prepared by us and all patients were evaluated for left ventricular function by Echocardiography. Equipment used for echocardiography-Mind ray DC USG, Doppler machine Probe used-7.5MHz.Results: On Echocardiography, Diastolic Dysfunction was found to be prevalent among individuals with Type 2 DM. Duration of DM and increasing age were found to be significantly associated with presence of Diastolic Dysfunction among individuals with Type 2 DM. Maximum number of patients were observed in the age group 51-60 years in our institute. 45% of the patients were asymptomatic, rest of the patients had predominantly cardiac symptoms.Conclusions: It is essential to screen diabetic patients with Echocardiography at an early stage to prevent future cardiovascular complications.

scholarly journals Assessing the Value of BMI and Aerobic Capacity as Surrogate Markers for the Severity of Left Ventricular Diastolic Dysfunction in Patients with Type 2 Diabetes who are Obese

2016 ◽  
Vol 10 ◽  
pp. CMC.S38116
Author(s):  
Cassandra Smith ◽  
Muhammad Asrar Ul Haq ◽  
George Jerums ◽  
Erik Hanson ◽  
Alan Hayes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Ejection Fraction ◽  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Aerobic Capacity ◽  
Systolic Function ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Diastolic Dysfunction

Left ventricular diastolic dysfunction (LVDD) is one of the earliest signs for abnormal cardiac function in patients with type 2 diabetes (T2DM). It is important to explore the risk factors that will assist in identifying the severity of the LVDD in this population. We examined the influences of fitness and fatness on the level of left ventricular (LV) impairment in patients with T2DM. Twenty-five patients (age: 64.0 ± 2.5 years, body mass index [BMI] = 36.0 ± 1.5 kg/m2, mean ± standard error of measurement) with T2DM and preserved systolic function, but impaired diastolic function, mitral valve (MV) E/e′, participated in the study. LV function was assessed using a stress echocardiograph, aerobic power was assessed with a sign- and symptom-limited graded exercise test, and the fatness level was assessed using Dual-energy X-ray absorptiometry and BMI. Patients in the higher 50% of BMI had higher lateral and septal MV E/e′ (~34% and ~25%, respectively, both P < 0.001), compared to those in the lower 50% of BMI, with no difference in LV ejection fraction (LVEF) ( P > 0.05). In addition, a higher BMI correlated with a higher lateral ( r = 0.62, P < 0.001) and septal ( r = 0.56, P < 0.01) E/é. There was no such relationship for VO2peak. BMI and VO2peak were not correlated with LV systolic function (ejection fraction). In individuals with T2DM and diastolic dysfunction, a higher BMI was associated with worsening diastolic function independent of their aerobic capacity. The data provide a simple and practical approach for clinicians to assist in the early identification and diagnostics of functional changes in the heart diastolic function in this population.

A STUDY ON THE CORRELATION BETWEEN MORPHOLOGIC ANORMALIES AND LEFT VENTRICULAR DIASTOLIC FUNCTION IN DILATED CARDIO-MYOPATHY

2011 ◽  
pp. 137-144
Author(s):  
Thi Ngoc Ha Hoang ◽  
Anh Vu Nguyen ◽  
Minh Loi Hoang ◽  
Cuu Long Nguyen ◽  
Thi Thuy Hang Nguyen
Keyword(s):  
Pulmonary Artery ◽  
Dilated Cardiomyopathy ◽  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Pulmonary Arteries ◽  
Left Ventricular ◽  
University Hospital ◽  
Cross Sectional ◽  
X Ray ◽  
Key Words Dilated Cardiomyopathy

Purposes: Describe the morphological and diastolic function of left ventricular changes in the patients with dilated cardiomyopathy (DCM) on US, X-ray findings, and Evaluate the correlation between morphology and diastolic function of left ventricular. Materials and method: Cross sectional study from Dec 2009 to Aug 2010, on 39 patients with dilated cardiomyopathy were evaluated at the University Hospital of Hue College of Medical and Pharmaceutical. Results: 1. X-ray and US findings characteristics of DCM is significantly increased in diameter of L, H and mG; LVM, LVMI, LVDd and LAD. 2. The pression of pulmonary artery has been significantly increased with redistribution pulmonary arteries in 61.5% cases and 23.1% have reversed pulmonary artery distribution. 3. DCM have diastolic dysfunction in 100% patients, including severe disorders to 61.5%; the restrictive dysfunction has ratio E/A>2 and E/Em average was 23.89± 17.23. 4.The correlation between the morphology and function in DCM: the diameter of H and L on the X-ray, LAD and ratio LA/AO on US correlated with the level of diastolic dysfunction (p< 0.05). All three radiographic parameters on the radio standard (H, L, the index Cardio/Thoracic) and LVDd on US have negative correlated with EF and FS with p <0.05. Key words: dilated cardiomyopathy, diastolic dysfunction, cardiac tissue Doppler, reversed pulmonary artery distribution

Nghiên cứu đánh giá chức năng tâm trương thất trái theo khuyến cáo ASE/EACVI 2016 ở bệnh nhân bệnh cơ tim giãn

2021 ◽  
Author(s):  
Quang Tuan Pham
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Diastolic Function ◽  
Ventricular Diastolic Dysfunction ◽  
The Mean

TÓM TẮT Mục tiêu: Khảo sát chức năng tâm trương thất trái theo khuyến cáo ASE/EACVI 2016 ở bệnh nhân bệnh cơ tim giãn bằng siêu âm tim. Tìm hiểu mối liên quan giữa chức năng tâm trương thất trái với tình trạng giãn thất trái, độ suy tim NYHA, phân suất tống máu thất trái, phân suất co cơ thất trái. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 56 bệnh nhân bệnh cơ tim giãn nguyên phát được nhập viện và điều trị tại bệnh viện Trung ương Huế từ tháng 4/2018 đến tháng 8/2020. Kết quả: Đường kính thất trái cuối tâm trương và cuối tâm thu trung bình là 66,11 ± 7,3 mm và 57,7 ± 8,02 mm. Đường kính nhĩ trái trung bình là 40,61 ± 7,65 mm. Phân suất tống máu thất trái trung bình là 24,68 ± 5,97 %. Phân suất co cơ thất trái trung bình là 12,91 ± 4,55 %. Tất cả các bệnh nhân nhóm nghiên cứu đều có rối loạn chức năng tâm trương thất trái. Chiếm tỷ lệ cao nhất là rối loạn chức năng tâm trương độ II (44,6%), tiếp sau là rối loạn chức năng tâm trương độ III (35,8%) và rối loạn chức năng tâm trương độ I là 19,6%. Không có sự liên quan có ý nghĩa thống kê giữa mức độ rối loạn tâm trương thất trái với đường kính thất trái cuối thì tâm thu và tâm trương (p > 0,05). Có mối liên quan giữa rối loạn chức năng tâm trương thất trái với các thông số phân suất tống máu EF và phân suất co cơ FS (p < 0,005). Có sự tương quan thuận mức độ vừa giữa phân độ rối loạn chức năng tâm trương thất trái với phân độ suy tim theo NYHA với r = 0,445, sự tương quan đó có ý nghĩa thống kê (p < 0,001). Kết luận: Tất cả các bệnh nhân bệnh cơ tim giãn trong nhóm nghiên cứu đều có rối loạn chức năng tâm trương thất trái, chủ yếu là rối loạn chức năng tâm trương nặng độ II - III. Sự rối loạn này thể hiện rõ qua sự biến đổi các thông số đánh giá chức năng tâm trương thất trái trên siêu âm tim theo khuyến cáo ASE/ EACVI 2016, một khuyến cáo mới đưa ra nhằm tiếp cận đánh giá chức năng tâm trương một cách thuận tiện và dễ dàng hơn. Từ khóa: Bệnh cơ tim giãn, rối loạn chức năng tâm trương thất trái, khuyến cáo ASE/EACVI 2016 ABSTRACT EVALUATION OF LEFT DYSTOLIC FUNCTION ACCORDING TO THE RECOMMENDATION ASE/EACVI 2016 INPATIENTS WITH DILATED CARDIOMYPAHTIES Background: Dilated cardiomyopathy is a disease of the heart muscle, characterized by dilatation of the heart chamber and a dysfunction of the left or both ventricles. It often leads to progressive heart failure, and is the leading cause of heart transplant among all cardiomyopathy. The annual rate of sudden cardiac death in dilated cardiomyopathy is 2 - 4%, with sudden death accounting for half of all deaths [9]. Echocardiography is an evaluation of a patient with dilated cardiomyopathy. There have been many studies on dilated cardiomyopathy in the world. However, there are still few studies evaluating diastolic function in patients with dilated cardiomyopathy using cardiac Doppler echocardiography. Experts around the world have made many recommendations in assessing left ventricular diastolic function, most recently is the recommendation ASE/EACVI 2016. Comparing with the 2009 EAE/ASE recommendation, the recommendation ASE/EACVI 2016 for assessment of left ventricular diastolic function has fewer parameters, so it is easier to implement and more convenient in clinical practice. Objective: Surveying left ventricular diastolic function according to the recommendation ASE/EACVI 2016 in patients with dilated cardiomyopathy by echocardiography and investigating the relationship between left ventricular diastolic function with left ventricular dilatation, heart failure NYHA, left ventricular ejection fraction, left ventricle fractional shortening. Methods: Research was designed as a cross - sectional descriptive study. Studied on 56 patients with primary dilated cardiomyopathy were hospitalized and treated at Hue Central Hospital. Results: The results showed: The mean end - diastolic and end - systolic left ventricular diameters were 66,11 ± 7,3 mm and 57,7 ± 8,02 mm. The mean left atrial diameter was 40,61 ± 7,65 mm. The mean left ventricular ejection fraction was 24,68 ± 5,97%. The mean fractional shortening of left ventricular contraction was 12,91 ± 4,55%. All patients in the study group had left ventricular diastolic dysfunction. The highest proportion is diastolic dysfunction grade II (44,6%), followed by diastolic dysfunction grade III (35,8%) and diastolic dysfunction grade I is 19,6%. There was no statistically significant relationship between the classification of left ventricular diastolic dysfunction and left ventricular systolic and diastolic diameter (p > 0.05). There is a relationship between left ventricular diastolic dysfunction and parameters of ejection fraction EF and contraction fraction FS (p < 0.005). There is a moderate positive correlation between the classification of left ventricular diastolic dysfunction and the heart failure rating according to NYHA (r = 0,445, p < 0,001). Conclusion: All patients in the study group had left ventricular diastolic dysfunction, mostly grade II and grade III diastolic dysfunction. This disorder is clearly demonstrated by the change in the parameters of the left ventricular diastolic function assessment on echocardiography according to the 2016 ASE/ EACVI recommendations, a new recommendation introduced to approach the assessment of diastolic functionmore convenient and easier way. Key words: Dilated cardiomyopathy, left ventricular diastolic dysfunction, the recommendation ASE / EACVI 2016.

scholarly journals Characteristics of Cirrhosis Patients With Left Ventricular Diastolic Dysfunction In China: A Single-Center Retrospective Study.

2021 ◽  
Author(s):  
Jingjing Hu ◽  
Zhaobin Cai
Keyword(s):  
Diastolic Dysfunction ◽  
Demographic Data ◽  
Laboratory Data ◽  
Alcoholic Cirrhosis ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Cross Sectional ◽  
Ventricular Diastolic Dysfunction ◽  
Inner Diameter

Abstract Objective: Mounting evidence links cirrhosis patients with left ventricular diastolic dysfunction（LVDD） has a poor prognosis. However, little is known about these particular individuals. Therefore, we conducted this cross-sectional study to assess the prevalence of LVDD and its associated risk factors.Methods: Consecutive cirrhosis patient who were attending Hangzhou Xixi hospital from January 2018 to December 2019 were included in this study. According to the American Society of Echocardiography 2016 criteria, cirrhosis patients were sorted into two group: the left ventricular diastolic dysfunction(LVDD) group and left ventricular diastolic function normal(LVDDn) group. Patients’ demographic data, clinical characteristics, laboratory data were recorded. Furthermore, we conducted a multi-factor analysis.Results: A total of 398cirrhosis patients were included in the study. The incidence of LVDD in this study was 49.7% (198 cases). In this study, the mean age and BMI of the patients were 52.9±8.2 years and 23.0±3.3kg/m2，respectively. Of 398 patients, 255(64.1%) of them were males. With regard to etiology, there were 296 patients (74.4%) with hepatitis B cirrhosis and 59 patients (14.8%) with alcoholic cirrhosis. The LVDD group had higher age, higher BMI, greater frequency of ascites and esophageal varices, prolonged prothrombin time, increased international normalized ratio, increased bilirubin, increased CK and AST, and longer QT interval than the LVDDn group(p<0.05, both). In terms of echocardiography, the LVDD group had larger aortic inner diameter, left atrial inner diameter and left ventricular wall diastolic thickness than LVDDn group(p<0.05, both). The multivariate analysis showed age>55 years, BMI>24kg/m2, hepatic decompensated, QTcB>440ms were independently associated with risk of LVDD.Conclusion: The prevalence of LVDD among cirrhosis patients was 49.8%. Cirrhosis patients with LVDD had worse liver function. Further, age>55 years, BMI>24kg/m2, hepatic decompensated, QTcB>440ms were independent predictors of LVDD.

scholarly journals Echocardiographic evaluation of left ventricular diastolic dysfunction in recently diagnosed type 2 diabetes mellitus

2018 ◽  
Vol 6 (5) ◽  
pp. 1691
Author(s):  
Swapnil Jain ◽  
C. L. Nawal ◽  
Amandeep Singh ◽  
Radhey Shyam Chejara ◽  
Sagar Barasara ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
P Value ◽  
Diabetic Patients ◽  
Ventricular Diastolic Dysfunction

Background: Diastolic dysfunction in patients suffering from diabetes mellitus represents an earlier stage in the natural history of cardiomyopathy. This study was done to assess the left ventricular diastolic dysfunction in recently diagnosed (<5yr) Type 2 Diabetes Mellitus by Echocardiography and also to determine association of glycemic status (by HBA1c levels) with left ventricular diastolic dysfunction (LVDD).Methods: An observational descriptive study involving 100 diabetic patients, taken on first come first serve basis after applying inclusion and exclusion criteria. In all the subjects, other than routine investigations, HbA1c was estimated and echocardiography was done to evaluate LVDD.Results: Mean value of HbA1c in the study was 8.31+ 1.408 %. 63 out of 100 subjects had LVDD. There was significant positive correlation between HbA1c and LVDD (p value <0.001). As HbA1c increased, severity of LVDD increased. In this study, as BMI increased, HbA1c and LVDD increased & both findings were statistically significant (p value =0.001).Conclusion: Our study indicates that myocardial damage in patients with diabetes affects diastolic function before systolic function &higher HbA1C level is strongly associated with presence of LVDD. Patients should be advised strict control of diabetes in order to reduce the risk for developing LVDD which is a precursor for more advanced disease.Keywords: Diabetes mellitus, Diastolic dysfunction, BMI, HbA1c

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