Photodynamic therapy for bronchial carcinoid tumours: complete response over a 10-year follow-up

ABSTRACT:Fifty patients with malignant supratentorial tumours were treated with intra-operative photodynamic therapy (PDT); in 33 cases the tumour was recurrent. In 45 patients the tumour was a cerebral glioma and in 5 cases a solitary cerebral metastasis. All patients received a porphyrin photosensitizer 18-24 hours pre-operatively. Photoillumination was carried out at 630 nm to a tumour cavity created by radical tumour resection and/or tumour cyst drainage. The light energy density ranged from 8 to 175 J/cm2. In 8 patients additional interstitial light was administered. The operative mortality was 4%. Follow up has ranged from 1 to 30 months. The median survival for the 45 primary malignant tumours was 8.6 months with a 1 and 2 year actuarial survival rate of 32% and 18%, respectively. In 12 patients a complete or near complete CT scan response was identified post PDT. These patients tended to have a tumour geometry (eg. cystic) that allowed complete or near complete light distribution to the tumour. The median survival for this group was 17.1 months with a 1 and 2 year actuarial survival of 62% and 38%, respectively. In the 33 cases who did not have a complete response the median survival was 6.5 months with a 1 and 2 year actuarial survival of 22% and 11%, respectively. Photodynamic therapy of malignant brain tumours can be carried out with acceptable risk. Good responses appear to be related to adequate light delivery to the tumour.

Download Full-text

Photodynamic therapy for palliation of locally recurrent breast carcinoma.

Journal of Clinical Oncology ◽

10.1200/jco.1987.5.11.1766 ◽

1987 ◽

Vol 5 (11) ◽

pp. 1766-1770 ◽

Cited By ~ 46

Author(s):

M Schuh ◽

U O Nseyo ◽

W R Potter ◽

T L Dao ◽

T J Dougherty

Keyword(s):

Photodynamic Therapy ◽

Breast Carcinoma ◽

Chest Wall ◽

Complete Response ◽

Chest Wall Recurrence ◽

Heavily Pretreated ◽

Locally Recurrent ◽

Recurrent Breast ◽

Lost To Follow Up

Fourteen women with locally recurrent breast carcinoma on the chest wall following mastectomy were given 30 courses of photodynamic therapy (PDT). All patients had been heavily pretreated with conventional modes of therapy (radiation therapy, chemotherapy, hormonal therapy, surgical resection). Twenty-two courses yielded a partial response; two courses yielded a complete response; four courses showed no response; one patient was treated as an adjunct to surgery; and one patient was lost to follow-up. Duration to response was variable, ranging from 6 weeks to 8 months. Several women had chest wall disease controlled for prolonged periods of time using repeated courses of PDT. Two women had re-epithelialization of ulcerated lesions. Complications were minimal and included pain (two patients), sunburn (two), and infection (one). These results suggest that treatment with PDT can aid in local control of chest wall recurrence following mastectomy in selected patients.

Download Full-text

Long Term Effectiveness of Photodynamic Therapy for CIN Treatment

Pharmaceuticals ◽

10.3390/ph12030107 ◽

2019 ◽

Vol 12 (3) ◽

pp. 107 ◽

Cited By ~ 2

Author(s):

Natalia Mayumi Inada ◽

Hilde Harb Buzzá ◽

Marieli Fernanda Martins Leite ◽

Cristina Kurachi ◽

Jose Roberto Trujillo ◽

...

Keyword(s):

Cervical Cancer ◽

Photodynamic Therapy ◽

Placebo Group ◽

Cervical Intraepithelial Neoplasia ◽

Intraepithelial Neoplasia ◽

Complete Response ◽

Incidence Rates ◽

South Central

(1) Background: Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in women worldwide. The highest incidence rates are in Africa, followed by South-Central Asia and South America. According to the Brazilian National Institute of Cancer (INCA), 16,370 new cases of cervical cancer were estimated for each year of the biennium of 2018–2019. About 90% of cervical cancers originate from the malignant progression of cervical intraepithelial neoplasia (CIN) which is classified based on cytohistological characteristics (low- and high-grade lesions). The present study reports the long-term effectiveness of topical photodynamic therapy (PDT) for CIN grades 1 and 2/3 with up to two years of follow up. (2) Methods: A total of 56 patients with CIN 1, ten with CIN 2, and 14 patients for the placebo group were enrolled in this study. (3) Results: 75% (n = 42) of CIN 1 patients presented a complete response to PDT and only 23.2% (n = 13) of recurrence, progression, and/or lesions remaining two years after PDT. For CIN 2/3 patients, 90% were observed to be cured after one and two years of follow up. (4) Conclusions: PDT presented best results two years after a non-invasive, fast, and low-cost procedure and in comparison with the placebo group, preventing the progression of cervical intraepithelial neoplasia and preserving the cervix.

Download Full-text

Treatment of cutaneous lichen planus with ALA-mediated topical photodynamic therapy

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545815400040 ◽

2015 ◽

Vol 08 (01) ◽

pp. 1540004 ◽

Cited By ~ 2

Author(s):

Zhi-Xia Fan ◽

Ling-Lin Zhang ◽

Hong-Wei Wang ◽

Pei-Ru Wang ◽

Zheng Huang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Side Effects ◽

Lichen Planus ◽

Clinical Assessment ◽

Response Rate ◽

Aminolevulinic Acid ◽

Complete Response Rate ◽

Complete Response ◽

Chinese Patients

Purpose: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for the treatment of cutaneous lichen planus (LP). Methods: A total of 17 symptomatic LP lesions in 7 Chinese patients were assessed. ALA cream (10%) was applied topically to LP lesions for 3 h. The lesions were irradiated with a 635 nm diode laser at the dose level of 100 J/cm2. The treatment was repeated at two-week intervals. Clinical assessment was conducted before each treatment. Follow-up was performed once a month for up to six months. Results: Lesions showed significant improvement after one to four courses of treatments. Complete response was achieved in 13 lesions (five patients) and partial remission in four lesions (two patients). The complete response rate was 71%. There was no significant side effects except the feeling of pain that most patients could tolerate. Follow-up of five patients who achieved complete response showed no signs of recurrence. Conclusion: Topical ALA PDT is effective in the treatment of cutaneous LP.

Download Full-text

Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity

The Journal of Laryngology & Otology ◽

10.1017/s0022215100125496 ◽

1993 ◽

Vol 107 (12) ◽

pp. 1140-1145 ◽

Cited By ~ 91

Author(s):

W. E. Grant ◽

C. Hopper ◽

P. M. Speight ◽

A. J. Macrobert ◽

S. G. Bown

Keyword(s):

Photodynamic Therapy ◽

Oral Cavity ◽

Complete Response ◽

Premalignant Lesions ◽

Field Cancerization ◽

Multiple Primary Cancers ◽

Upper Aerodigestive Tract ◽

Multiple Primary ◽

Considerable Problem

The management of patients with ’field cancerization‘ of the oral mucosa, with multicentric foci of invasion, presents a considerable problem for the head and neck surgeon. Surgical resection of synchronous or metachronous primary squamous cell carcinomas, along with adjacent premalignant lesions, is likely to be associated with considerable mutilation. Photodynamic therapy (PDT) has been shown to be of value in the treatment of superficial tumours in the upper aerodigestive tract, with excellent healing of treated areas. This study reports the use of PDT to treat 11 patients with ’field cancerization‘ occurring in the oral cavity. Six patients had multiple primary cancers and five had single primary tumours. All had associated areas of leukoplakia. Each received Photofrin 2 mg/kg 48 hours prior to photoirradiation with 50–100 J/cm² red laser light by surface illumination. Six to eight weeks later treated areas in 10 of the 11 patients showed a complete response to PDT; one patient had areas of residual leukoplakia. Two patients developed further areas of leukoplakia or erythroplakia within 12 months but no patient has had evidence of recurrent invasive carcinoma in the treated areas. Longer term follow-up will be necessary to exclude further recurrence. It is concluded that PDT offers an effective repeatable treatment option, whether on its own or as an adjunct to local excision, for patients with ’field cancerization‘ of the oral cavity.

Download Full-text

Treatment of primary mucosal head and neck squamous cell carcinoma using photodynamic therapy: results after 25 treated cases

The Journal of Laryngology & Otology ◽

10.1258/002221503322334558 ◽

2003 ◽

Vol 117 (9) ◽

pp. 713-717 ◽

Cited By ~ 24

Author(s):

M. G. Dilkes ◽

E. Benjamin ◽

S. Ovaisi ◽

A. S. Banerjee

Keyword(s):

Squamous Cell Carcinoma ◽

Photodynamic Therapy ◽

Head And Neck ◽

Squamous Cell ◽

Complete Response ◽

Primary Treatment ◽

Squamous Cell Carcinomas ◽

Radical Radiotherapy ◽

Wide Range

The use of photodynamic therapy for the treatment of malignant and non-malignant conditions is increasing. This paper demonstrates the efficacy of a second-generation photosensitizer, Foscan®, in the primary treatment of a wide range of mucosal head and neck squamous cell carcinomas. Tumours ranged in stage from T1 to T3. A complete response to primary treatment was seen in 19/21 patients (90 per cent). In laryngeal cancer recurrent after radical radiotherapy, one out of four patients treated obtained a complete response (25 per cent). Six patients (24 per cent) required surgery after photodynamic therapy, for local recurrence or dysplasia. Mean follow up was for 27.3 months (standard deviation 20.6 months).

Download Full-text

A Preliminary Assessment of Macular Function by MF-ERG in Myopic Eyes with CNV with Complete Response to Photodynamic Therapy

European Journal of Ophthalmology ◽

10.1177/112067210301300507 ◽

2003 ◽

Vol 13 (5) ◽

pp. 461-467 ◽

Cited By ~ 9

Author(s):

M.N. Moschos ◽

D. Panayotidis ◽

M.M. Moschos ◽

Chr. Bouros ◽

P.G. Theodossiadis ◽

...

Keyword(s):

Photodynamic Therapy ◽

Electrical Response ◽

Multifocal Electroretinogram ◽

Complete Response ◽

Post Treatment ◽

Pathologic Myopia ◽

Macular Function ◽

Before And After ◽

Visual Acuity Testing

Purpose To evaluate by multifocal electroretinogram (MF-ERG) macular function before and after photodynamic therapy (PDT) in myopic eyes with choroidal neovascularization (CNV). Patients and Methods Ten eyes with classic subfoveal CNV due to pathologic myopia were studied with MF-ERG before and after PDT in order to evaluate the results of PDT with verteporfin. The post-treatment follow-up was 6 months. Visual acuity testing, ophthalmic examinations, fluorescein and indocyanine green angiograms, and MF-ERG recordings were used to evaluate the results of PDT with verteporfin. The post-treatment period was 6 months. Results Before treatment, the electrical response densities in the foveal and perifoveal areas were apparently decreased in all patients. Six months after treatment, the mean retinal response densities in the same areas were found to be higher than before treatment. Conclusions MF-ERG evaluates objectively the macular function in myopic eyes with CNV. After successful PDT, the electrical activity of the foveal and parafoveal areas is higher than before treatment. This finding postulates the efficacy of PDT in the treatment of CNV.

Download Full-text

Evaluation of R-CHOP and R-CVP in the treatment of elderly patient with non-Hodgkin lymphoma

MedPharmRes ◽

10.32895/ump.mpr.3.3.1 ◽

2019 ◽

Vol 3 (3) ◽

pp. 1-6

Author(s):

Truc Phan ◽

Tram Huynh ◽

Tuan Q. Tran ◽

Dung Co ◽

Khoi M. Tran

Keyword(s):

Elderly Patients ◽

Hodgkin Lymphoma ◽

B Cell Lymphoma ◽

Complete Response ◽

The Elderly ◽

Free Survival ◽

Non Hodgkin Lymphoma ◽

Common Sign ◽

Related Mortality

Introduction: Little information is available on the outcomes of R-CHOP (rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) and R-CVP (rituximab with cyclophosphamide, vincristine and prednisone) in treatment of the elderly patients with non-Hodgkin lymphoma (NHL), especially in Vietnam. Material and methods: All patients were newly diagnosed with CD20-positive non-Hodgkin lymphoma (NHL) at Blood Transfusion and Hematology Hospital, Ho Chi Minh city (BTH) between 01/2013 and 01/2018 who were age 60 years or older at diagnosis. A retrospective analysis of these patients was perfomed. Results: Twenty-one Vietnamese patients (6 males and 15 females) were identified and the median age was 68.9 (range 60-80). Most of patients have comorbidities and intermediate-risk. The most common sign was lymphadenopathy (over 95%). The proportion of diffuse large B cell lymphoma (DLBCL) was highest (71%). The percentage of patients reaching complete response (CR) after six cycle of chemotherapy was 76.2%. The median follow-up was 26 months, event-free survival (EFS) was 60% and overall survival (OS) was 75%. Adverse effects of rituximab were unremarkable, treatment-related mortality accounted for less than 10%. There was no difference in drug toxicity between two regimens. Conclusions: R-CHOP, R-CVP yielded a good result and acceptable toxicity in treatment of elderly patients with non-Hodgkin lymphoma. In patients with known cardiac history, omission of anthracyclines is reasonable and R-CVP provides a competitive complete response rate.

Download Full-text